Compound Information
Test on : RBC
Compound Name : Ro-32-0432
Inchikey : FXGHOAZJQNLNFD-KRWDZBQOSA-N
ChemSpider : 113324
Pubchem CID : 127757
ChEMBL : CHEMBL26501
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
AGC
AGC - PDK1
Bioactivity |
---|
Kinase | RBC |
---|
PDK1 | inactive (96.95%) |
AGC - Akt
Bioactivity |
---|
Kinase | RBC |
---|
AKT1 | inactive (98.69%) |
AKT2 | inactive (92.63%) |
AKT3 | inactive (56.29%) |
AGC - DMPK
Bioactivity |
---|
Kinase | RBC |
---|
DMPK1 | inactive (105.85%) |
MRCKa | inactive (98.1%) |
MRCKb | inactive (103.1%) |
ROCK1 | inactive (105.55%) |
ROCK2 | inactive (98.85%) |
AGC - GRK
Bioactivity |
---|
Kinase | RBC |
---|
BARK1 | inactive (102.71%) |
BARK2 | inactive (102.49%) |
GPRK4 | inactive (76.41%) |
GPRK5 | inactive (56.17%) |
GPRK6 | inactive (66.37%) |
GPRK7 | active (39.98%) |
AGC - RSK
Bioactivity |
---|
Kinase | RBC |
---|
MSK1 | active (24.79%) |
MSK2 | active (33.34%) |
p70S6K | active (20.03%) |
p70S6Kb | inactive (67.56%) |
RSK2 | active (1.81%) |
RSK4 | active (2.94%) |
RSK1 | active (5.9%) |
RSK3 | active (3.57%) |
AGC - PKA
Bioactivity |
---|
Kinase | RBC |
---|
PKACg | inactive (108.47%) |
PRKX | inactive (97.84%) |
PKACa | inactive (87.16%) |
AGC - PKC
Bioactivity |
---|
Kinase | RBC |
---|
PKCa | active (2.58%) |
PKCd | active (8.11%) |
PKCe | active (2.73%) |
PKCh | active (7.84%) |
PKCg | active (6.93%) |
PKCi | active (36.19%) |
PKCt | active (12.71%) |
PKCz | active (31.03%) |
PKCb | active (2.29%) |
AGC - PKG
Bioactivity |
---|
Kinase | RBC |
---|
PKG2 | inactive (90.69%) |
PKG1 | inactive (81.01%) |
AGC - PKN
Bioactivity |
---|
Kinase | RBC |
---|
PKN1 | active (7.06%) |
PKN2 | inactive (86.97%) |
AGC - SGK
Bioactivity |
---|
Kinase | RBC |
---|
SGK1 | inactive (72.88%) |
SGK2 | inactive (71.74%) |
SGK3 | inactive (95.01%) |
AGC - NDR
Bioactivity |
---|
Kinase | RBC |
---|
NDR1 | inactive (96.68%) |
TK
TK - Abl
Bioactivity |
---|
Kinase | RBC |
---|
ABL1 | inactive (97.97%) |
ABL2 | inactive (96.29%) |
TK - Ack
Bioactivity |
---|
Kinase | RBC |
---|
ACK | inactive (96.31%) |
TK - ALK
Bioactivity |
---|
Kinase | RBC |
---|
ALK | inactive (99.55%) |
LTK | inactive (100.61%) |
TK - Axl
Bioactivity |
---|
Kinase | RBC |
---|
AXL | inactive (99.3%) |
MER | inactive (95.41%) |
TYRO3 | inactive (99.32%) |
TK - Src
Bioactivity |
---|
Kinase | RBC |
---|
BLK | inactive (102.88%) |
BRK | inactive (90.44%) |
SRC | inactive (100.73%) |
FGR | inactive (97.19%) |
FRK | inactive (103.14%) |
FYN | inactive (92.78%) |
HCK | inactive (95.32%) |
LCK | inactive (96.49%) |
SRM | inactive (108.8%) |
YES | inactive (95.32%) |
LYN | inactive (100.44%) |
TK - Tec
Bioactivity |
---|
Kinase | RBC |
---|
BMX | inactive (91.67%) |
BTK | inactive (102.94%) |
ITK | inactive (94.94%) |
TEC | inactive (108.43%) |
TXK | inactive (103.1%) |
TK - PDGFR
Bioactivity |
---|
Kinase | RBC |
---|
KIT | inactive (92.67%) |
FLT3 | active (37.15%) |
FMS | inactive (98.08%) |
PDGFRb | inactive (102.04%) |
PDGFRa | inactive (93.07%) |
TK - Csk
Bioactivity |
---|
Kinase | RBC |
---|
CSK | inactive (104.39%) |
CTK | inactive (94.99%) |
