Compound Information
Test on : GPCR
Compound Name : GW694234A
Inchikey : HKPBZPKKYDOKSE-UHFFFAOYSA-N
ChemSpider : 28484237
Pubchem CID : 57396351
ChEMBL : CHEMBL1909370
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
TK
TK - JakA
Bioactivity |
---|
Kinase | GPCR |
---|
JAK1 | inactive (11.75%) |
TYK2 | inactive (0.6%) |
JAK2 | inactive (3.06%) |
JAK3 | inactive (1.27%) |
TK - Fer
Bioactivity |
---|
Kinase | GPCR |
---|
FER | inactive (4.33%) |
FES | inactive (2.25%) |
TK - Abl
Bioactivity |
---|
Kinase | GPCR |
---|
ABL1 | inactive (19.04%) |
ABL2 | inactive (34.36%) |
TK - Csk
Bioactivity |
---|
Kinase | GPCR |
---|
CSK | inactive (3.27%) |
TK - Tec
Bioactivity |
---|
Kinase | GPCR |
---|
BMX | inactive (1.32%) |
BTK | inactive (0.55%) |
TXK | inactive (4.17%) |
TEC | inactive (3.43%) |
ITK | inactive (1.87%) |
TK - Src
Bioactivity |
---|
Kinase | GPCR |
---|
BRK | inactive (4.63%) |
SRM | inactive (3.49%) |
FRK | inactive (1.12%) |
BLK | inactive (2.8%) |
LCK | inactive (10.53%) |
HCK | inactive (6.79%) |
FGR | inactive (2.98%) |
FYN | inactive (9.52%) |
SRC | inactive (6.9%) |
YES | inactive (6.98%) |
TK - Eph
Bioactivity |
---|
Kinase | GPCR |
---|
EphA2 | active (55.2%) |
EphA4 | active (76.88%) |
EphA3 | inactive (12.36%) |
EphB4 | inactive (26%) |
EphB3 | inactive (7.66%) |
EphB2 | active (80.38%) |
TK - FAK
Bioactivity |
---|
Kinase | GPCR |
---|
PYK2 | inactive (9.53%) |
TK - Syk
Bioactivity |
---|
Kinase | GPCR |
---|
SYK | inactive (0.53%) |
ZAP70 | inactive (3.22%) |
TK - ALK
Bioactivity |
---|
Kinase | GPCR |
---|
LTK | inactive (3.57%) |
ALK | inactive (3.65%) |
TK - Sev
Bioactivity |
---|
Kinase | GPCR |
---|
ROS | inactive (3.1%) |
TK - InsR
Bioactivity |
---|
Kinase | GPCR |
---|
INSR | inactive (5.63%) |
IGF1R | inactive (2.4%) |
IRR | inactive (-1.05%) |
TK - DDR
Bioactivity |
---|
Kinase | GPCR |
---|
DDR2 | active (93.69%) |
TK - Musk
Bioactivity |
---|
Kinase | GPCR |
---|
MUSK | inactive (49.34%) |
TK - Trk
Bioactivity |
---|
Kinase | GPCR |
---|
TRKA | active (55.6%) |
TRKB | inactive (32.52%) |
TRKC | inactive (38.84%) |
TK - Met
Bioactivity |
---|
Kinase | GPCR |
---|
RON | inactive (2.5%) |
MET | inactive (6.03%) |
TK - Axl
Bioactivity |
---|
Kinase | GPCR |
---|
AXL | inactive (9.52%) |
MER | inactive (3.46%) |
TYRO3 | inactive (15.32%) |
TK - Ret
Bioactivity |
---|
Kinase | GPCR |
---|
RET | active (80.58%) |
TK - FGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FGFR1 | inactive (0.5%) |
FGFR2 | inactive (3.33%) |
FGFR3 | inactive (2.66%) |
FGFR4 | inactive (2.05%) |
TK - VEGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FLT1 | active (53.66%) |
KDR | active (68.05%) |
FLT4 | inactive (11.88%) |
TK - PDGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FMS | inactive (43.23%) |
KIT | active (100.5%) |
FLT3 | active (56.71%) |
