Compound Information
Test on : GPCR
Compound Name : GSK554170A
Inchikey : JZMFBTBVTPAGEQ-UHFFFAOYSA-N
ChemSpider : 26639412
Pubchem CID : 56603995
ChEMBL : CHEMBL1794065
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
TK
TK - JakA
Bioactivity |
---|
Kinase | GPCR |
---|
JAK1 | inactive (12.53%) |
TYK2 | inactive (1.52%) |
JAK2 | inactive (1.31%) |
JAK3 | inactive (-3.39%) |
TK - Fer
Bioactivity |
---|
Kinase | GPCR |
---|
FER | inactive (6.84%) |
FES | inactive (4.04%) |
TK - Abl
Bioactivity |
---|
Kinase | GPCR |
---|
ABL1 | inactive (2.09%) |
ABL2 | inactive (-2.22%) |
TK - Csk
Bioactivity |
---|
Kinase | GPCR |
---|
CSK | inactive (3.99%) |
TK - Tec
Bioactivity |
---|
Kinase | GPCR |
---|
BMX | inactive (2.37%) |
BTK | inactive (-3.54%) |
TXK | inactive (-1.53%) |
TEC | inactive (0.43%) |
ITK | inactive (-1.96%) |
TK - Src
Bioactivity |
---|
Kinase | GPCR |
---|
BRK | inactive (4.11%) |
SRM | inactive (1.57%) |
FRK | inactive (1.21%) |
BLK | inactive (-1.39%) |
LCK | inactive (-1.12%) |
HCK | inactive (5.41%) |
FGR | inactive (4.9%) |
FYN | inactive (2.15%) |
SRC | inactive (8.65%) |
YES | inactive (6.72%) |
TK - Eph
Bioactivity |
---|
Kinase | GPCR |
---|
EphA2 | inactive (-3.81%) |
EphA4 | inactive (7.66%) |
EphA3 | inactive (-1.92%) |
EphB4 | inactive (-2.94%) |
EphB3 | inactive (-1.35%) |
EphB2 | inactive (7.37%) |
TK - FAK
Bioactivity |
---|
Kinase | GPCR |
---|
PYK2 | inactive (29.72%) |
TK - Syk
Bioactivity |
---|
Kinase | GPCR |
---|
SYK | inactive (-0.6%) |
ZAP70 | inactive (-3.17%) |
TK - ALK
Bioactivity |
---|
Kinase | GPCR |
---|
LTK | inactive (5.07%) |
ALK | inactive (0.19%) |
TK - Sev
Bioactivity |
---|
Kinase | GPCR |
---|
ROS | inactive (5.45%) |
TK - InsR
Bioactivity |
---|
Kinase | GPCR |
---|
INSR | inactive (1.72%) |
IGF1R | inactive (-4.46%) |
IRR | inactive (2.17%) |
TK - DDR
Bioactivity |
---|
Kinase | GPCR |
---|
DDR2 | inactive (1.71%) |
TK - Musk
Bioactivity |
---|
Kinase | GPCR |
---|
MUSK | inactive (3.71%) |
TK - Trk
Bioactivity |
---|
Kinase | GPCR |
---|
TRKA | inactive (2.62%) |
TRKB | inactive (1.98%) |
TRKC | inactive (3.69%) |
TK - Met
Bioactivity |
---|
Kinase | GPCR |
---|
RON | inactive (7.68%) |
MET | inactive (2.5%) |
TK - Axl
Bioactivity |
---|
Kinase | GPCR |
---|
AXL | inactive (-2.43%) |
MER | inactive (1.7%) |
TYRO3 | inactive (3.34%) |
TK - Ret
Bioactivity |
---|
Kinase | GPCR |
---|
RET | inactive (26.28%) |
TK - FGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FGFR1 | inactive (-0.27%) |
FGFR2 | inactive (3.89%) |
FGFR3 | inactive (-1.22%) |
FGFR4 | inactive (-3.68%) |
TK - VEGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FLT1 | inactive (23.53%) |
KDR | active (71.24%) |
FLT4 | inactive (34.82%) |
TK - PDGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FMS | inactive (1.19%) |
KIT | inactive (8.48%) |
FLT3 | inactive (4.4%) |
