Compound Information
Test on : DRx, RBC, Metz, Millipore
Compound Name
DRx : staurosporine
RBC, Millipore : staurosporine
Metz : Staurosporine, 98%
Inchikey
Same : HKSZLNNOFSGOKW-N
DRx : HKSZLNNOFSGOKW-FYTWVXJKSA-N
RBC, Millipore : HKSZLNNOFSGOKW-HMWZOHBLSA-N
Metz : HKSZLNNOFSGOKW-ZYSRIHRCSA-N
ChemSpider
DRx : 40272
RBC, Millipore : 397853
Metz : 24808335
Pubchem CID
DRx : 44259
RBC, Millipore : 451705
Metz : 49831000
ChEMBL
DRx : CHEMBL388978
RBC, Millipore : CHEMBL290084
Metz : -
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
Other
Other - NAK
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
AAK1 | active (1.2nM) | - | - | - |
BIKE | active (5.6nM) | - | - | - |
GAK | active (17nM) | - | - | - |
MPSK1 | active (270nM) | active (48.4%) | - | - |
Other - Aur
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
AurA | active (17nM) | active (2.43%) | active (2.51nM) | active (-9%) |
AurB | active (19nM) | active (4.3%) | active (2nM) | active (1%) |
AurC | active (23nM) | active (5.21%) | - | active (3%) |
Other - CAMKK
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
CaMKK1 | active (0.04nM) | active (-3.13%) | - | - |
CaMKK2 | active (0.16nM) | active (0.24%) | active (0.2nM) | - |
Other - PEK
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
HRI | inactive (10001nM) | - | - | - |
PKR | active (360nM) | - | - | - |
Other - IRE
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
IRE1 | active (21nM) | - | - | - |
Other - IKK
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
IKKa | active (5.8nM) | active (40.33%) | active (50.12nM) | active (6%) |
IKKb | active (31nM) | inactive (53.43%) | active (251.19nM) | active (35%) |
IKKe | active (5.1nM) | active (0.3%) | active (5.01nM) | - |
TBK1 | active (0.89nM) | active (-0.46%) | active (1.26nM) | active (2%) |
Other - NEK
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
NEK1 | active (860nM) | active (3.99%) | - | - |
NEK11 | inactive (3100nM) | active (37.02%) | - | inactive (54%) |
NEK2 | active (750nM) | inactive (79.9%) | inactive (2511.89nM) | inactive (63%) |
NEK3 | inactive (10001nM) | inactive (91.92%) | - | inactive (105%) |
NEK4 | inactive (10001nM) | active (46.8%) | - | - |
NEK5 | active (810nM) | - | - | - |
NEK6 | inactive (10001nM) | inactive (88.63%) | - | inactive (75%) |
NEK7 | inactive (4500nM) | inactive (95.78%) | - | inactive (93%) |
NEK9 | inactive (3100nM) | active (27.18%) | - | - |
Other - WEE
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
MYT1 | inactive (10001nM) | - | - | - |
Wee1 | active (1600nM) | inactive (73.1%) | inactive (1995.26nM) | - |
Wee1B | inactive (10001nM) | - | - | - |
Other - PLK
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
PLK1 | active (190nM) | active (36.88%) | inactive (1258.93nM) | inactive (53%) |
PLK2 | active (200nM) | inactive (94.75%) | - | inactive (69%) |
PLK3 | active (910nM) | active (37.79%) | inactive (1995.26nM) | inactive (81%) |
PLK4 | active (0.77nM) | - | active (7.94nM) | - |
Other - SgK496
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
SgK496 | active (11nM) | active (18.72%) | - | - |
Other - NKF1
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
SBK | active (3.2nM) | - | - | - |
SgK110 | active (25nM) | - | - | - |
Other - NKF4
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
CLIK1 | active (140nM) | - | - | - |
Other - ULK
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
Fused | inactive (6700nM) | - | - | - |
ULK1 | active (9.9nM) | active (3.27%) | - | - |
ULK2 | active (0.79nM) | active (2.7%) | - | active (2%) |
ULK3 | active (1.2nM) | active (1.82%) | - | active (-1%) |
Other - TLK
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
TLK1 | active (27nM) | - | - | - |
