Compound Information
Test on : RBC
Compound Name : Cdk1/5 Inhibitor
Inchikey : DWHVZCLBMTZRQM-UHFFFAOYSA-N
ChemSpider : 388165
Pubchem CID : 438981
ChEMBL : CHEMBL259389
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
AGC
AGC - PDK1
Bioactivity |
---|
Kinase | RBC |
---|
PDK1 | inactive (96.84%) |
AGC - Akt
Bioactivity |
---|
Kinase | RBC |
---|
AKT1 | inactive (106.42%) |
AKT2 | inactive (90.06%) |
AKT3 | inactive (95.29%) |
AGC - DMPK
Bioactivity |
---|
Kinase | RBC |
---|
DMPK1 | inactive (98.37%) |
MRCKa | inactive (95.36%) |
MRCKb | inactive (100.2%) |
ROCK1 | inactive (99.01%) |
ROCK2 | inactive (93.31%) |
AGC - GRK
Bioactivity |
---|
Kinase | RBC |
---|
BARK1 | inactive (100.78%) |
BARK2 | inactive (92.36%) |
GPRK4 | inactive (98.93%) |
GPRK5 | inactive (100.68%) |
GPRK6 | inactive (103.51%) |
GPRK7 | inactive (100.93%) |
AGC - RSK
Bioactivity |
---|
Kinase | RBC |
---|
MSK1 | inactive (92.4%) |
MSK2 | inactive (79.01%) |
p70S6K | inactive (99.83%) |
p70S6Kb | inactive (101.66%) |
RSK2 | inactive (87.97%) |
RSK4 | inactive (94.18%) |
RSK1 | inactive (97.94%) |
RSK3 | inactive (89.06%) |
AGC - PKA
Bioactivity |
---|
Kinase | RBC |
---|
PKACg | - |
PRKX | inactive (101.58%) |
PKACa | inactive (101.67%) |
AGC - PKC
Bioactivity |
---|
Kinase | RBC |
---|
PKCa | inactive (70.99%) |
PKCd | inactive (98.27%) |
PKCe | inactive (86.4%) |
PKCh | inactive (87.93%) |
PKCg | inactive (97.27%) |
PKCi | inactive (103.37%) |
PKCt | inactive (89.7%) |
PKCz | inactive (106.28%) |
PKCb | inactive (88.52%) |
AGC - PKG
Bioactivity |
---|
Kinase | RBC |
---|
PKG2 | inactive (66.69%) |
PKG1 | inactive (97.67%) |
AGC - PKN
Bioactivity |
---|
Kinase | RBC |
---|
PKN1 | inactive (91.96%) |
PKN2 | inactive (98.75%) |
AGC - SGK
Bioactivity |
---|
Kinase | RBC |
---|
SGK1 | inactive (114.37%) |
SGK2 | inactive (90.34%) |
SGK3 | inactive (96.62%) |
AGC - NDR
Bioactivity |
---|
Kinase | RBC |
---|
NDR1 | active (0%) |
TK
TK - Abl
Bioactivity |
---|
Kinase | RBC |
---|
ABL1 | inactive (91.57%) |
ABL2 | inactive (95.46%) |
TK - Ack
Bioactivity |
---|
Kinase | RBC |
---|
ACK | inactive (101.13%) |
TK - ALK
Bioactivity |
---|
Kinase | RBC |
---|
ALK | inactive (96.68%) |
LTK | inactive (89.42%) |
TK - Axl
Bioactivity |
---|
Kinase | RBC |
---|
AXL | inactive (91.25%) |
MER | inactive (92.88%) |
TYRO3 | inactive (101.29%) |
TK - Src
Bioactivity |
---|
Kinase | RBC |
---|
BLK | inactive (96.59%) |
BRK | inactive (84.14%) |
SRC | inactive (105.1%) |
FGR | inactive (96.25%) |
FRK | inactive (96.76%) |
FYN | inactive (96.05%) |
HCK | inactive (98.57%) |
LCK | inactive (93.57%) |
SRM | inactive (88.47%) |
YES | inactive (97.11%) |
LYN | inactive (97.02%) |
TK - Tec
Bioactivity |
---|
Kinase | RBC |
---|
BMX | inactive (99.48%) |
BTK | inactive (93.85%) |
ITK | inactive (100.87%) |
TEC | inactive (107.8%) |
TXK | inactive (97.59%) |
TK - PDGFR
Bioactivity |
---|
Kinase | RBC |
---|
KIT | inactive (100.45%) |
FLT3 | inactive (75.92%) |
FMS | inactive (95.28%) |
PDGFRb | inactive (98.12%) |
PDGFRa | inactive (102.87%) |
TK - Csk
Bioactivity |
---|
Kinase | RBC |
---|
