Compound Information
Test on : Metz, GPCR
Compound Name
Metz, GPCR : GW843682X
Inchikey
Same : JSKUWFIZUALZLX-N
Metz, GPCR : JSKUWFIZUALZLX-UHFFFAOYSA-N
ChemSpider
Metz, GPCR : 8002051
Pubchem CID
Metz, GPCR : 9826308
ChEMBL
Metz, GPCR : CHEMBL514499
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
AGC
AGC - Akt
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
AKT1 | inactive (>7943.28nM) | inactive (-2.44%) |
AKT2 | inactive (>7943.28nM) | inactive (-2.54%) |
AKT3 | inactive (>10000nM) | inactive (-1.66%) |
AGC - DMPK
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
MRCKa | inactive (>10000nM) | inactive (-3.27%) |
ROCK1 | inactive (>10000nM) | inactive (4.31%) |
ROCK2 | inactive (>7943.28nM) | inactive (8.03%) |
MRCKb | - | inactive (-0.14%) |
AGC - GRK
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
GPRK5 | - | - |
GPRK7 | - | inactive (6.72%) |
GPRK6 | - | inactive (0.91%) |
AGC - PDK1
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
PDK1 | inactive (>3981.07nM) | inactive (7.65%) |
AGC - PKA
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
PKACa | inactive (>7943.28nM) | - |
PRKX | active (1000nM) | inactive (2.8%) |
AGC - PKC
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
PKCd | - | - |
PKCg | inactive (>7943.28nM) | inactive (0.51%) |
PKCz | inactive (>7943.28nM) | - |
PKCi | - | inactive (3.32%) |
PKCt | - | inactive (3.1%) |
PKCh | - | inactive (5.95%) |
PKCa | - | inactive (-2.48%) |
AGC - PKG
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
PKG1 | active (316.23nM) | inactive (0.86%) |
PKG2 | inactive (>1584.89nM) | inactive (1.12%) |
AGC - PKN
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
PKN2 | inactive (>7943.28nM) | - |
AGC - RSK
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
RSK2 | inactive (7943.28nM) | inactive (11.05%) |
p70S6K | inactive (>6309.57nM) | inactive (3.22%) |
MSK1 | active (251.19nM) | inactive (1.02%) |
MSK2 | - | inactive (5.14%) |
RSK1 | - | inactive (9.54%) |
RSK4 | - | inactive (23.62%) |
RSK3 | - | inactive (8.42%) |
AGC - SGK
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
SGK1 | inactive (>10000nM) | inactive (1.49%) |
SGK3 | - | inactive (1.64%) |
SGK2 | - | inactive (0.81%) |
Atypical
Atypical
Test Member No. in Family |
---|
Family | no. Member on 518kinase | Metz | GPCR |
---|
Alpha | 6 | 1 | - |
Atypical - Alpha
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
eEF2K | inactive (>3981.07nM) | - |
CAMK
CAMK - CAMK1
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
CaMK1a | inactive (>7943.28nM) | - |
CaMK1d | - | inactive (-1.9%) |
CaMK4 | - | inactive (-1.47%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
CaMK2b | inactive (>7943.28nM) | - |
CaMK2d | inactive (>6309.57nM) | inactive (7.03%) |
CaMK2g | inactive (>6309.57nM) | - |
CaMK2a | - | inactive (-0.1%) |
CAMK - CAMKL
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
CHK1 | - | inactive (3.46%) |
BRSK1 | active (251.19nM) | inactive (41.06%) |
MARK2 | inactive (>7943.28nM) | - |
MARK3 | inactive (>6309.57nM) | inactive (21.53%) |
MELK | active (158.49nM) | inactive (10.35%) |
AMPKa1 | inactive (>5011.87nM) | inactive (19.15%) |
PASK | inactive (>1584.89nM) | inactive (0.3%) |
MARK4 | - | inactive (18.37%) |
QIK | - | inactive (35.44%) |
MARK1 | - | inactive (22.1%) |
SIK | - | active (56.61%) |
NuaK1 | - | active (65.53%) |
BRSK2 | - | active (52.38%) |
AMPKa2 | - | inactive (6.24%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
DAPK3 | inactive (>1258.93nM) | - |
DRAK1 | - | - |
DAPK1 | - | inactive (-4.22%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
DCLK1 | inactive (>10000nM) | - |
DCLK2 | - | inactive (-0.6%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
MAPKAPK2 | inactive (>7943.28nM) | inactive (1.47%) |
MAPKAPK3 | inactive (>10000nM) | inactive (4.41%) |
MNK2 | inactive (>10000nM) | inactive (7.89%) |
MAPKAPK5 | active (63.1nM) | inactive (2.23%) |
MNK1 | - | inactive (7.06%) |
CAMK - PHK
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
PHKg2 | inactive (>5011.87nM) | inactive (6.56%) |
PHKg1 | - | inactive (8.75%) |
CAMK - PIM
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
PIM1 | inactive (>10000nM) | inactive (2.8%) |
PIM2 | inactive (>1584.89nM) | inactive (-2.85%) |
PIM3 | - | inactive (5.54%) |
CAMK - PKD
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
PKD3 | inactive (>10000nM) | inactive (-0.49%) |
PKD2 | inactive (>10000nM) | inactive (-1.87%) |
PKD1 | - | inactive (0.99%) |
CAMK - RAD53
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
CHK2 | inactive (>5011.87nM) | inactive (5.56%) |