TLK2 | active (16nM) | active (2.83%) | - | active (1%) |
Other - TTK
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
TTK | active (61nM) | active (36.29%) | - | - |
Other - Haspin
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
Haspin | - | active (6.94%) | - | active (1%) |
Other - TOPK
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
PBK | - | active (27.77%) | - | - |
Other - WNK
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
Wnk2 | - | inactive (93.14%) | - | inactive (92%) |
Wnk3 | - | inactive (73.62%) | - | inactive (88%) |
Other - CDC7
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
CDC7 | - | - | - | - |
TK
TK - Abl
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
ABL1 | active (37nM) | active (23.01%) | active (100nM) | active (18%) |
ABL2 | active (110nM) | active (5.25%) | - | active (1%) |
TK - ALK
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
ALK | active (32nM) | active (0.86%) | active (5.01nM) | active (0%) |
LTK | active (37nM) | active (0.54%) | active (3.16nM) | - |
TK - Axl
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
AXL | active (6.8nM) | active (13.27%) | - | active (-2%) |
MER | active (6.4nM) | active (2.63%) | - | active (3%) |
TYRO3 | active (280nM) | active (7.27%) | active (10nM) | active (0%) |
TK - Src
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
BLK | active (15nM) | active (1.57%) | active (1.58nM) | active (0%) |
BRK | active (2300nM) | active (32.6%) | - | active (38%) |
FGR | active (17nM) | active (0.27%) | - | active (1%) |
FRK | active (45nM) | active (5.5%) | - | active (1%) |
FYN | active (33nM) | active (3.59%) | active (50.12nM) | active (-1%) |
HCK | active (20nM) | active (3.26%) | active (5.01nM) | active (0%) |
LCK | active (30nM) | active (1.84%) | active (25.12nM) | active (-1%) |
LYN | active (40nM) | active (1.18%) | active (6.31nM) | active (0%) |
SRC | active (86nM) | active (1.46%) | active (19.95nM) | active (8%) |
SRM | active (740nM) | inactive (110.98%) | - | - |
YES | active (52nM) | active (4.48%) | - | active (0%) |
TK - Tec
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
BMX | active (170nM) | active (6.22%) | - | active (3%) |
BTK | active (210nM) | active (7.82%) | active (79.43nM) | active (2%) |
ITK | active (19nM) | active (2.89%) | active (7.94nM) | active (3%) |
TEC | active (1300nM) | inactive (91.13%) | - | - |
TXK | active (230nM) | active (7.33%) | - | active (21%) |
TK - PDGFR
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
FMS | active (12nM) | active (1.76%) | active (7.94nM) | active (1%) |
FLT3 | active (2.9nM) | active (1.12%) | active (12.59nM) | active (-1%) |
KIT | active (19nM) | active (8.67%) | active (158.49nM) | active (10%) |
PDGFRa | active (10nM) | active (2.11%) | active (7.94nM) | active (5%) |
PDGFRb | active (1.8nM) | active (2.28%) | active (0.79nM) | active (4%) |
TK - Csk
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
CSK | active (330nM) | active (8.01%) | - | active (29%) |
CTK | active (260nM) | inactive (75%) | - | - |
TK - DDR
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
DDR1 | active (19nM) | - | - | - |
DDR2 | active (42nM) | active (3.83%) | - | active (6%) |
TK - EGFR
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
EGFR | active (370nM) | active (32.45%) | active (25.12nM) | inactive (53%) |
ErbB2 | active (190nM) | active (35.87%) | active (31.62nM) | - |
ErbB3 | inactive (10001nM) | - | - | - |
ErbB4 | active (770nM) | active (48.8%) | inactive (>251.19nM) | inactive (58%) |
TK - Eph
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
EphA1 | active (300nM) | active (31.03%) | - | active (5%) |
EphA2 | active (1200nM) | active (21.33%) | active (251.19nM) | active (32%) |
