Compound in Profiling

Compound Information

Test on : DRx, RBC, Metz, Millipore

Compound Name
DRx : staurosporine
RBC, Millipore : staurosporine
Metz : Staurosporine, 98%

Inchikey
Same : HKSZLNNOFSGOKW-N
DRx : HKSZLNNOFSGOKW-FYTWVXJKSA-N
RBC, Millipore : HKSZLNNOFSGOKW-HMWZOHBLSA-N
Metz : HKSZLNNOFSGOKW-ZYSRIHRCSA-N

ChemSpider
DRx : 40272
RBC, Millipore : 397853
Metz : 24808335

Pubchem CID
DRx : 44259
RBC, Millipore : 451705
Metz : 49831000

ChEMBL
DRx : CHEMBL388978
RBC, Millipore : CHEMBL290084
Metz : -

DRx	RBC, Millipore	Metz

	DRx	RBC	Metz	Millipore	GPCR
bioactivity	Kd (nM)	Remain Activity (%)	Ki (nM)	Remain Activity (%)	Inhibition (%)
active criteria	<3000nM	<50%	<1000nM	<50%	>50%

Other

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC	Metz	Millipore
NAK	4	4	1	-	-
Aur	3	3	3	2	3
CAMKK	2	2	2	1	-
PEK	4	2	-	-	-
IRE	2	1	-	-	-
IKK	4	4	4	4	3
NEK	11	9	8	2	5
WEE	3	3	1	1	-
PLK	4	4	3	3	3
SgK496	1	1	1	-	-
NKF1	3	2	-	-	-
NKF4	2	1	-	-	-
ULK	5	4	3	-	2
TLK	2	2	1	-	1
TTK	1	1	1	-	-
Haspin	1	-	1	-	1
TOPK	1	-	1	1	-
WNK	4	-	2	-	2
CDC7	1	-	-	1	-

Other - NAK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
AAK1	active (1.2nM)	-	-	-
BIKE	active (5.6nM)	-	-	-
GAK	active (17nM)	-	-	-
MPSK1	active (270nM)	active (48.4%)	-	-

Other - Aur

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
AurA	active (17nM)	active (2.43%)	active (2.51nM)	active (-9%)
AurB	active (19nM)	active (4.3%)	active (2nM)	active (1%)
AurC	active (23nM)	active (5.21%)	-	active (3%)

Other - CAMKK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
CaMKK1	active (0.04nM)	active (-3.13%)	-	-
CaMKK2	active (0.16nM)	active (0.24%)	active (0.2nM)	-

Other - PEK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
HRI	inactive (10001nM)	-	-	-
PKR	active (360nM)	-	-	-

Other - IRE

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
IRE1	active (21nM)	-	-	-

Other - IKK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
IKKa	active (5.8nM)	active (40.33%)	active (50.12nM)	active (6%)
IKKb	active (31nM)	inactive (53.43%)	active (251.19nM)	active (35%)
IKKe	active (5.1nM)	active (0.3%)	active (5.01nM)	-
TBK1	active (0.89nM)	active (-0.46%)	active (1.26nM)	active (2%)

Other - NEK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
NEK1	active (860nM)	active (3.99%)	-	-
NEK11	inactive (3100nM)	active (37.02%)	-	inactive (54%)
NEK2	active (750nM)	inactive (79.9%)	inactive (2511.89nM)	inactive (63%)
NEK3	inactive (10001nM)	inactive (91.92%)	-	inactive (105%)
NEK4	inactive (10001nM)	active (46.8%)	-	-
NEK5	active (810nM)	-	-	-
NEK6	inactive (10001nM)	inactive (88.63%)	-	inactive (75%)
NEK7	inactive (4500nM)	inactive (95.78%)	-	inactive (93%)
NEK9	inactive (3100nM)	active (27.18%)	-	-

Other - WEE

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
MYT1	inactive (10001nM)	-	-	-
Wee1	active (1600nM)	inactive (73.1%)	inactive (1995.26nM)	-
Wee1B	inactive (10001nM)	-	-	-

Other - PLK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
PLK1	active (190nM)	active (36.88%)	inactive (1258.93nM)	inactive (53%)
PLK2	active (200nM)	inactive (94.75%)	-	inactive (69%)
PLK3	active (910nM)	active (37.79%)	inactive (1995.26nM)	inactive (81%)
PLK4	active (0.77nM)	-	active (7.94nM)	-

