Compound Information
Test on : GPCR
Compound Name : GW429374A
Inchikey : FIGCSMLMEFLPMM-UHFFFAOYSA-N
ChemSpider : 26639368
Pubchem CID : 56667992
ChEMBL : CHEMBL1794050
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
TK
TK - JakA
Bioactivity |
---|
Kinase | GPCR |
---|
JAK1 | inactive (1.97%) |
TYK2 | inactive (6.13%) |
JAK2 | inactive (3.68%) |
JAK3 | inactive (15.85%) |
TK - Fer
Bioactivity |
---|
Kinase | GPCR |
---|
FER | inactive (9.05%) |
FES | inactive (2.85%) |
TK - Abl
Bioactivity |
---|
Kinase | GPCR |
---|
ABL1 | inactive (8.78%) |
ABL2 | inactive (5.72%) |
TK - Csk
Bioactivity |
---|
Kinase | GPCR |
---|
CSK | inactive (-1.69%) |
TK - Tec
Bioactivity |
---|
Kinase | GPCR |
---|
BMX | inactive (4.31%) |
BTK | inactive (1.61%) |
TXK | inactive (6.14%) |
TEC | inactive (8.99%) |
ITK | inactive (2.67%) |
TK - Src
Bioactivity |
---|
Kinase | GPCR |
---|
BRK | inactive (10.7%) |
SRM | active (57.94%) |
FRK | inactive (5.49%) |
BLK | inactive (10.78%) |
LCK | inactive (13.25%) |
HCK | inactive (11.12%) |
FGR | inactive (7.55%) |
FYN | inactive (10.48%) |
SRC | inactive (12.11%) |
YES | inactive (5.79%) |
TK - Eph
Bioactivity |
---|
Kinase | GPCR |
---|
EphA2 | inactive (0.76%) |
EphA4 | inactive (5.16%) |
EphA3 | inactive (3.94%) |
EphB4 | inactive (3.11%) |
EphB3 | inactive (2.28%) |
EphB2 | inactive (11.03%) |
TK - FAK
Bioactivity |
---|
Kinase | GPCR |
---|
PYK2 | inactive (9.16%) |
TK - Syk
Bioactivity |
---|
Kinase | GPCR |
---|
SYK | inactive (-2.96%) |
ZAP70 | inactive (-8.3%) |
TK - ALK
Bioactivity |
---|
Kinase | GPCR |
---|
LTK | inactive (22.96%) |
ALK | inactive (9.22%) |
TK - Sev
Bioactivity |
---|
Kinase | GPCR |
---|
ROS | inactive (18.32%) |
TK - InsR
Bioactivity |
---|
Kinase | GPCR |
---|
INSR | inactive (0.1%) |
IGF1R | inactive (4.14%) |
IRR | inactive (2.51%) |
TK - DDR
Bioactivity |
---|
Kinase | GPCR |
---|
DDR2 | inactive (5.97%) |
TK - Musk
Bioactivity |
---|
Kinase | GPCR |
---|
MUSK | inactive (5.67%) |
TK - Trk
Bioactivity |
---|
Kinase | GPCR |
---|
TRKA | inactive (12.84%) |
TRKB | inactive (12.17%) |
TRKC | inactive (24.08%) |
TK - Met
Bioactivity |
---|
Kinase | GPCR |
---|
RON | inactive (8.32%) |
MET | inactive (5.75%) |
TK - Axl
Bioactivity |
---|
Kinase | GPCR |
---|
AXL | inactive (-2.44%) |
MER | inactive (2.23%) |
TYRO3 | inactive (9.95%) |
TK - Ret
Bioactivity |
---|
Kinase | GPCR |
---|
RET | inactive (7.95%) |
TK - FGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FGFR1 | inactive (1.74%) |
FGFR2 | inactive (5.51%) |
FGFR3 | inactive (8.18%) |
FGFR4 | inactive (3.07%) |
TK - VEGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FLT1 | inactive (2.06%) |
KDR | inactive (10.05%) |
FLT4 | inactive (4.42%) |
TK - PDGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FMS | inactive (7.78%) |
KIT | inactive (3.66%) |
FLT3 | inactive (7.91%) |
