Compound Information
Test on : GPCR
Compound Name : GW680975X
Inchikey : HZJPBOLTWHOKEL-UHFFFAOYSA-N
ChemSpider : 8033784
Pubchem CID : 9858084
ChEMBL : CHEMBL381948
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
TK
TK - JakA
Bioactivity |
---|
Kinase | GPCR |
---|
JAK1 | inactive (14.19%) |
TYK2 | inactive (-4.52%) |
JAK2 | inactive (0.86%) |
JAK3 | inactive (-3.5%) |
TK - Fer
Bioactivity |
---|
Kinase | GPCR |
---|
FER | inactive (5.23%) |
FES | inactive (3.31%) |
TK - Abl
Bioactivity |
---|
Kinase | GPCR |
---|
ABL1 | inactive (30.35%) |
ABL2 | inactive (7.82%) |
TK - Csk
Bioactivity |
---|
Kinase | GPCR |
---|
CSK | inactive (6.45%) |
TK - Tec
Bioactivity |
---|
Kinase | GPCR |
---|
BMX | inactive (3.99%) |
BTK | inactive (-1.93%) |
TXK | inactive (2.28%) |
TEC | inactive (3.67%) |
ITK | inactive (0.13%) |
TK - Src
Bioactivity |
---|
Kinase | GPCR |
---|
BRK | inactive (7.81%) |
SRM | inactive (-1.26%) |
FRK | inactive (1.26%) |
BLK | inactive (2.43%) |
LCK | inactive (2.35%) |
HCK | inactive (6.04%) |
FGR | inactive (3.11%) |
FYN | inactive (5%) |
SRC | inactive (9%) |
YES | inactive (9.04%) |
TK - Eph
Bioactivity |
---|
Kinase | GPCR |
---|
EphA2 | inactive (0.94%) |
EphA4 | inactive (14.77%) |
EphA3 | inactive (4.31%) |
EphB4 | inactive (0.96%) |
EphB3 | inactive (4.44%) |
EphB2 | inactive (10.63%) |
TK - FAK
Bioactivity |
---|
Kinase | GPCR |
---|
PYK2 | inactive (19.37%) |
TK - Syk
Bioactivity |
---|
Kinase | GPCR |
---|
SYK | inactive (-0.94%) |
ZAP70 | inactive (2.35%) |
TK - ALK
Bioactivity |
---|
Kinase | GPCR |
---|
LTK | inactive (5.88%) |
ALK | inactive (5.67%) |
TK - Sev
Bioactivity |
---|
Kinase | GPCR |
---|
ROS | inactive (8.14%) |
TK - InsR
Bioactivity |
---|
Kinase | GPCR |
---|
INSR | inactive (5.34%) |
IGF1R | inactive (1.04%) |
IRR | inactive (2.16%) |
TK - DDR
Bioactivity |
---|
Kinase | GPCR |
---|
DDR2 | inactive (1.14%) |
TK - Musk
Bioactivity |
---|
Kinase | GPCR |
---|
MUSK | inactive (-0.34%) |
TK - Trk
Bioactivity |
---|
Kinase | GPCR |
---|
TRKA | inactive (0.04%) |
TRKB | inactive (4.77%) |
TRKC | inactive (3.45%) |
TK - Met
Bioactivity |
---|
Kinase | GPCR |
---|
RON | inactive (8.86%) |
MET | inactive (8.44%) |
TK - Axl
Bioactivity |
---|
Kinase | GPCR |
---|
AXL | inactive (-8.99%) |
MER | inactive (2%) |
TYRO3 | inactive (5.06%) |
TK - Ret
Bioactivity |
---|
Kinase | GPCR |
---|
RET | inactive (2.43%) |
TK - FGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FGFR1 | inactive (6.81%) |
FGFR2 | inactive (5.13%) |
FGFR3 | - |
FGFR4 | inactive (-0.52%) |
TK - VEGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FLT1 | inactive (1.96%) |
KDR | inactive (22.17%) |
FLT4 | inactive (1.05%) |
TK - PDGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FMS | inactive (3.27%) |
KIT | inactive (6.81%) |
FLT3 | inactive (2.5%) |
PDGFRa | inactive (19.79%) |