Other - SgK496

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
SgK496	active (11nM)	active (18.72%)	-	-

Other - NKF1

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
SBK	active (3.2nM)	-	-	-
SgK110	active (25nM)	-	-	-

Other - NKF4

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
CLIK1	active (140nM)	-	-	-

Other - ULK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
Fused	inactive (6700nM)	-	-	-
ULK1	active (9.9nM)	active (3.27%)	-	-
ULK2	active (0.79nM)	active (2.7%)	-	active (2%)
ULK3	active (1.2nM)	active (1.82%)	-	active (-1%)

Other - TLK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
TLK1	active (27nM)	-	-	-
TLK2	active (16nM)	active (2.83%)	-	active (1%)

Other - TTK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
TTK	active (61nM)	active (36.29%)	-	-

Other - Haspin

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
Haspin	-	active (6.94%)	-	active (1%)

Other - TOPK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
PBK	-	active (27.77%)	-	-

Other - WNK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
Wnk2	-	inactive (93.14%)	-	inactive (92%)
Wnk3	-	inactive (73.62%)	-	inactive (88%)

Other - CDC7

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
CDC7	-	-	-	-

TK

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC	Metz	Millipore
Abl	2	2	2	1	2
ALK	2	2	2	2	1
Axl	3	3	3	2	3
Src	11	11	11	9	10
Tec	5	5	5	3	4
PDGFR	5	5	5	5	5
Csk	2	2	2	1	1
DDR	2	2	1	-	1
EGFR	4	4	3	3	2
Eph	14	13	12	1	11
FAK	2	2	2	2	2
Fer	2	2	2	2	2
FGFR	4	4	4	2	4
VEGFR	3	3	3	3	3
InsR	3	3	3	2	3
JakA	4	4	4	3	2
Met	2	2	2	2	2
Musk	1	1	1	-	1
Ret	1	1	1	1	1
Sev	1	1	1	1	1
Syk	2	2	2	1	2
Tie	2	2	1	-	1
Ack	2	2	1	1	1
Trk	3	3	3	3	2

TK - Abl

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
ABL1	active (37nM)	active (23.01%)	active (100nM)	active (18%)
ABL2	active (110nM)	active (5.25%)	-	active (1%)

TK - ALK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
ALK	active (32nM)	active (0.86%)	active (5.01nM)	active (0%)
LTK	active (37nM)	active (0.54%)	active (3.16nM)	-

TK - Axl

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
AXL	active (6.8nM)	active (13.27%)	-	active (-2%)
MER	active (6.4nM)	active (2.63%)	-	active (3%)
TYRO3	active (280nM)	active (7.27%)	active (10nM)	active (0%)

TK - Src

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
BLK	active (15nM)	active (1.57%)	active (1.58nM)	active (0%)
BRK	active (2300nM)	active (32.6%)	-	active (38%)
FGR	active (17nM)	active (0.27%)	-	active (1%)
FRK	active (45nM)	active (5.5%)	-	active (1%)
FYN	active (33nM)	active (3.59%)	active (50.12nM)	active (-1%)
HCK	active (20nM)	active (3.26%)	active (5.01nM)	active (0%)
LCK	active (30nM)	active (1.84%)	active (25.12nM)	active (-1%)
LYN	active (40nM)	active (1.18%)	active (6.31nM)	active (0%)
SRC	active (86nM)	active (1.46%)	active (19.95nM)	active (8%)
SRM	active (740nM)	inactive (110.98%)	-	-
YES	active (52nM)	active (4.48%)	-	active (0%)

TK - Tec

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
BMX	active (170nM)	active (6.22%)	-	active (3%)
BTK	active (210nM)	active (7.82%)	active (79.43nM)	active (2%)
ITK	active (19nM)	active (2.89%)	active (7.94nM)	active (3%)
TEC	active (1300nM)	inactive (91.13%)	-	-
TXK	active (230nM)	active (7.33%)	-	active (21%)

TK - PDGFR

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
FMS	active (12nM)	active (1.76%)	active (7.94nM)	active (1%)
FLT3	active (2.9nM)	active (1.12%)	active (12.59nM)	active (-1%)
KIT	active (19nM)	active (8.67%)	active (158.49nM)	active (10%)
PDGFRa	active (10nM)	active (2.11%)	active (7.94nM)	active (5%)
PDGFRb	active (1.8nM)	active (2.28%)	active (0.79nM)	active (4%)

