Compound Information
Test on : GPCR
Compound Name : GW580509X
Inchikey : GOGIUMBXFRNDRK-UHFFFAOYSA-N
ChemSpider : 4487011
Pubchem CID : 5329860
ChEMBL : CHEMBL179311
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
TK
TK - JakA
Bioactivity |
---|
Kinase | GPCR |
---|
JAK1 | inactive (-4.39%) |
TYK2 | inactive (-4.34%) |
JAK2 | inactive (1.58%) |
JAK3 | inactive (5.85%) |
TK - Fer
Bioactivity |
---|
Kinase | GPCR |
---|
FER | inactive (3.8%) |
FES | inactive (2.42%) |
TK - Abl
Bioactivity |
---|
Kinase | GPCR |
---|
ABL1 | active (77.65%) |
ABL2 | active (72.59%) |
TK - Csk
Bioactivity |
---|
Kinase | GPCR |
---|
CSK | inactive (10.58%) |
TK - Tec
Bioactivity |
---|
Kinase | GPCR |
---|
BMX | inactive (25.94%) |
BTK | inactive (21.64%) |
TXK | active (53.42%) |
TEC | inactive (35.47%) |
ITK | inactive (5.9%) |
TK - Src
Bioactivity |
---|
Kinase | GPCR |
---|
BRK | inactive (40.66%) |
SRM | inactive (30.57%) |
FRK | inactive (26.93%) |
BLK | active (64.27%) |
LCK | inactive (47.6%) |
HCK | active (67.18%) |
FGR | active (65.16%) |
FYN | active (76.47%) |
SRC | active (79.36%) |
YES | active (80.24%) |
TK - Eph
Bioactivity |
---|
Kinase | GPCR |
---|
EphA2 | inactive (3.85%) |
EphA4 | inactive (12%) |
EphA3 | inactive (8.5%) |
EphB4 | inactive (11.91%) |
EphB3 | inactive (2.36%) |
EphB2 | inactive (24.28%) |
TK - FAK
Bioactivity |
---|
Kinase | GPCR |
---|
PYK2 | inactive (10.95%) |
TK - Syk
Bioactivity |
---|
Kinase | GPCR |
---|
SYK | inactive (-2.39%) |
ZAP70 | inactive (-2.95%) |
TK - ALK
Bioactivity |
---|
Kinase | GPCR |
---|
LTK | inactive (3.16%) |
ALK | inactive (8.1%) |
TK - Sev
Bioactivity |
---|
Kinase | GPCR |
---|
ROS | inactive (43.27%) |
TK - InsR
Bioactivity |
---|
Kinase | GPCR |
---|
INSR | inactive (5.78%) |
IGF1R | inactive (4.95%) |
IRR | inactive (3.36%) |
TK - DDR
Bioactivity |
---|
Kinase | GPCR |
---|
DDR2 | inactive (20%) |
TK - Musk
Bioactivity |
---|
Kinase | GPCR |
---|
MUSK | - |
TK - Trk
Bioactivity |
---|
Kinase | GPCR |
---|
TRKA | inactive (30.87%) |
TRKB | inactive (43.51%) |
TRKC | inactive (49.3%) |
TK - Met
Bioactivity |
---|
Kinase | GPCR |
---|
RON | inactive (3.42%) |
MET | inactive (2.24%) |
TK - Axl
Bioactivity |
---|
Kinase | GPCR |
---|
AXL | inactive (-1.98%) |
MER | inactive (7.73%) |
TYRO3 | inactive (40.57%) |
TK - Ret
Bioactivity |
---|
Kinase | GPCR |
---|
RET | active (68.53%) |
TK - FGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FGFR1 | inactive (40.23%) |
FGFR2 | active (68.17%) |
FGFR3 | active (70.02%) |
FGFR4 | inactive (7.65%) |
TK - VEGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FLT1 | active (55.85%) |
KDR | active (73.18%) |
FLT4 | active (77.75%) |
TK - PDGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FMS | active (71.92%) |
KIT | active (96.99%) |
FLT3 | active (68.05%) |
PDGFRa | active (58.37%) |