PDGFRa | active (87.38%) |
PDGFRb | inactive (35.88%) |
TK - Tie
Bioactivity |
---|
Kinase | GPCR |
---|
TIE2 | active (54.01%) |
TK - Ack
Bioactivity |
---|
Kinase | GPCR |
---|
ACK | inactive (0.1%) |
TNK1 | inactive (8.8%) |
TK - EGFR
Bioactivity |
---|
Kinase | GPCR |
---|
EGFR | inactive (3.19%) |
ErbB2 | inactive (0.8%) |
ErbB4 | inactive (11.24%) |
TKL
TKL
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
IRAK | 4 | 1 |
RAF | 5 | 1 |
TKL - IRAK
Bioactivity |
---|
Kinase | GPCR |
---|
IRAK4 | inactive (1.23%) |
TKL - RAF
Bioactivity |
---|
Kinase | GPCR |
---|
BRAF | inactive (20.56%) |
STE
STE
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
STE20 | 31 | 12 |
STE7 | 7 | 1 |
STE - STE20
Bioactivity |
---|
Kinase | GPCR |
---|
GCK | inactive (10.25%) |
MST1 | inactive (2.71%) |
MST2 | inactive (3.92%) |
MST4 | inactive (9.97%) |
HGK | inactive (5.51%) |
MINK | inactive (5.66%) |
LOK | inactive (34.23%) |
PAK1 | inactive (6.23%) |
PAK3 | inactive (2.59%) |
PAK2 | inactive (0.39%) |
PAK5 | inactive (-0.7%) |
PAK6 | inactive (-4.46%) |
STE - STE7
Bioactivity |
---|
Kinase | GPCR |
---|
MAP2K1 | inactive (4%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
CK1 | 7 | 4 |
CK1 - CK1
Bioactivity |
---|
Kinase | GPCR |
---|
CK1a | inactive (9.35%) |
CK1g2 | inactive (1.6%) |
CK1g1 | inactive (2.02%) |
CK1g3 | inactive (1.82%) |
Other
Other
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
PLK | 4 | 1 |
Aur | 3 | 3 |
NEK | 11 | 5 |
IKK | 4 | 4 |
TTK | 1 | 1 |
Other - PLK
Bioactivity |
---|
Kinase | GPCR |
---|
PLK1 | inactive (2.36%) |
Other - Aur
Bioactivity |
---|
Kinase | GPCR |
---|
AurB | inactive (21.03%) |
AurC | inactive (42.54%) |
AurA | inactive (7.48%) |
Other - NEK
Bioactivity |
---|
Kinase | GPCR |
---|
NEK1 | inactive (2.19%) |
NEK2 | inactive (2.81%) |
NEK9 | inactive (15.38%) |
NEK7 | inactive (2.69%) |
NEK6 | inactive (3.38%) |
Other - IKK
Bioactivity |
---|
Kinase | GPCR |
---|
TBK1 | inactive (3.82%) |
IKKe | inactive (5.38%) |
IKKb | inactive (7.62%) |
IKKa | inactive (7.22%) |
Other - TTK
Bioactivity |
---|
Kinase | GPCR |
---|
TTK | inactive (8.12%) |
AGC
AGC - GRK
Bioactivity |
---|
Kinase | GPCR |
---|
GPRK7 | inactive (25.88%) |
GPRK6 | inactive (6.2%) |
AGC - PDK1
Bioactivity |
---|
Kinase | GPCR |
---|
PDK1 | inactive (3.1%) |
AGC - RSK
Bioactivity |
---|
Kinase | GPCR |
---|
MSK1 | inactive (1.7%) |
MSK2 | inactive (2.39%) |
RSK1 | inactive (1.53%) |
RSK2 | inactive (0.56%) |
RSK4 | inactive (1.35%) |
RSK3 | inactive (2.4%) |
p70S6K | inactive (3.21%) |
AGC - Akt
Bioactivity |
---|
Kinase | GPCR |
---|
AKT2 | inactive (1.01%) |
AKT1 | inactive (0.17%) |
AKT3 | inactive (-2.06%) |
AGC - SGK
Bioactivity |
---|
Kinase | GPCR |
---|
SGK1 | inactive (6.16%) |
SGK3 | inactive (3.45%) |
SGK2 | inactive (3.07%) |
AGC - PKC
Bioactivity |
---|
Kinase | GPCR |