CSK | inactive (100.39%) |
CTK | inactive (91.91%) |
TK - DDR
Bioactivity |
---|
Kinase | RBC |
---|
DDR2 | inactive (94.56%) |
TK - EGFR
Bioactivity |
---|
Kinase | RBC |
---|
EGFR | inactive (96.44%) |
ErbB2 | inactive (95.17%) |
ErbB4 | inactive (101.01%) |
TK - Eph
Bioactivity |
---|
Kinase | RBC |
---|
EphA1 | inactive (100.44%) |
EphA2 | inactive (98.45%) |
EphA3 | inactive (95.24%) |
EphA4 | inactive (86.55%) |
EphA5 | inactive (90.31%) |
EphA6 | - |
EphA7 | inactive (95.29%) |
EphA8 | inactive (103.81%) |
EphB1 | inactive (92.34%) |
EphB2 | inactive (103.07%) |
EphB3 | inactive (90.33%) |
EphB4 | inactive (84.91%) |
TK - FAK
Bioactivity |
---|
Kinase | RBC |
---|
FAK | inactive (94.65%) |
PYK2 | inactive (92%) |
TK - Fer
Bioactivity |
---|
Kinase | RBC |
---|
FER | inactive (94.41%) |
FES | inactive (96.81%) |
TK - FGFR
Bioactivity |
---|
Kinase | RBC |
---|
FGFR1 | inactive (93.92%) |
FGFR2 | inactive (98.05%) |
FGFR3 | inactive (96.52%) |
FGFR4 | inactive (94.95%) |
TK - VEGFR
Bioactivity |
---|
Kinase | RBC |
---|
FLT1 | inactive (92.13%) |
FLT4 | inactive (116.61%) |
KDR | inactive (95.82%) |
TK - InsR
Bioactivity |
---|
Kinase | RBC |
---|
IGF1R | inactive (97.47%) |
IRR | inactive (89.29%) |
INSR | inactive (95.27%) |
TK - JakA
Bioactivity |
---|
Kinase | RBC |
---|
JAK1 | inactive (99.85%) |
JAK2 | inactive (105.21%) |
JAK3 | inactive (67.96%) |
TYK2 | inactive (107.21%) |
TK - Musk
Bioactivity |
---|
Kinase | RBC |
---|
MUSK | inactive (82.59%) |
TK - Ret
Bioactivity |
---|
Kinase | RBC |
---|
RET | inactive (97.1%) |
TK - Met
Bioactivity |
---|
Kinase | RBC |
---|
RON | inactive (104.96%) |
MET | inactive (90.11%) |
TK - Sev
Bioactivity |
---|
Kinase | RBC |
---|
ROS | inactive (105.86%) |
TK - Syk
Bioactivity |
---|
Kinase | RBC |
---|
SYK | inactive (100.13%) |
ZAP70 | inactive (102.5%) |
TK - Tie
Bioactivity |
---|
Kinase | RBC |
---|
TIE2 | inactive (97.02%) |
TK - Trk
Bioactivity |
---|
Kinase | RBC |
---|
TRKA | inactive (88.34%) |
TRKB | inactive (96.37%) |
TRKC | inactive (92.11%) |
TKL
TKL - STKR
Bioactivity |
---|
Kinase | RBC |
---|
ALK1 | inactive (104.84%) |
ALK2 | inactive (94.32%) |
ALK4 | inactive (99.94%) |
TGFbR1 | inactive (98.08%) |
TGFbR2 | inactive (82.41%) |
TKL - RAF
Bioactivity |
---|
Kinase | RBC |
---|
ARAF | inactive (119.36%) |
BRAF | inactive (101.75%) |
RAF1 | inactive (94.44%) |
TKL - IRAK
Bioactivity |
---|
Kinase | RBC |
---|
IRAK1 | inactive (88.94%) |
IRAK4 | inactive (94.65%) |
TKL - LISK
Bioactivity |
---|
Kinase | RBC |
---|
LIMK1 | inactive (105.48%) |
TKL - LRRK
Bioactivity |
---|
Kinase | RBC |
---|
LRRK2 | inactive (90.51%) |
TKL - MLK
Bioactivity |
---|
Kinase | RBC |
---|
MLK1 | inactive (97.74%) |
MLK2 | inactive (93.11%) |
MLK3 | inactive (96.32%) |
TAK1 | inactive (100.02%) |
ZAK | inactive (96.31%) |
TKL - RIPK
Bioactivity |
---|
Kinase | RBC |
---|
RIPK2 | inactive (81.1%) |
CAMK
CAMK - CAMKL
Bioactivity |
---|
Kinase | RBC |
---|
NuaK1 | inactive (86.34%) |
BRSK1 | inactive (91.55%) |
BRSK2 | inactive (96.45%) |
CHK1 | inactive (187.11%) |
LKB1 | inactive (85.71%) |
MARK1 | inactive (95.7%) |
