Compound Information
Test on : RBC
Compound Name : MEK Inhibitor II
Inchikey : GYQSWJNGTWVFOL-UHFFFAOYSA-N
ChemSpider : 345595
Pubchem CID : 389898
ChEMBL : CHEMBL404939
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
AGC
AGC - PDK1
Bioactivity |
---|
Kinase | RBC |
---|
PDK1 | inactive (100.16%) |
AGC - Akt
Bioactivity |
---|
Kinase | RBC |
---|
AKT1 | inactive (103.31%) |
AKT2 | inactive (96.29%) |
AKT3 | inactive (104.54%) |
AGC - DMPK
Bioactivity |
---|
Kinase | RBC |
---|
DMPK1 | inactive (98.5%) |
MRCKa | inactive (102.89%) |
MRCKb | inactive (98.58%) |
ROCK1 | inactive (106.38%) |
ROCK2 | inactive (91.5%) |
AGC - GRK
Bioactivity |
---|
Kinase | RBC |
---|
BARK1 | inactive (105.48%) |
BARK2 | inactive (103.1%) |
GPRK4 | inactive (97.64%) |
GPRK5 | inactive (91.54%) |
GPRK6 | inactive (98.49%) |
GPRK7 | inactive (108.91%) |
AGC - RSK
Bioactivity |
---|
Kinase | RBC |
---|
MSK1 | inactive (101.07%) |
MSK2 | inactive (115.13%) |
p70S6K | inactive (100.77%) |
p70S6Kb | inactive (101.87%) |
RSK2 | inactive (101.3%) |
RSK4 | inactive (99.9%) |
RSK1 | inactive (96.58%) |
RSK3 | inactive (103.9%) |
AGC - PKA
Bioactivity |
---|
Kinase | RBC |
---|
PKACg | inactive (95.11%) |
PRKX | inactive (102.65%) |
PKACa | inactive (88.79%) |
AGC - PKC
Bioactivity |
---|
Kinase | RBC |
---|
PKCa | inactive (99.05%) |
PKCd | inactive (97.76%) |
PKCe | - |
PKCh | inactive (93.13%) |
PKCg | inactive (97.55%) |
PKCi | inactive (96.63%) |
PKCt | inactive (114.45%) |
PKCz | inactive (114.15%) |
PKCb | inactive (107.68%) |
AGC - PKG
Bioactivity |
---|
Kinase | RBC |
---|
PKG2 | inactive (113.51%) |
PKG1 | inactive (97.78%) |
AGC - PKN
Bioactivity |
---|
Kinase | RBC |
---|
PKN1 | inactive (108.2%) |
PKN2 | inactive (107.91%) |
AGC - SGK
Bioactivity |
---|
Kinase | RBC |
---|
SGK1 | inactive (104.16%) |
SGK2 | inactive (99.48%) |
SGK3 | inactive (102.59%) |
AGC - NDR
Bioactivity |
---|
Kinase | RBC |
---|
NDR1 | inactive (102.31%) |
TK
TK - Abl
Bioactivity |
---|
Kinase | RBC |
---|
ABL1 | inactive (103.08%) |
ABL2 | inactive (106.34%) |
TK - Ack
Bioactivity |
---|
Kinase | RBC |
---|
ACK | inactive (91.46%) |
TK - ALK
Bioactivity |
---|
Kinase | RBC |
---|
ALK | inactive (88.47%) |
LTK | inactive (100.29%) |
TK - Axl
Bioactivity |
---|
Kinase | RBC |
---|
AXL | inactive (103.65%) |
MER | inactive (90.29%) |
TYRO3 | inactive (114.24%) |
TK - Src
Bioactivity |
---|
Kinase | RBC |
---|
BLK | inactive (110.78%) |
BRK | inactive (94.77%) |
SRC | inactive (95.08%) |
FGR | inactive (102.1%) |
FRK | inactive (103.12%) |
FYN | inactive (111.26%) |
HCK | inactive (94.24%) |
LCK | inactive (105.57%) |
SRM | inactive (108.15%) |
YES | inactive (103.05%) |
LYN | inactive (93.46%) |
TK - Tec
Bioactivity |
---|
Kinase | RBC |
---|
BMX | inactive (102.89%) |
BTK | inactive (103.21%) |
ITK | inactive (87.49%) |
TEC | inactive (100.67%) |
TXK | inactive (95.55%) |
TK - PDGFR
Bioactivity |
---|
Kinase | RBC |
---|
KIT | inactive (84.74%) |
FLT3 | inactive (107.97%) |
FMS | inactive (101.75%) |
PDGFRb | inactive (102.82%) |
PDGFRa | inactive (109.33%) |
TK - Csk
Bioactivity |
---|
Kinase | RBC |
---|