TK - DDR
Bioactivity |
---|
Kinase | RBC |
---|
DDR2 | inactive (95.99%) |
TK - EGFR
Bioactivity |
---|
Kinase | RBC |
---|
EGFR | inactive (95.82%) |
ErbB2 | inactive (95.94%) |
ErbB4 | inactive (84.27%) |
TK - Eph
Bioactivity |
---|
Kinase | RBC |
---|
EphA1 | inactive (100.28%) |
EphA2 | inactive (101.51%) |
EphA3 | inactive (99.25%) |
EphA4 | inactive (103.12%) |
EphA5 | inactive (95.07%) |
EphA6 | inactive (99.98%) |
EphA7 | inactive (96.91%) |
EphA8 | inactive (101.61%) |
EphB1 | inactive (106.38%) |
EphB2 | inactive (110.36%) |
EphB3 | inactive (104.93%) |
EphB4 | inactive (90.88%) |
TK - FAK
Bioactivity |
---|
Kinase | RBC |
---|
FAK | inactive (95.92%) |
PYK2 | inactive (95.52%) |
TK - Fer
Bioactivity |
---|
Kinase | RBC |
---|
FER | inactive (69.15%) |
FES | inactive (101.79%) |
TK - FGFR
Bioactivity |
---|
Kinase | RBC |
---|
FGFR1 | inactive (87.83%) |
FGFR2 | inactive (103.52%) |
FGFR3 | inactive (96.33%) |
FGFR4 | inactive (89.64%) |
TK - VEGFR
Bioactivity |
---|
Kinase | RBC |
---|
FLT1 | inactive (91.31%) |
FLT4 | inactive (113.6%) |
KDR | inactive (101.4%) |
TK - InsR
Bioactivity |
---|
Kinase | RBC |
---|
IGF1R | inactive (100.97%) |
IRR | inactive (98.74%) |
INSR | inactive (88.04%) |
TK - JakA
Bioactivity |
---|
Kinase | RBC |
---|
JAK1 | inactive (108.23%) |
JAK2 | inactive (98.56%) |
JAK3 | inactive (89.45%) |
TYK2 | inactive (104.31%) |
TK - Musk
Bioactivity |
---|
Kinase | RBC |
---|
MUSK | inactive (85.57%) |
TK - Ret
Bioactivity |
---|
Kinase | RBC |
---|
RET | inactive (99.74%) |
TK - Met
Bioactivity |
---|
Kinase | RBC |
---|
RON | inactive (98.29%) |
MET | inactive (96.21%) |
TK - Sev
Bioactivity |
---|
Kinase | RBC |
---|
ROS | inactive (87.11%) |
TK - Syk
Bioactivity |
---|
Kinase | RBC |
---|
SYK | inactive (99.65%) |
ZAP70 | inactive (104.73%) |
TK - Tie
Bioactivity |
---|
Kinase | RBC |
---|
TIE2 | inactive (98.42%) |
TK - Trk
Bioactivity |
---|
Kinase | RBC |
---|
TRKA | inactive (107.65%) |
TRKB | inactive (102.3%) |
TRKC | inactive (75%) |
TKL
TKL - STKR
Bioactivity |
---|
Kinase | RBC |
---|
ALK1 | inactive (98.48%) |
ALK2 | inactive (93.32%) |
ALK4 | inactive (98.24%) |
TGFbR1 | inactive (99.82%) |
TGFbR2 | inactive (98.46%) |
TKL - RAF
Bioactivity |
---|
Kinase | RBC |
---|
ARAF | inactive (108.8%) |
BRAF | inactive (95.22%) |
RAF1 | inactive (96.58%) |
TKL - IRAK
Bioactivity |
---|
Kinase | RBC |
---|
IRAK1 | inactive (127.17%) |
IRAK4 | inactive (107.44%) |
TKL - LISK
Bioactivity |
---|
Kinase | RBC |
---|
LIMK1 | inactive (89.37%) |
TKL - LRRK
Bioactivity |
---|
Kinase | RBC |
---|
LRRK2 | inactive (93.11%) |
TKL - MLK
Bioactivity |
---|
Kinase | RBC |
---|
MLK1 | inactive (90.8%) |
MLK2 | inactive (101.56%) |
MLK3 | inactive (95.18%) |
TAK1 | inactive (95.34%) |
ZAK | inactive (87.34%) |
TKL - RIPK
Bioactivity |
---|
Kinase | RBC |
---|
RIPK2 | inactive (94.37%) |
CAMK
CAMK - CAMKL
Bioactivity |
---|
Kinase | RBC |
---|
NuaK1 | inactive (90.91%) |
BRSK1 | inactive (100.86%) |
BRSK2 | inactive (102.45%) |
CHK1 | inactive (69.82%) |
LKB1 | inactive (91.86%) |
MARK1 | inactive (92.77%) |
MARK3 | inactive (92.35%) |
