Compound Information
Test on : RBC
Compound Name : N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide dihydrochloride
Inchikey : GELOGQJVGPIKAM-UHFFFAOYSA-N
ChemSpider : 21465182
Pubchem CID : 2733490
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
AGC
AGC - PDK1
Bioactivity |
---|
Kinase | RBC |
---|
PDK1 | inactive (94.1%) |
AGC - Akt
Bioactivity |
---|
Kinase | RBC |
---|
AKT1 | active (41.57%) |
AKT2 | inactive (75.43%) |
AKT3 | inactive (68.97%) |
AGC - DMPK
Bioactivity |
---|
Kinase | RBC |
---|
DMPK1 | inactive (96.62%) |
MRCKa | inactive (97.52%) |
MRCKb | inactive (99.47%) |
ROCK1 | active (37.83%) |
ROCK2 | active (15.44%) |
AGC - GRK
Bioactivity |
---|
Kinase | RBC |
---|
BARK1 | inactive (91.34%) |
BARK2 | inactive (100.72%) |
GPRK4 | inactive (95.84%) |
GPRK5 | inactive (127.06%) |
GPRK6 | inactive (93.53%) |
GPRK7 | inactive (102.2%) |
AGC - RSK
Bioactivity |
---|
Kinase | RBC |
---|
MSK1 | active (39.35%) |
MSK2 | active (38.8%) |
p70S6K | active (25.61%) |
p70S6Kb | inactive (71.91%) |
RSK2 | inactive (70.88%) |
RSK4 | inactive (71.81%) |
RSK1 | inactive (68.36%) |
RSK3 | inactive (79.19%) |
AGC - PKA
Bioactivity |
---|
Kinase | RBC |
---|
PKACg | - |
PRKX | active (-2.49%) |
PKACa | active (10.51%) |
AGC - PKC
Bioactivity |
---|
Kinase | RBC |
---|
PKCa | inactive (85.65%) |
PKCd | active (38.1%) |
PKCe | inactive (86.36%) |
PKCh | inactive (53.16%) |
PKCg | inactive (83.77%) |
PKCi | inactive (88.39%) |
PKCt | inactive (103.59%) |
PKCz | inactive (79.78%) |
PKCb | inactive (90.18%) |
AGC - PKG
Bioactivity |
---|
Kinase | RBC |
---|
PKG2 | inactive (56.9%) |
PKG1 | active (26.25%) |
AGC - PKN
Bioactivity |
---|
Kinase | RBC |
---|
PKN1 | active (14.34%) |
PKN2 | inactive (78.9%) |
AGC - SGK
Bioactivity |
---|
Kinase | RBC |
---|
SGK1 | inactive (93.15%) |
SGK2 | inactive (84.24%) |
SGK3 | inactive (78.8%) |
AGC - NDR
Bioactivity |
---|
Kinase | RBC |
---|
NDR1 | active (0%) |
TK
TK - Abl
Bioactivity |
---|
Kinase | RBC |
---|
ABL1 | inactive (101%) |
ABL2 | inactive (84.41%) |
TK - Ack
Bioactivity |
---|
Kinase | RBC |
---|
ACK | inactive (88.3%) |
TK - ALK
Bioactivity |
---|
Kinase | RBC |
---|
ALK | inactive (101.32%) |
LTK | inactive (94.73%) |
TK - Axl
Bioactivity |
---|
Kinase | RBC |
---|
AXL | inactive (111.53%) |
MER | inactive (79.8%) |
TYRO3 | inactive (93.88%) |
TK - Src
Bioactivity |
---|
Kinase | RBC |
---|
BLK | inactive (82.36%) |
BRK | inactive (94.25%) |
SRC | inactive (90.15%) |
FGR | inactive (106.19%) |
FRK | inactive (106.26%) |
FYN | inactive (107.35%) |
HCK | inactive (99.42%) |
LCK | inactive (102.94%) |
SRM | inactive (97.82%) |
YES | inactive (91.57%) |
LYN | inactive (125.54%) |
TK - Tec
Bioactivity |
---|
Kinase | RBC |
---|
BMX | inactive (102.06%) |
BTK | inactive (97.44%) |
ITK | inactive (86.84%) |
TEC | inactive (101.66%) |
TXK | inactive (86.83%) |
TK - PDGFR
Bioactivity |
---|
Kinase | RBC |
---|
KIT | inactive (101.06%) |
FLT3 | inactive (89.64%) |
FMS | inactive (97.65%) |
PDGFRb | inactive (112.3%) |
PDGFRa | inactive (98.81%) |
TK - Csk
Bioactivity |
---|
Kinase | RBC |
---|