CSK | inactive (79.53%) |
CTK | inactive (88.04%) |
TK - DDR
Bioactivity |
---|
Kinase | RBC |
---|
DDR2 | inactive (95.76%) |
TK - EGFR
Bioactivity |
---|
Kinase | RBC |
---|
EGFR | inactive (98.4%) |
ErbB2 | inactive (95.41%) |
ErbB4 | inactive (109.57%) |
TK - Eph
Bioactivity |
---|
Kinase | RBC |
---|
EphA1 | inactive (97.59%) |
EphA2 | inactive (106.65%) |
EphA3 | inactive (105.12%) |
EphA4 | inactive (101.23%) |
EphA5 | inactive (112.53%) |
EphA6 | inactive (89.46%) |
EphA7 | inactive (106.28%) |
EphA8 | inactive (107%) |
EphB1 | inactive (97.16%) |
EphB2 | inactive (98.69%) |
EphB3 | inactive (97.05%) |
EphB4 | inactive (98.71%) |
TK - FAK
Bioactivity |
---|
Kinase | RBC |
---|
FAK | inactive (98.43%) |
PYK2 | inactive (105.23%) |
TK - Fer
Bioactivity |
---|
Kinase | RBC |
---|
FER | inactive (103.06%) |
FES | inactive (97.46%) |
TK - FGFR
Bioactivity |
---|
Kinase | RBC |
---|
FGFR1 | inactive (99.53%) |
FGFR2 | inactive (101.67%) |
FGFR3 | inactive (106.07%) |
FGFR4 | inactive (105.31%) |
TK - VEGFR
Bioactivity |
---|
Kinase | RBC |
---|
FLT1 | inactive (87.81%) |
FLT4 | inactive (102.44%) |
KDR | inactive (88.29%) |
TK - InsR
Bioactivity |
---|
Kinase | RBC |
---|
IGF1R | inactive (106.71%) |
IRR | inactive (96.94%) |
INSR | inactive (105.06%) |
TK - JakA
Bioactivity |
---|
Kinase | RBC |
---|
JAK1 | inactive (106.88%) |
JAK2 | inactive (103.67%) |
JAK3 | inactive (101.21%) |
TYK2 | inactive (101.96%) |
TK - Musk
Bioactivity |
---|
Kinase | RBC |
---|
MUSK | inactive (103.66%) |
TK - Ret
Bioactivity |
---|
Kinase | RBC |
---|
RET | inactive (97.97%) |
TK - Met
Bioactivity |
---|
Kinase | RBC |
---|
RON | inactive (94.54%) |
MET | inactive (109.39%) |
TK - Sev
Bioactivity |
---|
Kinase | RBC |
---|
ROS | inactive (95.79%) |
TK - Syk
Bioactivity |
---|
Kinase | RBC |
---|
SYK | inactive (95.94%) |
ZAP70 | inactive (93.77%) |
TK - Tie
Bioactivity |
---|
Kinase | RBC |
---|
TIE2 | inactive (96.7%) |
TK - Trk
Bioactivity |
---|
Kinase | RBC |
---|
TRKA | inactive (96.99%) |
TRKB | inactive (103.54%) |
TRKC | inactive (98.65%) |
TKL
TKL - STKR
Bioactivity |
---|
Kinase | RBC |
---|
ALK1 | inactive (105.03%) |
ALK2 | inactive (96.93%) |
ALK4 | inactive (105.69%) |
TGFbR1 | inactive (100.53%) |
TGFbR2 | inactive (130.07%) |
TKL - RAF
Bioactivity |
---|
Kinase | RBC |
---|
ARAF | inactive (104.99%) |
BRAF | inactive (96.26%) |
RAF1 | inactive (93.02%) |
TKL - IRAK
Bioactivity |
---|
Kinase | RBC |
---|
IRAK1 | inactive (100.55%) |
IRAK4 | inactive (89.13%) |
TKL - LISK
Bioactivity |
---|
Kinase | RBC |
---|
LIMK1 | inactive (92.49%) |
TKL - LRRK
Bioactivity |
---|
Kinase | RBC |
---|
LRRK2 | inactive (102.74%) |
TKL - MLK
Bioactivity |
---|
Kinase | RBC |
---|
MLK1 | inactive (105.75%) |
MLK2 | inactive (92.75%) |
MLK3 | inactive (101.8%) |
TAK1 | inactive (99.46%) |
ZAK | inactive (97.9%) |
TKL - RIPK
Bioactivity |
---|
Kinase | RBC |
---|
RIPK2 | inactive (84.78%) |
CAMK
CAMK - CAMKL
Bioactivity |
---|
Kinase | RBC |
---|
NuaK1 | inactive (105.22%) |
BRSK1 | inactive (96.93%) |
BRSK2 | inactive (100.27%) |
CHK1 | inactive (110.98%) |
LKB1 | inactive (99.75%) |
