Compound Information
Test on : GPCR
Compound Name : GW829055X
Inchikey : KFMDNTIUGNJKPB-UHFFFAOYSA-N
ChemSpider : 5021890
Pubchem CID : 6539424
ChEMBL : CHEMBL189148
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
TK
TK - JakA
Bioactivity |
---|
Kinase | GPCR |
---|
JAK1 | inactive (-2.06%) |
TYK2 | inactive (-0.64%) |
JAK2 | inactive (0.88%) |
JAK3 | inactive (2.99%) |
TK - Fer
Bioactivity |
---|
Kinase | GPCR |
---|
FER | inactive (4.34%) |
FES | inactive (1.62%) |
TK - Abl
Bioactivity |
---|
Kinase | GPCR |
---|
ABL1 | inactive (27.56%) |
ABL2 | inactive (18.22%) |
TK - Csk
Bioactivity |
---|
Kinase | GPCR |
---|
CSK | inactive (5.89%) |
TK - Tec
Bioactivity |
---|
Kinase | GPCR |
---|
BMX | inactive (13.94%) |
BTK | inactive (2.63%) |
TXK | inactive (14.95%) |
TEC | inactive (15.15%) |
ITK | inactive (2.29%) |
TK - Src
Bioactivity |
---|
Kinase | GPCR |
---|
BRK | inactive (40.24%) |
SRM | inactive (5.97%) |
FRK | inactive (3.48%) |
BLK | inactive (14.97%) |
LCK | active (60.02%) |
HCK | inactive (34.07%) |
FGR | active (70.22%) |
FYN | inactive (43.55%) |
SRC | inactive (39.27%) |
YES | active (89.53%) |
TK - Eph
Bioactivity |
---|
Kinase | GPCR |
---|
EphA2 | inactive (2.12%) |
EphA4 | inactive (23.33%) |
EphA3 | inactive (7.97%) |
EphB4 | inactive (37.2%) |
EphB3 | inactive (5.92%) |
EphB2 | active (55.39%) |
TK - FAK
Bioactivity |
---|
Kinase | GPCR |
---|
PYK2 | inactive (14.74%) |
TK - Syk
Bioactivity |
---|
Kinase | GPCR |
---|
SYK | inactive (2.04%) |
ZAP70 | inactive (0.42%) |
TK - ALK
Bioactivity |
---|
Kinase | GPCR |
---|
LTK | inactive (3.81%) |
ALK | inactive (2.67%) |
TK - Sev
Bioactivity |
---|
Kinase | GPCR |
---|
ROS | inactive (9.1%) |
TK - InsR
Bioactivity |
---|
Kinase | GPCR |
---|
INSR | inactive (4.44%) |
IGF1R | inactive (5.4%) |
IRR | inactive (0.7%) |
TK - DDR
Bioactivity |
---|
Kinase | GPCR |
---|
DDR2 | active (76.7%) |
TK - Musk
Bioactivity |
---|
Kinase | GPCR |
---|
MUSK | inactive (1.46%) |
TK - Trk
Bioactivity |
---|
Kinase | GPCR |
---|
TRKA | inactive (6%) |
TRKB | inactive (3.72%) |
TRKC | inactive (2.21%) |
TK - Met
Bioactivity |
---|
Kinase | GPCR |
---|
RON | inactive (4.63%) |
MET | inactive (4.06%) |
TK - Axl
Bioactivity |
---|
Kinase | GPCR |
---|
AXL | inactive (-0.77%) |
MER | inactive (6.33%) |
TYRO3 | inactive (5.63%) |
TK - Ret
Bioactivity |
---|
Kinase | GPCR |
---|
RET | inactive (41.97%) |
TK - FGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FGFR1 | inactive (7.85%) |
FGFR2 | inactive (10.29%) |
FGFR3 | inactive (6%) |
FGFR4 | inactive (1.94%) |
TK - VEGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FLT1 | inactive (14.63%) |
KDR | inactive (42.15%) |
FLT4 | inactive (16.22%) |
TK - PDGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FMS | inactive (32.29%) |
KIT | active (66.92%) |
FLT3 | inactive (4.19%) |