---|
PKCh | inactive (4.28%) |
PKCg | inactive (0.29%) |
PKCa | inactive (1.61%) |
PKCt | inactive (1.69%) |
PKCi | inactive (0.06%) |
AGC - PKG
Bioactivity |
---|
Kinase | GPCR |
---|
PKG2 | inactive (2.14%) |
PKG1 | inactive (2.02%) |
AGC - PKA
Bioactivity |
---|
Kinase | GPCR |
---|
PRKX | inactive (1.14%) |
AGC - DMPK
Bioactivity |
---|
Kinase | GPCR |
---|
ROCK1 | inactive (7.16%) |
ROCK2 | inactive (6.83%) |
MRCKb | inactive (-0.22%) |
MRCKa | inactive (0.85%) |
CAMK
CAMK - RAD53
Bioactivity |
---|
Kinase | GPCR |
---|
CHK2 | inactive (2.2%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
DCLK2 | inactive (4.24%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK4 | inactive (2.33%) |
CaMK1d | inactive (0.29%) |
CAMK - PHK
Bioactivity |
---|
Kinase | GPCR |
---|
PHKg1 | inactive (4.55%) |
PHKg2 | inactive (2.45%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK2d | inactive (3.53%) |
CaMK2a | inactive (2.07%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | GPCR |
---|
MAPKAPK5 | inactive (1.31%) |
MAPKAPK2 | inactive (1.19%) |
MAPKAPK3 | inactive (6.43%) |
MNK2 | inactive (4.55%) |
MNK1 | inactive (8.85%) |
CAMK - PKD
Bioactivity |
---|
Kinase | GPCR |
---|
PKD3 | inactive (3.88%) |
PKD1 | inactive (4.31%) |
PKD2 | inactive (4.58%) |
CAMK - CAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
MARK4 | inactive (1.17%) |
MARK3 | inactive (1.7%) |
MARK1 | inactive (1.86%) |
QIK | inactive (7.96%) |
SIK | inactive (11.93%) |
NuaK1 | inactive (2.47%) |
BRSK1 | inactive (0.86%) |
BRSK2 | inactive (0.84%) |
MELK | inactive (4.7%) |
CHK1 | inactive (2.72%) |
PASK | inactive (1.67%) |
AMPKa1 | inactive (2.58%) |
AMPKa2 | inactive (4.23%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | GPCR |
---|
TSSK2 | inactive (2.43%) |
TSSK1 | inactive (2.52%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | GPCR |
---|
DAPK1 | inactive (2.38%) |
CAMK - PIM
Bioactivity |
---|
Kinase | GPCR |
---|
PIM2 | inactive (-0.13%) |
PIM3 | inactive (0.5%) |
PIM1 | inactive (0.21%) |
CMGC
CMGC - MAPK
Bioactivity |
---|
Kinase | GPCR |
---|
JNK2 | inactive (4.83%) |
p38a | inactive (17.1%) |
p38b | inactive (16.97%) |
p38d | inactive (0.89%) |
Erk2 | inactive (2.49%) |
Erk1 | inactive (3.83%) |
CMGC - GSK
Bioactivity |
---|
Kinase | GPCR |
---|
GSK3A | inactive (5.24%) |
GSK3B | inactive (6.86%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | GPCR |
---|
SRPK1 | inactive (-2.45%) |
MSSK1 | inactive (1.64%) |
CMGC - CLK
Bioactivity |
---|
Kinase | GPCR |
---|
CLK3 | inactive (1.74%) |
CLK2 | inactive (1.48%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | GPCR |
---|
HIPK1 | inactive (2.41%) |
HIPK4 | inactive (19.46%) |
DYRK1B | inactive (1.17%) |
DYRK1A | inactive (2.3%) |
DYRK2 | inactive (3.59%) |
CMGC - CK2
Bioactivity |
---|
Kinase | GPCR |
---|
CK2a1 | inactive (2.62%) |