PDGFRa | inactive (28.55%) |
PDGFRb | inactive (44.62%) |
TK - Tie
Bioactivity |
---|
Kinase | GPCR |
---|
TIE2 | inactive (3.85%) |
TK - Ack
Bioactivity |
---|
Kinase | GPCR |
---|
ACK | inactive (1.2%) |
TNK1 | inactive (10.55%) |
TK - EGFR
Bioactivity |
---|
Kinase | GPCR |
---|
EGFR | inactive (-3.68%) |
ErbB2 | inactive (5.1%) |
ErbB4 | inactive (3.14%) |
TKL
TKL
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
IRAK | 4 | 1 |
RAF | 5 | 1 |
TKL - IRAK
Bioactivity |
---|
Kinase | GPCR |
---|
IRAK4 | inactive (1.24%) |
TKL - RAF
Bioactivity |
---|
Kinase | GPCR |
---|
BRAF | inactive (2.78%) |
STE
STE
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
STE20 | 31 | 12 |
STE7 | 7 | 1 |
STE - STE20
Bioactivity |
---|
Kinase | GPCR |
---|
GCK | inactive (1.95%) |
MST1 | inactive (16.29%) |
MST2 | inactive (14.65%) |
MST4 | inactive (3.31%) |
HGK | inactive (17.57%) |
MINK | inactive (13.26%) |
LOK | inactive (13.55%) |
PAK1 | inactive (7.18%) |
PAK3 | inactive (7.15%) |
PAK2 | inactive (12.73%) |
PAK5 | active (76.03%) |
PAK6 | active (69.3%) |
STE - STE7
Bioactivity |
---|
Kinase | GPCR |
---|
MAP2K1 | inactive (4.1%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
CK1 | 7 | 4 |
CK1 - CK1
Bioactivity |
---|
Kinase | GPCR |
---|
CK1a | inactive (4.34%) |
CK1g2 | inactive (0.7%) |
CK1g1 | inactive (0.65%) |
CK1g3 | inactive (-0.62%) |
Other
Other
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
PLK | 4 | 1 |
Aur | 3 | 3 |
NEK | 11 | 5 |
IKK | 4 | 4 |
TTK | 1 | 1 |
Other - PLK
Bioactivity |
---|
Kinase | GPCR |
---|
PLK1 | inactive (3.24%) |
Other - Aur
Bioactivity |
---|
Kinase | GPCR |
---|
AurB | inactive (0.45%) |
AurC | inactive (-10.37%) |
AurA | inactive (3.09%) |
Other - NEK
Bioactivity |
---|
Kinase | GPCR |
---|
NEK1 | inactive (3.24%) |
NEK2 | inactive (3.71%) |
NEK9 | inactive (8.54%) |
NEK7 | inactive (3.34%) |
NEK6 | inactive (4.94%) |
Other - IKK
Bioactivity |
---|
Kinase | GPCR |
---|
TBK1 | inactive (44.66%) |
IKKe | active (99.1%) |
IKKb | inactive (4.77%) |
IKKa | inactive (7.37%) |
Other - TTK
Bioactivity |
---|
Kinase | GPCR |
---|
TTK | inactive (11.39%) |
AGC
AGC - GRK
Bioactivity |
---|
Kinase | GPCR |
---|
GPRK7 | inactive (23.32%) |
GPRK6 | inactive (11.05%) |
AGC - PDK1
Bioactivity |
---|
Kinase | GPCR |
---|
PDK1 | inactive (6.43%) |
AGC - RSK
Bioactivity |
---|
Kinase | GPCR |
---|
MSK1 | inactive (16.16%) |
MSK2 | inactive (19.24%) |
RSK1 | inactive (19.93%) |
RSK2 | inactive (19.02%) |
RSK4 | inactive (7.82%) |
RSK3 | inactive (7.78%) |
p70S6K | inactive (15.39%) |
AGC - Akt
Bioactivity |
---|
Kinase | GPCR |
---|
AKT2 | active (89.35%) |
AKT1 | active (88.21%) |
AKT3 | active (85.99%) |
AGC - SGK
Bioactivity |
---|
Kinase | GPCR |
---|
SGK1 | inactive (10.53%) |
SGK3 | active (67.36%) |
SGK2 | inactive (8.07%) |
AGC - PKC
Bioactivity |
---|
Kinase | GPCR |