PDGFRa | inactive (31.34%) |
PDGFRb | inactive (39.4%) |
TK - Tie
Bioactivity |
---|
Kinase | GPCR |
---|
TIE2 | inactive (18.5%) |
TK - Ack
Bioactivity |
---|
Kinase | GPCR |
---|
ACK | inactive (4.09%) |
TNK1 | inactive (11.21%) |
TK - EGFR
Bioactivity |
---|
Kinase | GPCR |
---|
EGFR | active (61.72%) |
ErbB2 | inactive (6.14%) |
ErbB4 | active (69.46%) |
TKL
TKL
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
IRAK | 4 | 1 |
RAF | 5 | 1 |
TKL - IRAK
Bioactivity |
---|
Kinase | GPCR |
---|
IRAK4 | inactive (1.51%) |
TKL - RAF
Bioactivity |
---|
Kinase | GPCR |
---|
BRAF | inactive (4.94%) |
STE
STE
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
STE20 | 31 | 12 |
STE7 | 7 | 1 |
STE - STE20
Bioactivity |
---|
Kinase | GPCR |
---|
GCK | inactive (5.08%) |
MST1 | inactive (0.46%) |
MST2 | inactive (-0.67%) |
MST4 | inactive (2.44%) |
HGK | inactive (39.88%) |
MINK | inactive (33.04%) |
LOK | inactive (40.76%) |
PAK1 | inactive (-0.81%) |
PAK3 | inactive (0.87%) |
PAK2 | inactive (-0.15%) |
PAK5 | inactive (-0.84%) |
PAK6 | inactive (1.5%) |
STE - STE7
Bioactivity |
---|
Kinase | GPCR |
---|
MAP2K1 | inactive (2.28%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
CK1 | 7 | 4 |
CK1 - CK1
Bioactivity |
---|
Kinase | GPCR |
---|
CK1a | inactive (39.57%) |
CK1g2 | inactive (1.83%) |
CK1g1 | inactive (1.87%) |
CK1g3 | inactive (4.02%) |
Other
Other
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
PLK | 4 | 1 |
Aur | 3 | 3 |
NEK | 11 | 5 |
IKK | 4 | 4 |
TTK | 1 | 1 |
Other - PLK
Bioactivity |
---|
Kinase | GPCR |
---|
PLK1 | inactive (3.17%) |
Other - Aur
Bioactivity |
---|
Kinase | GPCR |
---|
AurB | inactive (20.16%) |
AurC | inactive (36.06%) |
AurA | inactive (25.51%) |
Other - NEK
Bioactivity |
---|
Kinase | GPCR |
---|
NEK1 | inactive (1.38%) |
NEK2 | inactive (1.79%) |
NEK9 | inactive (-3.71%) |
NEK7 | inactive (1.34%) |
NEK6 | inactive (2.29%) |
Other - IKK
Bioactivity |
---|
Kinase | GPCR |
---|
TBK1 | inactive (2.57%) |
IKKe | inactive (-3.51%) |
IKKb | inactive (-3.62%) |
IKKa | inactive (0.14%) |
Other - TTK
Bioactivity |
---|
Kinase | GPCR |
---|
TTK | inactive (4.5%) |
AGC
AGC - GRK
Bioactivity |
---|
Kinase | GPCR |
---|
GPRK7 | inactive (-1.87%) |
GPRK6 | inactive (1.72%) |
AGC - PDK1
Bioactivity |
---|
Kinase | GPCR |
---|
PDK1 | inactive (3.32%) |
AGC - RSK
Bioactivity |
---|
Kinase | GPCR |
---|
MSK1 | inactive (2.07%) |
MSK2 | inactive (2.91%) |
RSK1 | inactive (2.48%) |
RSK2 | inactive (1.89%) |
RSK4 | inactive (1.59%) |
RSK3 | inactive (1.37%) |
p70S6K | inactive (-0.24%) |
AGC - Akt
Bioactivity |
---|
Kinase | GPCR |
---|
AKT2 | inactive (1.15%) |
AKT1 | inactive (0.62%) |
AKT3 | inactive (-0.89%) |
AGC - SGK
Bioactivity |
---|
Kinase | GPCR |
---|
SGK1 | inactive (1.09%) |
SGK3 | inactive (-1.01%) |
SGK2 | inactive (0.53%) |
AGC - PKC
Bioactivity |
---|
Kinase | GPCR |
