Compound Information
Test on : GPCR
Compound Name : PYRAZOLOPYRIDAZINE 1
Inchikey : GBNWWXHUOVAUHT-UHFFFAOYSA-N
ChemSpider : 5021827
Pubchem CID : 6539361
ChEMBL : CHEMBL187081
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
TK
TK - JakA
Bioactivity |
---|
Kinase | GPCR |
---|
JAK1 | inactive (13.17%) |
TYK2 | inactive (30.29%) |
JAK2 | inactive (29.24%) |
JAK3 | inactive (44.17%) |
TK - Fer
Bioactivity |
---|
Kinase | GPCR |
---|
FER | inactive (48.01%) |
FES | active (50.31%) |
TK - Abl
Bioactivity |
---|
Kinase | GPCR |
---|
ABL1 | inactive (40.85%) |
ABL2 | inactive (44.2%) |
TK - Csk
Bioactivity |
---|
Kinase | GPCR |
---|
CSK | inactive (11.79%) |
TK - Tec
Bioactivity |
---|
Kinase | GPCR |
---|
BMX | inactive (21.79%) |
BTK | inactive (4.57%) |
TXK | inactive (15.53%) |
TEC | inactive (25.13%) |
ITK | inactive (6.45%) |
TK - Src
Bioactivity |
---|
Kinase | GPCR |
---|
BRK | inactive (10.08%) |
SRM | inactive (-1.9%) |
FRK | inactive (4.45%) |
BLK | inactive (14.01%) |
LCK | inactive (11.17%) |
HCK | inactive (17.41%) |
FGR | inactive (19.33%) |
FYN | inactive (16.21%) |
SRC | inactive (41.61%) |
YES | inactive (20.48%) |
TK - Eph
Bioactivity |
---|
Kinase | GPCR |
---|
EphA2 | inactive (12.15%) |
EphA4 | inactive (36.59%) |
EphA3 | inactive (8.81%) |
EphB4 | inactive (16.06%) |
EphB3 | inactive (-3.88%) |
EphB2 | inactive (35.96%) |
TK - FAK
Bioactivity |
---|
Kinase | GPCR |
---|
PYK2 | active (86.62%) |
TK - Syk
Bioactivity |
---|
Kinase | GPCR |
---|
SYK | inactive (34.16%) |
ZAP70 | inactive (11.7%) |
TK - ALK
Bioactivity |
---|
Kinase | GPCR |
---|
LTK | inactive (18.22%) |
ALK | inactive (32.32%) |
TK - Sev
Bioactivity |
---|
Kinase | GPCR |
---|
ROS | active (71.07%) |
TK - InsR
Bioactivity |
---|
Kinase | GPCR |
---|
INSR | active (54.16%) |
IGF1R | active (52.42%) |
IRR | inactive (15.42%) |
TK - DDR
Bioactivity |
---|
Kinase | GPCR |
---|
DDR2 | inactive (4.16%) |
TK - Musk
Bioactivity |
---|
Kinase | GPCR |
---|
MUSK | inactive (25.33%) |
TK - Trk
Bioactivity |
---|
Kinase | GPCR |
---|
TRKA | inactive (17.44%) |
TRKB | inactive (34.07%) |
TRKC | inactive (37.61%) |
TK - Met
Bioactivity |
---|
Kinase | GPCR |
---|
RON | inactive (15.06%) |
MET | inactive (12.05%) |
TK - Axl
Bioactivity |
---|
Kinase | GPCR |
---|
AXL | inactive (11.4%) |
MER | inactive (12.07%) |
TYRO3 | inactive (21.19%) |
TK - Ret
Bioactivity |
---|
Kinase | GPCR |
---|
RET | inactive (17.15%) |
TK - FGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FGFR1 | inactive (4.55%) |
FGFR2 | inactive (16.61%) |
FGFR3 | inactive (10.92%) |
FGFR4 | inactive (1.33%) |
TK - VEGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FLT1 | inactive (25.13%) |
KDR | inactive (42.15%) |
FLT4 | inactive (30.21%) |
TK - PDGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FMS | active (90.86%) |
KIT | active (99.35%) |
