Compound Information


Test on : Metz

Compound Name : Kinome_1071

Inchikey : FDBPGAHVEGEARY-UHFFFAOYSA-N

ChemSpider : 24808959

Pubchem CID : 49830462

ChEMBL : CHEMBL1986970




DRx RBC Metz Millipore GPCR
bioactivity Kd (nM) Remain Activity (%) Ki (nM) Remain Activity (%) Inhibition (%)
active criteria <3000nM <50% <1000nM <50% >50%

AGC


Test Member No. in Family
Familyno. Member on 518kinaseMetz
33
73
71
11
52
95
22
31
84
31
AGC - Akt

Bioactivity
KinaseMetz
AKT1inactive (3162.28nM)
AKT2inactive (>7943.28nM)
AKT3inactive (>10000nM)
AGC - DMPK

Bioactivity
KinaseMetz
MRCKaactive (158.49nM)
ROCK1active (125.89nM)
ROCK2active (31.62nM)
AGC - GRK

Bioactivity
KinaseMetz
GPRK5-
AGC - PDK1

Bioactivity
KinaseMetz
PDK1inactive (>3981.07nM)
AGC - PKA

Bioactivity
KinaseMetz
PKACaactive (316.23nM)
PRKXactive (50.12nM)
AGC - PKC

Bioactivity
KinaseMetz
PKCdinactive (1258.93nM)
PKCginactive (>7943.28nM)
PKCzinactive (>7943.28nM)
PKCiinactive (>5011.87nM)
PKCt-
AGC - PKG

Bioactivity
KinaseMetz
PKG1active (794.33nM)
PKG2inactive (1584.89nM)
AGC - PKN

Bioactivity
KinaseMetz
PKN2active (1000nM)
AGC - RSK

Bioactivity
KinaseMetz
RSK2inactive (1995.26nM)
p70S6K-
MSK1active (100nM)
MSK2-
AGC - SGK

Bioactivity
KinaseMetz
SGK1inactive (1584.89nM)

Atypical


Test Member No. in Family
Familyno. Member on 518kinaseMetz
61
Atypical - Alpha

Bioactivity
KinaseMetz
eEF2K-

CAMK


Test Member No. in Family
Familyno. Member on 518kinaseMetz
52
44
209
52
31
54
21
33
32
11
11
52
CAMK - CAMK1

Bioactivity
KinaseMetz
CaMK1ainactive (7943.28nM)
CaMK1d-
CAMK - CAMK2

Bioactivity
KinaseMetz
CaMK2binactive (>7943.28nM)
CaMK2dinactive (>6309.57nM)
CaMK2ginactive (>6309.57nM)
CaMK2a-
CAMK - CAMKL

Bioactivity
KinaseMetz
CHK1inactive (>7943.28nM)
BRSK1inactive (>10000nM)
MARK2inactive (2511.89nM)
MARK3inactive (3981.07nM)
MELKinactive (1258.93nM)
AMPKa1active (501.19nM)
PASK-
MARK4-
QIK-
CAMK - DAPK

Bioactivity
KinaseMetz
DAPK3inactive (>1258.93nM)
DRAK1inactive (>3981.07nM)
CAMK - DCAMKL

Bioactivity
KinaseMetz
DCLK1inactive (>10000nM)
CAMK - MAPKAPK

Bioactivity
KinaseMetz
MAPKAPK2inactive (>7943.28nM)
MAPKAPK3inactive (>10000nM)
MNK2inactive (6309.57nM)
MAPKAPK5inactive (>1584.89nM)
CAMK - PHK

Bioactivity
KinaseMetz
PHKg2inactive (>5011.87nM)
CAMK - PIM

Bioactivity
KinaseMetz
PIM1inactive (3162.28nM)
PIM2inactive (>1584.89nM)
PIM3inactive (>7943.28nM)
CAMK - PKD

Bioactivity
KinaseMetz
PKD3inactive (10000nM)
PKD2inactive (>10000nM)
CAMK - RAD53

Bioactivity
KinaseMetz
CHK2inactive (>1584.89nM)
CAMK - STK33

Bioactivity
KinaseMetz
STK33-
CAMK - TSSK

Bioactivity
KinaseMetz
TSSK1inactive (>1584.89nM)
TSSK2inactive (>1584.89nM)

CK1


Test Member No. in Family
Familyno. Member on 518kinaseMetz
75
CK1 - CK1

Bioactivity
KinaseMetz
CK1ainactive (>6309.57nM)
CK1dinactive (>7943.28nM)
CK1g1inactive (>6309.57nM)
CK1g2inactive (7943.28nM)
CK1g3inactive (>6309.57nM)

CMGC


Test Member No. in Family
Familyno. Member on 518kinaseMetz
207
31
42
106
22
148
31
CMGC - CDK

Bioactivity
KinaseMetz
CDC2active (501.19nM)
CDK2active (630.96nM)
CDK5inactive (1995.26nM)
CDK8-
CDK7-
CDK9-
CDK11-
CMGC - CK2

Bioactivity
KinaseMetz
CK2a1inactive (>6309.57nM)
CMGC - CLK

Bioactivity
KinaseMetz
CLK2inactive (3981.07nM)
CLK4active (794.33nM)
CMGC - DYRK

Bioactivity
KinaseMetz
DYRK1Aactive (125.89nM)
DYRK3inactive (>6309.57nM)
DYRK4inactive (>7943.28nM)
HIPK2inactive (>3162.28nM)
HIPK4inactive (>7943.28nM)
DYRK1B-
CMGC - GSK

Bioactivity
KinaseMetz
GSK3Aactive (125.89nM)
GSK3Bactive (100nM)
CMGC - MAPK

Bioactivity
KinaseMetz
Erk2active (794.33nM)
p38ginactive (>6309.57nM)
p38dinactive (>7943.28nM)
JNK1inactive (>3162.28nM)
JNK2inactive (>3981.07nM)
p38a-
JNK3-
NLK-
CMGC - SRPK

