Compound Information
Test on : GPCR
Compound Name : GW572401X
Inchikey : IXAUVBHKVRFJHO-UHFFFAOYSA-N
ChemSpider : 4487006
Pubchem CID : 5329855
ChEMBL : CHEMBL275473
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
TK
TK - JakA
Bioactivity |
---|
Kinase | GPCR |
---|
JAK1 | inactive (0.33%) |
TYK2 | inactive (0.12%) |
JAK2 | inactive (1.73%) |
JAK3 | inactive (2.16%) |
TK - Fer
Bioactivity |
---|
Kinase | GPCR |
---|
FER | inactive (4.52%) |
FES | inactive (-0.42%) |
TK - Abl
Bioactivity |
---|
Kinase | GPCR |
---|
ABL1 | inactive (28.05%) |
ABL2 | inactive (36.61%) |
TK - Csk
Bioactivity |
---|
Kinase | GPCR |
---|
CSK | inactive (5.35%) |
TK - Tec
Bioactivity |
---|
Kinase | GPCR |
---|
BMX | inactive (7.38%) |
BTK | inactive (3.38%) |
TXK | inactive (24.95%) |
TEC | inactive (11.9%) |
ITK | inactive (2.62%) |
TK - Src
Bioactivity |
---|
Kinase | GPCR |
---|
BRK | inactive (3.3%) |
SRM | inactive (3.53%) |
FRK | inactive (9.88%) |
BLK | inactive (31.44%) |
LCK | inactive (24.84%) |
HCK | inactive (28.1%) |
FGR | inactive (38.84%) |
FYN | inactive (45.22%) |
SRC | active (56.36%) |
YES | active (58.58%) |
TK - Eph
Bioactivity |
---|
Kinase | GPCR |
---|
EphA2 | inactive (2.14%) |
EphA4 | inactive (13.75%) |
EphA3 | inactive (2.35%) |
EphB4 | inactive (7.93%) |
EphB3 | inactive (0.54%) |
EphB2 | inactive (15.14%) |
TK - FAK
Bioactivity |
---|
Kinase | GPCR |
---|
PYK2 | inactive (16.48%) |
TK - Syk
Bioactivity |
---|
Kinase | GPCR |
---|
SYK | inactive (-0.04%) |
ZAP70 | inactive (-0.02%) |
TK - ALK
Bioactivity |
---|
Kinase | GPCR |
---|
LTK | inactive (-0.4%) |
ALK | inactive (4.19%) |
TK - Sev
Bioactivity |
---|
Kinase | GPCR |
---|
ROS | inactive (19%) |
TK - InsR
Bioactivity |
---|
Kinase | GPCR |
---|
INSR | inactive (2.35%) |
IGF1R | inactive (7.98%) |
IRR | inactive (0.72%) |
TK - DDR
Bioactivity |
---|
Kinase | GPCR |
---|
DDR2 | inactive (17.53%) |
TK - Musk
Bioactivity |
---|
Kinase | GPCR |
---|
MUSK | inactive (6.08%) |
TK - Trk
Bioactivity |
---|
Kinase | GPCR |
---|
TRKA | inactive (41.48%) |
TRKB | inactive (41.46%) |
TRKC | inactive (35.23%) |
TK - Met
Bioactivity |
---|
Kinase | GPCR |
---|
RON | inactive (-1.9%) |
MET | inactive (4.3%) |
TK - Axl
Bioactivity |
---|
Kinase | GPCR |
---|
AXL | inactive (-0.53%) |
MER | inactive (2.09%) |
TYRO3 | inactive (45.81%) |
TK - Ret
Bioactivity |
---|
Kinase | GPCR |
---|
RET | inactive (36.2%) |
TK - FGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FGFR1 | inactive (23.69%) |
FGFR2 | active (54.61%) |
FGFR3 | active (59.51%) |
FGFR4 | inactive (3.57%) |
TK - VEGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FLT1 | inactive (30.57%) |
KDR | active (68.05%) |
FLT4 | active (85.54%) |
TK - PDGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FMS | active (84.81%) |
KIT | active (87.83%) |
FLT3 | active (53.4%) |
