Compound Information
Test on : GPCR
Compound Name : SB-732881-H
Inchikey : ICEJPUIRDWMBNZ-BTJKTKAUSA-N
ChemSpider : 28483959
Pubchem CID : 136068093
ChEMBL : CHEMBL1909347
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
TK
TK - JakA
Bioactivity |
---|
Kinase | GPCR |
---|
JAK1 | inactive (3.43%) |
TYK2 | inactive (-0.98%) |
JAK2 | inactive (1.42%) |
JAK3 | inactive (0.59%) |
TK - Fer
Bioactivity |
---|
Kinase | GPCR |
---|
FER | inactive (5.02%) |
FES | inactive (1.81%) |
TK - Abl
Bioactivity |
---|
Kinase | GPCR |
---|
ABL1 | inactive (12.25%) |
ABL2 | inactive (4.83%) |
TK - Csk
Bioactivity |
---|
Kinase | GPCR |
---|
CSK | inactive (4.28%) |
TK - Tec
Bioactivity |
---|
Kinase | GPCR |
---|
BMX | inactive (4.39%) |
BTK | inactive (0.46%) |
TXK | inactive (3.3%) |
TEC | inactive (2.96%) |
ITK | inactive (1.71%) |
TK - Src
Bioactivity |
---|
Kinase | GPCR |
---|
BRK | inactive (6.4%) |
SRM | inactive (-1%) |
FRK | inactive (3.98%) |
BLK | inactive (4.39%) |
LCK | inactive (12.36%) |
HCK | inactive (4.64%) |
FGR | inactive (3.79%) |
FYN | inactive (4.52%) |
SRC | inactive (8.29%) |
YES | inactive (3.33%) |
TK - Eph
Bioactivity |
---|
Kinase | GPCR |
---|
EphA2 | inactive (-1.38%) |
EphA4 | inactive (9.16%) |
EphA3 | inactive (3.96%) |
EphB4 | inactive (4.54%) |
EphB3 | inactive (4.59%) |
EphB2 | inactive (8.66%) |
TK - FAK
Bioactivity |
---|
Kinase | GPCR |
---|
PYK2 | inactive (6.02%) |
TK - Syk
Bioactivity |
---|
Kinase | GPCR |
---|
SYK | inactive (0.42%) |
ZAP70 | inactive (2.11%) |
TK - ALK
Bioactivity |
---|
Kinase | GPCR |
---|
LTK | inactive (45.5%) |
ALK | inactive (35.42%) |
TK - Sev
Bioactivity |
---|
Kinase | GPCR |
---|
ROS | inactive (1.96%) |
TK - InsR
Bioactivity |
---|
Kinase | GPCR |
---|
INSR | inactive (6.55%) |
IGF1R | inactive (3.41%) |
IRR | inactive (1.64%) |
TK - DDR
Bioactivity |
---|
Kinase | GPCR |
---|
DDR2 | inactive (3.34%) |
TK - Musk
Bioactivity |
---|
Kinase | GPCR |
---|
MUSK | inactive (7.11%) |
TK - Trk
Bioactivity |
---|
Kinase | GPCR |
---|
TRKA | inactive (2.04%) |
TRKB | inactive (2.74%) |
TRKC | inactive (0.79%) |
TK - Met
Bioactivity |
---|
Kinase | GPCR |
---|
RON | inactive (11.8%) |
MET | inactive (6.92%) |
TK - Axl
Bioactivity |
---|
Kinase | GPCR |
---|
AXL | inactive (-3.39%) |
MER | inactive (6.1%) |
TYRO3 | inactive (4.86%) |
TK - Ret
Bioactivity |
---|
Kinase | GPCR |
---|
RET | inactive (0.25%) |
TK - FGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FGFR1 | inactive (5.39%) |
FGFR2 | inactive (5.43%) |
FGFR3 | inactive (4.41%) |
FGFR4 | inactive (2.44%) |
TK - VEGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FLT1 | inactive (2.84%) |
KDR | inactive (23.25%) |
FLT4 | inactive (2.2%) |
TK - PDGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FMS | inactive (5.04%) |
KIT | inactive (9.42%) |
FLT3 | inactive (2.93%) |
