Compound Information
Test on : GPCR
Compound Name : SB-431542-A
Inchikey : DUZCSXXJVYCEKF-UHFFFAOYSA-N
ChemSpider : 28484797
Pubchem CID : 57403318
ChEMBL : CHEMBL1909378
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
TK
TK - JakA
Bioactivity |
---|
Kinase | GPCR |
---|
JAK1 | inactive (8.87%) |
TYK2 | inactive (-0.31%) |
JAK2 | inactive (1.92%) |
JAK3 | inactive (0.2%) |
TK - Fer
Bioactivity |
---|
Kinase | GPCR |
---|
FER | inactive (6.64%) |
FES | inactive (2.16%) |
TK - Abl
Bioactivity |
---|
Kinase | GPCR |
---|
ABL1 | inactive (6.95%) |
ABL2 | inactive (6.03%) |
TK - Csk
Bioactivity |
---|
Kinase | GPCR |
---|
CSK | inactive (6.81%) |
TK - Tec
Bioactivity |
---|
Kinase | GPCR |
---|
BMX | inactive (2.22%) |
BTK | inactive (0.83%) |
TXK | inactive (3.28%) |
TEC | inactive (2.63%) |
ITK | inactive (1.43%) |
TK - Src
Bioactivity |
---|
Kinase | GPCR |
---|
BRK | inactive (1.4%) |
SRM | inactive (1.98%) |
FRK | inactive (-0.16%) |
BLK | inactive (3.67%) |
LCK | inactive (4.07%) |
HCK | inactive (4.66%) |
FGR | inactive (5.27%) |
FYN | inactive (8.01%) |
SRC | inactive (4.86%) |
YES | inactive (7.17%) |
TK - Eph
Bioactivity |
---|
Kinase | GPCR |
---|
EphA2 | inactive (-0.13%) |
EphA4 | inactive (7.96%) |
EphA3 | inactive (1.89%) |
EphB4 | inactive (1.95%) |
EphB3 | inactive (1.89%) |
EphB2 | inactive (6.48%) |
TK - FAK
Bioactivity |
---|
Kinase | GPCR |
---|
PYK2 | inactive (6.61%) |
TK - Syk
Bioactivity |
---|
Kinase | GPCR |
---|
SYK | inactive (0.21%) |
ZAP70 | inactive (-2.34%) |
TK - ALK
Bioactivity |
---|
Kinase | GPCR |
---|
LTK | inactive (3.18%) |
ALK | inactive (2.39%) |
TK - Sev
Bioactivity |
---|
Kinase | GPCR |
---|
ROS | inactive (2.89%) |
TK - InsR
Bioactivity |
---|
Kinase | GPCR |
---|
INSR | inactive (5.06%) |
IGF1R | inactive (2.2%) |
IRR | inactive (-0.59%) |
TK - DDR
Bioactivity |
---|
Kinase | GPCR |
---|
DDR2 | inactive (4.42%) |
TK - Musk
Bioactivity |
---|
Kinase | GPCR |
---|
MUSK | inactive (3.59%) |
TK - Trk
Bioactivity |
---|
Kinase | GPCR |
---|
TRKA | inactive (3.43%) |
TRKB | inactive (0.41%) |
TRKC | inactive (1.77%) |
TK - Met
Bioactivity |
---|
Kinase | GPCR |
---|
RON | inactive (-1.49%) |
MET | inactive (9.28%) |
TK - Axl
Bioactivity |
---|
Kinase | GPCR |
---|
AXL | inactive (-1.2%) |
MER | inactive (3.36%) |
TYRO3 | inactive (1.12%) |
TK - Ret
Bioactivity |
---|
Kinase | GPCR |
---|
RET | inactive (8.97%) |
TK - FGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FGFR1 | inactive (2.26%) |
FGFR2 | inactive (1.31%) |
FGFR3 | inactive (1.9%) |
FGFR4 | inactive (-0.14%) |
TK - VEGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FLT1 | inactive (-1%) |
KDR | inactive (3.09%) |
FLT4 | inactive (-0.31%) |
TK - PDGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FMS | inactive (2.49%) |
KIT | inactive (4.68%) |
FLT3 | inactive (2.37%) |