MARK3 | inactive (101.57%) |
MARK4 | inactive (99.81%) |
MELK | inactive (92.88%) |
PASK | inactive (93.72%) |
QIK | inactive (101.74%) |
NuaK2 | inactive (96.3%) |
MARK2 | inactive (109.83%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | RBC |
---|
CaMK1a | inactive (94.38%) |
CaMK1b | inactive (102.31%) |
CaMK1d | inactive (98.25%) |
CaMK1g | inactive (97.91%) |
CaMK4 | inactive (104.07%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | RBC |
---|
CaMK2a | inactive (99.51%) |
CaMK2b | inactive (89.96%) |
CaMK2d | inactive (89.38%) |
CaMK2g | inactive (108.13%) |
CAMK - RAD53
Bioactivity |
---|
Kinase | RBC |
---|
CHK2 | inactive (94.45%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | RBC |
---|
DAPK1 | inactive (91.46%) |
DAPK2 | inactive (91.03%) |
DRAK1 | inactive (95.16%) |
DAPK3 | inactive (98.22%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | RBC |
---|
DCLK2 | inactive (94.59%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | RBC |
---|
MAPKAPK2 | inactive (105.26%) |
MAPKAPK3 | inactive (100.65%) |
MAPKAPK5 | inactive (82.65%) |
MNK1 | inactive (97.36%) |
MNK2 | inactive (89.09%) |
CAMK - MLCK
Bioactivity |
---|
Kinase | RBC |
---|
smMLCK | inactive (93.65%) |
skMLCK | inactive (90.53%) |
CAMK - PHK
Bioactivity |
---|
Kinase | RBC |
---|
PHKg1 | inactive (86.93%) |
PHKg2 | inactive (96.62%) |
CAMK - PIM
Bioactivity |
---|
Kinase | RBC |
---|
PIM1 | inactive (94.04%) |
PIM2 | inactive (104.73%) |
PIM3 | inactive (94.01%) |
CAMK - PKD
Bioactivity |
---|
Kinase | RBC |
---|
PKD1 | inactive (94.89%) |
PKD3 | inactive (87.27%) |
PKD2 | inactive (94.49%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | RBC |
---|
TSSK1 | inactive (95.37%) |
TSSK2 | inactive (110.35%) |
CAMK - STK33
Bioactivity |
---|
Kinase | RBC |
---|
STK33 | inactive (98.66%) |
STE
STE - STE11
Bioactivity |
---|
Kinase | RBC |
---|
MAP3K5 | inactive (103.24%) |
MAP3K2 | inactive (92.57%) |
MAP3K3 | inactive (103.41%) |
STE - STE-Unique
Bioactivity |
---|
Kinase | RBC |
---|
COT | inactive (81.27%) |
NIK | inactive (99.16%) |
STE - STE20
Bioactivity |
---|
Kinase | RBC |
---|
GCK | inactive (91.73%) |
HGK | inactive (76.15%) |
KHS1 | inactive (96.76%) |
LOK | inactive (94.63%) |
MINK | inactive (97.88%) |
MST1 | inactive (94.52%) |
MST2 | inactive (88.95%) |
MST3 | inactive (89.1%) |
MST4 | inactive (91.22%) |
OSR1 | inactive (92.7%) |
PAK1 | inactive (97.11%) |
PAK2 | inactive (103.57%) |
PAK3 | inactive (98.28%) |
PAK4 | inactive (104.39%) |
PAK5 | inactive (98.42%) |
PAK6 | inactive (96.28%) |
SLK | inactive (92.51%) |
YSK1 | inactive (99.93%) |
STLK3 | inactive (116.04%) |
TAO1 | inactive (100.62%) |
TAO2 | inactive (102.62%) |
TAO3 | inactive (97.1%) |
MYO3B | active (0%) |
STE - STE7
Bioactivity |
---|
Kinase | RBC |
---|
MAP2K1 | inactive (98.76%) |
MAP2K2 | inactive (104.29%) |
MAP2K6 | inactive (100.45%) |
Other
Other - Aur
Bioactivity |
---|
Kinase | RBC |
---|
AurA | inactive (110.68%) |
AurB | inactive (100.82%) |
AurC | inactive (90.83%) |
Other - CAMKK
Bioactivity |
---|
Kinase | RBC |
---|
CaMKK1 | inactive (112.17%) |