CAMK - STK33
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
STK33 | - | - |
CAMK - TSSK
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
TSSK1 | active (199.53nM) | inactive (6.32%) |
TSSK2 | active (63.1nM) | inactive (2.55%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | Metz | GPCR |
---|
CK1 | 7 | 5 | 4 |
CK1 - CK1
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
CK1a | inactive (>6309.57nM) | inactive (3.61%) |
CK1d | inactive (>7943.28nM) | - |
CK1g1 | inactive (>6309.57nM) | inactive (2.06%) |
CK1g2 | inactive (>7943.28nM) | inactive (1.15%) |
CK1g3 | - | inactive (1.63%) |
CMGC
CMGC - CDK
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
CDC2 | inactive (>7943.28nM) | - |
CDK2 | inactive (>7943.28nM) | - |
CDK5 | inactive (>10000nM) | - |
CDK8 | - | - |
CDK7 | - | - |
CDK9 | - | - |
CDK11 | inactive (>100000nM) | - |
CMGC - CK2
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
CK2a1 | - | inactive (8.83%) |
CMGC - CLK
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
CLK2 | inactive (>7943.28nM) | inactive (6.82%) |
CLK4 | active (398.11nM) | - |
CLK3 | - | inactive (-2.17%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
DYRK1A | inactive (5011.87nM) | inactive (2.2%) |
DYRK3 | inactive (>6309.57nM) | - |
DYRK4 | - | - |
HIPK2 | inactive (>3162.28nM) | - |
HIPK4 | inactive (>7943.28nM) | inactive (40.65%) |
DYRK1B | - | inactive (-2.84%) |
HIPK1 | - | inactive (4.22%) |
DYRK2 | - | inactive (3.25%) |
CMGC - GSK
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
GSK3A | inactive (>7943.28nM) | inactive (4.9%) |
GSK3B | inactive (1995.26nM) | inactive (7.21%) |
CMGC - MAPK
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
Erk2 | inactive (>7943.28nM) | inactive (6.38%) |
p38g | inactive (>6309.57nM) | - |
p38d | inactive (>7943.28nM) | inactive (5.14%) |
JNK1 | inactive (>3162.28nM) | - |
JNK2 | inactive (>3981.07nM) | inactive (2.16%) |
p38a | - | inactive (9.56%) |
JNK3 | - | - |
NLK | - | - |
p38b | - | inactive (7.82%) |
Erk1 | - | inactive (3.77%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
SRPK1 | inactive (>7943.28nM) | inactive (0.47%) |
MSSK1 | - | inactive (5.51%) |
Other
Other - Aur
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
AurB | inactive (>6309.57nM) | inactive (26.55%) |
AurA | inactive (>3981.07nM) | inactive (13.73%) |
AurC | - | inactive (35.93%) |
Other - CAMKK
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
CaMKK2 | - | - |
Other - CDC7
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
CDC7 | inactive (>1258.93nM) | - |
Other - IKK
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
IKKe | - | inactive (5.84%) |
TBK1 | - | inactive (13.58%) |
IKKa | inactive (>3981.07nM) | inactive (3.6%) |
IKKb | inactive (>3162.28nM) | inactive (5.75%) |
Other - NEK
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
NEK2 | active (501.19nM) | inactive (17.09%) |
NEK4 | inactive (>6309.57nM) | - |
NEK1 | - | inactive (19.05%) |
NEK9 | - | active (58.69%) |
NEK7 | - | inactive (5.2%) |
NEK6 | - | inactive (2.1%) |
Other - PLK
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
PLK1 | active (12.59nM) | active (96.27%) |
PLK3 | active (7.94nM) | - |
PLK4 | active (199.53nM) | - |
Other - TOPK
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
PBK | inactive (>10000nM) | - |
Other - WEE
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
Wee1 | - | - |
Other - TTK
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
TTK | - | inactive (10.1%) |
STE
STE
Test Member No. in Family |
---|
Family | no. Member on 518kinase | Metz | GPCR |
---|
STE20 | 31 | 9 | 12 |
STE7 | 7 | 2 | 1 |
STE - STE20
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
GCK | inactive (>6309.57nM) | inactive (18.1%) |
HGK | active (251.19nM) | inactive (30.15%) |
KHS1 | active (199.53nM) | - |
MINK | inactive (>7943.28nM) | inactive (25.5%) |
PAK1 | inactive (>10000nM) | inactive (7.26%) |
PAK4 | inactive (>5011.87nM) | - |
SLK | active (12.59nM) | - |
MST2 | active (199.53nM) | active (52.76%) |
TAO1 | inactive (>10000nM) | - |
MST1 | - | active (55.54%) |
MST4 | - | inactive (-13.33%) |
LOK | - | active (88.3%) |
PAK3 | - | inactive (5.02%) |
PAK2 | - | inactive (1.77%) |
PAK5 | - | inactive (2.59%) |
PAK6 | - | inactive (-0.46%) |
STE - STE7
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
MAP2K1 | - | inactive (2.9%) |
MAP2K2 | - | - |
TK
TK - Abl
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
ABL1 | inactive (>630.96nM) | inactive (17.87%) |
ABL2 | - | inactive (13.24%) |
TK - Ack
