Compound in Profiling

Compound Information

Test on : RBC, Metz

Compound Name
RBC, Metz : VX-702

Inchikey
Same : FYSRKRZDBHOFAY-N
RBC, Metz : FYSRKRZDBHOFAY-UHFFFAOYSA-N

ChemSpider
RBC, Metz : 8516613

Pubchem CID
RBC, Metz : 10341154

ChEMBL
RBC, Metz : CHEMBL1090090

	DRx	RBC	Metz	Millipore	GPCR
bioactivity	Kd (nM)	Remain Activity (%)	Ki (nM)	Remain Activity (%)	Inhibition (%)
active criteria	<3000nM	<50%	<1000nM	<50%	>50%

AGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Metz
PDK1	1	1	1
Akt	3	3	3
DMPK	7	5	3
GRK	7	6	1
RSK	8	8	4
PKA	5	3	2
PKC	9	9	5
PKG	2	3	2
PKN	3	2	1
SGK	3	3	1
NDR	4	1	-

AGC - PDK1

Bioactivity
Kinase	RBC	Metz
PDK1	inactive (87.4%)	-

AGC - Akt

Bioactivity
Kinase	RBC	Metz
AKT1	inactive (84.72%)	-
AKT2	inactive (118.28%)	-
AKT3	inactive (86.24%)	-

AGC - DMPK

Bioactivity
Kinase	RBC	Metz
DMPK1	inactive (103.72%)	-
MRCKa	inactive (93.8%)	-
MRCKb	inactive (96.52%)	-
ROCK1	inactive (107.81%)	inactive (2511.89nM)
ROCK2	inactive (97.66%)	-

AGC - GRK

Bioactivity
Kinase	RBC	Metz
BARK1	inactive (99.03%)	-
BARK2	inactive (98.14%)	-
GPRK4	inactive (90.74%)	-
GPRK5	inactive (103.21%)	-
GPRK6	inactive (97.05%)	-
GPRK7	inactive (108.5%)	-

AGC - RSK

Bioactivity
Kinase	RBC	Metz
MSK1	inactive (92.85%)	-
MSK2	inactive (99.01%)	-
p70S6K	inactive (100.13%)	-
p70S6Kb	inactive (100.08%)	-
RSK2	inactive (99.84%)	-
RSK4	inactive (101.25%)	-
RSK1	inactive (108.84%)	-
RSK3	inactive (97.53%)	-

AGC - PKA

Bioactivity
Kinase	RBC	Metz
PKACg	inactive (109.18%)	-
PRKX	inactive (123.07%)	-
PKACa	inactive (100.84%)	-

AGC - PKC

Bioactivity
Kinase	RBC	Metz
PKCa	inactive (85.96%)	-
PKCd	inactive (103.55%)	-
PKCe	inactive (100.78%)	-
PKCh	inactive (112.44%)	-
PKCg	inactive (91.25%)	-
PKCi	inactive (99.14%)	-
PKCt	inactive (85.11%)	-
PKCz	inactive (89.94%)	-
PKCb	inactive (94.64%)	-

AGC - PKG

Bioactivity
Kinase	RBC	Metz
PKG2	inactive (98.09%)	-
PKG1	inactive (88.06%)	-

AGC - PKN

Bioactivity
Kinase	RBC	Metz
PKN1	inactive (101.2%)	-
PKN2	inactive (99.71%)	-

AGC - SGK

Bioactivity
Kinase	RBC	Metz
SGK1	inactive (121.07%)	-
SGK2	inactive (106.76%)	-
SGK3	inactive (99.92%)	-

AGC - NDR

Bioactivity
Kinase	RBC	Metz
NDR1	inactive (101.19%)	-

TK

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Metz
Abl	2	2	1
Ack	2	1	1
ALK	2	2	2
Axl	3	3	2
Src	11	11	9
Tec	5	5	3
PDGFR	5	5	5
Csk	2	2	1
DDR	2	1	-
EGFR	4	3	3
Eph	14	12	1
FAK	2	2	2
Fer	2	2	2
FGFR	4	4	2
VEGFR	3	3	3
InsR	3	3	2
JakA	4	4	3
Musk	1	1	-
Ret	1	1	1
Met	2	2	2
Sev	1	1	1
Syk	2	2	1
Tie	2	1	-
Trk	3	3	3