PDGFRa | inactive (21.07%) |
PDGFRb | inactive (17.31%) |
TK - Tie
Bioactivity |
---|
Kinase | GPCR |
---|
TIE2 | inactive (7.69%) |
TK - Ack
Bioactivity |
---|
Kinase | GPCR |
---|
ACK | inactive (1.56%) |
TNK1 | inactive (6.06%) |
TK - EGFR
Bioactivity |
---|
Kinase | GPCR |
---|
EGFR | inactive (5.5%) |
ErbB2 | inactive (4.93%) |
ErbB4 | inactive (8.92%) |
TKL
TKL
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
IRAK | 4 | 1 |
RAF | 5 | 1 |
TKL - IRAK
Bioactivity |
---|
Kinase | GPCR |
---|
IRAK4 | inactive (1.33%) |
TKL - RAF
Bioactivity |
---|
Kinase | GPCR |
---|
BRAF | inactive (14.54%) |
STE
STE
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
STE20 | 31 | 12 |
STE7 | 7 | 1 |
STE - STE20
Bioactivity |
---|
Kinase | GPCR |
---|
GCK | inactive (19.88%) |
MST1 | inactive (2.3%) |
MST2 | inactive (3.69%) |
MST4 | inactive (19.76%) |
HGK | inactive (22.46%) |
MINK | inactive (15.2%) |
LOK | inactive (9.07%) |
PAK1 | inactive (3.31%) |
PAK3 | inactive (1.71%) |
PAK2 | inactive (-0.53%) |
PAK5 | inactive (0.52%) |
PAK6 | inactive (-4.52%) |
STE - STE7
Bioactivity |
---|
Kinase | GPCR |
---|
MAP2K1 | inactive (2.15%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
CK1 | 7 | 4 |
CK1 - CK1
Bioactivity |
---|
Kinase | GPCR |
---|
CK1a | inactive (3%) |
CK1g2 | inactive (1.66%) |
CK1g1 | inactive (2.3%) |
CK1g3 | inactive (0.25%) |
Other
Other
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
PLK | 4 | 1 |
Aur | 3 | 3 |
NEK | 11 | 5 |
IKK | 4 | 4 |
TTK | 1 | 1 |
Other - PLK
Bioactivity |
---|
Kinase | GPCR |
---|
PLK1 | inactive (3.17%) |
Other - Aur
Bioactivity |
---|
Kinase | GPCR |
---|
AurB | inactive (6.84%) |
AurC | inactive (5.17%) |
AurA | inactive (3.89%) |
Other - NEK
Bioactivity |
---|
Kinase | GPCR |
---|
NEK1 | inactive (3.3%) |
NEK2 | inactive (2.08%) |
NEK9 | inactive (6.47%) |
NEK7 | inactive (8.97%) |
NEK6 | inactive (0.79%) |
Other - IKK
Bioactivity |
---|
Kinase | GPCR |
---|
TBK1 | inactive (2.08%) |
IKKe | inactive (4.68%) |
IKKb | inactive (4.3%) |
IKKa | inactive (2.39%) |
Other - TTK
Bioactivity |
---|
Kinase | GPCR |
---|
TTK | inactive (6.37%) |
AGC
AGC - GRK
Bioactivity |
---|
Kinase | GPCR |
---|
GPRK7 | inactive (-0.01%) |
GPRK6 | inactive (5.9%) |
AGC - PDK1
Bioactivity |
---|
Kinase | GPCR |
---|
PDK1 | inactive (2.77%) |
AGC - RSK
Bioactivity |
---|
Kinase | GPCR |
---|
MSK1 | inactive (1.49%) |
MSK2 | inactive (1.19%) |
RSK1 | inactive (0.84%) |
RSK2 | inactive (1.92%) |
RSK4 | inactive (9.62%) |
RSK3 | inactive (6.17%) |
p70S6K | inactive (-0.02%) |
AGC - Akt
Bioactivity |
---|
Kinase | GPCR |
---|
AKT2 | inactive (1.31%) |
AKT1 | inactive (-0.05%) |
AKT3 | inactive (3.11%) |
AGC - SGK
Bioactivity |
---|
Kinase | GPCR |
---|
SGK1 | inactive (4.16%) |
SGK3 | inactive (0.32%) |
SGK2 | inactive (6.21%) |
AGC - PKC
Bioactivity |
---|
Kinase | GPCR |