EphA3 | active (27nM) | active (13.99%) | - | active (3%) |
EphA4 | active (290nM) | active (6.7%) | - | active (15%) |
EphA5 | active (95nM) | active (9.28%) | - | active (7%) |
EphA6 | active (290nM) | active (5.57%) | - | - |
EphA7 | active (630nM) | active (11.52%) | - | active (22%) |
EphA8 | active (190nM) | active (25.67%) | - | active (33%) |
EphB1 | active (240nM) | active (11.97%) | - | active (21%) |
EphB2 | active (2100nM) | active (27.6%) | - | active (20%) |
EphB3 | inactive (10001nM) | inactive (75.16%) | - | inactive (119%) |
EphB4 | active (2200nM) | active (37.57%) | - | inactive (79%) |
EphB6 | active (210nM) | - | - | - |
TK - FAK
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
FAK | active (64nM) | active (4.34%) | active (100nM) | active (3%) |
PYK2 | active (3.5nM) | active (2.71%) | - | active (2%) |
TK - Fer
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
FER | active (24nM) | active (0.82%) | active (3.16nM) | active (2%) |
FES | active (23nM) | active (4.11%) | - | active (0%) |
TK - FGFR
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
FGFR1 | active (90nM) | active (1.71%) | active (39.81nM) | active (-1%) |
FGFR2 | active (100nM) | active (3.25%) | - | active (1%) |
FGFR3 | active (88nM) | active (3.69%) | active (39.81nM) | active (3%) |
FGFR4 | active (250nM) | active (47.2%) | - | active (49%) |
TK - VEGFR
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
FLT1 | active (150nM) | active (7.88%) | active (5.01nM) | active (0%) |
FLT4 | active (28nM) | active (4.29%) | active (6.31nM) | active (1%) |
KDR | active (220nM) | active (4.46%) | active (6.31nM) | active (2%) |
TK - InsR
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
IGF1R | active (210nM) | active (14.78%) | active (25.12nM) | inactive (112%) |
INSR | active (110nM) | active (3.14%) | active (12.59nM) | active (13%) |
IRR | active (81nM) | active (1.71%) | - | active (-1%) |
TK - JakA
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
JAK1 | active (6.1nM) | active (2.07%) | - | - |
JAK2 | active (9.8nM) | active (1.85%) | active (0.79nM) | active (0%) |
JAK3 | active (12nM) | active (0.74%) | active (2nM) | active (0%) |
TYK2 | active (56nM) | active (1.85%) | - | - |
TK - Met
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
MET | active (190nM) | active (32.74%) | active (100nM) | active (5%) |
RON | active (400nM) | active (44.75%) | active (0.25nM) | active (13%) |
TK - Musk
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
MUSK | active (86nM) | active (12.21%) | - | active (-1%) |
TK - Ret
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
RET | active (15nM) | active (0.64%) | active (2.51nM) | active (3%) |
TK - Sev
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
ROS | active (30nM) | active (0.86%) | active (0.5nM) | active (3%) |
TK - Syk
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
SYK | active (14nM) | active (4.66%) | active (3.16nM) | active (1%) |
ZAP70 | active (44nM) | active (5.36%) | - | active (6%) |
TK - Tie
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
TIE1 | active (65nM) | - | - | - |
TIE2 | active (140nM) | active (22%) | - | active (0%) |
TK - Ack
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
TNK1 | active (2.5nM) | - | - | - |
ACK | active (16nM) | active (2.17%) | active (1.58nM) | active (-2%) |
TK - Trk
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
TRKA | active (4nM) | active (0.77%) | active (6.31nM) | active (-1%) |
TRKB | active (3.8nM) | active (0.37%) | active (0.79nM) | active (29%) |
TRKC | active (17nM) | active (0.99%) | active (2nM) | - |
TKL
TKL
Test Member No. in Family |
---|
Family | no. Member on 518kinase | DRx | RBC | Metz | Millipore |
---|
STKR | 12 | 10 | 5 | 1 | 2 |
