Compound Information
Test on : GPCR
Compound Name : GW2974
Inchikey : DYYZXRCFCVDSKD-UHFFFAOYSA-N
ChemSpider : 5036165
Pubchem CID : 6603857
ChEMBL : CHEMBL30432
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
TK
TK - JakA
Bioactivity |
---|
Kinase | GPCR |
---|
JAK1 | inactive (-0.82%) |
TYK2 | inactive (-5.95%) |
JAK2 | inactive (2.18%) |
JAK3 | inactive (0.54%) |
TK - Fer
Bioactivity |
---|
Kinase | GPCR |
---|
FER | inactive (7.22%) |
FES | inactive (3.25%) |
TK - Abl
Bioactivity |
---|
Kinase | GPCR |
---|
ABL1 | inactive (5.43%) |
ABL2 | inactive (8.48%) |
TK - Csk
Bioactivity |
---|
Kinase | GPCR |
---|
CSK | inactive (27.62%) |
TK - Tec
Bioactivity |
---|
Kinase | GPCR |
---|
BMX | inactive (20.83%) |
BTK | inactive (9.11%) |
TXK | inactive (4.31%) |
TEC | inactive (9.92%) |
ITK | inactive (0.99%) |
TK - Src
Bioactivity |
---|
Kinase | GPCR |
---|
BRK | inactive (29.24%) |
SRM | inactive (1.29%) |
FRK | inactive (2.5%) |
BLK | inactive (22.64%) |
LCK | inactive (22.6%) |
HCK | inactive (19.93%) |
FGR | inactive (33.25%) |
FYN | inactive (15.29%) |
SRC | inactive (13.06%) |
YES | inactive (49.75%) |
TK - Eph
Bioactivity |
---|
Kinase | GPCR |
---|
EphA2 | inactive (0.17%) |
EphA4 | inactive (2.96%) |
EphA3 | inactive (3.25%) |
EphB4 | inactive (2.11%) |
EphB3 | inactive (1.55%) |
EphB2 | inactive (0.46%) |
TK - FAK
Bioactivity |
---|
Kinase | GPCR |
---|
PYK2 | inactive (5.1%) |
TK - Syk
Bioactivity |
---|
Kinase | GPCR |
---|
SYK | inactive (0.09%) |
ZAP70 | inactive (5.85%) |
TK - ALK
Bioactivity |
---|
Kinase | GPCR |
---|
LTK | inactive (3.01%) |
ALK | inactive (4.13%) |
TK - Sev
Bioactivity |
---|
Kinase | GPCR |
---|
ROS | inactive (2.03%) |
TK - InsR
Bioactivity |
---|
Kinase | GPCR |
---|
INSR | inactive (6.13%) |
IGF1R | inactive (2.94%) |
IRR | inactive (0.35%) |
TK - DDR
Bioactivity |
---|
Kinase | GPCR |
---|
DDR2 | inactive (3.09%) |
TK - Musk
Bioactivity |
---|
Kinase | GPCR |
---|
MUSK | inactive (1.56%) |
TK - Trk
Bioactivity |
---|
Kinase | GPCR |
---|
TRKA | inactive (1.97%) |
TRKB | inactive (0.6%) |
TRKC | inactive (1.66%) |
TK - Met
Bioactivity |
---|
Kinase | GPCR |
---|
RON | inactive (0.62%) |
MET | inactive (0.45%) |
TK - Axl
Bioactivity |
---|
Kinase | GPCR |
---|
AXL | inactive (-3.44%) |
MER | inactive (40.87%) |
TYRO3 | inactive (7.51%) |
TK - Ret
Bioactivity |
---|
Kinase | GPCR |
---|
RET | inactive (13.63%) |
TK - FGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FGFR1 | inactive (4.22%) |
FGFR2 | inactive (2.51%) |
FGFR3 | inactive (4.14%) |
FGFR4 | inactive (7.89%) |
TK - VEGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FLT1 | inactive (1.36%) |
KDR | inactive (18.23%) |
FLT4 | inactive (2.4%) |
TK - PDGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FMS | inactive (3.34%) |
KIT | inactive (3.38%) |
FLT3 | inactive (1.77%) |
