Compound Information
Test on : GPCR
Compound Name : GSK2213727A
Inchikey : IKWHWJFNGWUVIJ-UHFFFAOYSA-N
ChemSpider : 24714489
Pubchem CID : 25211574
ChEMBL : CHEMBL511765
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
TK
TK - JakA
Bioactivity |
---|
Kinase | GPCR |
---|
JAK1 | inactive (-4.44%) |
TYK2 | inactive (-1.61%) |
JAK2 | inactive (0.22%) |
JAK3 | inactive (-1.63%) |
TK - Fer
Bioactivity |
---|
Kinase | GPCR |
---|
FER | active (86.81%) |
FES | active (89.01%) |
TK - Abl
Bioactivity |
---|
Kinase | GPCR |
---|
ABL1 | inactive (4.55%) |
ABL2 | inactive (-0.02%) |
TK - Csk
Bioactivity |
---|
Kinase | GPCR |
---|
CSK | inactive (-0.35%) |
TK - Tec
Bioactivity |
---|
Kinase | GPCR |
---|
BMX | inactive (2.64%) |
BTK | inactive (0.16%) |
TXK | inactive (-0.74%) |
TEC | inactive (3.64%) |
ITK | inactive (1.95%) |
TK - Src
Bioactivity |
---|
Kinase | GPCR |
---|
BRK | inactive (23.83%) |
SRM | inactive (1.18%) |
FRK | inactive (1%) |
BLK | inactive (4.45%) |
LCK | inactive (1.74%) |
HCK | inactive (3.71%) |
FGR | inactive (2.7%) |
FYN | inactive (2.42%) |
SRC | inactive (6.65%) |
YES | inactive (-2.14%) |
TK - Eph
Bioactivity |
---|
Kinase | GPCR |
---|
EphA2 | inactive (-1.18%) |
EphA4 | inactive (-1.05%) |
EphA3 | inactive (1.85%) |
EphB4 | inactive (1.31%) |
EphB3 | inactive (0.2%) |
EphB2 | inactive (8.75%) |
TK - FAK
Bioactivity |
---|
Kinase | GPCR |
---|
PYK2 | active (97.96%) |
TK - Syk
Bioactivity |
---|
Kinase | GPCR |
---|
SYK | inactive (0.44%) |
ZAP70 | inactive (3.93%) |
TK - ALK
Bioactivity |
---|
Kinase | GPCR |
---|
LTK | active (95.6%) |
ALK | active (88.91%) |
TK - Sev
Bioactivity |
---|
Kinase | GPCR |
---|
ROS | active (86%) |
TK - InsR
Bioactivity |
---|
Kinase | GPCR |
---|
INSR | active (99.89%) |
IGF1R | active (95.54%) |
IRR | active (97.69%) |
TK - DDR
Bioactivity |
---|
Kinase | GPCR |
---|
DDR2 | inactive (0.4%) |
TK - Musk
Bioactivity |
---|
Kinase | GPCR |
---|
MUSK | inactive (28.92%) |
TK - Trk
Bioactivity |
---|
Kinase | GPCR |
---|
TRKA | inactive (13%) |
TRKB | inactive (1.27%) |
TRKC | inactive (4.14%) |
TK - Met
Bioactivity |
---|
Kinase | GPCR |
---|
RON | inactive (3.91%) |
MET | inactive (-1.66%) |
TK - Axl
Bioactivity |
---|
Kinase | GPCR |
---|
AXL | active (63.71%) |
MER | inactive (7.53%) |
TYRO3 | inactive (7.81%) |
TK - Ret
Bioactivity |
---|
Kinase | GPCR |
---|
RET | inactive (5.56%) |
TK - FGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FGFR1 | inactive (1.43%) |
FGFR2 | inactive (4.39%) |
FGFR3 | inactive (1.03%) |
FGFR4 | inactive (1.48%) |
TK - VEGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FLT1 | inactive (0.42%) |
KDR | inactive (4.13%) |
FLT4 | inactive (1.77%) |
TK - PDGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FMS | inactive (26.62%) |
KIT | inactive (4.07%) |
FLT3 | inactive (4.08%) |
PDGFRa | inactive (16.94%) |
