Compound Information
Test on : GPCR
Compound Name : SB-610251-B
Inchikey : IBPFBGKKYDZPON-UHFFFAOYSA-N
ChemSpider : 28485373
Pubchem CID : 57399804
ChEMBL : CHEMBL1909413
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
TK
TK - JakA
Bioactivity |
---|
Kinase | GPCR |
---|
JAK1 | inactive (5.42%) |
TYK2 | inactive (-1.42%) |
JAK2 | inactive (2.51%) |
JAK3 | inactive (9.09%) |
TK - Fer
Bioactivity |
---|
Kinase | GPCR |
---|
FER | inactive (0.53%) |
FES | inactive (1.64%) |
TK - Abl
Bioactivity |
---|
Kinase | GPCR |
---|
ABL1 | inactive (43.31%) |
ABL2 | active (50.84%) |
TK - Csk
Bioactivity |
---|
Kinase | GPCR |
---|
CSK | inactive (16.52%) |
TK - Tec
Bioactivity |
---|
Kinase | GPCR |
---|
BMX | inactive (8.97%) |
BTK | inactive (2.36%) |
TXK | inactive (13.82%) |
TEC | inactive (9.92%) |
ITK | inactive (1.61%) |
TK - Src
Bioactivity |
---|
Kinase | GPCR |
---|
BRK | active (55.36%) |
SRM | inactive (8.65%) |
FRK | inactive (16.51%) |
BLK | inactive (8.82%) |
LCK | inactive (17.68%) |
HCK | active (51.23%) |
FGR | inactive (19.52%) |
FYN | inactive (17.95%) |
SRC | active (63.23%) |
YES | inactive (21.91%) |
TK - Eph
Bioactivity |
---|
Kinase | GPCR |
---|
EphA2 | inactive (7.66%) |
EphA4 | inactive (32.86%) |
EphA3 | inactive (6.42%) |
EphB4 | inactive (9.99%) |
EphB3 | inactive (19.27%) |
EphB2 | inactive (26.05%) |
TK - FAK
Bioactivity |
---|
Kinase | GPCR |
---|
PYK2 | inactive (14.22%) |
TK - Syk
Bioactivity |
---|
Kinase | GPCR |
---|
SYK | inactive (1.53%) |
ZAP70 | inactive (3.35%) |
TK - ALK
Bioactivity |
---|
Kinase | GPCR |
---|
LTK | inactive (7.05%) |
ALK | inactive (4.75%) |
TK - Sev
Bioactivity |
---|
Kinase | GPCR |
---|
ROS | inactive (9.95%) |
TK - InsR
Bioactivity |
---|
Kinase | GPCR |
---|
INSR | inactive (2.18%) |
IGF1R | inactive (5.15%) |
IRR | inactive (0.88%) |
TK - DDR
Bioactivity |
---|
Kinase | GPCR |
---|
DDR2 | inactive (10.92%) |
TK - Musk
Bioactivity |
---|
Kinase | GPCR |
---|
MUSK | inactive (8.69%) |
TK - Trk
Bioactivity |
---|
Kinase | GPCR |
---|
TRKA | inactive (5.31%) |
TRKB | inactive (5.72%) |
TRKC | inactive (7.3%) |
TK - Met
Bioactivity |
---|
Kinase | GPCR |
---|
RON | inactive (5.25%) |
MET | inactive (11.09%) |
TK - Axl
Bioactivity |
---|
Kinase | GPCR |
---|
AXL | inactive (-0.19%) |
MER | inactive (6.42%) |
TYRO3 | inactive (9.74%) |
TK - Ret
Bioactivity |
---|
Kinase | GPCR |
---|
RET | active (72.85%) |
TK - FGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FGFR1 | inactive (7.19%) |
FGFR2 | inactive (9.16%) |
FGFR3 | inactive (5.69%) |
FGFR4 | inactive (1.85%) |
TK - VEGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FLT1 | inactive (43.82%) |
KDR | active (70.9%) |
FLT4 | inactive (30.35%) |
TK - PDGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FMS | inactive (5.02%) |
KIT | inactive (8.38%) |
FLT3 | inactive (19.47%) |