CSK | inactive (95.61%) |
CTK | inactive (96.14%) |
TK - DDR
Bioactivity |
---|
Kinase | RBC |
---|
DDR2 | inactive (93.78%) |
TK - EGFR
Bioactivity |
---|
Kinase | RBC |
---|
EGFR | inactive (98.96%) |
ErbB2 | inactive (118.55%) |
ErbB4 | inactive (94.18%) |
TK - Eph
Bioactivity |
---|
Kinase | RBC |
---|
EphA1 | inactive (83.75%) |
EphA2 | inactive (101.42%) |
EphA3 | inactive (108.96%) |
EphA4 | inactive (86.8%) |
EphA5 | inactive (96.86%) |
EphA6 | - |
EphA7 | inactive (109.23%) |
EphA8 | inactive (117.65%) |
EphB1 | inactive (106.23%) |
EphB2 | inactive (81.69%) |
EphB3 | inactive (92.48%) |
EphB4 | inactive (107.58%) |
TK - FAK
Bioactivity |
---|
Kinase | RBC |
---|
FAK | inactive (64.1%) |
PYK2 | inactive (85.01%) |
TK - Fer
Bioactivity |
---|
Kinase | RBC |
---|
FER | inactive (97.56%) |
FES | inactive (114.96%) |
TK - FGFR
Bioactivity |
---|
Kinase | RBC |
---|
FGFR1 | inactive (87.64%) |
FGFR2 | inactive (95.07%) |
FGFR3 | inactive (91.32%) |
FGFR4 | inactive (85.34%) |
TK - VEGFR
Bioactivity |
---|
Kinase | RBC |
---|
FLT1 | inactive (90.82%) |
FLT4 | inactive (108.23%) |
KDR | inactive (79.11%) |
TK - InsR
Bioactivity |
---|
Kinase | RBC |
---|
IGF1R | inactive (103.91%) |
IRR | inactive (103.37%) |
INSR | inactive (94.32%) |
TK - JakA
Bioactivity |
---|
Kinase | RBC |
---|
JAK1 | inactive (87.28%) |
JAK2 | inactive (108.88%) |
JAK3 | inactive (121.92%) |
TYK2 | inactive (103.45%) |
TK - Musk
Bioactivity |
---|
Kinase | RBC |
---|
MUSK | inactive (80.74%) |
TK - Ret
Bioactivity |
---|
Kinase | RBC |
---|
RET | inactive (102.26%) |
TK - Met
Bioactivity |
---|
Kinase | RBC |
---|
RON | inactive (97.45%) |
MET | inactive (97.21%) |
TK - Sev
Bioactivity |
---|
Kinase | RBC |
---|
ROS | inactive (99.6%) |
TK - Syk
Bioactivity |
---|
Kinase | RBC |
---|
SYK | inactive (77.7%) |
ZAP70 | inactive (97.88%) |
TK - Tie
Bioactivity |
---|
Kinase | RBC |
---|
TIE2 | inactive (99.81%) |
TK - Trk
Bioactivity |
---|
Kinase | RBC |
---|
TRKA | inactive (84.94%) |
TRKB | inactive (95.06%) |
TRKC | inactive (79.62%) |
TKL
TKL - STKR
Bioactivity |
---|
Kinase | RBC |
---|
ALK1 | inactive (118.71%) |
ALK2 | inactive (96.37%) |
ALK4 | inactive (101.09%) |
TGFbR1 | inactive (96.99%) |
TGFbR2 | inactive (92.12%) |
TKL - RAF
Bioactivity |
---|
Kinase | RBC |
---|
ARAF | inactive (95.85%) |
BRAF | inactive (99.85%) |
RAF1 | inactive (96.42%) |
TKL - IRAK
Bioactivity |
---|
Kinase | RBC |
---|
IRAK1 | inactive (95.73%) |
IRAK4 | inactive (109.78%) |
TKL - LISK
Bioactivity |
---|
Kinase | RBC |
---|
LIMK1 | inactive (90.62%) |
TKL - LRRK
Bioactivity |
---|
Kinase | RBC |
---|
LRRK2 | inactive (86.16%) |
TKL - MLK
Bioactivity |
---|
Kinase | RBC |
---|
MLK1 | inactive (99.64%) |
MLK2 | inactive (85.54%) |
MLK3 | inactive (95.6%) |
TAK1 | inactive (108.91%) |
ZAK | inactive (105.32%) |
TKL - RIPK
Bioactivity |
---|
Kinase | RBC |
---|
RIPK2 | inactive (77.76%) |
CAMK
CAMK - CAMKL
Bioactivity |
---|
Kinase | RBC |
---|
NuaK1 | active (32.81%) |
BRSK1 | inactive (92.02%) |
BRSK2 | inactive (92.41%) |
CHK1 | inactive (90.78%) |
LKB1 | inactive (101.51%) |