RIPK | 5 | 4 | 1 | - | 1 |
RAF | 5 | 2 | 3 | 1 | 1 |
MLK | 10 | 8 | 5 | 2 | 2 |
IRAK | 4 | 3 | 2 | 2 | 2 |
LISK | 4 | 3 | 1 | 1 | 1 |
LRRK | 2 | 1 | 1 | 1 | - |
TKL - STKR
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
ALK2 | active (470nM) | inactive (91.87%) | active (63.1nM) | - |
ALK4 | active (680nM) | inactive (117.27%) | - | inactive (70%) |
ACTR2 | inactive (8900nM) | - | - | - |
ACTR2B | inactive (4600nM) | - | - | - |
ALK1 | inactive (10001nM) | inactive (83.74%) | - | - |
BMPR1A | inactive (3700nM) | - | - | - |
BMPR1B | active (170nM) | - | - | - |
BMPR2 | active (2300nM) | - | - | - |
TGFbR1 | active (2000nM) | inactive (114.21%) | - | inactive (79%) |
TGFbR2 | inactive (10001nM) | inactive (132.65%) | - | - |
TKL - RIPK
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
SgK288 | active (270nM) | - | - | - |
RIPK1 | inactive (10001nM) | - | - | - |
RIPK2 | inactive (5200nM) | active (46.96%) | - | active (49%) |
ANKRD3 | active (110nM) | - | - | - |
TKL - RAF
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
BRAF | inactive (10001nM) | inactive (112.82%) | - | - |
RAF1 | inactive (10001nM) | inactive (119.46%) | - | inactive (109%) |
ARAF | - | inactive (134.41%) | - | - |
TKL - MLK
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
DLK | active (1500nM) | - | - | - |
LZK | active (210nM) | - | - | - |
MLK1 | active (10nM) | active (7.1%) | - | active (0%) |
MLK2 | active (52nM) | active (3.26%) | active (3.16nM) | - |
MLK3 | active (20nM) | active (1.09%) | - | - |
TAK1 | active (67nM) | active (7.96%) | - | active (14%) |
HH498 | active (1000nM) | - | - | - |
ZAK | inactive (10001nM) | inactive (98.32%) | - | - |
TKL - IRAK
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
IRAK1 | active (40nM) | active (7.47%) | - | active (5%) |
IRAK3 | active (13nM) | - | - | - |
IRAK4 | active (1.7nM) | active (3.46%) | active (10nM) | active (1%) |
TKL - LISK
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
LIMK1 | active (480nM) | active (5.51%) | active (100nM) | active (1%) |
LIMK2 | inactive (9200nM) | - | - | - |
TESK1 | active (320nM) | - | - | - |
TKL - LRRK
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
LRRK2 | active (3.1nM) | active (1.01%) | active (0.4nM) | - |
Atypical
Atypical
Test Member No. in Family |
---|
Family | no. Member on 518kinase | DRx | RBC | Metz | Millipore |
---|
ABC1 | 5 | 2 | - | - | - |
PIKK | 6 | 1 | - | - | 1 |
RIO | 3 | 3 | - | - | - |
Alpha | 6 | 1 | - | 1 | 1 |
PDHK | 5 | - | 1 | - | - |
Atypical - ABC1
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
ADCK3 | inactive (10001nM) | - | - | - |
ADCK4 | inactive (10001nM) | - | - | - |
Atypical - PIKK
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
FRAP | inactive (10001nM) | - | - | inactive (87%) |
Atypical - RIO
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
RIOK1 | active (130nM) | - | - | - |
RIOK2 | active (390nM) | - | - | - |
RIOK3 | active (76nM) | - | - | - |
Atypical - Alpha
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
ChaK2 | inactive (10001nM) | - | - | - |
eEF2K | - | - | inactive (>1000nM) | inactive (74%) |
Atypical - PDHK
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
PDHK1 | - | active (4.41%) | - | - |
AGC
AGC - Akt
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
AKT1 | active (20nM) | active (7.49%) | inactive (>2.51nM) | active (13%) |
AKT2 | active (44nM) | active (5.51%) | active (10nM) | active (4%) |
AKT3 | active (170nM) | active (2.97%) | active (6.31nM) | active (-1%) |
AGC - DMPK
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
CRIK | active (340nM) | - | - | - |
DMPK1 | active (3.5nM) | active (4.83%) | - | active (16%) |
DMPK2 | active (37nM) | - | - | - |
