Compound Information
Test on : GPCR
Compound Name : GSK2110236A
Inchikey : KKPGTCOUMOPLRX-UHFFFAOYSA-N
ChemSpider : 24689155
Pubchem CID : 25210971
ChEMBL : CHEMBL456252
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
TK
TK - JakA
Bioactivity |
---|
Kinase | GPCR |
---|
JAK1 | inactive (1.85%) |
TYK2 | inactive (-1.13%) |
JAK2 | inactive (-0.28%) |
JAK3 | inactive (-1.7%) |
TK - Fer
Bioactivity |
---|
Kinase | GPCR |
---|
FER | active (81.63%) |
FES | active (86.81%) |
TK - Abl
Bioactivity |
---|
Kinase | GPCR |
---|
ABL1 | inactive (3.88%) |
ABL2 | inactive (8.21%) |
TK - Csk
Bioactivity |
---|
Kinase | GPCR |
---|
CSK | inactive (-4.71%) |
TK - Tec
Bioactivity |
---|
Kinase | GPCR |
---|
BMX | inactive (1.32%) |
BTK | inactive (1%) |
TXK | inactive (-1.59%) |
TEC | inactive (4.36%) |
ITK | inactive (0.88%) |
TK - Src
Bioactivity |
---|
Kinase | GPCR |
---|
BRK | inactive (3.39%) |
SRM | inactive (3.93%) |
FRK | inactive (8.84%) |
BLK | inactive (10.57%) |
LCK | inactive (6.92%) |
HCK | inactive (16.57%) |
FGR | inactive (10.65%) |
FYN | inactive (6.09%) |
SRC | inactive (6.64%) |
YES | inactive (2.18%) |
TK - Eph
Bioactivity |
---|
Kinase | GPCR |
---|
EphA2 | inactive (-1.44%) |
EphA4 | inactive (4.13%) |
EphA3 | inactive (-0.28%) |
EphB4 | inactive (1.55%) |
EphB3 | inactive (1.02%) |
EphB2 | inactive (5.1%) |
TK - FAK
Bioactivity |
---|
Kinase | GPCR |
---|
PYK2 | active (95.56%) |
TK - Syk
Bioactivity |
---|
Kinase | GPCR |
---|
SYK | inactive (11.24%) |
ZAP70 | inactive (1.86%) |
TK - ALK
Bioactivity |
---|
Kinase | GPCR |
---|
LTK | active (94.9%) |
ALK | active (85.42%) |
TK - Sev
Bioactivity |
---|
Kinase | GPCR |
---|
ROS | active (82.12%) |
TK - InsR
Bioactivity |
---|
Kinase | GPCR |
---|
INSR | active (99.91%) |
IGF1R | active (101.02%) |
IRR | active (97.33%) |
TK - DDR
Bioactivity |
---|
Kinase | GPCR |
---|
DDR2 | inactive (5.59%) |
TK - Musk
Bioactivity |
---|
Kinase | GPCR |
---|
MUSK | inactive (28.6%) |
TK - Trk
Bioactivity |
---|
Kinase | GPCR |
---|
TRKA | inactive (-26.28%) |
TRKB | inactive (3.59%) |
TRKC | inactive (3.92%) |
TK - Met
Bioactivity |
---|
Kinase | GPCR |
---|
RON | inactive (11.52%) |
MET | inactive (7.29%) |
TK - Axl
Bioactivity |
---|
Kinase | GPCR |
---|
AXL | active (66.82%) |
MER | inactive (6.9%) |
TYRO3 | inactive (-21.55%) |
TK - Ret
Bioactivity |
---|
Kinase | GPCR |
---|
RET | inactive (14.22%) |
TK - FGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FGFR1 | inactive (-1.8%) |
FGFR2 | inactive (0.97%) |
FGFR3 | inactive (2.61%) |
FGFR4 | inactive (1.79%) |
TK - VEGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FLT1 | inactive (1.49%) |
KDR | inactive (5.32%) |
FLT4 | inactive (-16.57%) |
TK - PDGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FMS | active (82.83%) |
KIT | inactive (-26.19%) |
FLT3 | inactive (1.45%) |