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
ACK | - | inactive (6.53%) |
TNK1 | - | active (59.13%) |
TK - ALK
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
ALK | - | inactive (5.04%) |
LTK | - | inactive (4.35%) |
TK - Axl
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
TYRO3 | - | inactive (10.34%) |
AXL | active (251.19nM) | inactive (-1.95%) |
MER | - | inactive (9.28%) |
TK - Csk
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
CTK | - | - |
CSK | - | inactive (9.28%) |
TK - EGFR
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
EGFR | active (251.19nM) | inactive (3.5%) |
ErbB2 | active (1000nM) | inactive (4.42%) |
ErbB4 | inactive (>3981.07nM) | inactive (11.76%) |
TK - Eph
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
EphA2 | inactive (>3162.28nM) | inactive (3.23%) |
EphA4 | - | inactive (23.34%) |
EphA3 | - | inactive (7.13%) |
EphB4 | - | inactive (1.61%) |
EphB3 | - | inactive (0.77%) |
EphB2 | - | inactive (17.27%) |
TK - FAK
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
FAK | active (501.19nM) | - |
PYK2 | active (158.49nM) | inactive (19.35%) |
TK - Fer
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
FER | - | inactive (10.53%) |
FES | - | inactive (1.4%) |
TK - FGFR
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
FGFR1 | inactive (3981.07nM) | inactive (13%) |
FGFR3 | inactive (>1995.26nM) | inactive (18.25%) |
FGFR2 | - | inactive (20.87%) |
FGFR4 | - | inactive (-1.16%) |
TK - InsR
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
IGF1R | inactive (>1000nM) | inactive (-2.72%) |
INSR | inactive (>5011.87nM) | inactive (2.13%) |
IRR | - | inactive (3.34%) |
TK - JakA
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
JAK2 | inactive (1258.93nM) | inactive (1.84%) |
JAK3 | active (199.53nM) | inactive (-2.61%) |
TYK2 | inactive (>1995.26nM) | inactive (-6.76%) |
JAK1 | - | inactive (2.62%) |
TK - Met
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
MET | inactive (>3162.28nM) | inactive (19.5%) |
RON | - | inactive (8.36%) |
TK - PDGFR
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
FMS | active (501.19nM) | inactive (29.05%) |
FLT3 | active (50.12nM) | inactive (9.95%) |
KIT | active (125.89nM) | inactive (20.46%) |
PDGFRa | - | active (83.53%) |
PDGFRb | - | active (83.5%) |
TK - Ret
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
RET | - | inactive (41.65%) |
TK - Sev
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
ROS | - | inactive (20.55%) |
TK - Src
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
BLK | inactive (>1584.89nM) | inactive (17.77%) |
LCK | inactive (1995.26nM) | inactive (12.6%) |
LYN | inactive (>1584.89nM) | - |
SRC | inactive (5011.87nM) | inactive (21.16%) |
FRK | - | inactive (3.46%) |
SRM | - | inactive (-0.81%) |
FYN | inactive (>794.33nM) | inactive (9.2%) |
BRK | - | inactive (5.16%) |
HCK | - | inactive (29.25%) |
FGR | - | inactive (14.59%) |
YES | - | inactive (7.91%) |
TK - Syk
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
SYK | - | inactive (-7.75%) |
ZAP70 | - | inactive (-1.32%) |
TK - Tec
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
BTK | - | inactive (-1.82%) |
ITK | active (1000nM) | inactive (-0.36%) |
BMX | - | inactive (8.1%) |
TXK | - | inactive (2.84%) |
TEC | - | inactive (7.03%) |
TK - Trk
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
TRKA | active (398.11nM) | inactive (5.01%) |
TRKB | inactive (>5011.87nM) | inactive (10.17%) |
TRKC | - | inactive (10.36%) |
TK - VEGFR
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
FLT4 | active (100nM) | active (53.11%) |
KDR | active (251.19nM) | active (68.9%) |
FLT1 | active (125.89nM) | inactive (9.39%) |
TK - DDR
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
DDR2 | - | inactive (7.43%) |
TK - Musk
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
MUSK | - | inactive (32.67%) |
TK - Tie
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
TIE2 | - | inactive (20.9%) |
TKL
TKL - IRAK
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
IRAK1 | inactive (>7943.28nM) | - |
IRAK4 | inactive (>10000nM) | inactive (1.85%) |
TKL - LISK
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
LIMK1 | inactive (7943.28nM) | - |
TKL - LRRK
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
LRRK2 | - | - |
TKL - MLK
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
ZAK | inactive (>7943.28nM) | - |
MLK2 | - | - |
TKL - RAF
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
BRAF | - | inactive (4.85%) |
TKL - STKR
Bioactivity |
---|
Kinase | Metz | GPCR |
---|
ALK2 | - | - |