PDGFRb | active (74.76%) |
TK - Tie
Bioactivity |
---|
Kinase | GPCR |
---|
TIE2 | inactive (16.09%) |
TK - Ack
Bioactivity |
---|
Kinase | GPCR |
---|
ACK | inactive (15.3%) |
TNK1 | active (90.64%) |
TK - EGFR
Bioactivity |
---|
Kinase | GPCR |
---|
EGFR | inactive (8.46%) |
ErbB2 | inactive (0.18%) |
ErbB4 | inactive (22.11%) |
TKL
TKL
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
IRAK | 4 | 1 |
RAF | 5 | 1 |
TKL - IRAK
Bioactivity |
---|
Kinase | GPCR |
---|
IRAK4 | inactive (2.08%) |
TKL - RAF
Bioactivity |
---|
Kinase | GPCR |
---|
BRAF | inactive (5.54%) |
STE
STE
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
STE20 | 31 | 12 |
STE7 | 7 | 1 |
STE - STE20
Bioactivity |
---|
Kinase | GPCR |
---|
GCK | inactive (6.14%) |
MST1 | inactive (10.57%) |
MST2 | inactive (7.22%) |
MST4 | inactive (-4.12%) |
HGK | inactive (25.87%) |
MINK | inactive (16.75%) |
LOK | inactive (8.64%) |
PAK1 | inactive (5.71%) |
PAK3 | inactive (2.36%) |
PAK2 | inactive (1.98%) |
PAK5 | inactive (-1.57%) |
PAK6 | inactive (2.64%) |
STE - STE7
Bioactivity |
---|
Kinase | GPCR |
---|
MAP2K1 | inactive (3.57%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
CK1 | 7 | 4 |
CK1 - CK1
Bioactivity |
---|
Kinase | GPCR |
---|
CK1a | inactive (6.31%) |
CK1g2 | inactive (3.73%) |
CK1g1 | inactive (6.2%) |
CK1g3 | inactive (5.62%) |
Other
Other
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
PLK | 4 | 1 |
Aur | 3 | 3 |
NEK | 11 | 5 |
IKK | 4 | 4 |
TTK | 1 | 1 |
Other - PLK
Bioactivity |
---|
Kinase | GPCR |
---|
PLK1 | inactive (1.04%) |
Other - Aur
Bioactivity |
---|
Kinase | GPCR |
---|
AurB | inactive (5.4%) |
AurC | inactive (14.62%) |
AurA | inactive (34.52%) |
Other - NEK
Bioactivity |
---|
Kinase | GPCR |
---|
NEK1 | inactive (1.45%) |
NEK2 | inactive (2.94%) |
NEK9 | inactive (4.07%) |
NEK7 | inactive (2.42%) |
NEK6 | inactive (0.87%) |
Other - IKK
Bioactivity |
---|
Kinase | GPCR |
---|
TBK1 | inactive (9.22%) |
IKKe | inactive (4.13%) |
IKKb | inactive (1.16%) |
IKKa | inactive (-4.47%) |
Other - TTK
Bioactivity |
---|
Kinase | GPCR |
---|
TTK | inactive (7.02%) |
AGC
AGC - GRK
Bioactivity |
---|
Kinase | GPCR |
---|
GPRK7 | inactive (-8.47%) |
GPRK6 | inactive (-5%) |
AGC - PDK1
Bioactivity |
---|
Kinase | GPCR |
---|
PDK1 | inactive (2.17%) |
AGC - RSK
Bioactivity |
---|
Kinase | GPCR |
---|
MSK1 | inactive (7.32%) |
MSK2 | inactive (3.76%) |
RSK1 | inactive (4.04%) |
RSK2 | inactive (0.81%) |
RSK4 | inactive (3.54%) |
RSK3 | inactive (4.86%) |
p70S6K | inactive (1.18%) |
AGC - Akt
Bioactivity |
---|
Kinase | GPCR |
---|
AKT2 | inactive (0.82%) |
AKT1 | inactive (0.85%) |
AKT3 | inactive (-0.57%) |
AGC - SGK
Bioactivity |
---|
Kinase | GPCR |
---|
SGK1 | inactive (2.05%) |
SGK3 | inactive (-0.11%) |
SGK2 | inactive (5.99%) |
AGC - PKC
Bioactivity |
---|
Kinase | GPCR |
---|
