Compound Information
Test on : GPCR
Compound Name : GW780056X
Inchikey : DQKZVZRKPRQVEU-UHFFFAOYSA-N
ChemSpider : 8391268
Pubchem CID : 10215776
ChEMBL : CHEMBL1882194
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
TK
TK - JakA
Bioactivity |
---|
Kinase | GPCR |
---|
JAK1 | inactive (4.83%) |
TYK2 | inactive (11.6%) |
JAK2 | inactive (20.85%) |
JAK3 | inactive (14.2%) |
TK - Fer
Bioactivity |
---|
Kinase | GPCR |
---|
FER | inactive (15.49%) |
FES | inactive (28.01%) |
TK - Abl
Bioactivity |
---|
Kinase | GPCR |
---|
ABL1 | inactive (29.54%) |
ABL2 | inactive (22.19%) |
TK - Csk
Bioactivity |
---|
Kinase | GPCR |
---|
CSK | inactive (8.18%) |
TK - Tec
Bioactivity |
---|
Kinase | GPCR |
---|
BMX | inactive (10.78%) |
BTK | inactive (-0.83%) |
TXK | inactive (1.91%) |
TEC | inactive (3.21%) |
ITK | inactive (-0.21%) |
TK - Src
Bioactivity |
---|
Kinase | GPCR |
---|
BRK | inactive (15.72%) |
SRM | inactive (0.74%) |
FRK | inactive (3.76%) |
BLK | inactive (1.7%) |
LCK | inactive (15.33%) |
HCK | inactive (13.49%) |
FGR | inactive (11.35%) |
FYN | inactive (5.04%) |
SRC | inactive (38.22%) |
YES | inactive (22.47%) |
TK - Eph
Bioactivity |
---|
Kinase | GPCR |
---|
EphA2 | inactive (-5.2%) |
EphA4 | inactive (15.21%) |
EphA3 | inactive (0.69%) |
EphB4 | inactive (8.4%) |
EphB3 | inactive (0.55%) |
EphB2 | inactive (27.23%) |
TK - FAK
Bioactivity |
---|
Kinase | GPCR |
---|
PYK2 | active (81.34%) |
TK - Syk
Bioactivity |
---|
Kinase | GPCR |
---|
SYK | inactive (-0.45%) |
ZAP70 | inactive (-4.19%) |
TK - ALK
Bioactivity |
---|
Kinase | GPCR |
---|
LTK | inactive (9.98%) |
ALK | inactive (24.4%) |
TK - Sev
Bioactivity |
---|
Kinase | GPCR |
---|
ROS | active (70.49%) |
TK - InsR
Bioactivity |
---|
Kinase | GPCR |
---|
INSR | active (73.22%) |
IGF1R | active (54.57%) |
IRR | inactive (7.36%) |
TK - DDR
Bioactivity |
---|
Kinase | GPCR |
---|
DDR2 | inactive (4.24%) |
TK - Musk
Bioactivity |
---|
Kinase | GPCR |
---|
MUSK | inactive (30.52%) |
TK - Trk
Bioactivity |
---|
Kinase | GPCR |
---|
TRKA | inactive (12.07%) |
TRKB | inactive (7.47%) |
TRKC | inactive (5.86%) |
TK - Met
Bioactivity |
---|
Kinase | GPCR |
---|
RON | inactive (22.4%) |
MET | inactive (10.42%) |
TK - Axl
Bioactivity |
---|
Kinase | GPCR |
---|
AXL | inactive (16.34%) |
MER | inactive (9.85%) |
TYRO3 | inactive (18.21%) |
TK - Ret
Bioactivity |
---|
Kinase | GPCR |
---|
RET | inactive (12.78%) |
TK - FGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FGFR1 | inactive (11.55%) |
FGFR2 | inactive (8.8%) |
FGFR3 | inactive (5.35%) |
FGFR4 | inactive (-3.39%) |
TK - VEGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FLT1 | inactive (16.2%) |
KDR | inactive (39.09%) |
FLT4 | inactive (0.13%) |
TK - PDGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FMS | active (68.87%) |
KIT | active (93.11%) |