PDGFRa | inactive (18.47%) |
PDGFRb | inactive (17.06%) |
TK - Tie
Bioactivity |
---|
Kinase | GPCR |
---|
TIE2 | inactive (15.74%) |
TK - Ack
Bioactivity |
---|
Kinase | GPCR |
---|
ACK | inactive (2.85%) |
TNK1 | inactive (12.28%) |
TK - EGFR
Bioactivity |
---|
Kinase | GPCR |
---|
EGFR | inactive (4.4%) |
ErbB2 | inactive (3.87%) |
ErbB4 | inactive (19.37%) |
TKL
TKL
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
IRAK | 4 | 1 |
RAF | 5 | 1 |
TKL - IRAK
Bioactivity |
---|
Kinase | GPCR |
---|
IRAK4 | inactive (2.23%) |
TKL - RAF
Bioactivity |
---|
Kinase | GPCR |
---|
BRAF | inactive (30.01%) |
STE
STE
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
STE20 | 31 | 12 |
STE7 | 7 | 1 |
STE - STE20
Bioactivity |
---|
Kinase | GPCR |
---|
GCK | inactive (4.27%) |
MST1 | inactive (8.96%) |
MST2 | inactive (7.6%) |
MST4 | inactive (4.67%) |
HGK | inactive (11.56%) |
MINK | inactive (8.96%) |
LOK | inactive (16.6%) |
PAK1 | inactive (6.51%) |
PAK3 | inactive (3.48%) |
PAK2 | inactive (1.52%) |
PAK5 | inactive (15.67%) |
PAK6 | inactive (2.02%) |
STE - STE7
Bioactivity |
---|
Kinase | GPCR |
---|
MAP2K1 | inactive (4.94%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
CK1 | 7 | 4 |
CK1 - CK1
Bioactivity |
---|
Kinase | GPCR |
---|
CK1a | inactive (23.86%) |
CK1g2 | inactive (2.78%) |
CK1g1 | inactive (3.29%) |
CK1g3 | inactive (2.68%) |
Other
Other
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
PLK | 4 | 1 |
Aur | 3 | 3 |
NEK | 11 | 5 |
IKK | 4 | 4 |
TTK | 1 | 1 |
Other - PLK
Bioactivity |
---|
Kinase | GPCR |
---|
PLK1 | inactive (1.85%) |
Other - Aur
Bioactivity |
---|
Kinase | GPCR |
---|
AurB | inactive (8.4%) |
AurC | inactive (-2.07%) |
AurA | inactive (4.61%) |
Other - NEK
Bioactivity |
---|
Kinase | GPCR |
---|
NEK1 | inactive (3.39%) |
NEK2 | inactive (4.3%) |
NEK9 | inactive (6.73%) |
NEK7 | inactive (5.32%) |
NEK6 | inactive (4.45%) |
Other - IKK
Bioactivity |
---|
Kinase | GPCR |
---|
TBK1 | inactive (2.77%) |
IKKe | inactive (4.72%) |
IKKb | inactive (3.12%) |
IKKa | inactive (5.47%) |
Other - TTK
Bioactivity |
---|
Kinase | GPCR |
---|
TTK | inactive (12.44%) |
AGC
AGC - GRK
Bioactivity |
---|
Kinase | GPCR |
---|
GPRK7 | inactive (-0.71%) |
GPRK6 | inactive (4.9%) |
AGC - PDK1
Bioactivity |
---|
Kinase | GPCR |
---|
PDK1 | inactive (2.59%) |
AGC - RSK
Bioactivity |
---|
Kinase | GPCR |
---|
MSK1 | inactive (4.64%) |
MSK2 | inactive (3.89%) |
RSK1 | inactive (3.62%) |
RSK2 | inactive (2.76%) |
RSK4 | inactive (2.67%) |
RSK3 | inactive (3.22%) |
p70S6K | inactive (6.44%) |
AGC - Akt
Bioactivity |
---|
Kinase | GPCR |
---|
AKT2 | inactive (2.47%) |
AKT1 | inactive (1.39%) |
AKT3 | inactive (3.85%) |
AGC - SGK
Bioactivity |
---|
Kinase | GPCR |
---|
SGK1 | inactive (4.8%) |
SGK3 | inactive (1.35%) |
SGK2 | inactive (4.97%) |
AGC - PKC
Bioactivity |
---|
Kinase | GPCR |