MARK1 | inactive (91.18%) |
MARK3 | inactive (96.22%) |
MARK4 | inactive (94.29%) |
MELK | inactive (75.06%) |
PASK | inactive (94.54%) |
QIK | inactive (94.98%) |
NuaK2 | inactive (78.14%) |
MARK2 | inactive (89.29%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | RBC |
---|
CaMK1a | inactive (107.48%) |
CaMK1b | inactive (100.28%) |
CaMK1d | inactive (85.49%) |
CaMK1g | inactive (99.14%) |
CaMK4 | inactive (95.24%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | RBC |
---|
CaMK2a | inactive (101.79%) |
CaMK2b | inactive (93.28%) |
CaMK2d | inactive (97.05%) |
CaMK2g | inactive (98.7%) |
CAMK - RAD53
Bioactivity |
---|
Kinase | RBC |
---|
CHK2 | inactive (82.78%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | RBC |
---|
DAPK1 | inactive (81.47%) |
DAPK2 | inactive (72.1%) |
DRAK1 | inactive (100.28%) |
DAPK3 | inactive (97.44%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | RBC |
---|
DCLK2 | inactive (90.09%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | RBC |
---|
MAPKAPK2 | inactive (104.82%) |
MAPKAPK3 | inactive (97.79%) |
MAPKAPK5 | inactive (90.18%) |
MNK1 | inactive (93.39%) |
MNK2 | inactive (78.72%) |
CAMK - MLCK
Bioactivity |
---|
Kinase | RBC |
---|
smMLCK | inactive (90.8%) |
skMLCK | inactive (96.49%) |
CAMK - PHK
Bioactivity |
---|
Kinase | RBC |
---|
PHKg1 | inactive (91.6%) |
PHKg2 | inactive (88.84%) |
CAMK - PIM
Bioactivity |
---|
Kinase | RBC |
---|
PIM1 | inactive (90.07%) |
PIM2 | inactive (103.59%) |
PIM3 | inactive (98.34%) |
CAMK - PKD
Bioactivity |
---|
Kinase | RBC |
---|
PKD1 | inactive (98.73%) |
PKD3 | inactive (79.23%) |
PKD2 | inactive (75.94%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | RBC |
---|
TSSK1 | inactive (93.52%) |
TSSK2 | inactive (103.95%) |
CAMK - STK33
Bioactivity |
---|
Kinase | RBC |
---|
STK33 | inactive (79.53%) |
STE
STE - STE11
Bioactivity |
---|
Kinase | RBC |
---|
MAP3K5 | inactive (93.17%) |
MAP3K2 | inactive (91.52%) |
MAP3K3 | inactive (85.4%) |
STE - STE-Unique
Bioactivity |
---|
Kinase | RBC |
---|
COT | inactive (99.42%) |
NIK | inactive (83.62%) |
STE - STE20
Bioactivity |
---|
Kinase | RBC |
---|
GCK | inactive (51.07%) |
HGK | active (43.85%) |
KHS1 | active (30.9%) |
LOK | inactive (89.17%) |
MINK | inactive (91.08%) |
MST1 | inactive (92.65%) |
MST2 | inactive (65.63%) |
MST3 | inactive (71.97%) |
MST4 | inactive (94.75%) |
OSR1 | inactive (95.9%) |
PAK1 | inactive (90.16%) |
PAK2 | inactive (78.57%) |
PAK3 | inactive (102.54%) |
PAK4 | inactive (98.93%) |
PAK5 | inactive (91.41%) |
PAK6 | inactive (85.46%) |
SLK | inactive (93.03%) |
YSK1 | inactive (104.19%) |
STLK3 | inactive (102.91%) |
TAO1 | inactive (100.98%) |
TAO2 | inactive (90.74%) |
TAO3 | inactive (95.4%) |
MYO3B | active (0%) |
STE - STE7
Bioactivity |
---|
Kinase | RBC |
---|
MAP2K1 | inactive (90.51%) |
MAP2K2 | inactive (102.56%) |
MAP2K6 | inactive (81.26%) |
Other
Other - Aur
Bioactivity |
---|
Kinase | RBC |
---|
AurA | inactive (103.8%) |
AurB | inactive (97.78%) |
AurC | inactive (89.03%) |
Other - CAMKK
Bioactivity |
---|
Kinase | RBC |
---|
CaMKK1 | inactive (99.06%) |