MARK1 | inactive (99.26%) |
MARK3 | inactive (87.78%) |
MARK4 | inactive (99.62%) |
MELK | inactive (96.43%) |
PASK | inactive (102.71%) |
QIK | inactive (92.81%) |
NuaK2 | inactive (86.7%) |
MARK2 | inactive (79.44%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | RBC |
---|
CaMK1a | inactive (98.25%) |
CaMK1b | inactive (100.35%) |
CaMK1d | inactive (101.52%) |
CaMK1g | inactive (98.19%) |
CaMK4 | inactive (102.61%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | RBC |
---|
CaMK2a | inactive (89.65%) |
CaMK2b | inactive (105.53%) |
CaMK2d | inactive (108.6%) |
CaMK2g | inactive (103.74%) |
CAMK - RAD53
Bioactivity |
---|
Kinase | RBC |
---|
CHK2 | inactive (95.66%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | RBC |
---|
DAPK1 | inactive (100.56%) |
DAPK2 | inactive (133.27%) |
DRAK1 | inactive (101.28%) |
DAPK3 | inactive (113.81%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | RBC |
---|
DCLK2 | inactive (100.22%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | RBC |
---|
MAPKAPK2 | inactive (104.53%) |
MAPKAPK3 | inactive (103.48%) |
MAPKAPK5 | inactive (73.56%) |
MNK1 | inactive (135.03%) |
MNK2 | inactive (84.48%) |
CAMK - MLCK
Bioactivity |
---|
Kinase | RBC |
---|
smMLCK | inactive (99.42%) |
skMLCK | inactive (98.08%) |
CAMK - PHK
Bioactivity |
---|
Kinase | RBC |
---|
PHKg1 | inactive (96.53%) |
PHKg2 | inactive (100.5%) |
CAMK - PIM
Bioactivity |
---|
Kinase | RBC |
---|
PIM1 | inactive (100.07%) |
PIM2 | inactive (122.94%) |
PIM3 | inactive (100.92%) |
CAMK - PKD
Bioactivity |
---|
Kinase | RBC |
---|
PKD1 | inactive (104.02%) |
PKD3 | inactive (88.17%) |
PKD2 | inactive (95.72%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | RBC |
---|
TSSK1 | inactive (103.97%) |
TSSK2 | inactive (103.19%) |
CAMK - STK33
Bioactivity |
---|
Kinase | RBC |
---|
STK33 | inactive (91.51%) |
STE
STE - STE11
Bioactivity |
---|
Kinase | RBC |
---|
MAP3K5 | inactive (99.14%) |
MAP3K2 | inactive (108.35%) |
MAP3K3 | inactive (95.46%) |
STE - STE-Unique
Bioactivity |
---|
Kinase | RBC |
---|
COT | inactive (91.81%) |
NIK | inactive (102.35%) |
STE - STE20
Bioactivity |
---|
Kinase | RBC |
---|
GCK | inactive (89.58%) |
HGK | inactive (93.72%) |
KHS1 | inactive (90.39%) |
LOK | - |
MINK | inactive (95.63%) |
MST1 | inactive (89.05%) |
MST2 | inactive (98.18%) |
MST3 | inactive (86.98%) |
MST4 | inactive (98.25%) |
OSR1 | inactive (107.89%) |
PAK1 | inactive (96.3%) |
PAK2 | inactive (103.59%) |
PAK3 | inactive (103.9%) |
PAK4 | inactive (113.77%) |
PAK5 | inactive (107.79%) |
PAK6 | inactive (89.59%) |
SLK | inactive (104.43%) |
YSK1 | inactive (107.43%) |
STLK3 | inactive (97.29%) |
TAO1 | inactive (83.11%) |
TAO2 | inactive (99.17%) |
TAO3 | inactive (95.35%) |
MYO3B | inactive (112.06%) |
STE - STE7
Bioactivity |
---|
Kinase | RBC |
---|
MAP2K1 | inactive (76.5%) |
MAP2K2 | inactive (106.01%) |
MAP2K6 | inactive (107.32%) |
Other
Other - Aur
Bioactivity |
---|
Kinase | RBC |
---|
AurA | inactive (104.5%) |
AurB | inactive (103.19%) |
AurC | inactive (97.87%) |
Other - CAMKK
Bioactivity |
---|
Kinase | RBC |
---|
CaMKK1 | inactive (112.36%) |