PDGFRa | inactive (9.06%) |
PDGFRb | inactive (7.47%) |
TK - Tie
Bioactivity |
---|
Kinase | GPCR |
---|
TIE2 | inactive (5.38%) |
TK - Ack
Bioactivity |
---|
Kinase | GPCR |
---|
ACK | inactive (1.03%) |
TNK1 | inactive (-0.98%) |
TK - EGFR
Bioactivity |
---|
Kinase | GPCR |
---|
EGFR | inactive (4.7%) |
ErbB2 | inactive (0.42%) |
ErbB4 | inactive (11.42%) |
TKL
TKL
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
IRAK | 4 | 1 |
RAF | 5 | 1 |
TKL - IRAK
Bioactivity |
---|
Kinase | GPCR |
---|
IRAK4 | inactive (1.06%) |
TKL - RAF
Bioactivity |
---|
Kinase | GPCR |
---|
BRAF | inactive (4.12%) |
STE
STE
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
STE20 | 31 | 12 |
STE7 | 7 | 1 |
STE - STE20
Bioactivity |
---|
Kinase | GPCR |
---|
GCK | inactive (2.35%) |
MST1 | inactive (3.51%) |
MST2 | inactive (3.42%) |
MST4 | inactive (2.93%) |
HGK | inactive (5.75%) |
MINK | inactive (7.53%) |
LOK | inactive (3.54%) |
PAK1 | inactive (5.77%) |
PAK3 | inactive (2.97%) |
PAK2 | inactive (1.08%) |
PAK5 | inactive (-0.72%) |
PAK6 | inactive (-5.81%) |
STE - STE7
Bioactivity |
---|
Kinase | GPCR |
---|
MAP2K1 | inactive (3.52%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
CK1 | 7 | 4 |
CK1 - CK1
Bioactivity |
---|
Kinase | GPCR |
---|
CK1a | inactive (48.5%) |
CK1g2 | inactive (3.29%) |
CK1g1 | inactive (4.22%) |
CK1g3 | inactive (5.91%) |
Other
Other
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
PLK | 4 | 1 |
Aur | 3 | 3 |
NEK | 11 | 5 |
IKK | 4 | 4 |
TTK | 1 | 1 |
Other - PLK
Bioactivity |
---|
Kinase | GPCR |
---|
PLK1 | inactive (2.1%) |
Other - Aur
Bioactivity |
---|
Kinase | GPCR |
---|
AurB | inactive (4.45%) |
AurC | inactive (-2.72%) |
AurA | inactive (3.93%) |
Other - NEK
Bioactivity |
---|
Kinase | GPCR |
---|
NEK1 | inactive (3.26%) |
NEK2 | inactive (2.69%) |
NEK9 | inactive (6.43%) |
NEK7 | inactive (1.68%) |
NEK6 | inactive (4.68%) |
Other - IKK
Bioactivity |
---|
Kinase | GPCR |
---|
TBK1 | inactive (2.25%) |
IKKe | inactive (4.06%) |
IKKb | inactive (3.61%) |
IKKa | inactive (3.9%) |
Other - TTK
Bioactivity |
---|
Kinase | GPCR |
---|
TTK | inactive (3.14%) |
AGC
AGC - GRK
Bioactivity |
---|
Kinase | GPCR |
---|
GPRK7 | inactive (6.3%) |
GPRK6 | inactive (5.54%) |
AGC - PDK1
Bioactivity |
---|
Kinase | GPCR |
---|
PDK1 | inactive (3.36%) |
AGC - RSK
Bioactivity |
---|
Kinase | GPCR |
---|
MSK1 | inactive (1.56%) |
MSK2 | inactive (4.23%) |
RSK1 | inactive (2.33%) |
RSK2 | inactive (2.09%) |
RSK4 | inactive (1.4%) |
RSK3 | inactive (1.65%) |
p70S6K | inactive (2.46%) |
AGC - Akt
Bioactivity |
---|
Kinase | GPCR |
---|
AKT2 | inactive (1.16%) |
AKT1 | inactive (0.86%) |
AKT3 | inactive (0.48%) |
AGC - SGK
Bioactivity |
---|
Kinase | GPCR |
---|
SGK1 | inactive (3.63%) |
SGK3 | inactive (4.38%) |
SGK2 | inactive (8.98%) |
AGC - PKC
Bioactivity |
---|
Kinase | GPCR |
