Compound Information


Test on : Metz

Compound Name : Kinome_2079

Inchikey : JZTOUVBEZONDKA-UHFFFAOYSA-N

ChemSpider : 11531888

Pubchem CID : 22665513

ChEMBL : CHEMBL1974328




DRx RBC Metz Millipore GPCR
bioactivity Kd (nM) Remain Activity (%) Ki (nM) Remain Activity (%) Inhibition (%)
active criteria <3000nM <50% <1000nM <50% >50%

AGC


Test Member No. in Family
Familyno. Member on 518kinaseMetz
33
73
71
11
52
95
22
31
84
31
AGC - Akt

Bioactivity
KinaseMetz
AKT1inactive (>7943.28nM)
AKT2inactive (>7943.28nM)
AKT3active (316.23nM)
AGC - DMPK

Bioactivity
KinaseMetz
MRCKainactive (1995.26nM)
ROCK1active (63.1nM)
ROCK2active (25.12nM)
AGC - GRK

Bioactivity
KinaseMetz
GPRK5inactive (>1584.89nM)
AGC - PDK1

Bioactivity
KinaseMetz
PDK1active (39.81nM)
AGC - PKA

Bioactivity
KinaseMetz
PKACaactive (158.49nM)
PRKXinactive (>1258.93nM)
AGC - PKC

Bioactivity
KinaseMetz
PKCdactive (125.89nM)
PKCgactive (63.1nM)
PKCz-
PKCiinactive (3162.28nM)
PKCtactive (398.11nM)
AGC - PKG

Bioactivity
KinaseMetz
PKG1inactive (>1995.26nM)
PKG2inactive (>1584.89nM)
AGC - PKN

Bioactivity
KinaseMetz
PKN2active (501.19nM)
AGC - RSK

Bioactivity
KinaseMetz
RSK2active (398.11nM)
p70S6Kactive (125.89nM)
MSK1active (1000nM)
MSK2-
AGC - SGK

Bioactivity
KinaseMetz
SGK1inactive (>7943.28nM)

Atypical


Test Member No. in Family
Familyno. Member on 518kinaseMetz
61
Atypical - Alpha

Bioactivity
KinaseMetz
eEF2K-

CAMK


Test Member No. in Family
Familyno. Member on 518kinaseMetz
52
44
209
52
31
54
21
33
32
11
11
52
CAMK - CAMK1

Bioactivity
KinaseMetz
CaMK1aactive (630.96nM)
CaMK1dinactive (>1584.89nM)
CAMK - CAMK2

Bioactivity
KinaseMetz
CaMK2binactive (>7943.28nM)
CaMK2dactive (398.11nM)
CaMK2gactive (398.11nM)
CaMK2ainactive (>5011.87nM)
CAMK - CAMKL

Bioactivity
KinaseMetz
CHK1inactive (1258.93nM)
BRSK1inactive (3981.07nM)
MARK2-
MARK3active (251.19nM)
MELKinactive (>1000nM)
AMPKa1active (794.33nM)
PASK-
MARK4active (251.19nM)
QIKactive (15.85nM)
CAMK - DAPK

Bioactivity
KinaseMetz
DAPK3active (100nM)
DRAK1active (794.33nM)
CAMK - DCAMKL

Bioactivity
KinaseMetz
DCLK1inactive (>10000nM)
CAMK - MAPKAPK

Bioactivity
KinaseMetz
MAPKAPK2inactive (3981.07nM)
MAPKAPK3inactive (>10000nM)
MNK2active (398.11nM)
MAPKAPK5inactive (>1584.89nM)
CAMK - PHK

Bioactivity
KinaseMetz
PHKg2active (251.19nM)
CAMK - PIM

Bioactivity
KinaseMetz
PIM1inactive (1995.26nM)
PIM2active (100nM)
PIM3active (10nM)
CAMK - PKD

Bioactivity
KinaseMetz
PKD3active (79.43nM)
PKD2active (125.89nM)
CAMK - RAD53

Bioactivity
KinaseMetz
CHK2active (100nM)
CAMK - STK33

Bioactivity
KinaseMetz
STK33-
CAMK - TSSK

Bioactivity
KinaseMetz
TSSK1active (79.43nM)
TSSK2active (79.43nM)

CK1


Test Member No. in Family
Familyno. Member on 518kinaseMetz
75
CK1 - CK1

Bioactivity
KinaseMetz
CK1aactive (1000nM)
CK1dinactive (>7943.28nM)
CK1g1active (1000nM)
CK1g2active (501.19nM)
CK1g3inactive (2511.89nM)

CMGC


Test Member No. in Family
Familyno. Member on 518kinaseMetz
207
31
42
106
22
148
31
CMGC - CDK

Bioactivity
KinaseMetz
CDC2inactive (3981.07nM)
CDK2active (100nM)
CDK5active (316.23nM)
CDK8inactive (3162.28nM)
CDK7active (158.49nM)
CDK9inactive (>1584.89nM)
CDK11-
CMGC - CK2

Bioactivity
KinaseMetz
CK2a1inactive (5011.87nM)
CMGC - CLK

Bioactivity
KinaseMetz
CLK2active (1000nM)
CLK4active (79.43nM)
CMGC - DYRK

Bioactivity
KinaseMetz
DYRK1Ainactive (>1584.89nM)
DYRK3inactive (3981.07nM)
DYRK4inactive (>7943.28nM)
HIPK2active (794.33nM)
HIPK4inactive (5011.87nM)
DYRK1Bactive (794.33nM)
CMGC - GSK

Bioactivity
KinaseMetz
GSK3Ainactive (2511.89nM)
GSK3Binactive (>3162.28nM)
CMGC - MAPK