---|
PKCh | active (97.78%) |
PKCg | inactive (39.93%) |
PKCa | inactive (13.38%) |
PKCt | active (65.47%) |
PKCi | inactive (13.47%) |
AGC - PKG
Bioactivity |
---|
Kinase | GPCR |
---|
PKG2 | active (70.07%) |
PKG1 | inactive (48.92%) |
AGC - PKA
Bioactivity |
---|
Kinase | GPCR |
---|
PRKX | active (75.67%) |
AGC - DMPK
Bioactivity |
---|
Kinase | GPCR |
---|
ROCK1 | inactive (13.69%) |
ROCK2 | inactive (27.49%) |
MRCKb | inactive (21.11%) |
MRCKa | inactive (33.25%) |
CAMK
CAMK - RAD53
Bioactivity |
---|
Kinase | GPCR |
---|
CHK2 | inactive (6.65%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
DCLK2 | inactive (-1.26%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK4 | inactive (-2.31%) |
CaMK1d | inactive (0.97%) |
CAMK - PHK
Bioactivity |
---|
Kinase | GPCR |
---|
PHKg1 | inactive (9.61%) |
PHKg2 | inactive (6.94%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK2d | inactive (4.75%) |
CaMK2a | inactive (2.25%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | GPCR |
---|
MAPKAPK5 | inactive (2.94%) |
MAPKAPK2 | inactive (1.63%) |
MAPKAPK3 | inactive (1.31%) |
MNK2 | inactive (4.38%) |
MNK1 | inactive (9.05%) |
CAMK - PKD
Bioactivity |
---|
Kinase | GPCR |
---|
PKD3 | inactive (4.23%) |
PKD1 | inactive (6.01%) |
PKD2 | inactive (3.59%) |
CAMK - CAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
MARK4 | active (54.46%) |
MARK3 | active (68.75%) |
MARK1 | active (61.28%) |
QIK | inactive (18.43%) |
SIK | inactive (18.02%) |
NuaK1 | inactive (37.17%) |
BRSK1 | inactive (6.72%) |
BRSK2 | inactive (10.77%) |
MELK | inactive (31.57%) |
CHK1 | inactive (5.91%) |
PASK | inactive (12.8%) |
AMPKa1 | active (51.91%) |
AMPKa2 | inactive (16.15%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | GPCR |
---|
TSSK2 | inactive (5.17%) |
TSSK1 | active (73.02%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | GPCR |
---|
DAPK1 | inactive (1.75%) |
CAMK - PIM
Bioactivity |
---|
Kinase | GPCR |
---|
PIM2 | inactive (3.34%) |
PIM3 | inactive (20.99%) |
PIM1 | inactive (17.33%) |
CMGC
CMGC - MAPK
Bioactivity |
---|
Kinase | GPCR |
---|
JNK2 | inactive (2.67%) |
p38a | inactive (5.69%) |
p38b | inactive (4.04%) |
p38d | inactive (2.26%) |
Erk2 | inactive (4.1%) |
Erk1 | inactive (6.52%) |
CMGC - GSK
Bioactivity |
---|
Kinase | GPCR |
---|
GSK3A | active (53.94%) |
GSK3B | active (55.41%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | GPCR |
---|
SRPK1 | inactive (1.81%) |
MSSK1 | inactive (3.41%) |
CMGC - CLK
Bioactivity |
---|
Kinase | GPCR |
---|
CLK3 | inactive (-1.7%) |
CLK2 | inactive (29.41%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | GPCR |
---|
HIPK1 | inactive (19.68%) |
HIPK4 | inactive (11.12%) |
DYRK1B | inactive (-0.01%) |
DYRK1A | inactive (1.2%) |
DYRK2 | inactive (1.98%) |
CMGC - CK2
Bioactivity |
---|
Kinase | GPCR |
---|
CK2a1 | inactive (12.81%) |