CaMKK2 | inactive (86.12%) |
Other - Haspin
Bioactivity |
---|
Kinase | RBC |
---|
Haspin | inactive (100.8%) |
Other - IKK
Bioactivity |
---|
Kinase | RBC |
---|
IKKa | inactive (101.15%) |
IKKb | inactive (100.82%) |
IKKe | inactive (99.6%) |
TBK1 | inactive (97.88%) |
Other - NEK
Bioactivity |
---|
Kinase | RBC |
---|
NEK1 | inactive (89.99%) |
NEK11 | inactive (100.57%) |
NEK2 | inactive (88.62%) |
NEK4 | inactive (99.57%) |
NEK6 | inactive (103.71%) |
NEK7 | inactive (95.42%) |
NEK9 | inactive (98.34%) |
NEK3 | inactive (102.09%) |
Other - TOPK
Bioactivity |
---|
Kinase | RBC |
---|
PBK | inactive (105.88%) |
Other - PLK
Bioactivity |
---|
Kinase | RBC |
---|
PLK1 | inactive (97.61%) |
PLK2 | inactive (96%) |
PLK3 | inactive (96.62%) |
Other - SgK496
Bioactivity |
---|
Kinase | RBC |
---|
SgK496 | inactive (95.44%) |
Other - NAK
Bioactivity |
---|
Kinase | RBC |
---|
MPSK1 | inactive (100.21%) |
Other - TTK
Bioactivity |
---|
Kinase | RBC |
---|
TTK | inactive (108.17%) |
Other - ULK
Bioactivity |
---|
Kinase | RBC |
---|
ULK1 | inactive (107.4%) |
ULK2 | inactive (108.2%) |
ULK3 | inactive (102.24%) |
Other - WEE
Bioactivity |
---|
Kinase | RBC |
---|
Wee1 | inactive (93.01%) |
Other - WNK
Bioactivity |
---|
Kinase | RBC |
---|
Wnk2 | inactive (108.33%) |
Wnk3 | inactive (96.41%) |
Other - TLK
Bioactivity |
---|
Kinase | RBC |
---|
TLK2 | inactive (117%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | RBC |
---|
CK1 | 7 | 6 |
VRK | 3 | 1 |
CK1 - CK1
Bioactivity |
---|
Kinase | RBC |
---|
CK1d | inactive (99.42%) |
CK1g1 | inactive (147.05%) |
CK1g2 | inactive (99.29%) |
CK1g3 | inactive (93.45%) |
CK1a | inactive (99.25%) |
CK1e | inactive (101.86%) |
CK1 - VRK
Bioactivity |
---|
Kinase | RBC |
---|
VRK1 | inactive (92.37%) |
CMGC
CMGC - CK2
Bioactivity |
---|
Kinase | RBC |
---|
CK2a1 | inactive (99.29%) |
CK2a2 | inactive (100.38%) |
CMGC - CLK
Bioactivity |
---|
Kinase | RBC |
---|
CLK1 | inactive (103.12%) |
CLK2 | inactive (90.71%) |
CLK3 | inactive (113.52%) |
CLK4 | inactive (94.11%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | RBC |
---|
DYRK1A | inactive (99.05%) |
DYRK1B | inactive (102.92%) |
DYRK2 | inactive (98.57%) |
DYRK3 | inactive (95.42%) |
DYRK4 | inactive (94.11%) |
HIPK1 | inactive (103.82%) |
HIPK2 | inactive (104.49%) |
HIPK3 | inactive (111.94%) |
HIPK4 | inactive (98.16%) |
CMGC - MAPK
Bioactivity |
---|
Kinase | RBC |
---|
Erk1 | inactive (99.28%) |
Erk2 | inactive (73.64%) |
JNK3 | inactive (93.56%) |
NLK | inactive (104.77%) |
p38a | inactive (88.11%) |
p38b | inactive (105.46%) |
p38d | inactive (105.84%) |
p38g | inactive (100.14%) |
JNK1 | inactive (122.2%) |
JNK2 | inactive (93.63%) |
CMGC - GSK
Bioactivity |
---|
Kinase | RBC |
---|
GSK3A | inactive (99.76%) |
GSK3B | inactive (99.97%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | RBC |
---|
MSSK1 | inactive (93.62%) |
SRPK1 | inactive (102.8%) |
SRPK2 | inactive (100.28%) |
Atypical
Atypical
Test Member No. in Family |
---|
Family | no. Member on 518kinase | RBC |
---|
PDHK | 5 | 1 |
Atypical - PDHK
Bioactivity |
---|
Kinase | RBC |
---|
PDHK1 | inactive (100.16%) |