---|
PKCh | inactive (3.54%) |
PKCg | inactive (8.57%) |
PKCa | inactive (11.16%) |
PKCt | inactive (2.97%) |
PKCi | inactive (5.91%) |
AGC - PKG
Bioactivity |
---|
Kinase | GPCR |
---|
PKG2 | inactive (4.33%) |
PKG1 | inactive (6.39%) |
AGC - PKA
Bioactivity |
---|
Kinase | GPCR |
---|
PRKX | inactive (1.62%) |
AGC - DMPK
Bioactivity |
---|
Kinase | GPCR |
---|
ROCK1 | inactive (-0.83%) |
ROCK2 | inactive (0.92%) |
MRCKb | inactive (12.67%) |
MRCKa | inactive (19.53%) |
CAMK
CAMK - RAD53
Bioactivity |
---|
Kinase | GPCR |
---|
CHK2 | inactive (3.76%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
DCLK2 | inactive (10.24%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK4 | inactive (1.46%) |
CaMK1d | inactive (15.67%) |
CAMK - PHK
Bioactivity |
---|
Kinase | GPCR |
---|
PHKg1 | inactive (3.32%) |
PHKg2 | inactive (2.52%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK2d | inactive (11.08%) |
CaMK2a | inactive (4.76%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | GPCR |
---|
MAPKAPK5 | inactive (0.86%) |
MAPKAPK2 | inactive (1.12%) |
MAPKAPK3 | inactive (1.9%) |
MNK2 | inactive (34.66%) |
MNK1 | active (84.89%) |
CAMK - PKD
Bioactivity |
---|
Kinase | GPCR |
---|
PKD3 | inactive (2.68%) |
PKD1 | inactive (5.75%) |
PKD2 | inactive (3.02%) |
CAMK - CAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
MARK4 | inactive (0.65%) |
MARK3 | inactive (3.23%) |
MARK1 | inactive (1.5%) |
QIK | inactive (5.33%) |
SIK | inactive (8.23%) |
NuaK1 | inactive (2.56%) |
BRSK1 | inactive (25.95%) |
BRSK2 | inactive (27.17%) |
MELK | inactive (8.84%) |
CHK1 | inactive (2.46%) |
PASK | inactive (-0.48%) |
AMPKa1 | inactive (10.56%) |
AMPKa2 | inactive (5.07%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | GPCR |
---|
TSSK2 | inactive (1.94%) |
TSSK1 | inactive (2.61%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | GPCR |
---|
DAPK1 | inactive (1.28%) |
CAMK - PIM
Bioactivity |
---|
Kinase | GPCR |
---|
PIM2 | inactive (16.46%) |
PIM3 | inactive (44.83%) |
PIM1 | inactive (33.38%) |
CMGC
CMGC - MAPK
Bioactivity |
---|
Kinase | GPCR |
---|
JNK2 | inactive (13.86%) |
p38a | inactive (10.53%) |
p38b | inactive (8.93%) |
p38d | inactive (11.55%) |
Erk2 | inactive (3.95%) |
Erk1 | inactive (1.2%) |
CMGC - GSK
Bioactivity |
---|
Kinase | GPCR |
---|
GSK3A | active (81.69%) |
GSK3B | active (80.04%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | GPCR |
---|
SRPK1 | inactive (-0.81%) |
MSSK1 | inactive (-0.97%) |
CMGC - CLK
Bioactivity |
---|
Kinase | GPCR |
---|
CLK3 | inactive (4.52%) |
CLK2 | inactive (2.87%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | GPCR |
---|
HIPK1 | inactive (19.27%) |
HIPK4 | inactive (4.37%) |
DYRK1B | active (67%) |
DYRK1A | active (51.79%) |
DYRK2 | inactive (34%) |
CMGC - CK2
Bioactivity |
---|
Kinase | GPCR |
---|
CK2a1 | inactive (1.03%) |