PDGFRa | inactive (20.18%) |
PDGFRb | - |
TK - Tie
Bioactivity |
---|
Kinase | GPCR |
---|
TIE2 | inactive (2.63%) |
TK - Ack
Bioactivity |
---|
Kinase | GPCR |
---|
ACK | inactive (3.05%) |
TNK1 | active (80.57%) |
TK - EGFR
Bioactivity |
---|
Kinase | GPCR |
---|
EGFR | inactive (5.08%) |
ErbB2 | inactive (4.88%) |
ErbB4 | inactive (14.86%) |
TKL
TKL
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
IRAK | 4 | 1 |
RAF | 5 | 1 |
TKL - IRAK
Bioactivity |
---|
Kinase | GPCR |
---|
IRAK4 | inactive (4.22%) |
TKL - RAF
Bioactivity |
---|
Kinase | GPCR |
---|
BRAF | inactive (18.29%) |
STE
STE
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
STE20 | 31 | 12 |
STE7 | 7 | 1 |
STE - STE20
Bioactivity |
---|
Kinase | GPCR |
---|
GCK | inactive (2.93%) |
MST1 | inactive (39.59%) |
MST2 | inactive (37.31%) |
MST4 | inactive (36.04%) |
HGK | active (91.6%) |
MINK | active (81.56%) |
LOK | inactive (3.51%) |
PAK1 | inactive (6.31%) |
PAK3 | inactive (4.77%) |
PAK2 | inactive (2.17%) |
PAK5 | inactive (-0.35%) |
PAK6 | inactive (7.69%) |
STE - STE7
Bioactivity |
---|
Kinase | GPCR |
---|
MAP2K1 | inactive (5.62%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
CK1 | 7 | 4 |
CK1 - CK1
Bioactivity |
---|
Kinase | GPCR |
---|
CK1a | inactive (3.87%) |
CK1g2 | inactive (4.44%) |
CK1g1 | inactive (4.74%) |
CK1g3 | inactive (3.74%) |
Other
Other
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
PLK | 4 | 1 |
Aur | 3 | 3 |
NEK | 11 | 5 |
IKK | 4 | 4 |
TTK | 1 | 1 |
Other - PLK
Bioactivity |
---|
Kinase | GPCR |
---|
PLK1 | inactive (7.7%) |
Other - Aur
Bioactivity |
---|
Kinase | GPCR |
---|
AurB | inactive (15.97%) |
AurC | inactive (31.67%) |
AurA | active (88.35%) |
Other - NEK
Bioactivity |
---|
Kinase | GPCR |
---|
NEK1 | inactive (0.46%) |
NEK2 | inactive (2.79%) |
NEK9 | inactive (0.27%) |
NEK7 | inactive (4.87%) |
NEK6 | inactive (0.55%) |
Other - IKK
Bioactivity |
---|
Kinase | GPCR |
---|
TBK1 | inactive (7.51%) |
IKKe | active (92.13%) |
IKKb | inactive (2.14%) |
IKKa | inactive (7.66%) |
Other - TTK
Bioactivity |
---|
Kinase | GPCR |
---|
TTK | inactive (7.48%) |
AGC
AGC - GRK
Bioactivity |
---|
Kinase | GPCR |
---|
GPRK7 | active (60.3%) |
GPRK6 | inactive (46.13%) |
AGC - PDK1
Bioactivity |
---|
Kinase | GPCR |
---|
PDK1 | inactive (7.6%) |
AGC - RSK
Bioactivity |
---|
Kinase | GPCR |
---|
MSK1 | inactive (3.39%) |
MSK2 | inactive (2.67%) |
RSK1 | inactive (2.73%) |
RSK2 | inactive (-1.29%) |
RSK4 | inactive (5.51%) |
RSK3 | inactive (3.66%) |
p70S6K | inactive (2.15%) |
AGC - Akt
Bioactivity |
---|
Kinase | GPCR |
---|
AKT2 | inactive (2.84%) |
AKT1 | inactive (2.74%) |
AKT3 | inactive (1.67%) |
AGC - SGK
Bioactivity |
---|
Kinase | GPCR |
---|
SGK1 | inactive (3.05%) |
SGK3 | inactive (2%) |
SGK2 | inactive (6.41%) |
AGC - PKC
Bioactivity |
---|
Kinase | GPCR |
---|