CaMKK2 | inactive (98.83%) |
Other - Haspin
Bioactivity |
---|
Kinase | RBC |
---|
Haspin | inactive (82.05%) |
Other - IKK
Bioactivity |
---|
Kinase | RBC |
---|
IKKa | inactive (85.89%) |
IKKb | inactive (102.38%) |
IKKe | inactive (99.38%) |
TBK1 | inactive (92%) |
Other - NEK
Bioactivity |
---|
Kinase | RBC |
---|
NEK1 | inactive (91.74%) |
NEK11 | inactive (110%) |
NEK2 | inactive (99.65%) |
NEK4 | inactive (97.77%) |
NEK6 | inactive (95.54%) |
NEK7 | inactive (93.06%) |
NEK9 | inactive (98.47%) |
NEK3 | inactive (94.89%) |
Other - TOPK
Bioactivity |
---|
Kinase | RBC |
---|
PBK | inactive (106.19%) |
Other - PLK
Bioactivity |
---|
Kinase | RBC |
---|
PLK1 | inactive (94.46%) |
PLK2 | inactive (101.17%) |
PLK3 | inactive (96.34%) |
Other - SgK496
Bioactivity |
---|
Kinase | RBC |
---|
SgK496 | inactive (96.04%) |
Other - NAK
Bioactivity |
---|
Kinase | RBC |
---|
MPSK1 | inactive (91.94%) |
Other - TTK
Bioactivity |
---|
Kinase | RBC |
---|
TTK | inactive (101.86%) |
Other - ULK
Bioactivity |
---|
Kinase | RBC |
---|
ULK1 | inactive (105.55%) |
ULK2 | inactive (95.88%) |
ULK3 | active (0%) |
Other - WEE
Bioactivity |
---|
Kinase | RBC |
---|
Wee1 | inactive (101.36%) |
Other - WNK
Bioactivity |
---|
Kinase | RBC |
---|
Wnk2 | inactive (95.85%) |
Wnk3 | inactive (98.03%) |
Other - TLK
Bioactivity |
---|
Kinase | RBC |
---|
TLK2 | active (0%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | RBC |
---|
CK1 | 7 | 6 |
VRK | 3 | 1 |
CK1 - CK1
Bioactivity |
---|
Kinase | RBC |
---|
CK1d | inactive (94.21%) |
CK1g1 | inactive (99.03%) |
CK1g2 | inactive (93.78%) |
CK1g3 | inactive (95.57%) |
CK1a | inactive (100.73%) |
CK1e | inactive (90.17%) |
CK1 - VRK
Bioactivity |
---|
Kinase | RBC |
---|
VRK1 | inactive (102.55%) |
CMGC
CMGC - CK2
Bioactivity |
---|
Kinase | RBC |
---|
CK2a1 | inactive (87.58%) |
CK2a2 | inactive (93.96%) |
CMGC - CLK
Bioactivity |
---|
Kinase | RBC |
---|
CLK1 | inactive (99.2%) |
CLK2 | inactive (96.08%) |
CLK3 | inactive (94.33%) |
CLK4 | inactive (86.87%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | RBC |
---|
DYRK1A | inactive (95.07%) |
DYRK1B | inactive (96.03%) |
DYRK2 | inactive (91.57%) |
DYRK3 | inactive (101.72%) |
DYRK4 | inactive (89.2%) |
HIPK1 | inactive (104.57%) |
HIPK2 | inactive (95.86%) |
HIPK3 | inactive (97.44%) |
HIPK4 | inactive (95.77%) |
CMGC - MAPK
Bioactivity |
---|
Kinase | RBC |
---|
Erk1 | inactive (113.34%) |
Erk2 | inactive (100.21%) |
JNK3 | inactive (92.12%) |
NLK | inactive (95.23%) |
p38a | inactive (96.62%) |
p38b | inactive (93.77%) |
p38d | inactive (101.36%) |
p38g | inactive (100.46%) |
JNK1 | inactive (89.61%) |
JNK2 | inactive (102.99%) |
CMGC - GSK
Bioactivity |
---|
Kinase | RBC |
---|
GSK3A | inactive (91.61%) |
GSK3B | inactive (99.72%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | RBC |
---|
MSSK1 | inactive (95.61%) |
SRPK1 | inactive (101.29%) |
SRPK2 | inactive (95.9%) |
Atypical
Atypical
Test Member No. in Family |
---|
Family | no. Member on 518kinase | RBC |
---|
PDHK | 5 | 1 |
Atypical - PDHK
Bioactivity |
---|
Kinase | RBC |
---|
PDHK1 | inactive (96.84%) |