TK - Abl

Bioactivity
Kinase	RBC	Metz
ABL1	inactive (99.67%)	-
ABL2	inactive (100%)	-

TK - Ack

Bioactivity
Kinase	RBC	Metz
ACK	inactive (96.1%)	-

TK - ALK

Bioactivity
Kinase	RBC	Metz
ALK	inactive (99.57%)	-
LTK	inactive (95.02%)	-

TK - Axl

Bioactivity
Kinase	RBC	Metz
AXL	inactive (100.77%)	-
MER	inactive (113.77%)	-
TYRO3	inactive (100.71%)	-

TK - Src

Bioactivity
Kinase	RBC	Metz
BLK	inactive (100.05%)	-
BRK	inactive (98.72%)	-
SRC	inactive (108.84%)	-
FGR	inactive (94.73%)	-
FRK	inactive (105.78%)	-
FYN	inactive (110.36%)	-
HCK	inactive (89.54%)	-
LCK	inactive (86.3%)	-
SRM	inactive (92.93%)	-
YES	inactive (97.77%)	-
LYN	inactive (98.14%)	-

TK - Tec

Bioactivity
Kinase	RBC	Metz
BMX	inactive (107.75%)	-
BTK	inactive (98.23%)	-
ITK	inactive (104.65%)	-
TEC	inactive (114.21%)	-
TXK	inactive (103.69%)	-

TK - PDGFR

Bioactivity
Kinase	RBC	Metz
KIT	inactive (97.69%)	-
FLT3	inactive (97.21%)	-
FMS	inactive (109.14%)	-
PDGFRb	inactive (62.76%)	-
PDGFRa	inactive (101.99%)	-

TK - Csk

Bioactivity
Kinase	RBC	Metz
CSK	inactive (89.97%)	-
CTK	inactive (77.59%)	-

TK - DDR

Bioactivity
Kinase	RBC	Metz
DDR2	inactive (100.26%)	-

TK - EGFR

Bioactivity
Kinase	RBC	Metz
EGFR	inactive (92.73%)	-
ErbB2	inactive (105.56%)	-
ErbB4	inactive (98.1%)	-

TK - Eph

Bioactivity
Kinase	RBC	Metz
EphA1	inactive (99.07%)	-
EphA2	inactive (88.97%)	-
EphA3	inactive (96.97%)	-
EphA4	inactive (104.93%)	-
EphA5	inactive (104.56%)	-
EphA6	inactive (95%)	-
EphA7	inactive (79.9%)	-
EphA8	inactive (98.66%)	-
EphB1	inactive (100.14%)	-
EphB2	inactive (106.73%)	-
EphB3	inactive (65.77%)	-
EphB4	inactive (83.88%)	-

TK - FAK

Bioactivity
Kinase	RBC	Metz
FAK	inactive (98.9%)	-
PYK2	inactive (101.68%)	-

TK - Fer

Bioactivity
Kinase	RBC	Metz
FER	inactive (95.56%)	-
FES	inactive (99.03%)	-

TK - FGFR

Bioactivity
Kinase	RBC	Metz
FGFR1	inactive (99.02%)	-
FGFR2	inactive (99.51%)	-
FGFR3	inactive (90.17%)	-
FGFR4	inactive (96.18%)	-

TK - VEGFR

Bioactivity
Kinase	RBC	Metz
FLT1	inactive (101.87%)	-
FLT4	inactive (97.5%)	-
KDR	inactive (96.55%)	-

TK - InsR

Bioactivity
Kinase	RBC	Metz
IGF1R	inactive (92.33%)	-
IRR	inactive (102.41%)	-
INSR	inactive (104.4%)	-

TK - JakA

Bioactivity
Kinase	RBC	Metz
JAK1	inactive (98.82%)	-
JAK2	inactive (106.83%)	-
JAK3	inactive (95.72%)	-
TYK2	inactive (93.46%)	-

TK - Musk

Bioactivity
Kinase	RBC	Metz
MUSK	inactive (101.9%)	-

TK - Ret

Bioactivity
Kinase	RBC	Metz
RET	inactive (93.12%)	-

TK - Met

Bioactivity
Kinase	RBC	Metz
RON	inactive (90.13%)	-
MET	inactive (89.43%)	-

TK - Sev

Bioactivity
Kinase	RBC	Metz
ROS	inactive (95.02%)	-

TK - Syk

Bioactivity
Kinase	RBC	Metz
SYK	inactive (109.95%)	-
ZAP70	inactive (100.12%)	-

TK - Tie

Bioactivity
Kinase	RBC	Metz
TIE2	inactive (96.73%)	-

TK - Trk

Bioactivity
Kinase	RBC	Metz
TRKA	inactive (96.26%)	-
TRKB	inactive (101.7%)	-
TRKC	inactive (95.87%)	-