PKCh | inactive (1.66%) |
PKCg | inactive (3.87%) |
PKCa | inactive (5.21%) |
PKCt | inactive (0.3%) |
PKCi | inactive (3.38%) |
AGC - PKG
Bioactivity |
---|
Kinase | GPCR |
---|
PKG2 | inactive (2.95%) |
PKG1 | inactive (2.34%) |
AGC - PKA
Bioactivity |
---|
Kinase | GPCR |
---|
PRKX | inactive (-2.35%) |
AGC - DMPK
Bioactivity |
---|
Kinase | GPCR |
---|
ROCK1 | inactive (2.35%) |
ROCK2 | inactive (1.18%) |
MRCKb | inactive (0.59%) |
MRCKa | inactive (-0.94%) |
CAMK
CAMK - RAD53
Bioactivity |
---|
Kinase | GPCR |
---|
CHK2 | inactive (2.17%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
DCLK2 | inactive (-0.14%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK4 | inactive (1.2%) |
CaMK1d | inactive (1.97%) |
CAMK - PHK
Bioactivity |
---|
Kinase | GPCR |
---|
PHKg1 | inactive (18.29%) |
PHKg2 | inactive (-0.05%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK2d | inactive (9.35%) |
CaMK2a | inactive (6.74%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | GPCR |
---|
MAPKAPK5 | inactive (-0.22%) |
MAPKAPK2 | inactive (0.67%) |
MAPKAPK3 | inactive (3.53%) |
MNK2 | inactive (10.55%) |
MNK1 | inactive (16.98%) |
CAMK - PKD
Bioactivity |
---|
Kinase | GPCR |
---|
PKD3 | inactive (3.64%) |
PKD1 | inactive (4.41%) |
PKD2 | inactive (3.71%) |
CAMK - CAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
MARK4 | inactive (1.64%) |
MARK3 | inactive (2.05%) |
MARK1 | inactive (2.37%) |
QIK | inactive (31.24%) |
SIK | inactive (28.56%) |
NuaK1 | inactive (13.38%) |
BRSK1 | inactive (-0.15%) |
BRSK2 | inactive (0.66%) |
MELK | inactive (11.45%) |
CHK1 | inactive (3.19%) |
PASK | inactive (-1.97%) |
AMPKa1 | inactive (1.33%) |
AMPKa2 | inactive (4.19%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | GPCR |
---|
TSSK2 | inactive (-3.49%) |
TSSK1 | inactive (-0.25%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | GPCR |
---|
DAPK1 | inactive (4.19%) |
CAMK - PIM
Bioactivity |
---|
Kinase | GPCR |
---|
PIM2 | inactive (0.96%) |
PIM3 | inactive (-0.55%) |
PIM1 | inactive (2.93%) |
CMGC
CMGC - MAPK
Bioactivity |
---|
Kinase | GPCR |
---|
JNK2 | inactive (6.62%) |
p38a | inactive (7.73%) |
p38b | inactive (5.17%) |
p38d | inactive (4.76%) |
Erk2 | inactive (1.18%) |
Erk1 | inactive (-2.17%) |
CMGC - GSK
Bioactivity |
---|
Kinase | GPCR |
---|
GSK3A | inactive (9.4%) |
GSK3B | inactive (11.15%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | GPCR |
---|
SRPK1 | inactive (-1.28%) |
MSSK1 | inactive (0.2%) |
CMGC - CLK
Bioactivity |
---|
Kinase | GPCR |
---|
CLK3 | inactive (13.23%) |
CLK2 | active (85.97%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | GPCR |
---|
HIPK1 | inactive (48.34%) |
HIPK4 | active (65.67%) |
DYRK1B | inactive (37.7%) |
DYRK1A | inactive (41.35%) |
DYRK2 | inactive (18.39%) |
CMGC - CK2
Bioactivity |
---|
Kinase | GPCR |
---|
CK2a1 | inactive (29.27%) |