TK - Csk

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
CSK	active (330nM)	active (8.01%)	-	active (29%)
CTK	active (260nM)	inactive (75%)	-	-

TK - DDR

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
DDR1	active (19nM)	-	-	-
DDR2	active (42nM)	active (3.83%)	-	active (6%)

TK - EGFR

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
EGFR	active (370nM)	active (32.45%)	active (25.12nM)	inactive (53%)
ErbB2	active (190nM)	active (35.87%)	active (31.62nM)	-
ErbB3	inactive (10001nM)	-	-	-
ErbB4	active (770nM)	active (48.8%)	inactive (>251.19nM)	inactive (58%)

TK - Eph

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
EphA1	active (300nM)	active (31.03%)	-	active (5%)
EphA2	active (1200nM)	active (21.33%)	active (251.19nM)	active (32%)
EphA3	active (27nM)	active (13.99%)	-	active (3%)
EphA4	active (290nM)	active (6.7%)	-	active (15%)
EphA5	active (95nM)	active (9.28%)	-	active (7%)
EphA6	active (290nM)	active (5.57%)	-	-
EphA7	active (630nM)	active (11.52%)	-	active (22%)
EphA8	active (190nM)	active (25.67%)	-	active (33%)
EphB1	active (240nM)	active (11.97%)	-	active (21%)
EphB2	active (2100nM)	active (27.6%)	-	active (20%)
EphB3	inactive (10001nM)	inactive (75.16%)	-	inactive (119%)
EphB4	active (2200nM)	active (37.57%)	-	inactive (79%)
EphB6	active (210nM)	-	-	-

TK - FAK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
FAK	active (64nM)	active (4.34%)	active (100nM)	active (3%)
PYK2	active (3.5nM)	active (2.71%)	-	active (2%)

TK - Fer

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
FER	active (24nM)	active (0.82%)	active (3.16nM)	active (2%)
FES	active (23nM)	active (4.11%)	-	active (0%)

TK - FGFR

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
FGFR1	active (90nM)	active (1.71%)	active (39.81nM)	active (-1%)
FGFR2	active (100nM)	active (3.25%)	-	active (1%)
FGFR3	active (88nM)	active (3.69%)	active (39.81nM)	active (3%)
FGFR4	active (250nM)	active (47.2%)	-	active (49%)

TK - VEGFR

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
FLT1	active (150nM)	active (7.88%)	active (5.01nM)	active (0%)
FLT4	active (28nM)	active (4.29%)	active (6.31nM)	active (1%)
KDR	active (220nM)	active (4.46%)	active (6.31nM)	active (2%)

TK - InsR

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
IGF1R	active (210nM)	active (14.78%)	active (25.12nM)	inactive (112%)
INSR	active (110nM)	active (3.14%)	active (12.59nM)	active (13%)
IRR	active (81nM)	active (1.71%)	-	active (-1%)

TK - JakA

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
JAK1	active (6.1nM)	active (2.07%)	-	-
JAK2	active (9.8nM)	active (1.85%)	active (0.79nM)	active (0%)
JAK3	active (12nM)	active (0.74%)	active (2nM)	active (0%)
TYK2	active (56nM)	active (1.85%)	-	-

TK - Met

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
MET	active (190nM)	active (32.74%)	active (100nM)	active (5%)
RON	active (400nM)	active (44.75%)	active (0.25nM)	active (13%)

TK - Musk

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
MUSK	active (86nM)	active (12.21%)	-	active (-1%)

TK - Ret

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
RET	active (15nM)	active (0.64%)	active (2.51nM)	active (3%)

TK - Sev

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
ROS	active (30nM)	active (0.86%)	active (0.5nM)	active (3%)

TK - Syk

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
SYK	active (14nM)	active (4.66%)	active (3.16nM)	active (1%)
ZAP70	active (44nM)	active (5.36%)	-	active (6%)

TK - Tie

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
TIE1	active (65nM)	-	-	-
TIE2	active (140nM)	active (22%)	-	active (0%)

TK - Ack

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
TNK1	active (2.5nM)	-	-	-
ACK	active (16nM)	active (2.17%)	active (1.58nM)	active (-2%)

