Compound Information
Test on : GPCR
Compound Name : GW759710A
Inchikey : JSNDMDCDIXZZDC-UHFFFAOYSA-N
ChemSpider : 28485077
Pubchem CID : 57398149
ChEMBL : CHEMBL1909382
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
TK
TK - JakA
Bioactivity |
---|
Kinase | GPCR |
---|
JAK1 | inactive (31.98%) |
TYK2 | inactive (32.36%) |
JAK2 | inactive (46.65%) |
JAK3 | inactive (2.72%) |
TK - Fer
Bioactivity |
---|
Kinase | GPCR |
---|
FER | inactive (14.6%) |
FES | inactive (7.67%) |
TK - Abl
Bioactivity |
---|
Kinase | GPCR |
---|
ABL1 | active (55.64%) |
ABL2 | active (51.88%) |
TK - Csk
Bioactivity |
---|
Kinase | GPCR |
---|
CSK | inactive (9.32%) |
TK - Tec
Bioactivity |
---|
Kinase | GPCR |
---|
BMX | inactive (37.88%) |
BTK | inactive (7.3%) |
TXK | inactive (28.98%) |
TEC | inactive (34.29%) |
ITK | inactive (2.4%) |
TK - Src
Bioactivity |
---|
Kinase | GPCR |
---|
BRK | inactive (36.25%) |
SRM | inactive (5.6%) |
FRK | inactive (11.82%) |
BLK | inactive (13.81%) |
LCK | inactive (14.98%) |
HCK | inactive (30.81%) |
FGR | inactive (30.02%) |
FYN | inactive (43.18%) |
SRC | active (64.77%) |
YES | inactive (22.54%) |
TK - Eph
Bioactivity |
---|
Kinase | GPCR |
---|
EphA2 | inactive (17.92%) |
EphA4 | inactive (29.08%) |
EphA3 | inactive (7.65%) |
EphB4 | inactive (5.23%) |
EphB3 | inactive (2.83%) |
EphB2 | inactive (18.11%) |
TK - FAK
Bioactivity |
---|
Kinase | GPCR |
---|
PYK2 | inactive (25.41%) |
TK - Syk
Bioactivity |
---|
Kinase | GPCR |
---|
SYK | inactive (-2.49%) |
ZAP70 | inactive (4.21%) |
TK - ALK
Bioactivity |
---|
Kinase | GPCR |
---|
LTK | inactive (6.92%) |
ALK | inactive (10.08%) |
TK - Sev
Bioactivity |
---|
Kinase | GPCR |
---|
ROS | active (60.83%) |
TK - InsR
Bioactivity |
---|
Kinase | GPCR |
---|
INSR | inactive (21.13%) |
IGF1R | inactive (20.93%) |
IRR | inactive (1.15%) |
TK - DDR
Bioactivity |
---|
Kinase | GPCR |
---|
DDR2 | inactive (6.93%) |
TK - Musk
Bioactivity |
---|
Kinase | GPCR |
---|
MUSK | inactive (7.74%) |
TK - Trk
Bioactivity |
---|
Kinase | GPCR |
---|
TRKA | inactive (2.65%) |
TRKB | inactive (14.76%) |
TRKC | inactive (5.94%) |
TK - Met
Bioactivity |
---|
Kinase | GPCR |
---|
RON | inactive (5.75%) |
MET | inactive (9.64%) |
TK - Axl
Bioactivity |
---|
Kinase | GPCR |
---|
AXL | inactive (-2.93%) |
MER | inactive (4.99%) |
TYRO3 | active (56.96%) |
TK - Ret
Bioactivity |
---|
Kinase | GPCR |
---|
RET | inactive (26.75%) |
TK - FGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FGFR1 | inactive (10.22%) |
FGFR2 | inactive (12.99%) |
FGFR3 | inactive (9.81%) |
FGFR4 | inactive (1.79%) |
TK - VEGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FLT1 | inactive (16.44%) |
KDR | inactive (44.73%) |
FLT4 | inactive (30.6%) |
TK - PDGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FMS | active (62.55%) |
KIT | active (82.63%) |
FLT3 | inactive (16.5%) |