MARK4 | inactive (93.87%) |
MELK | inactive (96.38%) |
PASK | inactive (92.99%) |
QIK | inactive (88.83%) |
NuaK2 | inactive (121.34%) |
MARK2 | inactive (94.87%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | RBC |
---|
CaMK1a | inactive (105.15%) |
CaMK1b | inactive (95.22%) |
CaMK1d | inactive (100.79%) |
CaMK1g | inactive (95.85%) |
CaMK4 | inactive (95.54%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | RBC |
---|
CaMK2a | inactive (100.46%) |
CaMK2b | inactive (96.92%) |
CaMK2d | inactive (82.37%) |
CaMK2g | inactive (99.98%) |
CAMK - RAD53
Bioactivity |
---|
Kinase | RBC |
---|
CHK2 | inactive (94.99%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | RBC |
---|
DAPK1 | inactive (94.09%) |
DAPK2 | inactive (90.41%) |
DRAK1 | inactive (87.63%) |
DAPK3 | inactive (95.24%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | RBC |
---|
DCLK2 | inactive (97.81%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | RBC |
---|
MAPKAPK2 | inactive (101.52%) |
MAPKAPK3 | inactive (97.93%) |
MAPKAPK5 | inactive (95.44%) |
MNK1 | inactive (99.97%) |
MNK2 | inactive (85.8%) |
CAMK - MLCK
Bioactivity |
---|
Kinase | RBC |
---|
smMLCK | inactive (83.99%) |
skMLCK | inactive (74.2%) |
CAMK - PHK
Bioactivity |
---|
Kinase | RBC |
---|
PHKg1 | inactive (78.41%) |
PHKg2 | inactive (103.87%) |
CAMK - PIM
Bioactivity |
---|
Kinase | RBC |
---|
PIM1 | inactive (63.24%) |
PIM2 | inactive (102.18%) |
PIM3 | inactive (83.09%) |
CAMK - PKD
Bioactivity |
---|
Kinase | RBC |
---|
PKD1 | inactive (100.7%) |
PKD3 | inactive (93.63%) |
PKD2 | inactive (97.65%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | RBC |
---|
TSSK1 | inactive (104.05%) |
TSSK2 | inactive (97.13%) |
CAMK - STK33
Bioactivity |
---|
Kinase | RBC |
---|
STK33 | inactive (94.83%) |
STE
STE - STE11
Bioactivity |
---|
Kinase | RBC |
---|
MAP3K5 | inactive (106.68%) |
MAP3K2 | inactive (94.62%) |
MAP3K3 | inactive (86.12%) |
STE - STE-Unique
Bioactivity |
---|
Kinase | RBC |
---|
COT | inactive (94.97%) |
NIK | inactive (105.18%) |
STE - STE20
Bioactivity |
---|
Kinase | RBC |
---|
GCK | inactive (98.98%) |
HGK | inactive (82.52%) |
KHS1 | inactive (99.94%) |
LOK | active (26.61%) |
MINK | inactive (97.85%) |
MST1 | inactive (80.12%) |
MST2 | inactive (101.9%) |
MST3 | inactive (66.51%) |
MST4 | inactive (78.04%) |
OSR1 | inactive (98.4%) |
PAK1 | inactive (99.83%) |
PAK2 | inactive (85.05%) |
PAK3 | inactive (102.37%) |
PAK4 | inactive (103.95%) |
PAK5 | inactive (100.43%) |
PAK6 | inactive (113.82%) |
SLK | inactive (83.12%) |
YSK1 | inactive (96.02%) |
STLK3 | inactive (101.64%) |
TAO1 | inactive (93%) |
TAO2 | inactive (87.69%) |
TAO3 | inactive (96.45%) |
MYO3B | inactive (87.94%) |
STE - STE7
Bioactivity |
---|
Kinase | RBC |
---|
MAP2K1 | inactive (98.81%) |
MAP2K2 | inactive (100.63%) |
MAP2K6 | inactive (108.71%) |
Other
Other - Aur
Bioactivity |
---|
Kinase | RBC |
---|
AurA | inactive (87.74%) |
AurB | inactive (96.32%) |
AurC | inactive (93.06%) |
Other - CAMKK
Bioactivity |
---|
Kinase | RBC |
---|
CaMKK1 | inactive (115.98%) |
CaMKK2 | inactive (107.96%) |
Other - Haspin