PKCh | inactive (0.7%) |
PKCg | inactive (6.29%) |
PKCa | inactive (2.45%) |
PKCt | inactive (2.57%) |
PKCi | inactive (3.35%) |
AGC - PKG
Bioactivity |
---|
Kinase | GPCR |
---|
PKG2 | inactive (4.63%) |
PKG1 | inactive (11%) |
AGC - PKA
Bioactivity |
---|
Kinase | GPCR |
---|
PRKX | inactive (-0.22%) |
AGC - DMPK
Bioactivity |
---|
Kinase | GPCR |
---|
ROCK1 | inactive (4.77%) |
ROCK2 | inactive (7.43%) |
MRCKb | inactive (1.01%) |
MRCKa | inactive (-0.62%) |
CAMK
CAMK - RAD53
Bioactivity |
---|
Kinase | GPCR |
---|
CHK2 | inactive (8.93%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
DCLK2 | inactive (0.92%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK4 | inactive (-0.48%) |
CaMK1d | inactive (4.01%) |
CAMK - PHK
Bioactivity |
---|
Kinase | GPCR |
---|
PHKg1 | inactive (9.21%) |
PHKg2 | inactive (-0.09%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK2d | inactive (7.6%) |
CaMK2a | inactive (5.84%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | GPCR |
---|
MAPKAPK5 | inactive (0.45%) |
MAPKAPK2 | inactive (1.49%) |
MAPKAPK3 | inactive (2.92%) |
MNK2 | inactive (35.97%) |
MNK1 | inactive (12.73%) |
CAMK - PKD
Bioactivity |
---|
Kinase | GPCR |
---|
PKD3 | inactive (5.23%) |
PKD1 | inactive (4.25%) |
PKD2 | inactive (4.38%) |
CAMK - CAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
MARK4 | inactive (3.53%) |
MARK3 | inactive (6.43%) |
MARK1 | inactive (9.1%) |
QIK | inactive (-0.16%) |
SIK | inactive (4.86%) |
NuaK1 | inactive (4.71%) |
BRSK1 | inactive (4.37%) |
BRSK2 | inactive (2.32%) |
MELK | inactive (10.43%) |
CHK1 | inactive (0.96%) |
PASK | inactive (1.32%) |
AMPKa1 | inactive (3.3%) |
AMPKa2 | inactive (7.03%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | GPCR |
---|
TSSK2 | inactive (-0.14%) |
TSSK1 | inactive (1.29%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | GPCR |
---|
DAPK1 | inactive (-6.21%) |
CAMK - PIM
Bioactivity |
---|
Kinase | GPCR |
---|
PIM2 | inactive (46.51%) |
PIM3 | inactive (49.04%) |
PIM1 | inactive (37.63%) |
CMGC
CMGC - MAPK
Bioactivity |
---|
Kinase | GPCR |
---|
JNK2 | inactive (3.04%) |
p38a | inactive (7.67%) |
p38b | inactive (1.36%) |
p38d | inactive (3.3%) |
Erk2 | inactive (3.37%) |
Erk1 | inactive (1.77%) |
CMGC - GSK
Bioactivity |
---|
Kinase | GPCR |
---|
GSK3A | inactive (26.14%) |
GSK3B | inactive (21.39%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | GPCR |
---|
SRPK1 | inactive (-2.45%) |
MSSK1 | inactive (1.95%) |
CMGC - CLK
Bioactivity |
---|
Kinase | GPCR |
---|
CLK3 | inactive (38.62%) |
CLK2 | active (84.59%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | GPCR |
---|
HIPK1 | inactive (22.36%) |
HIPK4 | inactive (13.83%) |
DYRK1B | inactive (46.7%) |
DYRK1A | active (63.48%) |
DYRK2 | inactive (15.5%) |
CMGC - CK2
Bioactivity |
---|
Kinase | GPCR |
---|
CK2a1 | inactive (14.51%) |