MRCKa | active (57nM) | active (1.75%) | active (3.98nM) | active (1%) |
MRCKb | active (42nM) | active (1.99%) | - | active (0%) |
ROCK1 | active (0.28nM) | active (0.61%) | active (0.79nM) | active (5%) |
ROCK2 | active (0.24nM) | active (0.72%) | active (0.5nM) | active (2%) |
AGC - GRK
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
RHOK | active (0.97nM) | - | - | - |
GPRK4 | active (37nM) | active (20.52%) | - | - |
GPRK7 | active (0.86nM) | active (0.74%) | - | active (0%) |
BARK1 | - | inactive (56.82%) | - | - |
BARK2 | - | inactive (50.31%) | - | - |
GPRK5 | - | active (20.79%) | active (25.12nM) | active (10%) |
GPRK6 | - | active (7.36%) | - | active (17%) |
AGC - NDR
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
LATS1 | active (42nM) | - | - | - |
LATS2 | active (17nM) | - | - | - |
NDR1 | active (56nM) | active (10.02%) | - | - |
NDR2 | active (28nM) | - | - | - |
AGC - MAST
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
MAST1 | active (150nM) | - | - | - |
AGC - PDK1
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
PDK1 | active (1.7nM) | active (4.41%) | active (1.26nM) | active (1%) |
AGC - PKA
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
PKACa | active (19nM) | active (1.93%) | active (0.79nM) | active (1%) |
PKACb | active (29nM) | - | - | - |
PRKX | active (13nM) | active (3.5%) | active (0.32nM) | active (0%) |
PKACg | - | active (3.05%) | - | - |
AGC - PKN
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
PKN1 | active (1.3nM) | active (0.15%) | - | - |
PKN2 | active (2.5nM) | active (2.96%) | active (0.79nM) | active (1%) |
AGC - PKC
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
PKCd | active (1.5nM) | active (5.61%) | inactive (>3.16nM) | active (2%) |
PKCe | active (0.25nM) | active (0.8%) | - | active (1%) |
PKCh | active (4.8nM) | active (0.41%) | - | active (3%) |
PKCi | active (26nM) | active (4.59%) | - | active (50%) |
PKCt | active (8.5nM) | active (2.81%) | active (2nM) | active (0%) |
PKCa | - | active (1.23%) | - | active (1%) |
PKCg | - | active (-3.22%) | active (3.16nM) | active (2%) |
PKCz | - | active (21.98%) | active (50.12nM) | active (20%) |
PKCb | - | active (3.03%) | - | - |
AGC - PKG
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
PKG1 | active (32nM) | active (5.01%) | - | - |
PKG2 | active (16nM) | active (7.12%) | - | - |
AGC - RSK
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
p70S6K | active (1.3nM) | active (0.14%) | active (5.01nM) | active (1%) |
MSK1 | - | active (1.24%) | - | active (1%) |
MSK2 | - | active (6.74%) | - | active (1%) |
p70S6Kb | - | active (4.7%) | - | - |
RSK2 | - | active (-1.27%) | active (1.58nM) | active (0%) |
RSK4 | - | active (1.67%) | - | active (2%) |
RSK1 | - | active (3.52%) | - | active (1%) |
RSK3 | - | active (1.61%) | - | active (1%) |
AGC - SGK
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
SGK3 | active (3.4nM) | active (23.47%) | - | active (42%) |
SGK1 | - | active (8.59%) | active (7.94nM) | active (8%) |
SGK2 | - | active (7.77%) | - | active (11%) |
AGC - YANK
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
YANK1 | active (13nM) | - | - | - |
YANK2 | active (98nM) | - | - | - |
YANK3 | active (310nM) | - | - | - |
CAMK
CAMK - CAMKL
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
AMPKa1 | active (3.7nM) | - | active (0.32nM) | active (1%) |
AMPKa2 | active (12nM) | - | - | active (-2%) |
NuaK1 | active (4.4nM) | active (1.59%) | - | active (8%) |
BRSK1 | active (26nM) | active (0.52%) | - | active (3%) |
BRSK2 | active (3.5nM) | active (3.53%) | - | active (-1%) |
CHK1 | active (3.2nM) | active (1.63%) | active (2.51nM) | active (-1%) |
HUNK | active (620nM) | - | - | - |
LKB1 | active (61nM) | active (18.65%) | - | inactive (74%) |