PDGFRa | active (50.67%) |
PDGFRb | active (63.8%) |
TK - Tie
Bioactivity |
---|
Kinase | GPCR |
---|
TIE2 | inactive (14%) |
TK - Ack
Bioactivity |
---|
Kinase | GPCR |
---|
ACK | inactive (1.62%) |
TNK1 | active (72.06%) |
TK - EGFR
Bioactivity |
---|
Kinase | GPCR |
---|
EGFR | inactive (3.96%) |
ErbB2 | inactive (2.81%) |
ErbB4 | inactive (6.51%) |
TKL
TKL
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
IRAK | 4 | 1 |
RAF | 5 | 1 |
TKL - IRAK
Bioactivity |
---|
Kinase | GPCR |
---|
IRAK4 | inactive (0.8%) |
TKL - RAF
Bioactivity |
---|
Kinase | GPCR |
---|
BRAF | inactive (0.29%) |
STE
STE
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
STE20 | 31 | 12 |
STE7 | 7 | 1 |
STE - STE20
Bioactivity |
---|
Kinase | GPCR |
---|
GCK | inactive (1.77%) |
MST1 | inactive (11.02%) |
MST2 | inactive (9.26%) |
MST4 | inactive (2.13%) |
HGK | inactive (7.43%) |
MINK | inactive (7.11%) |
LOK | inactive (8.37%) |
PAK1 | inactive (3.9%) |
PAK3 | inactive (1.76%) |
PAK2 | inactive (0.12%) |
PAK5 | inactive (-0.8%) |
PAK6 | inactive (4.66%) |
STE - STE7
Bioactivity |
---|
Kinase | GPCR |
---|
MAP2K1 | inactive (0.32%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
CK1 | 7 | 4 |
CK1 - CK1
Bioactivity |
---|
Kinase | GPCR |
---|
CK1a | inactive (1.02%) |
CK1g2 | inactive (-0.29%) |
CK1g1 | inactive (0.27%) |
CK1g3 | inactive (1.34%) |
Other
Other
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
PLK | 4 | 1 |
Aur | 3 | 3 |
NEK | 11 | 5 |
IKK | 4 | 4 |
TTK | 1 | 1 |
Other - PLK
Bioactivity |
---|
Kinase | GPCR |
---|
PLK1 | inactive (0.24%) |
Other - Aur
Bioactivity |
---|
Kinase | GPCR |
---|
AurB | inactive (4.64%) |
AurC | inactive (-4.34%) |
AurA | inactive (13.91%) |
Other - NEK
Bioactivity |
---|
Kinase | GPCR |
---|
NEK1 | inactive (1.95%) |
NEK2 | inactive (-0.71%) |
NEK9 | inactive (1.83%) |
NEK7 | inactive (-0.03%) |
NEK6 | inactive (1.12%) |
Other - IKK
Bioactivity |
---|
Kinase | GPCR |
---|
TBK1 | inactive (4.22%) |
IKKe | inactive (1.73%) |
IKKb | inactive (-0.16%) |
IKKa | inactive (-6.23%) |
Other - TTK
Bioactivity |
---|
Kinase | GPCR |
---|
TTK | inactive (8.57%) |
AGC
AGC - GRK
Bioactivity |
---|
Kinase | GPCR |
---|
GPRK7 | inactive (-3.96%) |
GPRK6 | inactive (-0.46%) |
AGC - PDK1
Bioactivity |
---|
Kinase | GPCR |
---|
PDK1 | inactive (0.81%) |
AGC - RSK
Bioactivity |
---|
Kinase | GPCR |
---|
MSK1 | inactive (6.51%) |
MSK2 | inactive (1.06%) |
RSK1 | inactive (5.22%) |
RSK2 | inactive (-0.03%) |
RSK4 | inactive (2.89%) |
RSK3 | inactive (1.51%) |
p70S6K | inactive (0.49%) |
AGC - Akt
Bioactivity |
---|
Kinase | GPCR |
---|
AKT2 | inactive (0.18%) |
AKT1 | inactive (-0.4%) |
AKT3 | inactive (-1.03%) |
AGC - SGK
Bioactivity |
---|
Kinase | GPCR |
---|
SGK1 | inactive (3.29%) |
SGK3 | inactive (0.56%) |
SGK2 | inactive (1.93%) |
AGC - PKC
Bioactivity |
---|
Kinase | GPCR |