PDGFRa | inactive (26.08%) |
PDGFRb | inactive (33.93%) |
TK - Tie
Bioactivity |
---|
Kinase | GPCR |
---|
TIE2 | inactive (10.53%) |
TK - Ack
Bioactivity |
---|
Kinase | GPCR |
---|
ACK | inactive (13.19%) |
TNK1 | active (80.19%) |
TK - EGFR
Bioactivity |
---|
Kinase | GPCR |
---|
EGFR | inactive (-20.03%) |
ErbB2 | inactive (1.76%) |
ErbB4 | inactive (35.32%) |
TKL
TKL
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
IRAK | 4 | 1 |
RAF | 5 | 1 |
TKL - IRAK
Bioactivity |
---|
Kinase | GPCR |
---|
IRAK4 | inactive (-1.26%) |
TKL - RAF
Bioactivity |
---|
Kinase | GPCR |
---|
BRAF | inactive (1.67%) |
STE
STE
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
STE20 | 31 | 12 |
STE7 | 7 | 1 |
STE - STE20
Bioactivity |
---|
Kinase | GPCR |
---|
GCK | inactive (11.8%) |
MST1 | inactive (8.27%) |
MST2 | inactive (-17.4%) |
MST4 | inactive (0.17%) |
HGK | inactive (14.93%) |
MINK | inactive (16.98%) |
LOK | inactive (17.4%) |
PAK1 | inactive (0.73%) |
PAK3 | inactive (7.24%) |
PAK2 | inactive (2.11%) |
PAK5 | inactive (-3.49%) |
PAK6 | inactive (5.48%) |
STE - STE7
Bioactivity |
---|
Kinase | GPCR |
---|
MAP2K1 | inactive (-5.54%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
CK1 | 7 | 4 |
CK1 - CK1
Bioactivity |
---|
Kinase | GPCR |
---|
CK1a | inactive (4.2%) |
CK1g2 | inactive (-7.97%) |
CK1g1 | inactive (5.86%) |
CK1g3 | inactive (10.34%) |
Other
Other
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
PLK | 4 | 1 |
Aur | 3 | 3 |
NEK | 11 | 5 |
IKK | 4 | 4 |
TTK | 1 | 1 |
Other - PLK
Bioactivity |
---|
Kinase | GPCR |
---|
PLK1 | active (97.08%) |
Other - Aur
Bioactivity |
---|
Kinase | GPCR |
---|
AurB | inactive (2.92%) |
AurC | inactive (2.53%) |
AurA | inactive (-11.21%) |
Other - NEK
Bioactivity |
---|
Kinase | GPCR |
---|
NEK1 | inactive (0.97%) |
NEK2 | inactive (6.67%) |
NEK9 | inactive (-3.87%) |
NEK7 | inactive (9.62%) |
NEK6 | inactive (-0.11%) |
Other - IKK
Bioactivity |
---|
Kinase | GPCR |
---|
TBK1 | inactive (25.01%) |
IKKe | inactive (9.27%) |
IKKb | inactive (-1.2%) |
IKKa | inactive (-1.3%) |
Other - TTK
Bioactivity |
---|
Kinase | GPCR |
---|
TTK | inactive (36.37%) |
AGC
AGC - GRK
Bioactivity |
---|
Kinase | GPCR |
---|
GPRK7 | active (60.26%) |
GPRK6 | active (82.8%) |
AGC - PDK1
Bioactivity |
---|
Kinase | GPCR |
---|
PDK1 | inactive (0.96%) |
AGC - RSK
Bioactivity |
---|
Kinase | GPCR |
---|
MSK1 | inactive (-0.04%) |
MSK2 | inactive (-0.18%) |
RSK1 | inactive (34.82%) |
RSK2 | inactive (-1.3%) |
RSK4 | inactive (16.38%) |
RSK3 | inactive (7.85%) |
p70S6K | inactive (0.53%) |
AGC - Akt
Bioactivity |
---|
Kinase | GPCR |
---|
AKT2 | inactive (0.91%) |
AKT1 | inactive (-0.06%) |
AKT3 | inactive (4.75%) |
AGC - SGK
Bioactivity |
---|
Kinase | GPCR |
---|
SGK1 | inactive (2.11%) |
SGK3 | inactive (-0.04%) |
SGK2 | inactive (2.84%) |
AGC - PKC
Bioactivity |
---|
Kinase | GPCR |