TK - Trk

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
TRKA	active (4nM)	active (0.77%)	active (6.31nM)	active (-1%)
TRKB	active (3.8nM)	active (0.37%)	active (0.79nM)	active (29%)
TRKC	active (17nM)	active (0.99%)	active (2nM)	-

TKL

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC	Metz	Millipore
STKR	12	10	5	1	2
RIPK	5	4	1	-	1
RAF	5	2	3	1	1
MLK	10	8	5	2	2
IRAK	4	3	2	2	2
LISK	4	3	1	1	1
LRRK	2	1	1	1	-

TKL - STKR

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
ALK2	active (470nM)	inactive (91.87%)	active (63.1nM)	-
ALK4	active (680nM)	inactive (117.27%)	-	inactive (70%)
ACTR2	inactive (8900nM)	-	-	-
ACTR2B	inactive (4600nM)	-	-	-
ALK1	inactive (10001nM)	inactive (83.74%)	-	-
BMPR1A	inactive (3700nM)	-	-	-
BMPR1B	active (170nM)	-	-	-
BMPR2	active (2300nM)	-	-	-
TGFbR1	active (2000nM)	inactive (114.21%)	-	inactive (79%)
TGFbR2	inactive (10001nM)	inactive (132.65%)	-	-

TKL - RIPK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
SgK288	active (270nM)	-	-	-
RIPK1	inactive (10001nM)	-	-	-
RIPK2	inactive (5200nM)	active (46.96%)	-	active (49%)
ANKRD3	active (110nM)	-	-	-

TKL - RAF

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
BRAF	inactive (10001nM)	inactive (112.82%)	-	-
RAF1	inactive (10001nM)	inactive (119.46%)	-	inactive (109%)
ARAF	-	inactive (134.41%)	-	-

TKL - MLK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
DLK	active (1500nM)	-	-	-
LZK	active (210nM)	-	-	-
MLK1	active (10nM)	active (7.1%)	-	active (0%)
MLK2	active (52nM)	active (3.26%)	active (3.16nM)	-
MLK3	active (20nM)	active (1.09%)	-	-
TAK1	active (67nM)	active (7.96%)	-	active (14%)
HH498	active (1000nM)	-	-	-
ZAK	inactive (10001nM)	inactive (98.32%)	-	-

TKL - IRAK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
IRAK1	active (40nM)	active (7.47%)	-	active (5%)
IRAK3	active (13nM)	-	-	-
IRAK4	active (1.7nM)	active (3.46%)	active (10nM)	active (1%)

TKL - LISK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
LIMK1	active (480nM)	active (5.51%)	active (100nM)	active (1%)
LIMK2	inactive (9200nM)	-	-	-
TESK1	active (320nM)	-	-	-

TKL - LRRK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
LRRK2	active (3.1nM)	active (1.01%)	active (0.4nM)	-

Atypical

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC	Metz	Millipore
ABC1	5	2	-	-	-
PIKK	6	1	-	-	1
RIO	3	3	-	-	-
Alpha	6	1	-	1	1
PDHK	5	-	1	-	-

Atypical - ABC1

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
ADCK3	inactive (10001nM)	-	-	-
ADCK4	inactive (10001nM)	-	-	-

Atypical - PIKK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
FRAP	inactive (10001nM)	-	-	inactive (87%)

Atypical - RIO

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
RIOK1	active (130nM)	-	-	-
RIOK2	active (390nM)	-	-	-
RIOK3	active (76nM)	-	-	-

Atypical - Alpha

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
ChaK2	inactive (10001nM)	-	-	-
eEF2K	-	-	inactive (>1000nM)	inactive (74%)

Atypical - PDHK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
PDHK1	-	active (4.41%)	-	-

AGC

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC	Metz	Millipore
Akt	3	3	3	3	3
DMPK	7	7	5	3	5
GRK	7	3	6	1	3
NDR	4	4	1	-	-
MAST	5	1	-	-	-
PDK1	1	1	1	1	1
PKA	5	3	3	2	2
PKN	3	2	2	1	1
PKC	9	5	9	5	8
PKG	2	2	3	2	-
RSK	8	1	8	4	7
SGK	3	1	3	1	3
YANK	3	3	-	-	-

AGC - Akt

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
AKT1	active (20nM)	active (7.49%)	inactive (>2.51nM)	active (13%)
AKT2	active (44nM)	active (5.51%)	active (10nM)	active (4%)
AKT3	active (170nM)	active (2.97%)	active (6.31nM)	active (-1%)