PDGFRa | inactive (43.44%) |
PDGFRb | active (54.2%) |
TK - Tie
Bioactivity |
---|
Kinase | GPCR |
---|
TIE2 | inactive (10.14%) |
TK - Ack
Bioactivity |
---|
Kinase | GPCR |
---|
ACK | inactive (22.22%) |
TNK1 | inactive (44.29%) |
TK - EGFR
Bioactivity |
---|
Kinase | GPCR |
---|
EGFR | inactive (10.64%) |
ErbB2 | inactive (3.14%) |
ErbB4 | inactive (13.17%) |
TKL
TKL
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
IRAK | 4 | 1 |
RAF | 5 | 1 |
TKL - IRAK
Bioactivity |
---|
Kinase | GPCR |
---|
IRAK4 | inactive (2.52%) |
TKL - RAF
Bioactivity |
---|
Kinase | GPCR |
---|
BRAF | inactive (3.59%) |
STE
STE
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
STE20 | 31 | 12 |
STE7 | 7 | 1 |
STE - STE20
Bioactivity |
---|
Kinase | GPCR |
---|
GCK | inactive (14.06%) |
MST1 | inactive (12.23%) |
MST2 | inactive (6.4%) |
MST4 | inactive (2.97%) |
HGK | inactive (44.85%) |
MINK | inactive (33.3%) |
LOK | inactive (12.26%) |
PAK1 | inactive (2.79%) |
PAK3 | inactive (2.37%) |
PAK2 | inactive (0.69%) |
PAK5 | inactive (1.21%) |
PAK6 | inactive (-5.46%) |
STE - STE7
Bioactivity |
---|
Kinase | GPCR |
---|
MAP2K1 | inactive (1.42%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
CK1 | 7 | 4 |
CK1 - CK1
Bioactivity |
---|
Kinase | GPCR |
---|
CK1a | inactive (1.32%) |
CK1g2 | inactive (1.73%) |
CK1g1 | inactive (1.67%) |
CK1g3 | inactive (0.09%) |
Other
Other
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
PLK | 4 | 1 |
Aur | 3 | 3 |
NEK | 11 | 5 |
IKK | 4 | 4 |
TTK | 1 | 1 |
Other - PLK
Bioactivity |
---|
Kinase | GPCR |
---|
PLK1 | inactive (6.07%) |
Other - Aur
Bioactivity |
---|
Kinase | GPCR |
---|
AurB | inactive (49.3%) |
AurC | active (85.2%) |
AurA | active (65.45%) |
Other - NEK
Bioactivity |
---|
Kinase | GPCR |
---|
NEK1 | inactive (5.37%) |
NEK2 | inactive (1.09%) |
NEK9 | inactive (10.98%) |
NEK7 | inactive (1.47%) |
NEK6 | inactive (0.89%) |
Other - IKK
Bioactivity |
---|
Kinase | GPCR |
---|
TBK1 | inactive (6.93%) |
IKKe | inactive (3.29%) |
IKKb | inactive (22.29%) |
IKKa | inactive (4.67%) |
Other - TTK
Bioactivity |
---|
Kinase | GPCR |
---|
TTK | inactive (6.29%) |
AGC
AGC - GRK
Bioactivity |
---|
Kinase | GPCR |
---|
GPRK7 | inactive (2.39%) |
GPRK6 | inactive (0.77%) |
AGC - PDK1
Bioactivity |
---|
Kinase | GPCR |
---|
PDK1 | inactive (2.72%) |
AGC - RSK
Bioactivity |
---|
Kinase | GPCR |
---|
MSK1 | inactive (0.2%) |
MSK2 | inactive (1.21%) |
RSK1 | inactive (1.35%) |
RSK2 | inactive (1.16%) |
RSK4 | inactive (6.03%) |
RSK3 | inactive (1.94%) |
p70S6K | inactive (1.99%) |
AGC - Akt
Bioactivity |
---|
Kinase | GPCR |
---|
AKT2 | inactive (0.58%) |
AKT1 | inactive (-0.29%) |
AKT3 | inactive (3.46%) |
AGC - SGK
Bioactivity |
---|
Kinase | GPCR |
---|
SGK1 | inactive (-0.08%) |
SGK3 | inactive (-1.45%) |
SGK2 | inactive (3.3%) |
AGC - PKC
Bioactivity |
---|