TKL

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Metz
STKR	12	5	1
RAF	5	3	1
IRAK	4	2	2
LISK	4	1	1
LRRK	2	1	1
MLK	10	5	2
RIPK	5	1	-

TKL - STKR

Bioactivity
Kinase	RBC	Metz
ALK1	inactive (99.29%)	-
ALK2	inactive (105.05%)	-
ALK4	inactive (113.39%)	-
TGFbR1	inactive (96.69%)	-
TGFbR2	inactive (102.17%)	-

TKL - RAF

Bioactivity
Kinase	RBC	Metz
ARAF	inactive (99.36%)	-
BRAF	inactive (94.06%)	-
RAF1	inactive (97.53%)	-

TKL - IRAK

Bioactivity
Kinase	RBC	Metz
IRAK1	inactive (94.2%)	-
IRAK4	inactive (87.52%)	-

TKL - LISK

Bioactivity
Kinase	RBC	Metz
LIMK1	inactive (98.51%)	-

TKL - LRRK

Bioactivity
Kinase	RBC	Metz
LRRK2	inactive (82.03%)	-

TKL - MLK

Bioactivity
Kinase	RBC	Metz
MLK1	inactive (112.25%)	-
MLK2	inactive (104.16%)	-
MLK3	inactive (104.89%)	-
TAK1	inactive (104.72%)	-
ZAK	inactive (97.93%)	-

TKL - RIPK

Bioactivity
Kinase	RBC	Metz
RIPK2	inactive (101.09%)	-

CAMK

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Metz
CAMKL	20	13	9
CAMK1	5	5	2
CAMK2	4	4	4
RAD53	1	1	1
DAPK	5	4	2
DCAMKL	3	1	1
MAPKAPK	5	5	4
MLCK	5	2	-
PHK	2	2	1
PIM	3	3	3
PKD	3	3	2
TSSK	5	2	2
STK33	1	-	1

CAMK - CAMKL

Bioactivity
Kinase	RBC	Metz
NuaK1	inactive (108.41%)	-
BRSK1	inactive (94.15%)	-
BRSK2	inactive (96.55%)	-
CHK1	inactive (89.17%)	-
LKB1	inactive (99.46%)	-
MARK1	inactive (131.85%)	-
MARK3	inactive (98.14%)	-
MARK4	inactive (102.26%)	-
MELK	inactive (87.15%)	-
PASK	inactive (103.04%)	-
QIK	inactive (95.11%)	-
NuaK2	inactive (98.72%)	-
MARK2	inactive (130.96%)	-
AMPKa1	-	-

CAMK - CAMK1

Bioactivity
Kinase	RBC	Metz
CaMK1a	inactive (98.11%)	-
CaMK1b	inactive (108.06%)	-
CaMK1d	inactive (113.75%)	-
CaMK1g	inactive (108.33%)	-
CaMK4	inactive (91.87%)	-

CAMK - CAMK2

Bioactivity
Kinase	RBC	Metz
CaMK2a	inactive (90.95%)	-
CaMK2b	inactive (104.27%)	-
CaMK2d	inactive (87.25%)	-
CaMK2g	inactive (105.43%)	-

CAMK - RAD53

Bioactivity
Kinase	RBC	Metz
CHK2	inactive (97.64%)	-

CAMK - DAPK

Bioactivity
Kinase	RBC	Metz
DAPK1	inactive (98.16%)	-
DAPK2	inactive (86.77%)	-
DRAK1	inactive (100.17%)	-
DAPK3	inactive (107.03%)	-

CAMK - DCAMKL

Bioactivity
Kinase	RBC	Metz
DCLK2	inactive (97.48%)	-
DCLK1	-	-

CAMK - MAPKAPK

Bioactivity
Kinase	RBC	Metz
MAPKAPK2	inactive (98.9%)	-
MAPKAPK3	inactive (99.05%)	-
MAPKAPK5	inactive (93.38%)	-
MNK1	inactive (91.43%)	-
MNK2	inactive (100.81%)	-