AGC - DMPK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
CRIK	active (340nM)	-	-	-
DMPK1	active (3.5nM)	active (4.83%)	-	active (16%)
DMPK2	active (37nM)	-	-	-
MRCKa	active (57nM)	active (1.75%)	active (3.98nM)	active (1%)
MRCKb	active (42nM)	active (1.99%)	-	active (0%)
ROCK1	active (0.28nM)	active (0.61%)	active (0.79nM)	active (5%)
ROCK2	active (0.24nM)	active (0.72%)	active (0.5nM)	active (2%)

AGC - GRK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
RHOK	active (0.97nM)	-	-	-
GPRK4	active (37nM)	active (20.52%)	-	-
GPRK7	active (0.86nM)	active (0.74%)	-	active (0%)
BARK1	-	inactive (56.82%)	-	-
BARK2	-	inactive (50.31%)	-	-
GPRK5	-	active (20.79%)	active (25.12nM)	active (10%)
GPRK6	-	active (7.36%)	-	active (17%)

AGC - NDR

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
LATS1	active (42nM)	-	-	-
LATS2	active (17nM)	-	-	-
NDR1	active (56nM)	active (10.02%)	-	-
NDR2	active (28nM)	-	-	-

AGC - MAST

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
MAST1	active (150nM)	-	-	-

AGC - PDK1

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
PDK1	active (1.7nM)	active (4.41%)	active (1.26nM)	active (1%)

AGC - PKA

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
PKACa	active (19nM)	active (1.93%)	active (0.79nM)	active (1%)
PKACb	active (29nM)	-	-	-
PRKX	active (13nM)	active (3.5%)	active (0.32nM)	active (0%)
PKACg	-	active (3.05%)	-	-

AGC - PKN

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
PKN1	active (1.3nM)	active (0.15%)	-	-
PKN2	active (2.5nM)	active (2.96%)	active (0.79nM)	active (1%)

AGC - PKC

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
PKCd	active (1.5nM)	active (5.61%)	inactive (>3.16nM)	active (2%)
PKCe	active (0.25nM)	active (0.8%)	-	active (1%)
PKCh	active (4.8nM)	active (0.41%)	-	active (3%)
PKCi	active (26nM)	active (4.59%)	-	active (50%)
PKCt	active (8.5nM)	active (2.81%)	active (2nM)	active (0%)
PKCa	-	active (1.23%)	-	active (1%)
PKCg	-	active (-3.22%)	active (3.16nM)	active (2%)
PKCz	-	active (21.98%)	active (50.12nM)	active (20%)
PKCb	-	active (3.03%)	-	-

AGC - PKG

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
PKG1	active (32nM)	active (5.01%)	-	-
PKG2	active (16nM)	active (7.12%)	-	-

AGC - RSK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
p70S6K	active (1.3nM)	active (0.14%)	active (5.01nM)	active (1%)
MSK1	-	active (1.24%)	-	active (1%)
MSK2	-	active (6.74%)	-	active (1%)
p70S6Kb	-	active (4.7%)	-	-
RSK2	-	active (-1.27%)	active (1.58nM)	active (0%)
RSK4	-	active (1.67%)	-	active (2%)
RSK1	-	active (3.52%)	-	active (1%)
RSK3	-	active (1.61%)	-	active (1%)

AGC - SGK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
SGK3	active (3.4nM)	active (23.47%)	-	active (42%)
SGK1	-	active (8.59%)	active (7.94nM)	active (8%)
SGK2	-	active (7.77%)	-	active (11%)

AGC - YANK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
YANK1	active (13nM)	-	-	-
YANK2	active (98nM)	-	-	-
YANK3	active (310nM)	-	-	-

CAMK

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC	Metz	Millipore
CAMKL	20	19	13	9	12
CAMK1	5	4	5	2	3
CAMK2	4	4	4	4	3
CASK	1	1	-	-	-
RAD53	1	1	1	1	1
DAPK	5	5	4	2	4
DCAMKL	3	3	1	1	1
MAPKAPK	5	4	5	4	4
MLCK	5	4	2	-	1
PHK	2	2	2	1	1
PIM	3	3	3	3	3
PKD	3	3	3	2	2
STK33	1	1	-	1	-
TSSK	5	1	2	2	2