PDGFRb | inactive (14.96%) |
TK - Tie
Bioactivity |
---|
Kinase | GPCR |
---|
TIE2 | inactive (0.17%) |
TK - Ack
Bioactivity |
---|
Kinase | GPCR |
---|
ACK | inactive (13.96%) |
TNK1 | active (73.43%) |
TK - EGFR
Bioactivity |
---|
Kinase | GPCR |
---|
EGFR | inactive (5.3%) |
ErbB2 | inactive (-0.4%) |
ErbB4 | inactive (32.07%) |
TKL
TKL
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
IRAK | 4 | 1 |
RAF | 5 | 1 |
TKL - IRAK
Bioactivity |
---|
Kinase | GPCR |
---|
IRAK4 | inactive (2%) |
TKL - RAF
Bioactivity |
---|
Kinase | GPCR |
---|
BRAF | inactive (6.44%) |
STE
STE
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
STE20 | 31 | 12 |
STE7 | 7 | 1 |
STE - STE20
Bioactivity |
---|
Kinase | GPCR |
---|
GCK | inactive (43.89%) |
MST1 | inactive (17.7%) |
MST2 | inactive (7.94%) |
MST4 | inactive (-2.75%) |
HGK | inactive (17.81%) |
MINK | inactive (13.77%) |
LOK | inactive (3.17%) |
PAK1 | inactive (3.36%) |
PAK3 | inactive (2.37%) |
PAK2 | inactive (1.5%) |
PAK5 | inactive (-5.11%) |
PAK6 | inactive (-2.96%) |
STE - STE7
Bioactivity |
---|
Kinase | GPCR |
---|
MAP2K1 | inactive (6.41%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
CK1 | 7 | 4 |
CK1 - CK1
Bioactivity |
---|
Kinase | GPCR |
---|
CK1a | inactive (21.46%) |
CK1g2 | inactive (20.01%) |
CK1g1 | inactive (12.87%) |
CK1g3 | inactive (20.58%) |
Other
Other
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
PLK | 4 | 1 |
Aur | 3 | 3 |
NEK | 11 | 5 |
IKK | 4 | 4 |
TTK | 1 | 1 |
Other - PLK
Bioactivity |
---|
Kinase | GPCR |
---|
PLK1 | active (92.25%) |
Other - Aur
Bioactivity |
---|
Kinase | GPCR |
---|
AurB | inactive (6.07%) |
AurC | inactive (12.28%) |
AurA | inactive (13.54%) |
Other - NEK
Bioactivity |
---|
Kinase | GPCR |
---|
NEK1 | inactive (-0.24%) |
NEK2 | inactive (3.95%) |
NEK9 | inactive (2.11%) |
NEK7 | inactive (9.65%) |
NEK6 | inactive (-0.26%) |
Other - IKK
Bioactivity |
---|
Kinase | GPCR |
---|
TBK1 | inactive (25.51%) |
IKKe | inactive (5.68%) |
IKKb | inactive (-5.7%) |
IKKa | inactive (-6.41%) |
Other - TTK
Bioactivity |
---|
Kinase | GPCR |
---|
TTK | active (53.49%) |
AGC
AGC - GRK
Bioactivity |
---|
Kinase | GPCR |
---|
GPRK7 | inactive (28.15%) |
GPRK6 | active (51.21%) |
AGC - PDK1
Bioactivity |
---|
Kinase | GPCR |
---|
PDK1 | inactive (2.71%) |
AGC - RSK
Bioactivity |
---|
Kinase | GPCR |
---|
MSK1 | inactive (0.97%) |
MSK2 | inactive (2.07%) |
RSK1 | inactive (40.74%) |
RSK2 | inactive (23.09%) |
RSK4 | inactive (23.11%) |
RSK3 | inactive (11.51%) |
p70S6K | inactive (3.01%) |
AGC - Akt
Bioactivity |
---|
Kinase | GPCR |
---|
AKT2 | inactive (1.17%) |
AKT1 | inactive (0.96%) |
AKT3 | inactive (1.72%) |
AGC - SGK
Bioactivity |
---|
Kinase | GPCR |
---|
SGK1 | inactive (-1.3%) |
SGK3 | inactive (0.16%) |
SGK2 | inactive (0.65%) |
AGC - PKC
Bioactivity |
---|
Kinase | GPCR |
---|