CAMK - MLCK

Bioactivity
Kinase	RBC	Metz
smMLCK	inactive (101.08%)	-
skMLCK	inactive (100.8%)	-

CAMK - PHK

Bioactivity
Kinase	RBC	Metz
PHKg1	inactive (92.04%)	-
PHKg2	inactive (93.14%)	-

CAMK - PIM

Bioactivity
Kinase	RBC	Metz
PIM1	inactive (98.77%)	-
PIM2	inactive (98.3%)	-
PIM3	inactive (97.66%)	-

CAMK - PKD

Bioactivity
Kinase	RBC	Metz
PKD1	inactive (97.75%)	-
PKD3	inactive (85.1%)	inactive (2511.89nM)
PKD2	inactive (81.84%)	inactive (5011.87nM)

CAMK - TSSK

Bioactivity
Kinase	RBC	Metz
TSSK1	inactive (83.02%)	-
TSSK2	inactive (88.59%)	-

CAMK - STK33

Bioactivity
Kinase	RBC	Metz
STK33	inactive (93.97%)	-

STE

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Metz
STE11	8	3	-
STE-Unique	2	2	-
STE20	31	23	9
STE7	7	3	2

STE - STE11

Bioactivity
Kinase	RBC	Metz
MAP3K5	inactive (101.84%)	-
MAP3K2	inactive (121.52%)	-
MAP3K3	inactive (118.17%)	-

STE - STE-Unique

Bioactivity
Kinase	RBC	Metz
COT	inactive (94.3%)	-
NIK	inactive (113.96%)	-

STE - STE20

Bioactivity
Kinase	RBC	Metz
GCK	inactive (107.96%)	-
HGK	inactive (108.19%)	-
KHS1	inactive (98.26%)	-
LOK	inactive (93.79%)	-
MINK	inactive (100.39%)	-
MST1	inactive (100.52%)	-
MST2	inactive (94.08%)	-
MST3	inactive (105.33%)	-
MST4	inactive (117.24%)	-
OSR1	inactive (96.88%)	-
PAK1	inactive (110.38%)	-
PAK2	inactive (100.87%)	-
PAK3	inactive (98.29%)	-
PAK4	inactive (92.62%)	-
PAK5	inactive (96.35%)	-
PAK6	inactive (103.29%)	-
SLK	inactive (90.75%)	-
YSK1	inactive (97.08%)	-
STLK3	inactive (93.66%)	-
TAO1	inactive (96.24%)	-
TAO2	inactive (98.74%)	-
TAO3	inactive (95.74%)	-
MYO3B	inactive (99.25%)	-

STE - STE7

Bioactivity
Kinase	RBC	Metz
MAP2K1	inactive (88.98%)	-
MAP2K2	inactive (92.35%)	-
MAP2K6	inactive (96.54%)	-

Other

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Metz
Aur	3	3	2
CAMKK	2	2	1
Haspin	1	1	-
IKK	4	4	4
NEK	11	8	2
TOPK	1	1	1
PLK	4	3	3
SgK496	1	1	-
NAK	4	1	-
TTK	1	1	-
ULK	5	3	-
WEE	3	1	1
WNK	4	2	-
TLK	2	1	-
CDC7	1	-	1

Other - Aur

Bioactivity
Kinase	RBC	Metz
AurA	inactive (86.43%)	-
AurB	inactive (91.27%)	-
AurC	inactive (83.76%)	-

Other - CAMKK

Bioactivity
Kinase	RBC	Metz
CaMKK1	inactive (98.9%)	-
CaMKK2	inactive (101.19%)	-

Other - Haspin

Bioactivity
Kinase	RBC	Metz
Haspin	inactive (81.27%)	-

Other - IKK

Bioactivity
Kinase	RBC	Metz
IKKa	inactive (100.37%)	-
IKKb	inactive (94.85%)	-
IKKe	inactive (87.96%)	-
TBK1	inactive (106.41%)	-

Other - NEK

Bioactivity
Kinase	RBC	Metz
NEK1	inactive (69.61%)	-
NEK11	inactive (92.86%)	-
NEK2	inactive (108.75%)	-
NEK4	inactive (103.56%)	-
NEK6	inactive (90.48%)	-
NEK7	inactive (90.11%)	-
NEK9	inactive (104.44%)	-
NEK3	inactive (96%)	-