PDGFRa | inactive (8.21%) |
PDGFRb | inactive (7.75%) |
TK - Tie
Bioactivity |
---|
Kinase | GPCR |
---|
TIE2 | inactive (5.29%) |
TK - Ack
Bioactivity |
---|
Kinase | GPCR |
---|
ACK | inactive (1.68%) |
TNK1 | inactive (14.67%) |
TK - EGFR
Bioactivity |
---|
Kinase | GPCR |
---|
EGFR | active (87.31%) |
ErbB2 | active (86.62%) |
ErbB4 | active (94.6%) |
TKL
TKL
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
IRAK | 4 | 1 |
RAF | 5 | 1 |
TKL - IRAK
Bioactivity |
---|
Kinase | GPCR |
---|
IRAK4 | inactive (1.57%) |
TKL - RAF
Bioactivity |
---|
Kinase | GPCR |
---|
BRAF | inactive (3.71%) |
STE
STE
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
STE20 | 31 | 12 |
STE7 | 7 | 1 |
STE - STE20
Bioactivity |
---|
Kinase | GPCR |
---|
GCK | inactive (0.49%) |
MST1 | inactive (1.68%) |
MST2 | inactive (2.67%) |
MST4 | inactive (-0.54%) |
HGK | inactive (6.51%) |
MINK | inactive (4.78%) |
LOK | inactive (13.89%) |
PAK1 | inactive (6.67%) |
PAK3 | inactive (3.39%) |
PAK2 | inactive (0.51%) |
PAK5 | inactive (-2.02%) |
PAK6 | inactive (-3.27%) |
STE - STE7
Bioactivity |
---|
Kinase | GPCR |
---|
MAP2K1 | inactive (2.77%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
CK1 | 7 | 4 |
CK1 - CK1
Bioactivity |
---|
Kinase | GPCR |
---|
CK1a | inactive (4.63%) |
CK1g2 | inactive (2.69%) |
CK1g1 | inactive (3.24%) |
CK1g3 | inactive (2.19%) |
Other
Other
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
PLK | 4 | 1 |
Aur | 3 | 3 |
NEK | 11 | 5 |
IKK | 4 | 4 |
TTK | 1 | 1 |
Other - PLK
Bioactivity |
---|
Kinase | GPCR |
---|
PLK1 | inactive (3.09%) |
Other - Aur
Bioactivity |
---|
Kinase | GPCR |
---|
AurB | inactive (8.49%) |
AurC | inactive (27.64%) |
AurA | inactive (12.85%) |
Other - NEK
Bioactivity |
---|
Kinase | GPCR |
---|
NEK1 | inactive (2.49%) |
NEK2 | inactive (3.45%) |
NEK9 | inactive (6.27%) |
NEK7 | inactive (1.66%) |
NEK6 | inactive (2.34%) |
Other - IKK
Bioactivity |
---|
Kinase | GPCR |
---|
TBK1 | inactive (3.14%) |
IKKe | inactive (3.38%) |
IKKb | inactive (3.14%) |
IKKa | inactive (8.41%) |
Other - TTK
Bioactivity |
---|
Kinase | GPCR |
---|
TTK | inactive (6.41%) |
AGC
AGC - GRK
Bioactivity |
---|
Kinase | GPCR |
---|
GPRK7 | inactive (3.15%) |
GPRK6 | inactive (3.36%) |
AGC - PDK1
Bioactivity |
---|
Kinase | GPCR |
---|
PDK1 | inactive (3.41%) |
AGC - RSK
Bioactivity |
---|
Kinase | GPCR |
---|
MSK1 | inactive (6.2%) |
MSK2 | inactive (6.24%) |
RSK1 | inactive (3.04%) |
RSK2 | inactive (2.13%) |
RSK4 | inactive (1.71%) |
RSK3 | inactive (3.42%) |
p70S6K | inactive (3.88%) |
AGC - Akt
Bioactivity |
---|
Kinase | GPCR |
---|
AKT2 | inactive (1.16%) |
AKT1 | inactive (0.62%) |
AKT3 | inactive (1.23%) |
AGC - SGK
Bioactivity |
---|
Kinase | GPCR |
---|
SGK1 | inactive (2.27%) |
SGK3 | inactive (1.33%) |
SGK2 | inactive (-0.04%) |
AGC - PKC
Bioactivity |
---|
Kinase | GPCR |