MARK1 | active (4nM) | active (0.21%) | - | active (-1%) |
MARK2 | active (0.7nM) | active (0.02%) | active (7.94nM) | active (0%) |
MARK3 | active (3nM) | active (0.72%) | active (0.4nM) | - |
MARK4 | active (5.4nM) | active (-0.01%) | active (0.79nM) | - |
MELK | active (33nM) | active (0.97%) | active (0.32nM) | active (2%) |
NIM1 | active (140nM) | - | - | - |
QSK | active (0.46nM) | - | - | - |
SIK | active (2.2nM) | - | - | active (1%) |
QIK | active (1.1nM) | active (0.14%) | active (0.63nM) | - |
NuaK2 | active (0.09nM) | active (20.35%) | - | - |
SNRK | active (90nM) | - | - | - |
PASK | - | active (3.74%) | - | active (1%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
CaMK1a | active (27nM) | active (2.22%) | active (12.59nM) | active (1%) |
CaMK1d | active (1.1nM) | active (0.89%) | active (3.98nM) | active (2%) |
CaMK1g | active (23nM) | active (4.71%) | - | - |
CaMK4 | active (41nM) | active (34.82%) | - | active (3%) |
CaMK1b | - | active (4.82%) | - | - |
CAMK - CAMK2
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
CaMK2a | active (0.16nM) | active (0.47%) | active (3.16nM) | - |
CaMK2b | active (1.3nM) | active (1.64%) | - | active (-1%) |
CaMK2d | active (0.32nM) | active (3.05%) | - | active (2%) |
CaMK2g | active (0.55nM) | active (0.7%) | - | active (0%) |
CAMK - CASK
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
CASK | active (19nM) | - | - | - |
CAMK - RAD53
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
CHK2 | active (74nM) | active (1.33%) | active (10nM) | active (3%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
DAPK1 | active (1.4nM) | active (3.55%) | - | active (6%) |
DAPK2 | active (1.6nM) | active (4.07%) | - | active (6%) |
DAPK3 | active (1nM) | active (1.91%) | active (2nM) | active (0%) |
DRAK1 | active (14nM) | active (3.12%) | active (2.51nM) | active (1%) |
DRAK2 | active (21nM) | - | - | - |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
DCLK1 | active (110nM) | - | - | - |
DCLK2 | active (73nM) | active (11.03%) | - | active (9%) |
DCLK3 | active (17nM) | - | - | - |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
MAPKAPK2 | active (880nM) | active (40.4%) | active (79.43nM) | active (14%) |
MAPKAPK5 | active (270nM) | active (45.97%) | - | active (29%) |
MNK1 | active (170nM) | active (20.33%) | - | - |
MNK2 | active (17nM) | active (5%) | - | active (8%) |
MAPKAPK3 | - | inactive (85.14%) | inactive (>3981.07nM) | inactive (101%) |
CAMK - MLCK
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
caMLCK | active (140nM) | - | - | - |
smMLCK | active (15nM) | active (2.18%) | - | active (0%) |
skMLCK | active (61nM) | active (7.59%) | - | - |
SgK085 | active (470nM) | - | - | - |
CAMK - PHK
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
PHKg1 | active (0.65nM) | active (1.43%) | - | - |
PHKg2 | active (0.14nM) | active (3.42%) | - | active (2%) |
CAMK - PIM
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
PIM1 | active (3.2nM) | active (1.47%) | inactive (3162.28nM) | active (2%) |
PIM2 | active (1.9nM) | active (10.4%) | active (3.16nM) | active (8%) |
PIM3 | active (0.51nM) | active (0.63%) | - | active (5%) |
CAMK - PKD
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
PKD1 | active (27nM) | active (1.42%) | - | active (2%) |
PKD2 | active (72nM) | active (1%) | active (2.51nM) | active (5%) |
PKD3 | active (18nM) | active (0.98%) | active (39.81nM) | - |
CAMK - STK33
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
STK33 | active (1.8nM) | active (10.67%) | - | active (3%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
TSSK1 | active (24nM) | active (1%) | - | active (0%) |
TSSK2 | - | active (1.18%) | - | active (0%) |
STE
STE
Test Member No. in Family |