---|
PKCh | inactive (0.58%) |
PKCg | inactive (3.98%) |
PKCa | inactive (1.64%) |
PKCt | inactive (1.38%) |
PKCi | inactive (-0.91%) |
AGC - PKG
Bioactivity |
---|
Kinase | GPCR |
---|
PKG2 | inactive (0.95%) |
PKG1 | inactive (0.61%) |
AGC - PKA
Bioactivity |
---|
Kinase | GPCR |
---|
PRKX | inactive (0.62%) |
AGC - DMPK
Bioactivity |
---|
Kinase | GPCR |
---|
ROCK1 | inactive (2.02%) |
ROCK2 | inactive (2.3%) |
MRCKb | inactive (-0.04%) |
MRCKa | inactive (0.2%) |
CAMK
CAMK - RAD53
Bioactivity |
---|
Kinase | GPCR |
---|
CHK2 | inactive (2.66%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
DCLK2 | inactive (3.38%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK4 | inactive (-1.66%) |
CaMK1d | inactive (-0.06%) |
CAMK - PHK
Bioactivity |
---|
Kinase | GPCR |
---|
PHKg1 | inactive (12.35%) |
PHKg2 | inactive (2.3%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK2d | inactive (8.27%) |
CaMK2a | inactive (6.08%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | GPCR |
---|
MAPKAPK5 | inactive (0.24%) |
MAPKAPK2 | inactive (1.48%) |
MAPKAPK3 | inactive (-0.47%) |
MNK2 | inactive (2.53%) |
MNK1 | inactive (5.6%) |
CAMK - PKD
Bioactivity |
---|
Kinase | GPCR |
---|
PKD3 | inactive (0.06%) |
PKD1 | inactive (0.39%) |
PKD2 | inactive (1.51%) |
CAMK - CAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
MARK4 | inactive (0.8%) |
MARK3 | inactive (18.71%) |
MARK1 | inactive (2.58%) |
QIK | inactive (2.83%) |
SIK | inactive (6.72%) |
NuaK1 | inactive (3.38%) |
BRSK1 | inactive (0.94%) |
BRSK2 | inactive (6.08%) |
MELK | inactive (7.01%) |
CHK1 | inactive (2.79%) |
PASK | inactive (1.76%) |
AMPKa1 | inactive (3.48%) |
AMPKa2 | inactive (0.95%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | GPCR |
---|
TSSK2 | inactive (-0.01%) |
TSSK1 | inactive (-0.98%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | GPCR |
---|
DAPK1 | inactive (4.29%) |
CAMK - PIM
Bioactivity |
---|
Kinase | GPCR |
---|
PIM2 | inactive (0.18%) |
PIM3 | inactive (3.12%) |
PIM1 | inactive (0.97%) |
CMGC
CMGC - MAPK
Bioactivity |
---|
Kinase | GPCR |
---|
JNK2 | inactive (1.02%) |
p38a | inactive (1.27%) |
p38b | inactive (4.45%) |
p38d | inactive (-0.16%) |
Erk2 | inactive (-0.08%) |
Erk1 | inactive (4.26%) |
CMGC - GSK
Bioactivity |
---|
Kinase | GPCR |
---|
GSK3A | inactive (2.7%) |
GSK3B | inactive (3.89%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | GPCR |
---|
SRPK1 | inactive (2.14%) |
MSSK1 | inactive (0.88%) |
CMGC - CLK
Bioactivity |
---|
Kinase | GPCR |
---|
CLK3 | inactive (8.6%) |
CLK2 | inactive (40.31%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | GPCR |
---|
HIPK1 | inactive (10.2%) |
HIPK4 | inactive (17.82%) |
DYRK1B | inactive (14.68%) |
DYRK1A | inactive (10.86%) |
DYRK2 | inactive (6.15%) |
CMGC - CK2
Bioactivity |
---|
Kinase | GPCR |
---|
CK2a1 | inactive (15.09%) |