---|
PKCh | inactive (-0.29%) |
PKCg | inactive (3.47%) |
PKCa | inactive (3.42%) |
PKCt | inactive (1.31%) |
PKCi | inactive (-0.05%) |
AGC - PKG
Bioactivity |
---|
Kinase | GPCR |
---|
PKG2 | inactive (3.18%) |
PKG1 | inactive (3.55%) |
AGC - PKA
Bioactivity |
---|
Kinase | GPCR |
---|
PRKX | inactive (2.01%) |
AGC - DMPK
Bioactivity |
---|
Kinase | GPCR |
---|
ROCK1 | inactive (0.39%) |
ROCK2 | inactive (3.61%) |
MRCKb | inactive (0.59%) |
MRCKa | inactive (2.49%) |
CAMK
CAMK - RAD53
Bioactivity |
---|
Kinase | GPCR |
---|
CHK2 | inactive (1.89%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
DCLK2 | inactive (-8.11%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK4 | inactive (0.4%) |
CaMK1d | inactive (0.23%) |
CAMK - PHK
Bioactivity |
---|
Kinase | GPCR |
---|
PHKg1 | inactive (4.79%) |
PHKg2 | inactive (3.73%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK2d | inactive (1.87%) |
CaMK2a | inactive (3.33%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | GPCR |
---|
MAPKAPK5 | inactive (1.22%) |
MAPKAPK2 | inactive (0.74%) |
MAPKAPK3 | inactive (5.05%) |
MNK2 | inactive (3.13%) |
MNK1 | inactive (5.1%) |
CAMK - PKD
Bioactivity |
---|
Kinase | GPCR |
---|
PKD3 | inactive (5.59%) |
PKD1 | inactive (5.43%) |
PKD2 | inactive (6.06%) |
CAMK - CAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
MARK4 | inactive (0.93%) |
MARK3 | inactive (10.99%) |
MARK1 | inactive (3.27%) |
QIK | inactive (11.58%) |
SIK | inactive (5.25%) |
NuaK1 | inactive (1.15%) |
BRSK1 | inactive (-0.03%) |
BRSK2 | inactive (1.06%) |
MELK | inactive (2.1%) |
CHK1 | inactive (2.65%) |
PASK | inactive (1.31%) |
AMPKa1 | inactive (2.55%) |
AMPKa2 | inactive (2.23%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | GPCR |
---|
TSSK2 | inactive (0.84%) |
TSSK1 | inactive (0.88%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | GPCR |
---|
DAPK1 | inactive (2.62%) |
CAMK - PIM
Bioactivity |
---|
Kinase | GPCR |
---|
PIM2 | inactive (0.78%) |
PIM3 | inactive (0.3%) |
PIM1 | inactive (0.92%) |
CMGC
CMGC - MAPK
Bioactivity |
---|
Kinase | GPCR |
---|
JNK2 | inactive (5.34%) |
p38a | inactive (15.52%) |
p38b | inactive (10.58%) |
p38d | inactive (2.44%) |
Erk2 | inactive (1.22%) |
Erk1 | inactive (1.38%) |
CMGC - GSK
Bioactivity |
---|
Kinase | GPCR |
---|
GSK3A | inactive (3.92%) |
GSK3B | inactive (6.9%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | GPCR |
---|
SRPK1 | inactive (-2.03%) |
MSSK1 | inactive (0.34%) |
CMGC - CLK
Bioactivity |
---|
Kinase | GPCR |
---|
CLK3 | inactive (1.76%) |
CLK2 | inactive (1.07%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | GPCR |
---|
HIPK1 | inactive (2.8%) |
HIPK4 | inactive (1.67%) |
DYRK1B | inactive (0.83%) |
DYRK1A | inactive (3.08%) |
DYRK2 | inactive (1.31%) |
CMGC - CK2
Bioactivity |
---|
Kinase | GPCR |
---|
CK2a1 | inactive (4.61%) |