Bioactivity
KinaseMetz
SRPK1inactive (>7943.28nM)

Other


Test Member No. in Family
Familyno. Member on 518kinaseMetz
32
21
11
44
112
43
11
31
Other - Aur

Bioactivity
KinaseMetz
AurBactive (794.33nM)
AurAactive (316.23nM)
Other - CAMKK

Bioactivity
KinaseMetz
CaMKK2-
Other - CDC7

Bioactivity
KinaseMetz
CDC7inactive (>1258.93nM)
Other - IKK

Bioactivity
KinaseMetz
IKKe-
TBK1-
IKKa-
IKKb-
Other - NEK

Bioactivity
KinaseMetz
NEK2inactive (>10000nM)
NEK4inactive (>6309.57nM)
Other - PLK

Bioactivity
KinaseMetz
PLK1inactive (>7943.28nM)
PLK3inactive (>7943.28nM)
PLK4active (1000nM)
Other - TOPK

Bioactivity
KinaseMetz
PBKinactive (>10000nM)
Other - WEE

Bioactivity
KinaseMetz
Wee1-

STE


Test Member No. in Family
Familyno. Member on 518kinaseMetz
319
72
STE - STE20

Bioactivity
KinaseMetz
GCKinactive (3162.28nM)
HGKinactive (>10000nM)
KHS1inactive (>7943.28nM)
MINKinactive (>7943.28nM)
PAK1inactive (>10000nM)
PAK4inactive (>5011.87nM)
SLKinactive (>10000nM)
MST2inactive (>7943.28nM)
TAO1inactive (>10000nM)
STE - STE7

Bioactivity
KinaseMetz
MAP2K1-
MAP2K2-

TK


Test Member No. in Family
Familyno. Member on 518kinaseMetz
21
21
22
32
21
43
141
22
22
42
32
43
22
55
11
11
119
21
53
33
33
TK - Abl

Bioactivity
KinaseMetz
ABL1inactive (>630.96nM)
TK - Ack

Bioactivity
KinaseMetz
ACK-
TK - ALK

Bioactivity
KinaseMetz
ALKinactive (>1258.93nM)
LTK-
TK - Axl

Bioactivity
KinaseMetz
TYRO3inactive (>1995.26nM)
AXLinactive (>1995.26nM)
TK - Csk

Bioactivity
KinaseMetz
CTKinactive (>1995.26nM)
TK - EGFR

Bioactivity
KinaseMetz
EGFRinactive (>1995.26nM)
ErbB2inactive (>1584.89nM)
ErbB4inactive (>3981.07nM)
TK - Eph

Bioactivity
KinaseMetz
EphA2inactive (>3162.28nM)
TK - FAK

Bioactivity
KinaseMetz
FAKinactive (>1584.89nM)
PYK2inactive (>1584.89nM)
TK - Fer

Bioactivity
KinaseMetz
FERinactive (>1584.89nM)
FESinactive (>1995.26nM)
TK - FGFR

Bioactivity
KinaseMetz
FGFR1inactive (>5011.87nM)
FGFR3inactive (>1995.26nM)
TK - InsR

Bioactivity
KinaseMetz
IGF1Rinactive (>1995.26nM)
INSRinactive (>5011.87nM)
TK - JakA

Bioactivity
KinaseMetz
JAK2inactive (>1584.89nM)
JAK3inactive (>1584.89nM)
TYK2inactive (>1995.26nM)
TK - Met

Bioactivity
KinaseMetz
METinactive (>3162.28nM)
RON-
TK - PDGFR

Bioactivity
KinaseMetz
FMSinactive (>2511.89nM)
FLT3inactive (>2511.89nM)
KITinactive (>1258.93nM)
PDGFRa-
PDGFRb-
TK - Ret

Bioactivity
KinaseMetz
RET-
TK - Sev

Bioactivity
KinaseMetz
ROSinactive (>1995.26nM)
TK - Src

Bioactivity
KinaseMetz
BLKinactive (>1584.89nM)
LCKinactive (>2511.89nM)
LYNinactive (>1584.89nM)
SRCinactive (>1995.26nM)
FRKinactive (>2511.89nM)
SRMinactive (>1584.89nM)
FYNinactive (>794.33nM)
BRKinactive (>2511.89nM)
HCK-
TK - Syk

Bioactivity
KinaseMetz
SYKinactive (>1584.89nM)
TK - Tec

Bioactivity
KinaseMetz
BTKinactive (>1258.93nM)
ITKinactive (>1584.89nM)
BMX-
TK - Trk

Bioactivity
KinaseMetz
TRKAinactive (>2511.89nM)
TRKBinactive (>5011.87nM)
TRKCinactive (>1258.93nM)
TK - VEGFR

Bioactivity
KinaseMetz
FLT4inactive (>6309.57nM)
KDRinactive (>7943.28nM)
FLT1inactive (>398.11nM)

TKL


Test Member No. in Family
Familyno. Member on 518kinaseMetz
42
41
21
102
51
121
TKL - IRAK

Bioactivity
KinaseMetz
IRAK1inactive (2511.89nM)
IRAK4inactive (>10000nM)
TKL - LISK

Bioactivity
KinaseMetz
LIMK1inactive (>10000nM)
TKL - LRRK

Bioactivity
KinaseMetz
LRRK2-
TKL - MLK

Bioactivity
KinaseMetz
ZAKinactive (>7943.28nM)
MLK2-
TKL - RAF

Bioactivity
KinaseMetz
BRAF-
TKL - STKR

Bioactivity
KinaseMetz
ALK2-