FLT3 | active (78.93%) |
PDGFRa | inactive (49.32%) |
PDGFRb | active (70.01%) |
TK - Tie
Bioactivity |
---|
Kinase | GPCR |
---|
TIE2 | inactive (21.32%) |
TK - Ack
Bioactivity |
---|
Kinase | GPCR |
---|
ACK | inactive (21.7%) |
TNK1 | active (65.89%) |
TK - EGFR
Bioactivity |
---|
Kinase | GPCR |
---|
EGFR | inactive (5.8%) |
ErbB2 | inactive (1.64%) |
ErbB4 | inactive (3.05%) |
TKL
TKL
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
IRAK | 4 | 1 |
RAF | 5 | 1 |
TKL - IRAK
Bioactivity |
---|
Kinase | GPCR |
---|
IRAK4 | inactive (11.08%) |
TKL - RAF
Bioactivity |
---|
Kinase | GPCR |
---|
BRAF | inactive (31.62%) |
STE
STE
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
STE20 | 31 | 12 |
STE7 | 7 | 1 |
STE - STE20
Bioactivity |
---|
Kinase | GPCR |
---|
GCK | active (60.1%) |
MST1 | inactive (29.98%) |
MST2 | inactive (24.64%) |
MST4 | inactive (3.21%) |
HGK | active (63.21%) |
MINK | active (57.58%) |
LOK | inactive (17.45%) |
PAK1 | inactive (2.16%) |
PAK3 | inactive (1.63%) |
PAK2 | inactive (2.62%) |
PAK5 | inactive (5.51%) |
PAK6 | inactive (5.36%) |
STE - STE7
Bioactivity |
---|
Kinase | GPCR |
---|
MAP2K1 | inactive (29.08%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
CK1 | 7 | 4 |
CK1 - CK1
Bioactivity |
---|
Kinase | GPCR |
---|
CK1a | inactive (48.03%) |
CK1g2 | inactive (47.18%) |
CK1g1 | inactive (20.53%) |
CK1g3 | inactive (38.56%) |
Other
Other
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
PLK | 4 | 1 |
Aur | 3 | 3 |
NEK | 11 | 5 |
IKK | 4 | 4 |
TTK | 1 | 1 |
Other - PLK
Bioactivity |
---|
Kinase | GPCR |
---|
PLK1 | inactive (21.29%) |
Other - Aur
Bioactivity |
---|
Kinase | GPCR |
---|
AurB | active (72.31%) |
AurC | active (97.29%) |
AurA | active (86.4%) |
Other - NEK
Bioactivity |
---|
Kinase | GPCR |
---|
NEK1 | inactive (18.34%) |
NEK2 | inactive (5.64%) |
NEK9 | inactive (26.14%) |
NEK7 | inactive (4.19%) |
NEK6 | inactive (1.04%) |
Other - IKK
Bioactivity |
---|
Kinase | GPCR |
---|
TBK1 | inactive (22.9%) |
IKKe | inactive (18.08%) |
IKKb | inactive (27.07%) |
IKKa | active (53.65%) |
Other - TTK
Bioactivity |
---|
Kinase | GPCR |
---|
TTK | inactive (22.84%) |
AGC
AGC - GRK
Bioactivity |
---|
Kinase | GPCR |
---|
GPRK7 | inactive (-2.16%) |
GPRK6 | inactive (0.06%) |
AGC - PDK1
Bioactivity |
---|
Kinase | GPCR |
---|
PDK1 | inactive (6.27%) |
AGC - RSK
Bioactivity |
---|
Kinase | GPCR |
---|
MSK1 | inactive (4.32%) |
MSK2 | inactive (10.51%) |
RSK1 | inactive (4.33%) |
RSK2 | inactive (2.48%) |
RSK4 | inactive (4.34%) |
RSK3 | inactive (2.4%) |
p70S6K | inactive (3.93%) |
AGC - Akt
Bioactivity |
---|
Kinase | GPCR |
---|
AKT2 | inactive (0.61%) |
AKT1 | inactive (0.43%) |
AKT3 | inactive (-0.03%) |
AGC - SGK
Bioactivity |
---|
Kinase | GPCR |
---|
SGK1 | inactive (9.81%) |
SGK3 | inactive (2.03%) |
SGK2 | inactive (6.98%) |
AGC - PKC
Bioactivity |
---|
Kinase | GPCR |