---|
Family | no. Member on 518kinase | DRx | RBC | Metz | Millipore |
---|
STE11 | 8 | 8 | 3 | - | 1 |
STE20 | 31 | 27 | 23 | 9 | 14 |
STE7 | 7 | 7 | 3 | 2 | 3 |
STE-Unique | 2 | - | 2 | - | - |
STE - STE11
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
MAP3K5 | active (110nM) | active (4.72%) | - | active (-1%) |
MAP3K6 | active (260nM) | - | - | - |
MAP3K1 | active (350nM) | - | - | - |
MAP3K7 | active (2.5nM) | - | - | - |
MAP3K2 | active (2.4nM) | active (1.25%) | - | - |
MAP3K3 | active (2800nM) | active (5.41%) | - | - |
MAP3K4 | active (1200nM) | - | - | - |
MAP3K8 | active (0.86nM) | - | - | - |
STE - STE20
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
HPK1 | active (4.3nM) | - | - | - |
LOK | active (0.04nM) | active (0.28%) | - | active (0%) |
GCK | active (8.8nM) | active (0.53%) | active (5.01nM) | active (-1%) |
KHS2 | active (8.2nM) | - | - | - |
HGK | active (24nM) | active (1.91%) | active (1.58nM) | - |
KHS1 | active (18nM) | active (0.46%) | active (0.63nM) | - |
MINK | active (1nM) | active (1.57%) | - | active (0%) |
MST1 | active (0.19nM) | active (-0.2%) | - | active (-1%) |
MST2 | active (0.18nM) | active (1.11%) | active (0.4nM) | active (5%) |
MST3 | active (120nM) | active (1.6%) | - | active (1%) |
MST4 | active (140nM) | active (4.43%) | - | - |
MYO3A | active (500nM) | - | - | - |
MYO3B | active (300nM) | active (2.77%) | - | - |
OSR1 | active (440nM) | active (14.2%) | - | - |
PAK1 | active (0.57nM) | active (1.59%) | active (5.01nM) | - |
PAK2 | active (3.1nM) | active (0.68%) | - | active (5%) |
PAK3 | active (7.1nM) | active (2.37%) | - | active (0%) |
PAK4 | active (6.3nM) | active (4.95%) | active (7.94nM) | active (0%) |
PAK6 | active (0.57nM) | active (4.74%) | - | active (0%) |
PAK5 | active (1.2nM) | active (2.34%) | - | active (1%) |
SLK | active (0.02nM) | active (1.83%) | - | - |
STLK3 | active (130nM) | active (8%) | - | - |
TAO1 | active (0.45nM) | active (0.93%) | active (10nM) | active (0%) |
TAO2 | active (12nM) | active (1.02%) | - | active (0%) |
TAO3 | active (0.22nM) | active (2.11%) | - | active (0%) |
TNIK | active (4.7nM) | - | - | - |
YSK1 | active (110nM) | active (3.22%) | - | - |
STE - STE7
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
MAP2K1 | active (21nM) | active (3.83%) | active (6.31nM) | active (6%) |
MAP2K2 | active (28nM) | active (8.43%) | active (630.96nM) | - |
MAP2K3 | active (5nM) | - | - | - |
MAP2K4 | active (70nM) | - | - | - |
MAP2K5 | active (2.9nM) | - | - | - |
MAP2K6 | active (3.4nM) | active (15.22%) | - | active (0%) |
MAP2K7 | active (30nM) | - | - | active (12%) |
STE - STE-Unique
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
COT | - | inactive (106.02%) | - | - |
NIK | - | inactive (117.21%) | - | - |
CMGC
CMGC
Test Member No. in Family |
---|
Family | no. Member on 518kinase | DRx | RBC | Metz | Millipore |
---|
CDK | 20 | 8 | - | 7 | - |
CDKL | 5 | 4 | - | - | - |
CLK | 4 | 4 | 4 | 2 | 2 |
CK2 | 3 | 2 | 2 | 1 | 2 |
DYRK | 10 | 8 | 9 | 6 | 4 |
MAPK | 14 | 14 | 10 | 8 | 10 |
GSK | 2 | 2 | 2 | 2 | 2 |
RCK | 3 | 2 | - | - | - |
SRPK | 3 | 3 | 3 | 1 | 3 |
CMGC - CDK
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
PITSLRE | inactive (10001nM) | - | - | - |
CHED | active (70nM) | - | - | - |
CDK11 | active (190nM) | - | - | - |
PCTAIRE1 | active (24nM) | - | - | - |
PCTAIRE2 | active (96nM) | - | - | - |
PCTAIRE3 | active (270nM) | - | - | - |
PFTAIRE2 | active (260nM) | - | - | - |
PFTAIRE1 | active (160nM) | - | - | - |
CDC2 | - | - | active (3.98nM) | - |
CDK2 | - | - | - | - |
CDK5 | - | - | active (3.98nM) | - |
CDK8 | - | - | active (19.95nM) | - |
CDK7 | - | - | active (63.1nM) | - |
CDK9 | - | - | active (12.59nM) | - |
CMGC - CDKL