Bioactivity
KinaseMetz
Erk2inactive (1258.93nM)
p38ginactive (>6309.57nM)
p38dinactive (>7943.28nM)
JNK1inactive (>1584.89nM)
JNK2inactive (>3162.28nM)
p38ainactive (>3981.07nM)
JNK3active (501.19nM)
NLK-
CMGC - SRPK

Bioactivity
KinaseMetz
SRPK1inactive (>7943.28nM)

Other


Test Member No. in Family
Familyno. Member on 518kinaseMetz
32
21
11
44
112
43
11
31
Other - Aur

Bioactivity
KinaseMetz
AurBinactive (>1995.26nM)
AurAinactive (>1584.89nM)
Other - CAMKK

Bioactivity
KinaseMetz
CaMKK2active (158.49nM)
Other - CDC7

Bioactivity
KinaseMetz
CDC7active (63.1nM)
Other - IKK

Bioactivity
KinaseMetz
IKKeinactive (>1995.26nM)
TBK1inactive (>2511.89nM)
IKKa-
IKKb-
Other - NEK

Bioactivity
KinaseMetz
NEK2inactive (>3162.28nM)
NEK4active (1000nM)
Other - PLK

Bioactivity
KinaseMetz
PLK1inactive (>7943.28nM)
PLK3inactive (>7943.28nM)
PLK4active (125.89nM)
Other - TOPK

Bioactivity
KinaseMetz
PBKactive (10nM)
Other - WEE

Bioactivity
KinaseMetz
Wee1-

STE


Test Member No. in Family
Familyno. Member on 518kinaseMetz
319
72
STE - STE20

Bioactivity
KinaseMetz
GCKactive (19.95nM)
HGKactive (50.12nM)
KHS1active (19.95nM)
MINKactive (100nM)
PAK1inactive (3981.07nM)
PAK4active (10nM)
SLKactive (5.01nM)
MST2active (125.89nM)
TAO1inactive (1584.89nM)
STE - STE7

Bioactivity
KinaseMetz
MAP2K1active (501.19nM)
MAP2K2inactive (1258.93nM)

TK


Test Member No. in Family
Familyno. Member on 518kinaseMetz
21
21
22
32
21
43
141
22
22
42
32
43
22
55
11
11
119
21
53
33
33
TK - Abl

Bioactivity
KinaseMetz
ABL1active (251.19nM)
TK - Ack

Bioactivity
KinaseMetz
ACKactive (794.33nM)
TK - ALK

Bioactivity
KinaseMetz
ALKactive (63.1nM)
LTKactive (10nM)
TK - Axl

Bioactivity
KinaseMetz
TYRO3active (316.23nM)
AXL-
TK - Csk

Bioactivity
KinaseMetz
CTKinactive (>1995.26nM)
TK - EGFR

Bioactivity
KinaseMetz
EGFRinactive (>1995.26nM)
ErbB2inactive (>1584.89nM)
ErbB4inactive (>3981.07nM)
TK - Eph

Bioactivity
KinaseMetz
EphA2inactive (>3162.28nM)
TK - FAK

Bioactivity
KinaseMetz
FAKactive (316.23nM)
PYK2-
TK - Fer

Bioactivity
KinaseMetz
FERactive (3.16nM)
FES-
TK - FGFR

Bioactivity
KinaseMetz
FGFR1inactive (3162.28nM)
FGFR3inactive (>1995.26nM)
TK - InsR

Bioactivity
KinaseMetz
IGF1Ractive (199.53nM)
INSRinactive (>5011.87nM)
TK - JakA

Bioactivity
KinaseMetz
JAK2active (630.96nM)
JAK3active (1000nM)
TYK2inactive (1258.93nM)
TK - Met

Bioactivity
KinaseMetz
METactive (1000nM)
RONactive (199.53nM)
TK - PDGFR

Bioactivity
KinaseMetz
FMSactive (1000nM)
FLT3inactive (>1584.89nM)
KITinactive (>3162.28nM)
PDGFRainactive (1258.93nM)
PDGFRbactive (398.11nM)
TK - Ret

Bioactivity
KinaseMetz
RETactive (79.43nM)
TK - Sev

Bioactivity
KinaseMetz
ROSactive (6.31nM)
TK - Src

Bioactivity
KinaseMetz
BLKactive (125.89nM)
LCKinactive (1995.26nM)
LYN-
SRCactive (158.49nM)
FRKactive (10nM)
SRMinactive (>1584.89nM)
FYNactive (630.96nM)
BRKinactive (1995.26nM)
HCKactive (199.53nM)
TK - Syk

Bioactivity
KinaseMetz
SYK-
TK - Tec

Bioactivity
KinaseMetz
BTKinactive (2511.89nM)
ITKinactive (1258.93nM)
BMX-
TK - Trk

Bioactivity
KinaseMetz
TRKAinactive (>2511.89nM)
TRKBinactive (2511.89nM)
TRKCinactive (>2511.89nM)
TK - VEGFR

Bioactivity
KinaseMetz
FLT4-
KDRactive (398.11nM)
FLT1inactive (>1995.26nM)

TKL


Test Member No. in Family
Familyno. Member on 518kinaseMetz
42
41
21
102
51
121
TKL - IRAK

Bioactivity
KinaseMetz
IRAK1active (63.1nM)
IRAK4active (50.12nM)
TKL - LISK

Bioactivity
KinaseMetz
LIMK1inactive (>3162.28nM)
TKL - LRRK

Bioactivity
KinaseMetz
LRRK2active (12.59nM)
TKL - MLK

Bioactivity
KinaseMetz
ZAKinactive (>7943.28nM)
MLK2active (125.89nM)
TKL - RAF

Bioactivity
KinaseMetz
BRAF-
TKL - STKR

Bioactivity
KinaseMetz
ALK2inactive (>3981.07nM)