---|
PKCh | inactive (7.69%) |
PKCg | inactive (9.31%) |
PKCa | inactive (43.38%) |
PKCt | inactive (4.75%) |
PKCi | inactive (-1.07%) |
AGC - PKG
Bioactivity |
---|
Kinase | GPCR |
---|
PKG2 | inactive (14.51%) |
PKG1 | inactive (37.62%) |
AGC - PKA
Bioactivity |
---|
Kinase | GPCR |
---|
PRKX | inactive (-0.01%) |
AGC - DMPK
Bioactivity |
---|
Kinase | GPCR |
---|
ROCK1 | inactive (6.3%) |
ROCK2 | inactive (15.38%) |
MRCKb | inactive (-1.51%) |
MRCKa | inactive (-0.24%) |
CAMK
CAMK - RAD53
Bioactivity |
---|
Kinase | GPCR |
---|
CHK2 | inactive (11.16%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
DCLK2 | inactive (2.73%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK4 | inactive (-1.54%) |
CaMK1d | inactive (4.71%) |
CAMK - PHK
Bioactivity |
---|
Kinase | GPCR |
---|
PHKg1 | inactive (27.64%) |
PHKg2 | inactive (18.81%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK2d | inactive (35.39%) |
CaMK2a | inactive (13.81%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | GPCR |
---|
MAPKAPK5 | inactive (3.44%) |
MAPKAPK2 | inactive (-0.06%) |
MAPKAPK3 | inactive (2.89%) |
MNK2 | inactive (22.74%) |
MNK1 | inactive (11.33%) |
CAMK - PKD
Bioactivity |
---|
Kinase | GPCR |
---|
PKD3 | inactive (41.39%) |
PKD1 | inactive (38.2%) |
PKD2 | inactive (37.38%) |
CAMK - CAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
MARK4 | inactive (17.26%) |
MARK3 | inactive (29.57%) |
MARK1 | inactive (27.67%) |
QIK | inactive (13.63%) |
SIK | inactive (20.76%) |
NuaK1 | active (71%) |
BRSK1 | inactive (6.67%) |
BRSK2 | inactive (10.36%) |
MELK | active (52.31%) |
CHK1 | inactive (3.93%) |
PASK | inactive (-1.63%) |
AMPKa1 | inactive (10.87%) |
AMPKa2 | inactive (7.99%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | GPCR |
---|
TSSK2 | inactive (0.62%) |
TSSK1 | inactive (12.85%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | GPCR |
---|
DAPK1 | inactive (0.16%) |
CAMK - PIM
Bioactivity |
---|
Kinase | GPCR |
---|
PIM2 | inactive (2.39%) |
PIM3 | inactive (17.58%) |
PIM1 | inactive (6.56%) |
CMGC
CMGC - MAPK
Bioactivity |
---|
Kinase | GPCR |
---|
JNK2 | inactive (46.19%) |
p38a | inactive (9.35%) |
p38b | inactive (7.72%) |
p38d | inactive (15.18%) |
Erk2 | inactive (26.46%) |
Erk1 | inactive (13.14%) |
CMGC - GSK
Bioactivity |
---|
Kinase | GPCR |
---|
GSK3A | active (79.45%) |
GSK3B | active (79.02%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | GPCR |
---|
SRPK1 | inactive (4.98%) |
MSSK1 | inactive (0.66%) |
CMGC - CLK
Bioactivity |
---|
Kinase | GPCR |
---|
CLK3 | active (65.34%) |
CLK2 | active (98.21%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | GPCR |
---|
HIPK1 | active (92.59%) |
HIPK4 | active (87.3%) |
DYRK1B | active (89.99%) |
DYRK1A | active (88.33%) |
DYRK2 | inactive (37.64%) |
CMGC - CK2
Bioactivity |
---|
Kinase | GPCR |
---|
CK2a1 | inactive (40.91%) |