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
CDKL1 | active (330nM) | - | - | - |
CDKL2 | active (510nM) | - | - | - |
CDKL3 | inactive (5100nM) | - | - | - |
CDKL5 | active (340nM) | - | - | - |
CMGC - CLK
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
CLK1 | active (32nM) | active (11.88%) | - | - |
CLK2 | active (8.2nM) | active (3.71%) | active (19.95nM) | active (3%) |
CLK3 | active (910nM) | inactive (85.99%) | - | inactive (56%) |
CLK4 | active (9.6nM) | active (6.62%) | active (2nM) | - |
CMGC - CK2
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
CK2a1 | active (940nM) | inactive (87.9%) | inactive (1584.89nM) | inactive (81%) |
CK2a2 | active (230nM) | inactive (66.62%) | - | inactive (83%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
DYRK1A | active (4nM) | active (4.6%) | active (2.51nM) | - |
DYRK1B | active (28nM) | active (0.85%) | active (5.01nM) | - |
DYRK2 | active (250nM) | inactive (69.87%) | - | inactive (65%) |
HIPK1 | active (2700nM) | inactive (96.48%) | - | inactive (87%) |
HIPK2 | active (190nM) | inactive (84.68%) | active (125.89nM) | active (47%) |
HIPK3 | active (75nM) | inactive (100.71%) | - | inactive (74%) |
HIPK4 | active (390nM) | inactive (55.34%) | - | - |
PRP4 | active (220nM) | - | - | - |
DYRK3 | - | active (31.33%) | - | - |
DYRK4 | - | inactive (96.16%) | - | - |
CMGC - MAPK
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
Erk1 | inactive (8400nM) | inactive (97.21%) | - | inactive (66%) |
Erk2 | inactive (7300nM) | inactive (97.45%) | active (501.19nM) | inactive (82%) |
Erk3 | inactive (3100nM) | - | - | - |
Erk4 | inactive (10001nM) | - | - | - |
Erk5 | active (1600nM) | - | - | - |
Erk7 | active (35nM) | - | - | - |
JNK1 | active (220nM) | inactive (102.48%) | active (100nM) | inactive (64%) |
JNK2 | active (910nM) | inactive (100%) | inactive (1995.26nM) | inactive (67%) |
JNK3 | active (110nM) | inactive (123.23%) | active (50.12nM) | active (12%) |
NLK | active (220nM) | active (20.53%) | - | active (30%) |
p38a | inactive (10001nM) | inactive (101.04%) | inactive (>3981.07nM) | inactive (81%) |
p38b | inactive (10001nM) | inactive (98.83%) | - | inactive (97%) |
p38d | active (240nM) | inactive (86.64%) | active (199.53nM) | active (25%) |
p38g | active (42nM) | inactive (116.69%) | active (199.53nM) | active (35%) |
CMGC - GSK
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
GSK3A | active (140nM) | active (5.78%) | active (15.85nM) | active (1%) |
GSK3B | active (69nM) | active (4.4%) | active (31.62nM) | active (13%) |
CMGC - RCK
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
ICK | active (16nM) | - | - | - |
MAK | active (2600nM) | - | - | - |
CMGC - SRPK
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
SRPK1 | active (5.5nM) | active (17.84%) | - | active (11%) |
SRPK2 | active (67nM) | active (40.95%) | - | active (49%) |
MSSK1 | active (73nM) | inactive (79.63%) | - | inactive (92%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | DRx | RBC | Metz | Millipore |
---|
CK1 | 7 | 7 | 6 | 5 | 4 |
VRK | 3 | 1 | 1 | - | 1 |
CK1 - CK1
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
CK1a | active (970nM) | inactive (79.71%) | inactive (1258.93nM) | - |
CK1a2 | active (250nM) | - | - | - |
CK1d | active (2400nM) | inactive (91.23%) | inactive (>2511.89nM) | inactive (77%) |
CK1e | active (73nM) | inactive (78.21%) | - | - |
CK1g1 | inactive (3500nM) | inactive (91.45%) | - | inactive (90%) |
CK1g2 | active (780nM) | inactive (75.74%) | - | inactive (73%) |
CK1g3 | inactive (10001nM) | inactive (96.05%) | - | inactive (91%) |
CK1 - VRK
Bioactivity |
---|
Kinase | DRx | RBC | Metz | Millipore |
---|
VRK2 | inactive (10001nM) | - | - | inactive (108%) |
VRK1 | - | inactive (84.12%) | - | - |