Other - TOPK

Bioactivity
Kinase	RBC	Metz
PBK	inactive (110.3%)	-

Other - PLK

Bioactivity
Kinase	RBC	Metz
PLK1	inactive (95.11%)	-
PLK2	inactive (101.68%)	-
PLK3	inactive (94.67%)	-
PLK4	-	-

Other - SgK496

Bioactivity
Kinase	RBC	Metz
SgK496	inactive (100.68%)	-

Other - NAK

Bioactivity
Kinase	RBC	Metz
MPSK1	inactive (100.23%)	-

Other - TTK

Bioactivity
Kinase	RBC	Metz
TTK	inactive (98.77%)	-

Other - ULK

Bioactivity
Kinase	RBC	Metz
ULK1	inactive (103.57%)	-
ULK2	inactive (100.83%)	-
ULK3	inactive (101.14%)	-

Other - WEE

Bioactivity
Kinase	RBC	Metz
Wee1	inactive (100.97%)	-

Other - WNK

Bioactivity
Kinase	RBC	Metz
Wnk2	inactive (96.42%)	-
Wnk3	inactive (96.63%)	-

Other - TLK

Bioactivity
Kinase	RBC	Metz
TLK2	inactive (95.75%)	-

Other - CDC7

Bioactivity
Kinase	RBC	Metz
CDC7	-	-

CK1

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Metz
CK1	7	6	5
VRK	3	1	-

CK1 - CK1

Bioactivity
Kinase	RBC	Metz
CK1d	inactive (89.8%)	-
CK1g1	inactive (102.38%)	-
CK1g2	inactive (99.64%)	-
CK1g3	inactive (103.46%)	-
CK1a	active (0%)	-
CK1e	inactive (98.19%)	-

CK1 - VRK

Bioactivity
Kinase	RBC	Metz
VRK1	inactive (104.3%)	-

CMGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Metz
CK2	3	2	1
CLK	4	4	2
DYRK	10	9	6
MAPK	14	10	8
GSK	2	2	2
SRPK	3	3	1
CDK	20	-	7

CMGC - CK2

Bioactivity
Kinase	RBC	Metz
CK2a1	inactive (110.95%)	-
CK2a2	inactive (108.53%)	-

CMGC - CLK

Bioactivity
Kinase	RBC	Metz
CLK1	inactive (107.64%)	-
CLK2	inactive (86.92%)	-
CLK3	inactive (112.37%)	-
CLK4	inactive (113.91%)	-

CMGC - DYRK

Bioactivity
Kinase	RBC	Metz
DYRK1A	inactive (98.74%)	-
DYRK1B	inactive (97.05%)	-
DYRK2	inactive (101.75%)	-
DYRK3	inactive (104.54%)	-
DYRK4	inactive (96.26%)	-
HIPK1	inactive (100.14%)	-
HIPK2	inactive (100.41%)	-
HIPK3	inactive (98.4%)	-
HIPK4	inactive (90.47%)	-

CMGC - MAPK

Bioactivity
Kinase	RBC	Metz
Erk1	inactive (95.22%)	-
Erk2	inactive (85.72%)	-
JNK3	inactive (98.43%)	-
NLK	active (15.78%)	-
p38a	active (5.23%)	-
p38b	active (22.32%)	-
p38d	inactive (93.95%)	-
p38g	inactive (92.09%)	-
JNK1	inactive (100.35%)	-
JNK2	inactive (93.53%)	-

CMGC - GSK

Bioactivity
Kinase	RBC	Metz
GSK3A	inactive (98.56%)	-
GSK3B	inactive (101.43%)	-

CMGC - SRPK

Bioactivity
Kinase	RBC	Metz
MSSK1	inactive (105.01%)	-
SRPK1	inactive (98.96%)	-
SRPK2	-	-

CMGC - CDK

Bioactivity
Kinase	RBC	Metz
CDC2	-	-
CDK2	-	-
CDK5	-	-
CDK8	-	-
CDK7	-	-
CDK9	-	-
CDK11	-	-

Atypical

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Metz
PDHK	5	1	-
Alpha	6	-	1

Atypical - PDHK

Bioactivity
Kinase	RBC	Metz
PDHK1	inactive (87.4%)	-

Atypical - Alpha

Bioactivity
Kinase	RBC	Metz
eEF2K	-	-