---|
PKCh | inactive (-0.77%) |
PKCg | inactive (-1.39%) |
PKCa | inactive (-0.09%) |
PKCt | inactive (-0.72%) |
PKCi | inactive (0.46%) |
AGC - PKG
Bioactivity |
---|
Kinase | GPCR |
---|
PKG2 | inactive (3.41%) |
PKG1 | inactive (5.54%) |
AGC - PKA
Bioactivity |
---|
Kinase | GPCR |
---|
PRKX | inactive (2.02%) |
AGC - DMPK
Bioactivity |
---|
Kinase | GPCR |
---|
ROCK1 | inactive (4.03%) |
ROCK2 | inactive (3.84%) |
MRCKb | inactive (1.28%) |
MRCKa | inactive (0.52%) |
CAMK
CAMK - RAD53
Bioactivity |
---|
Kinase | GPCR |
---|
CHK2 | inactive (1.08%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
DCLK2 | inactive (6.65%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK4 | inactive (-0.99%) |
CaMK1d | inactive (1.17%) |
CAMK - PHK
Bioactivity |
---|
Kinase | GPCR |
---|
PHKg1 | inactive (3.66%) |
PHKg2 | inactive (0.51%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK2d | inactive (1.08%) |
CaMK2a | inactive (0.86%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | GPCR |
---|
MAPKAPK5 | inactive (-0.73%) |
MAPKAPK2 | inactive (-0.09%) |
MAPKAPK3 | inactive (32.06%) |
MNK2 | inactive (1.38%) |
MNK1 | inactive (3.07%) |
CAMK - PKD
Bioactivity |
---|
Kinase | GPCR |
---|
PKD3 | inactive (4.14%) |
PKD1 | inactive (2.76%) |
PKD2 | inactive (2.67%) |
CAMK - CAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
MARK4 | inactive (1.26%) |
MARK3 | inactive (8.43%) |
MARK1 | inactive (0.37%) |
QIK | inactive (13.9%) |
SIK | inactive (13.59%) |
NuaK1 | inactive (4.21%) |
BRSK1 | inactive (1.52%) |
BRSK2 | inactive (-0.21%) |
MELK | inactive (1.1%) |
CHK1 | inactive (-0.93%) |
PASK | inactive (0.05%) |
AMPKa1 | inactive (0.54%) |
AMPKa2 | inactive (2.26%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | GPCR |
---|
TSSK2 | inactive (-0.46%) |
TSSK1 | inactive (0.18%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | GPCR |
---|
DAPK1 | inactive (-0.24%) |
CAMK - PIM
Bioactivity |
---|
Kinase | GPCR |
---|
PIM2 | inactive (0.51%) |
PIM3 | inactive (0.33%) |
PIM1 | inactive (0.33%) |
CMGC
CMGC - MAPK
Bioactivity |
---|
Kinase | GPCR |
---|
JNK2 | active (73.4%) |
p38a | active (82.75%) |
p38b | active (58.75%) |
p38d | inactive (1.39%) |
Erk2 | inactive (1.18%) |
Erk1 | inactive (0.24%) |
CMGC - GSK
Bioactivity |
---|
Kinase | GPCR |
---|
GSK3A | inactive (12.25%) |
GSK3B | inactive (26.25%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | GPCR |
---|
SRPK1 | inactive (-1.1%) |
MSSK1 | inactive (-1.16%) |
CMGC - CLK
Bioactivity |
---|
Kinase | GPCR |
---|
CLK3 | inactive (2.2%) |
CLK2 | inactive (1.58%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | GPCR |
---|
HIPK1 | inactive (3.25%) |
HIPK4 | inactive (2.83%) |
DYRK1B | inactive (3.34%) |
DYRK1A | inactive (5.74%) |
DYRK2 | inactive (0.66%) |
CMGC - CK2
Bioactivity |
---|
Kinase | GPCR |
---|
CK2a1 | inactive (1.08%) |