PKCh | inactive (1.46%) |
PKCg | inactive (8.9%) |
PKCa | inactive (5.42%) |
PKCt | inactive (0.13%) |
PKCi | inactive (1.29%) |
AGC - PKG
Bioactivity |
---|
Kinase | GPCR |
---|
PKG2 | inactive (2.22%) |
PKG1 | inactive (4.26%) |
AGC - PKA
Bioactivity |
---|
Kinase | GPCR |
---|
PRKX | inactive (-1.72%) |
AGC - DMPK
Bioactivity |
---|
Kinase | GPCR |
---|
ROCK1 | inactive (11.41%) |
ROCK2 | inactive (7.68%) |
MRCKb | inactive (1.65%) |
MRCKa | inactive (2.53%) |
CAMK
CAMK - RAD53
Bioactivity |
---|
Kinase | GPCR |
---|
CHK2 | active (76.15%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
DCLK2 | inactive (-11.07%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK4 | inactive (39.96%) |
CaMK1d | inactive (16.66%) |
CAMK - PHK
Bioactivity |
---|
Kinase | GPCR |
---|
PHKg1 | inactive (43.49%) |
PHKg2 | inactive (8.82%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK2d | inactive (14.17%) |
CaMK2a | inactive (8.59%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | GPCR |
---|
MAPKAPK5 | inactive (1.56%) |
MAPKAPK2 | inactive (0.73%) |
MAPKAPK3 | inactive (3.56%) |
MNK2 | inactive (1.25%) |
MNK1 | inactive (0.39%) |
CAMK - PKD
Bioactivity |
---|
Kinase | GPCR |
---|
PKD3 | inactive (38.41%) |
PKD1 | inactive (18.07%) |
PKD2 | inactive (31.87%) |
CAMK - CAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
MARK4 | inactive (0.75%) |
MARK3 | inactive (0.73%) |
MARK1 | inactive (1.38%) |
QIK | inactive (-4.44%) |
SIK | inactive (5.28%) |
NuaK1 | inactive (4.12%) |
BRSK1 | inactive (0.73%) |
BRSK2 | inactive (-2.24%) |
MELK | inactive (18.13%) |
CHK1 | inactive (-1.09%) |
PASK | inactive (-3.17%) |
AMPKa1 | inactive (0.78%) |
AMPKa2 | inactive (4.27%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | GPCR |
---|
TSSK2 | active (73.24%) |
TSSK1 | active (89.26%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | GPCR |
---|
DAPK1 | inactive (34.99%) |
CAMK - PIM
Bioactivity |
---|
Kinase | GPCR |
---|
PIM2 | inactive (2.33%) |
PIM3 | inactive (16.28%) |
PIM1 | inactive (43.22%) |
CMGC
CMGC - MAPK
Bioactivity |
---|
Kinase | GPCR |
---|
JNK2 | inactive (12.63%) |
p38a | inactive (5.59%) |
p38b | inactive (3.23%) |
p38d | inactive (1.87%) |
Erk2 | inactive (4.47%) |
Erk1 | inactive (0.63%) |
CMGC - GSK
Bioactivity |
---|
Kinase | GPCR |
---|
GSK3A | inactive (1.07%) |
GSK3B | inactive (0.98%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | GPCR |
---|
SRPK1 | inactive (-3.29%) |
MSSK1 | inactive (7.69%) |
CMGC - CLK
Bioactivity |
---|
Kinase | GPCR |
---|
CLK3 | inactive (13.17%) |
CLK2 | active (88.77%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | GPCR |
---|
HIPK1 | active (60.61%) |
HIPK4 | active (63.37%) |
DYRK1B | inactive (14.79%) |
DYRK1A | inactive (19.96%) |
DYRK2 | inactive (5.3%) |
CMGC - CK2
Bioactivity |
---|
Kinase | GPCR |
---|
CK2a1 | inactive (35.45%) |