---|
PKCh | inactive (3.46%) |
PKCg | inactive (-10.24%) |
PKCa | inactive (10.19%) |
PKCt | inactive (10.15%) |
PKCi | inactive (-0.5%) |
AGC - PKG
Bioactivity |
---|
Kinase | GPCR |
---|
PKG2 | inactive (1.58%) |
PKG1 | inactive (-0.01%) |
AGC - PKA
Bioactivity |
---|
Kinase | GPCR |
---|
PRKX | inactive (1.29%) |
AGC - DMPK
Bioactivity |
---|
Kinase | GPCR |
---|
ROCK1 | inactive (26.13%) |
ROCK2 | inactive (23.21%) |
MRCKb | inactive (-0.44%) |
MRCKa | inactive (-0.12%) |
CAMK
CAMK - RAD53
Bioactivity |
---|
Kinase | GPCR |
---|
CHK2 | inactive (11.81%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
DCLK2 | inactive (0.34%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK4 | inactive (12.09%) |
CaMK1d | inactive (-16.3%) |
CAMK - PHK
Bioactivity |
---|
Kinase | GPCR |
---|
PHKg1 | inactive (41.34%) |
PHKg2 | inactive (-0.53%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK2d | inactive (13%) |
CaMK2a | inactive (-4.91%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | GPCR |
---|
MAPKAPK5 | inactive (1.23%) |
MAPKAPK2 | inactive (-2.2%) |
MAPKAPK3 | inactive (6.01%) |
MNK2 | inactive (0.28%) |
MNK1 | inactive (0.17%) |
CAMK - PKD
Bioactivity |
---|
Kinase | GPCR |
---|
PKD3 | active (51.13%) |
PKD1 | inactive (19.78%) |
PKD2 | inactive (39.67%) |
CAMK - CAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
MARK4 | inactive (0.65%) |
MARK3 | inactive (4.97%) |
MARK1 | inactive (5.99%) |
QIK | inactive (5.93%) |
SIK | inactive (-0.04%) |
NuaK1 | inactive (1.85%) |
BRSK1 | inactive (1.57%) |
BRSK2 | inactive (-0.28%) |
MELK | inactive (11.26%) |
CHK1 | inactive (-11.59%) |
PASK | inactive (1.03%) |
AMPKa1 | inactive (-0.4%) |
AMPKa2 | inactive (2.09%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | GPCR |
---|
TSSK2 | active (91.25%) |
TSSK1 | active (95.45%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | GPCR |
---|
DAPK1 | inactive (4.14%) |
CAMK - PIM
Bioactivity |
---|
Kinase | GPCR |
---|
PIM2 | inactive (3.29%) |
PIM3 | inactive (38.29%) |
PIM1 | active (79.83%) |
CMGC
CMGC - MAPK
Bioactivity |
---|
Kinase | GPCR |
---|
JNK2 | inactive (8.04%) |
p38a | inactive (-18.03%) |
p38b | inactive (6.9%) |
p38d | inactive (0.18%) |
Erk2 | inactive (-30.28%) |
Erk1 | inactive (1.75%) |
CMGC - GSK
Bioactivity |
---|
Kinase | GPCR |
---|
GSK3A | inactive (0.89%) |
GSK3B | inactive (2.63%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | GPCR |
---|
SRPK1 | inactive (-0.66%) |
MSSK1 | inactive (-0.38%) |
CMGC - CLK
Bioactivity |
---|
Kinase | GPCR |
---|
CLK3 | inactive (2.92%) |
CLK2 | active (72%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | GPCR |
---|
HIPK1 | inactive (5.85%) |
HIPK4 | inactive (5.44%) |
DYRK1B | inactive (4.64%) |
DYRK1A | inactive (0.58%) |
DYRK2 | inactive (-2.75%) |
CMGC - CK2
Bioactivity |
---|
Kinase | GPCR |
---|
CK2a1 | inactive (37.72%) |