PDGFRb | inactive (11.83%) |
TK - Tie
Bioactivity |
---|
Kinase | GPCR |
---|
TIE2 | inactive (2.49%) |
TK - Ack
Bioactivity |
---|
Kinase | GPCR |
---|
ACK | inactive (1.26%) |
TNK1 | inactive (17.82%) |
TK - EGFR
Bioactivity |
---|
Kinase | GPCR |
---|
EGFR | inactive (1.67%) |
ErbB2 | inactive (6.84%) |
ErbB4 | inactive (12.71%) |
TKL
TKL
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
IRAK | 4 | 1 |
RAF | 5 | 1 |
TKL - IRAK
Bioactivity |
---|
Kinase | GPCR |
---|
IRAK4 | inactive (1.76%) |
TKL - RAF
Bioactivity |
---|
Kinase | GPCR |
---|
BRAF | inactive (8.05%) |
STE
STE
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
STE20 | 31 | 12 |
STE7 | 7 | 1 |
STE - STE20
Bioactivity |
---|
Kinase | GPCR |
---|
GCK | inactive (1.6%) |
MST1 | inactive (6.92%) |
MST2 | inactive (7.79%) |
MST4 | inactive (1.02%) |
HGK | active (59.64%) |
MINK | inactive (44.4%) |
LOK | inactive (11.15%) |
PAK1 | inactive (5.42%) |
PAK3 | inactive (5.11%) |
PAK2 | inactive (1.38%) |
PAK5 | inactive (2.37%) |
PAK6 | inactive (-4.06%) |
STE - STE7
Bioactivity |
---|
Kinase | GPCR |
---|
MAP2K1 | inactive (3.85%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
CK1 | 7 | 4 |
CK1 - CK1
Bioactivity |
---|
Kinase | GPCR |
---|
CK1a | inactive (5.16%) |
CK1g2 | inactive (6.19%) |
CK1g1 | inactive (7.09%) |
CK1g3 | inactive (6.73%) |
Other
Other
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
PLK | 4 | 1 |
Aur | 3 | 3 |
NEK | 11 | 5 |
IKK | 4 | 4 |
TTK | 1 | 1 |
Other - PLK
Bioactivity |
---|
Kinase | GPCR |
---|
PLK1 | inactive (3.1%) |
Other - Aur
Bioactivity |
---|
Kinase | GPCR |
---|
AurB | inactive (5.17%) |
AurC | inactive (-4.87%) |
AurA | inactive (4.79%) |
Other - NEK
Bioactivity |
---|
Kinase | GPCR |
---|
NEK1 | inactive (0.44%) |
NEK2 | inactive (3.61%) |
NEK9 | inactive (12.63%) |
NEK7 | inactive (4.43%) |
NEK6 | inactive (7.77%) |
Other - IKK
Bioactivity |
---|
Kinase | GPCR |
---|
TBK1 | inactive (3.03%) |
IKKe | inactive (7.34%) |
IKKb | inactive (9.85%) |
IKKa | inactive (3.99%) |
Other - TTK
Bioactivity |
---|
Kinase | GPCR |
---|
TTK | inactive (9.65%) |
AGC
AGC - GRK
Bioactivity |
---|
Kinase | GPCR |
---|
GPRK7 | inactive (13.41%) |
GPRK6 | inactive (15.74%) |
AGC - PDK1
Bioactivity |
---|
Kinase | GPCR |
---|
PDK1 | inactive (0.07%) |
AGC - RSK
Bioactivity |
---|
Kinase | GPCR |
---|
MSK1 | inactive (1.68%) |
MSK2 | inactive (3.21%) |
RSK1 | inactive (5.2%) |
RSK2 | inactive (3.36%) |
RSK4 | inactive (0.89%) |
RSK3 | inactive (2.64%) |
p70S6K | inactive (2.4%) |
AGC - Akt
Bioactivity |
---|
Kinase | GPCR |
---|
AKT2 | inactive (2.45%) |
AKT1 | inactive (0.95%) |
AKT3 | inactive (1.5%) |
AGC - SGK
Bioactivity |
---|
Kinase | GPCR |
---|
SGK1 | inactive (5.98%) |
SGK3 | inactive (4.1%) |
SGK2 | inactive (0.65%) |
AGC - PKC
Bioactivity |
---|
Kinase | GPCR |
---|