CAMK - CAMKL

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
AMPKa1	active (3.7nM)	-	active (0.32nM)	active (1%)
AMPKa2	active (12nM)	-	-	active (-2%)
NuaK1	active (4.4nM)	active (1.59%)	-	active (8%)
BRSK1	active (26nM)	active (0.52%)	-	active (3%)
BRSK2	active (3.5nM)	active (3.53%)	-	active (-1%)
CHK1	active (3.2nM)	active (1.63%)	active (2.51nM)	active (-1%)
HUNK	active (620nM)	-	-	-
LKB1	active (61nM)	active (18.65%)	-	inactive (74%)
MARK1	active (4nM)	active (0.21%)	-	active (-1%)
MARK2	active (0.7nM)	active (0.02%)	active (7.94nM)	active (0%)
MARK3	active (3nM)	active (0.72%)	active (0.4nM)	-
MARK4	active (5.4nM)	active (-0.01%)	active (0.79nM)	-
MELK	active (33nM)	active (0.97%)	active (0.32nM)	active (2%)
NIM1	active (140nM)	-	-	-
QSK	active (0.46nM)	-	-	-
SIK	active (2.2nM)	-	-	active (1%)
QIK	active (1.1nM)	active (0.14%)	active (0.63nM)	-
NuaK2	active (0.09nM)	active (20.35%)	-	-
SNRK	active (90nM)	-	-	-
PASK	-	active (3.74%)	-	active (1%)

CAMK - CAMK1

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
CaMK1a	active (27nM)	active (2.22%)	active (12.59nM)	active (1%)
CaMK1d	active (1.1nM)	active (0.89%)	active (3.98nM)	active (2%)
CaMK1g	active (23nM)	active (4.71%)	-	-
CaMK4	active (41nM)	active (34.82%)	-	active (3%)
CaMK1b	-	active (4.82%)	-	-

CAMK - CAMK2

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
CaMK2a	active (0.16nM)	active (0.47%)	active (3.16nM)	-
CaMK2b	active (1.3nM)	active (1.64%)	-	active (-1%)
CaMK2d	active (0.32nM)	active (3.05%)	-	active (2%)
CaMK2g	active (0.55nM)	active (0.7%)	-	active (0%)

CAMK - CASK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
CASK	active (19nM)	-	-	-

CAMK - RAD53

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
CHK2	active (74nM)	active (1.33%)	active (10nM)	active (3%)

CAMK - DAPK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
DAPK1	active (1.4nM)	active (3.55%)	-	active (6%)
DAPK2	active (1.6nM)	active (4.07%)	-	active (6%)
DAPK3	active (1nM)	active (1.91%)	active (2nM)	active (0%)
DRAK1	active (14nM)	active (3.12%)	active (2.51nM)	active (1%)
DRAK2	active (21nM)	-	-	-

CAMK - DCAMKL

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
DCLK1	active (110nM)	-	-	-
DCLK2	active (73nM)	active (11.03%)	-	active (9%)
DCLK3	active (17nM)	-	-	-

CAMK - MAPKAPK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
MAPKAPK2	active (880nM)	active (40.4%)	active (79.43nM)	active (14%)
MAPKAPK5	active (270nM)	active (45.97%)	-	active (29%)
MNK1	active (170nM)	active (20.33%)	-	-
MNK2	active (17nM)	active (5%)	-	active (8%)
MAPKAPK3	-	inactive (85.14%)	inactive (>3981.07nM)	inactive (101%)

CAMK - MLCK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
caMLCK	active (140nM)	-	-	-
smMLCK	active (15nM)	active (2.18%)	-	active (0%)
skMLCK	active (61nM)	active (7.59%)	-	-
SgK085	active (470nM)	-	-	-

CAMK - PHK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
PHKg1	active (0.65nM)	active (1.43%)	-	-
PHKg2	active (0.14nM)	active (3.42%)	-	active (2%)

CAMK - PIM

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
PIM1	active (3.2nM)	active (1.47%)	inactive (3162.28nM)	active (2%)
PIM2	active (1.9nM)	active (10.4%)	active (3.16nM)	active (8%)
PIM3	active (0.51nM)	active (0.63%)	-	active (5%)

CAMK - PKD

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
PKD1	active (27nM)	active (1.42%)	-	active (2%)
PKD2	active (72nM)	active (1%)	active (2.51nM)	active (5%)
PKD3	active (18nM)	active (0.98%)	active (39.81nM)	-