---|
PKCh | inactive (1.17%) |
PKCg | inactive (-1.38%) |
PKCa | inactive (0.82%) |
PKCt | inactive (0.28%) |
PKCi | inactive (1.74%) |
AGC - PKG
Bioactivity |
---|
Kinase | GPCR |
---|
PKG2 | inactive (2.77%) |
PKG1 | inactive (4.15%) |
AGC - PKA
Bioactivity |
---|
Kinase | GPCR |
---|
PRKX | inactive (0.84%) |
AGC - DMPK
Bioactivity |
---|
Kinase | GPCR |
---|
ROCK1 | inactive (2.38%) |
ROCK2 | inactive (3.89%) |
MRCKb | inactive (1.67%) |
MRCKa | inactive (0.83%) |
CAMK
CAMK - RAD53
Bioactivity |
---|
Kinase | GPCR |
---|
CHK2 | inactive (17.94%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
DCLK2 | inactive (-0.18%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK4 | inactive (0.37%) |
CaMK1d | inactive (0.88%) |
CAMK - PHK
Bioactivity |
---|
Kinase | GPCR |
---|
PHKg1 | inactive (4.62%) |
PHKg2 | inactive (1.97%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK2d | inactive (2.7%) |
CaMK2a | inactive (2.41%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | GPCR |
---|
MAPKAPK5 | inactive (0.28%) |
MAPKAPK2 | inactive (1.29%) |
MAPKAPK3 | inactive (2.81%) |
MNK2 | inactive (22.97%) |
MNK1 | inactive (19.44%) |
CAMK - PKD
Bioactivity |
---|
Kinase | GPCR |
---|
PKD3 | inactive (4.21%) |
PKD1 | inactive (5.12%) |
PKD2 | inactive (4.01%) |
CAMK - CAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
MARK4 | inactive (1.04%) |
MARK3 | inactive (-0.35%) |
MARK1 | inactive (3.22%) |
QIK | inactive (4.92%) |
SIK | inactive (4.59%) |
NuaK1 | inactive (3.46%) |
BRSK1 | inactive (7.54%) |
BRSK2 | inactive (9.3%) |
MELK | inactive (2.1%) |
CHK1 | inactive (5.16%) |
PASK | inactive (-1.1%) |
AMPKa1 | inactive (3.27%) |
AMPKa2 | inactive (2.49%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | GPCR |
---|
TSSK2 | inactive (-1.33%) |
TSSK1 | inactive (-2.44%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | GPCR |
---|
DAPK1 | inactive (4%) |
CAMK - PIM
Bioactivity |
---|
Kinase | GPCR |
---|
PIM2 | inactive (0.31%) |
PIM3 | inactive (0.43%) |
PIM1 | inactive (1.78%) |
CMGC
CMGC - MAPK
Bioactivity |
---|
Kinase | GPCR |
---|
JNK2 | inactive (2.39%) |
p38a | inactive (8.31%) |
p38b | inactive (4.06%) |
p38d | inactive (2.47%) |
Erk2 | inactive (3.41%) |
Erk1 | inactive (-0.93%) |
CMGC - GSK
Bioactivity |
---|
Kinase | GPCR |
---|
GSK3A | inactive (5.95%) |
GSK3B | inactive (4.25%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | GPCR |
---|
SRPK1 | inactive (-3.59%) |
MSSK1 | inactive (-0.9%) |
CMGC - CLK
Bioactivity |
---|
Kinase | GPCR |
---|
CLK3 | inactive (1.41%) |
CLK2 | inactive (-0.06%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | GPCR |
---|
HIPK1 | inactive (2.06%) |
HIPK4 | inactive (0.89%) |
DYRK1B | inactive (3.5%) |
DYRK1A | inactive (6.83%) |
DYRK2 | inactive (2.63%) |
CMGC - CK2
Bioactivity |
---|
Kinase | GPCR |
---|
CK2a1 | inactive (-0.12%) |