PKCh | inactive (6.6%) |
PKCg | inactive (1.87%) |
PKCa | inactive (0.88%) |
PKCt | inactive (5.06%) |
PKCi | inactive (0.58%) |
AGC - PKG
Bioactivity |
---|
Kinase | GPCR |
---|
PKG2 | inactive (2.9%) |
PKG1 | inactive (4.77%) |
AGC - PKA
Bioactivity |
---|
Kinase | GPCR |
---|
PRKX | inactive (5.03%) |
AGC - DMPK
Bioactivity |
---|
Kinase | GPCR |
---|
ROCK1 | inactive (1.54%) |
ROCK2 | inactive (7.8%) |
MRCKb | inactive (-2.11%) |
MRCKa | inactive (2.14%) |
CAMK
CAMK - RAD53
Bioactivity |
---|
Kinase | GPCR |
---|
CHK2 | inactive (5.9%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
DCLK2 | inactive (-1.86%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK4 | inactive (-4.94%) |
CaMK1d | inactive (-1.28%) |
CAMK - PHK
Bioactivity |
---|
Kinase | GPCR |
---|
PHKg1 | inactive (9.03%) |
PHKg2 | inactive (8.42%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK2d | inactive (4.06%) |
CaMK2a | inactive (2.33%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | GPCR |
---|
MAPKAPK5 | inactive (4.27%) |
MAPKAPK2 | inactive (2.72%) |
MAPKAPK3 | inactive (18.37%) |
MNK2 | inactive (6.06%) |
MNK1 | inactive (10.41%) |
CAMK - PKD
Bioactivity |
---|
Kinase | GPCR |
---|
PKD3 | inactive (20.53%) |
PKD1 | inactive (26.92%) |
PKD2 | inactive (32.42%) |
CAMK - CAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
MARK4 | inactive (1.84%) |
MARK3 | inactive (0.81%) |
MARK1 | inactive (3.39%) |
QIK | inactive (8%) |
SIK | inactive (8.52%) |
NuaK1 | inactive (-3.39%) |
BRSK1 | inactive (0.81%) |
BRSK2 | inactive (1.96%) |
MELK | inactive (7.4%) |
CHK1 | inactive (-0.75%) |
PASK | inactive (0.53%) |
AMPKa1 | inactive (4.83%) |
AMPKa2 | inactive (1.61%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | GPCR |
---|
TSSK2 | inactive (6.99%) |
TSSK1 | inactive (9.18%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | GPCR |
---|
DAPK1 | inactive (3.05%) |
CAMK - PIM
Bioactivity |
---|
Kinase | GPCR |
---|
PIM2 | inactive (-1.45%) |
PIM3 | inactive (1.85%) |
PIM1 | inactive (0.76%) |
CMGC
CMGC - MAPK
Bioactivity |
---|
Kinase | GPCR |
---|
JNK2 | inactive (11.29%) |
p38a | inactive (37.03%) |
p38b | inactive (12.54%) |
p38d | inactive (3.97%) |
Erk2 | inactive (5.51%) |
Erk1 | inactive (4.81%) |
CMGC - GSK
Bioactivity |
---|
Kinase | GPCR |
---|
GSK3A | inactive (2.16%) |
GSK3B | inactive (2.88%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | GPCR |
---|
SRPK1 | inactive (1.31%) |
MSSK1 | inactive (1.09%) |
CMGC - CLK
Bioactivity |
---|
Kinase | GPCR |
---|
CLK3 | inactive (0.54%) |
CLK2 | inactive (2.71%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | GPCR |
---|
HIPK1 | inactive (0.95%) |
HIPK4 | inactive (4.16%) |
DYRK1B | inactive (-0.27%) |
DYRK1A | inactive (5.69%) |
DYRK2 | inactive (4.06%) |
CMGC - CK2
Bioactivity |
---|
Kinase | GPCR |
---|
CK2a1 | inactive (11.89%) |