CaMKK2 | inactive (95.59%) |
Other - Haspin
Bioactivity |
---|
Kinase | RBC |
---|
Haspin | inactive (55.06%) |
Other - IKK
Bioactivity |
---|
Kinase | RBC |
---|
IKKa | inactive (104.31%) |
IKKb | inactive (89.46%) |
IKKe | inactive (92.34%) |
TBK1 | inactive (101.12%) |
Other - NEK
Bioactivity |
---|
Kinase | RBC |
---|
NEK1 | inactive (94.44%) |
NEK11 | inactive (92.74%) |
NEK2 | inactive (97.09%) |
NEK4 | inactive (96.9%) |
NEK6 | inactive (100.04%) |
NEK7 | inactive (96.86%) |
NEK9 | inactive (99.31%) |
NEK3 | inactive (94.35%) |
Other - TOPK
Bioactivity |
---|
Kinase | RBC |
---|
PBK | inactive (106.99%) |
Other - PLK
Bioactivity |
---|
Kinase | RBC |
---|
PLK1 | inactive (98.68%) |
PLK2 | inactive (106.95%) |
PLK3 | inactive (98.22%) |
Other - SgK496
Bioactivity |
---|
Kinase | RBC |
---|
SgK496 | inactive (91.6%) |
Other - NAK
Bioactivity |
---|
Kinase | RBC |
---|
MPSK1 | inactive (94.37%) |
Other - TTK
Bioactivity |
---|
Kinase | RBC |
---|
TTK | inactive (99.72%) |
Other - ULK
Bioactivity |
---|
Kinase | RBC |
---|
ULK1 | inactive (101.75%) |
ULK2 | inactive (98.86%) |
ULK3 | active (0%) |
Other - WEE
Bioactivity |
---|
Kinase | RBC |
---|
Wee1 | inactive (84.6%) |
Other - WNK
Bioactivity |
---|
Kinase | RBC |
---|
Wnk2 | inactive (99.35%) |
Wnk3 | inactive (93.15%) |
Other - TLK
Bioactivity |
---|
Kinase | RBC |
---|
TLK2 | active (0%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | RBC |
---|
CK1 | 7 | 6 |
VRK | 3 | 1 |
CK1 - CK1
Bioactivity |
---|
Kinase | RBC |
---|
CK1d | inactive (93.67%) |
CK1g1 | inactive (97.22%) |
CK1g2 | inactive (86.82%) |
CK1g3 | inactive (93.33%) |
CK1a | inactive (57.86%) |
CK1e | inactive (106.56%) |
CK1 - VRK
Bioactivity |
---|
Kinase | RBC |
---|
VRK1 | inactive (80.12%) |
CMGC
CMGC - CK2
Bioactivity |
---|
Kinase | RBC |
---|
CK2a1 | inactive (97.77%) |
CK2a2 | inactive (86.56%) |
CMGC - CLK
Bioactivity |
---|
Kinase | RBC |
---|
CLK1 | inactive (103.48%) |
CLK2 | inactive (105.9%) |
CLK3 | inactive (87.61%) |
CLK4 | inactive (119.46%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | RBC |
---|
DYRK1A | inactive (98.54%) |
DYRK1B | inactive (95.28%) |
DYRK2 | inactive (95.17%) |
DYRK3 | inactive (83.49%) |
DYRK4 | inactive (96.44%) |
HIPK1 | inactive (91.39%) |
HIPK2 | inactive (99.17%) |
HIPK3 | inactive (81.65%) |
HIPK4 | inactive (97.69%) |
CMGC - MAPK
Bioactivity |
---|
Kinase | RBC |
---|
Erk1 | inactive (84.77%) |
Erk2 | inactive (108.48%) |
JNK3 | inactive (92.55%) |
NLK | inactive (94.91%) |
p38a | inactive (105.24%) |
p38b | inactive (87.16%) |
p38d | inactive (100.83%) |
p38g | inactive (102.22%) |
JNK1 | inactive (92.68%) |
JNK2 | inactive (93.43%) |
CMGC - GSK
Bioactivity |
---|
Kinase | RBC |
---|
GSK3A | inactive (94.29%) |
GSK3B | inactive (83.49%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | RBC |
---|
MSSK1 | inactive (97.96%) |
SRPK1 | inactive (110.21%) |
SRPK2 | inactive (88.32%) |
Atypical
Atypical
Test Member No. in Family |
---|
Family | no. Member on 518kinase | RBC |
---|
PDHK | 5 | 1 |
Atypical - PDHK
Bioactivity |
---|
Kinase | RBC |
---|
PDHK1 | inactive (94.1%) |