CAMK - STK33

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
STK33	active (1.8nM)	active (10.67%)	-	active (3%)

CAMK - TSSK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
TSSK1	active (24nM)	active (1%)	-	active (0%)
TSSK2	-	active (1.18%)	-	active (0%)

STE

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC	Metz	Millipore
STE11	8	8	3	-	1
STE20	31	27	23	9	14
STE7	7	7	3	2	3
STE-Unique	2	-	2	-	-

STE - STE11

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
MAP3K5	active (110nM)	active (4.72%)	-	active (-1%)
MAP3K6	active (260nM)	-	-	-
MAP3K1	active (350nM)	-	-	-
MAP3K7	active (2.5nM)	-	-	-
MAP3K2	active (2.4nM)	active (1.25%)	-	-
MAP3K3	active (2800nM)	active (5.41%)	-	-
MAP3K4	active (1200nM)	-	-	-
MAP3K8	active (0.86nM)	-	-	-

STE - STE20

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
HPK1	active (4.3nM)	-	-	-
LOK	active (0.04nM)	active (0.28%)	-	active (0%)
GCK	active (8.8nM)	active (0.53%)	active (5.01nM)	active (-1%)
KHS2	active (8.2nM)	-	-	-
HGK	active (24nM)	active (1.91%)	active (1.58nM)	-
KHS1	active (18nM)	active (0.46%)	active (0.63nM)	-
MINK	active (1nM)	active (1.57%)	-	active (0%)
MST1	active (0.19nM)	active (-0.2%)	-	active (-1%)
MST2	active (0.18nM)	active (1.11%)	active (0.4nM)	active (5%)
MST3	active (120nM)	active (1.6%)	-	active (1%)
MST4	active (140nM)	active (4.43%)	-	-
MYO3A	active (500nM)	-	-	-
MYO3B	active (300nM)	active (2.77%)	-	-
OSR1	active (440nM)	active (14.2%)	-	-
PAK1	active (0.57nM)	active (1.59%)	active (5.01nM)	-
PAK2	active (3.1nM)	active (0.68%)	-	active (5%)
PAK3	active (7.1nM)	active (2.37%)	-	active (0%)
PAK4	active (6.3nM)	active (4.95%)	active (7.94nM)	active (0%)
PAK6	active (0.57nM)	active (4.74%)	-	active (0%)
PAK5	active (1.2nM)	active (2.34%)	-	active (1%)
SLK	active (0.02nM)	active (1.83%)	-	-
STLK3	active (130nM)	active (8%)	-	-
TAO1	active (0.45nM)	active (0.93%)	active (10nM)	active (0%)
TAO2	active (12nM)	active (1.02%)	-	active (0%)
TAO3	active (0.22nM)	active (2.11%)	-	active (0%)
TNIK	active (4.7nM)	-	-	-
YSK1	active (110nM)	active (3.22%)	-	-

STE - STE7

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
MAP2K1	active (21nM)	active (3.83%)	active (6.31nM)	active (6%)
MAP2K2	active (28nM)	active (8.43%)	active (630.96nM)	-
MAP2K3	active (5nM)	-	-	-
MAP2K4	active (70nM)	-	-	-
MAP2K5	active (2.9nM)	-	-	-
MAP2K6	active (3.4nM)	active (15.22%)	-	active (0%)
MAP2K7	active (30nM)	-	-	active (12%)

STE - STE-Unique

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
COT	-	inactive (106.02%)	-	-
NIK	-	inactive (117.21%)	-	-

CMGC

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC	Metz	Millipore
CDK	20	8	-	7	-
CDKL	5	4	-	-	-
CLK	4	4	4	2	2
CK2	3	2	2	1	2
DYRK	10	8	9	6	4
MAPK	14	14	10	8	10
GSK	2	2	2	2	2
RCK	3	2	-	-	-
SRPK	3	3	3	1	3

CMGC - CDK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
PITSLRE	inactive (10001nM)	-	-	-
CHED	active (70nM)	-	-	-
CDK11	active (190nM)	-	-	-
PCTAIRE1	active (24nM)	-	-	-
PCTAIRE2	active (96nM)	-	-	-
PCTAIRE3	active (270nM)	-	-	-
PFTAIRE2	active (260nM)	-	-	-
PFTAIRE1	active (160nM)	-	-	-
CDC2	-	-	active (3.98nM)	-
CDK2	-	-	-	-
CDK5	-	-	active (3.98nM)	-
CDK8	-	-	active (19.95nM)	-
CDK7	-	-	active (63.1nM)	-
CDK9	-	-	active (12.59nM)	-