---|
PKCh | inactive (9.76%) |
PKCg | inactive (5.82%) |
PKCa | inactive (3.01%) |
PKCt | inactive (3.65%) |
PKCi | inactive (0.18%) |
AGC - PKG
Bioactivity |
---|
Kinase | GPCR |
---|
PKG2 | inactive (6.36%) |
PKG1 | inactive (5.69%) |
AGC - PKA
Bioactivity |
---|
Kinase | GPCR |
---|
PRKX | inactive (2.93%) |
AGC - DMPK
Bioactivity |
---|
Kinase | GPCR |
---|
ROCK1 | inactive (1.51%) |
ROCK2 | inactive (6.34%) |
MRCKb | inactive (0.92%) |
MRCKa | inactive (2.63%) |
CAMK
CAMK - RAD53
Bioactivity |
---|
Kinase | GPCR |
---|
CHK2 | inactive (1.68%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
DCLK2 | inactive (0.39%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK4 | inactive (0.29%) |
CaMK1d | inactive (1.01%) |
CAMK - PHK
Bioactivity |
---|
Kinase | GPCR |
---|
PHKg1 | inactive (3.93%) |
PHKg2 | inactive (4.95%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK2d | inactive (3.45%) |
CaMK2a | inactive (3.17%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | GPCR |
---|
MAPKAPK5 | inactive (1.19%) |
MAPKAPK2 | inactive (1.79%) |
MAPKAPK3 | inactive (25.37%) |
MNK2 | inactive (14.75%) |
MNK1 | inactive (25.61%) |
CAMK - PKD
Bioactivity |
---|
Kinase | GPCR |
---|
PKD3 | inactive (4.25%) |
PKD1 | inactive (5.51%) |
PKD2 | inactive (7.13%) |
CAMK - CAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
MARK4 | inactive (2.71%) |
MARK3 | inactive (6.43%) |
MARK1 | inactive (4.27%) |
QIK | inactive (10.25%) |
SIK | inactive (11.6%) |
NuaK1 | inactive (2.27%) |
BRSK1 | inactive (1.89%) |
BRSK2 | inactive (4.34%) |
MELK | inactive (5.5%) |
CHK1 | inactive (6.28%) |
PASK | inactive (0.32%) |
AMPKa1 | inactive (3.13%) |
AMPKa2 | inactive (4.6%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | GPCR |
---|
TSSK2 | inactive (2.57%) |
TSSK1 | inactive (2.8%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | GPCR |
---|
DAPK1 | inactive (6.12%) |
CAMK - PIM
Bioactivity |
---|
Kinase | GPCR |
---|
PIM2 | inactive (0.33%) |
PIM3 | inactive (1.72%) |
PIM1 | inactive (2.57%) |
CMGC
CMGC - MAPK
Bioactivity |
---|
Kinase | GPCR |
---|
JNK2 | inactive (10.67%) |
p38a | active (71.12%) |
p38b | inactive (47.74%) |
p38d | inactive (3.86%) |
Erk2 | inactive (5.82%) |
Erk1 | inactive (5.5%) |
CMGC - GSK
Bioactivity |
---|
Kinase | GPCR |
---|
GSK3A | inactive (14.85%) |
GSK3B | inactive (18.85%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | GPCR |
---|
SRPK1 | inactive (0.98%) |
MSSK1 | inactive (12.32%) |
CMGC - CLK
Bioactivity |
---|
Kinase | GPCR |
---|
CLK3 | inactive (2.52%) |
CLK2 | inactive (4.52%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | GPCR |
---|
HIPK1 | inactive (4.29%) |
HIPK4 | inactive (44.91%) |
DYRK1B | inactive (7.99%) |
DYRK1A | inactive (8.77%) |
DYRK2 | inactive (5.4%) |
CMGC - CK2
Bioactivity |
---|
Kinase | GPCR |
---|
CK2a1 | inactive (9.51%) |