Kinase | GPCR |
---|
PKCh | inactive (2.62%) |
PKCg | inactive (4.93%) |
PKCa | inactive (4.54%) |
PKCt | inactive (0.72%) |
PKCi | inactive (-1.03%) |
AGC - PKG
Bioactivity |
---|
Kinase | GPCR |
---|
PKG2 | inactive (0.47%) |
PKG1 | inactive (-0.32%) |
AGC - PKA
Bioactivity |
---|
Kinase | GPCR |
---|
PRKX | inactive (0.35%) |
AGC - DMPK
Bioactivity |
---|
Kinase | GPCR |
---|
ROCK1 | inactive (0.46%) |
ROCK2 | inactive (1.52%) |
MRCKb | inactive (1.43%) |
MRCKa | inactive (0.87%) |
CAMK
CAMK - RAD53
Bioactivity |
---|
Kinase | GPCR |
---|
CHK2 | inactive (2.39%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
DCLK2 | inactive (0.44%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK4 | inactive (1.02%) |
CaMK1d | inactive (3.1%) |
CAMK - PHK
Bioactivity |
---|
Kinase | GPCR |
---|
PHKg1 | inactive (3.35%) |
PHKg2 | inactive (0.54%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK2d | inactive (2.08%) |
CaMK2a | inactive (0.53%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | GPCR |
---|
MAPKAPK5 | inactive (-0.56%) |
MAPKAPK2 | inactive (0.05%) |
MAPKAPK3 | inactive (1.85%) |
MNK2 | inactive (8.7%) |
MNK1 | inactive (3.91%) |
CAMK - PKD
Bioactivity |
---|
Kinase | GPCR |
---|
PKD3 | inactive (1.01%) |
PKD1 | inactive (4.25%) |
PKD2 | inactive (0.2%) |
CAMK - CAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
MARK4 | inactive (3.28%) |
MARK3 | inactive (2.35%) |
MARK1 | inactive (2.94%) |
QIK | inactive (25.05%) |
SIK | inactive (36.98%) |
NuaK1 | active (58.18%) |
BRSK1 | inactive (7.42%) |
BRSK2 | inactive (8.9%) |
MELK | inactive (2.88%) |
CHK1 | inactive (1.52%) |
PASK | inactive (0.17%) |
AMPKa1 | inactive (3.96%) |
AMPKa2 | inactive (3.97%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | GPCR |
---|
TSSK2 | inactive (-0.96%) |
TSSK1 | inactive (0.75%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | GPCR |
---|
DAPK1 | inactive (-2.63%) |
CAMK - PIM
Bioactivity |
---|
Kinase | GPCR |
---|
PIM2 | inactive (0.31%) |
PIM3 | inactive (2%) |
PIM1 | inactive (-0.4%) |
CMGC
CMGC - MAPK
Bioactivity |
---|
Kinase | GPCR |
---|
JNK2 | inactive (8.39%) |
p38a | inactive (2.5%) |
p38b | inactive (1.67%) |
p38d | inactive (0.02%) |
Erk2 | inactive (2.19%) |
Erk1 | inactive (1.21%) |
CMGC - GSK
Bioactivity |
---|
Kinase | GPCR |
---|
GSK3A | inactive (21.03%) |
GSK3B | inactive (15.77%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | GPCR |
---|
SRPK1 | inactive (-1.96%) |
MSSK1 | inactive (-0.91%) |
CMGC - CLK
Bioactivity |
---|
Kinase | GPCR |
---|
CLK3 | inactive (2.19%) |
CLK2 | inactive (5.73%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | GPCR |
---|
HIPK1 | inactive (5.3%) |
HIPK4 | inactive (8.46%) |
DYRK1B | inactive (-0.2%) |
DYRK1A | inactive (0.26%) |
DYRK2 | inactive (1.82%) |
CMGC - CK2
Bioactivity |
---|
Kinase | GPCR |
---|
CK2a1 | inactive (3.67%) |