CMGC - CDKL

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
CDKL1	active (330nM)	-	-	-
CDKL2	active (510nM)	-	-	-
CDKL3	inactive (5100nM)	-	-	-
CDKL5	active (340nM)	-	-	-

CMGC - CLK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
CLK1	active (32nM)	active (11.88%)	-	-
CLK2	active (8.2nM)	active (3.71%)	active (19.95nM)	active (3%)
CLK3	active (910nM)	inactive (85.99%)	-	inactive (56%)
CLK4	active (9.6nM)	active (6.62%)	active (2nM)	-

CMGC - CK2

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
CK2a1	active (940nM)	inactive (87.9%)	inactive (1584.89nM)	inactive (81%)
CK2a2	active (230nM)	inactive (66.62%)	-	inactive (83%)

CMGC - DYRK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
DYRK1A	active (4nM)	active (4.6%)	active (2.51nM)	-
DYRK1B	active (28nM)	active (0.85%)	active (5.01nM)	-
DYRK2	active (250nM)	inactive (69.87%)	-	inactive (65%)
HIPK1	active (2700nM)	inactive (96.48%)	-	inactive (87%)
HIPK2	active (190nM)	inactive (84.68%)	active (125.89nM)	active (47%)
HIPK3	active (75nM)	inactive (100.71%)	-	inactive (74%)
HIPK4	active (390nM)	inactive (55.34%)	-	-
PRP4	active (220nM)	-	-	-
DYRK3	-	active (31.33%)	-	-
DYRK4	-	inactive (96.16%)	-	-

CMGC - MAPK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
Erk1	inactive (8400nM)	inactive (97.21%)	-	inactive (66%)
Erk2	inactive (7300nM)	inactive (97.45%)	active (501.19nM)	inactive (82%)
Erk3	inactive (3100nM)	-	-	-
Erk4	inactive (10001nM)	-	-	-
Erk5	active (1600nM)	-	-	-
Erk7	active (35nM)	-	-	-
JNK1	active (220nM)	inactive (102.48%)	active (100nM)	inactive (64%)
JNK2	active (910nM)	inactive (100%)	inactive (1995.26nM)	inactive (67%)
JNK3	active (110nM)	inactive (123.23%)	active (50.12nM)	active (12%)
NLK	active (220nM)	active (20.53%)	-	active (30%)
p38a	inactive (10001nM)	inactive (101.04%)	inactive (>3981.07nM)	inactive (81%)
p38b	inactive (10001nM)	inactive (98.83%)	-	inactive (97%)
p38d	active (240nM)	inactive (86.64%)	active (199.53nM)	active (25%)
p38g	active (42nM)	inactive (116.69%)	active (199.53nM)	active (35%)

CMGC - GSK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
GSK3A	active (140nM)	active (5.78%)	active (15.85nM)	active (1%)
GSK3B	active (69nM)	active (4.4%)	active (31.62nM)	active (13%)

CMGC - RCK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
ICK	active (16nM)	-	-	-
MAK	active (2600nM)	-	-	-

CMGC - SRPK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
SRPK1	active (5.5nM)	active (17.84%)	-	active (11%)
SRPK2	active (67nM)	active (40.95%)	-	active (49%)
MSSK1	active (73nM)	inactive (79.63%)	-	inactive (92%)

CK1

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC	Metz	Millipore
CK1	7	7	6	5	4
VRK	3	1	1	-	1

CK1 - CK1

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
CK1a	active (970nM)	inactive (79.71%)	inactive (1258.93nM)	-
CK1a2	active (250nM)	-	-	-
CK1d	active (2400nM)	inactive (91.23%)	inactive (>2511.89nM)	inactive (77%)
CK1e	active (73nM)	inactive (78.21%)	-	-
CK1g1	inactive (3500nM)	inactive (91.45%)	-	inactive (90%)
CK1g2	active (780nM)	inactive (75.74%)	-	inactive (73%)
CK1g3	inactive (10001nM)	inactive (96.05%)	-	inactive (91%)

CK1 - VRK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
VRK2	inactive (10001nM)	-	-	inactive (108%)
VRK1	-	inactive (84.12%)	-	-