Bioactivity |
---|
Kinase | RBC |
---|
Haspin | inactive (100.13%) |
Other - IKK
Bioactivity |
---|
Kinase | RBC |
---|
IKKa | inactive (103.33%) |
IKKb | inactive (104.84%) |
IKKe | inactive (78.84%) |
TBK1 | inactive (91.39%) |
Other - NEK
Bioactivity |
---|
Kinase | RBC |
---|
NEK1 | inactive (105.05%) |
NEK11 | inactive (74.14%) |
NEK2 | inactive (106.31%) |
NEK4 | inactive (96.73%) |
NEK6 | inactive (94.63%) |
NEK7 | inactive (100.34%) |
NEK9 | inactive (97.65%) |
NEK3 | inactive (99.39%) |
Other - TOPK
Bioactivity |
---|
Kinase | RBC |
---|
PBK | inactive (101.16%) |
Other - PLK
Bioactivity |
---|
Kinase | RBC |
---|
PLK1 | inactive (101.52%) |
PLK2 | inactive (99.93%) |
PLK3 | inactive (100.45%) |
Other - SgK496
Bioactivity |
---|
Kinase | RBC |
---|
SgK496 | inactive (89.44%) |
Other - NAK
Bioactivity |
---|
Kinase | RBC |
---|
MPSK1 | inactive (109.16%) |
Other - TTK
Bioactivity |
---|
Kinase | RBC |
---|
TTK | inactive (105.37%) |
Other - ULK
Bioactivity |
---|
Kinase | RBC |
---|
ULK1 | inactive (98.92%) |
ULK2 | inactive (104.67%) |
ULK3 | inactive (88.91%) |
Other - WEE
Bioactivity |
---|
Kinase | RBC |
---|
Wee1 | inactive (100.74%) |
Other - WNK
Bioactivity |
---|
Kinase | RBC |
---|
Wnk2 | inactive (103.25%) |
Wnk3 | inactive (100.02%) |
Other - TLK
Bioactivity |
---|
Kinase | RBC |
---|
TLK2 | inactive (88.43%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | RBC |
---|
CK1 | 7 | 6 |
VRK | 3 | 1 |
CK1 - CK1
Bioactivity |
---|
Kinase | RBC |
---|
CK1d | inactive (100.86%) |
CK1g1 | inactive (96.95%) |
CK1g2 | inactive (97.03%) |
CK1g3 | inactive (104.37%) |
CK1a | inactive (98.53%) |
CK1e | inactive (99.67%) |
CK1 - VRK
Bioactivity |
---|
Kinase | RBC |
---|
VRK1 | inactive (104.79%) |
CMGC
CMGC - CK2
Bioactivity |
---|
Kinase | RBC |
---|
CK2a1 | inactive (98.94%) |
CK2a2 | inactive (92.43%) |
CMGC - CLK
Bioactivity |
---|
Kinase | RBC |
---|
CLK1 | inactive (104.54%) |
CLK2 | inactive (85.87%) |
CLK3 | inactive (94.69%) |
CLK4 | inactive (111.33%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | RBC |
---|
DYRK1A | inactive (88.65%) |
DYRK1B | inactive (92.22%) |
DYRK2 | inactive (102.14%) |
DYRK3 | inactive (102.24%) |
DYRK4 | inactive (98.86%) |
HIPK1 | inactive (100.64%) |
HIPK2 | inactive (94.13%) |
HIPK3 | inactive (111.27%) |
HIPK4 | inactive (95.71%) |
CMGC - MAPK
Bioactivity |
---|
Kinase | RBC |
---|
Erk1 | inactive (101.53%) |
Erk2 | inactive (101.22%) |
JNK3 | inactive (101.38%) |
NLK | inactive (101.39%) |
p38a | inactive (107.52%) |
p38b | inactive (109.27%) |
p38d | inactive (117.45%) |
p38g | inactive (102.27%) |
JNK1 | inactive (100.35%) |
JNK2 | inactive (105.39%) |
CMGC - GSK
Bioactivity |
---|
Kinase | RBC |
---|
GSK3A | active (14.21%) |
GSK3B | active (11.24%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | RBC |
---|
MSSK1 | inactive (100.24%) |
SRPK1 | inactive (103.26%) |
SRPK2 | inactive (91.48%) |
Atypical
Atypical
Test Member No. in Family |
---|
Family | no. Member on 518kinase | RBC |
---|
PDHK | 5 | 1 |
Atypical - PDHK
Bioactivity |
---|
Kinase | RBC |
---|
PDHK1 | inactive (96.95%) |