FLT3 | inactive (47.68%) |
PDGFRa | active (55.53%) |
PDGFRb | active (71.78%) |
TK - Tie
Bioactivity |
---|
Kinase | GPCR |
---|
TIE2 | inactive (12.18%) |
TK - Ack
Bioactivity |
---|
Kinase | GPCR |
---|
ACK | inactive (3.2%) |
TNK1 | inactive (32.04%) |
TK - EGFR
Bioactivity |
---|
Kinase | GPCR |
---|
EGFR | inactive (-1.76%) |
ErbB2 | inactive (3.96%) |
ErbB4 | inactive (5.17%) |
TKL
TKL
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
IRAK | 4 | 1 |
RAF | 5 | 1 |
TKL - IRAK
Bioactivity |
---|
Kinase | GPCR |
---|
IRAK4 | inactive (3.85%) |
TKL - RAF
Bioactivity |
---|
Kinase | GPCR |
---|
BRAF | inactive (17.71%) |
STE
STE
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
STE20 | 31 | 12 |
STE7 | 7 | 1 |
STE - STE20
Bioactivity |
---|
Kinase | GPCR |
---|
GCK | inactive (21.17%) |
MST1 | inactive (15.95%) |
MST2 | inactive (9.79%) |
MST4 | inactive (0.74%) |
HGK | inactive (20.35%) |
MINK | inactive (17.02%) |
LOK | inactive (18.02%) |
PAK1 | inactive (9.08%) |
PAK3 | inactive (6%) |
PAK2 | inactive (3.41%) |
PAK5 | inactive (5.43%) |
PAK6 | inactive (-2.98%) |
STE - STE7
Bioactivity |
---|
Kinase | GPCR |
---|
MAP2K1 | inactive (13.13%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
CK1 | 7 | 4 |
CK1 - CK1
Bioactivity |
---|
Kinase | GPCR |
---|
CK1a | active (54.28%) |
CK1g2 | inactive (13.74%) |
CK1g1 | inactive (6.01%) |
CK1g3 | inactive (10.55%) |
Other
Other
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
PLK | 4 | 1 |
Aur | 3 | 3 |
NEK | 11 | 5 |
IKK | 4 | 4 |
TTK | 1 | 1 |
Other - PLK
Bioactivity |
---|
Kinase | GPCR |
---|
PLK1 | inactive (8.15%) |
Other - Aur
Bioactivity |
---|
Kinase | GPCR |
---|
AurB | active (63.66%) |
AurC | active (84.58%) |
AurA | inactive (34.31%) |
Other - NEK
Bioactivity |
---|
Kinase | GPCR |
---|
NEK1 | inactive (4.48%) |
NEK2 | inactive (3.41%) |
NEK9 | inactive (13.69%) |
NEK7 | inactive (9.4%) |
NEK6 | inactive (-0.16%) |
Other - IKK
Bioactivity |
---|
Kinase | GPCR |
---|
TBK1 | inactive (12.29%) |
IKKe | inactive (17.81%) |
IKKb | inactive (17.5%) |
IKKa | inactive (34.86%) |
Other - TTK
Bioactivity |
---|
Kinase | GPCR |
---|
TTK | inactive (29.36%) |
AGC
AGC - GRK
Bioactivity |
---|
Kinase | GPCR |
---|
GPRK7 | inactive (3.71%) |
GPRK6 | inactive (1.08%) |
AGC - PDK1
Bioactivity |
---|
Kinase | GPCR |
---|
PDK1 | inactive (2.98%) |
AGC - RSK
Bioactivity |
---|
Kinase | GPCR |
---|
MSK1 | inactive (2.51%) |
MSK2 | inactive (7.32%) |
RSK1 | inactive (2.52%) |
RSK2 | inactive (2.49%) |
RSK4 | inactive (9.62%) |
RSK3 | inactive (3.81%) |
p70S6K | inactive (7.85%) |
AGC - Akt
Bioactivity |
---|
Kinase | GPCR |
---|
AKT2 | inactive (-2.22%) |
AKT1 | inactive (-1.93%) |
AKT3 | inactive (-1.26%) |
AGC - SGK
Bioactivity |
---|
Kinase | GPCR |
---|
SGK1 | inactive (7.61%) |
SGK3 | inactive (2.8%) |
SGK2 | inactive (4.57%) |
AGC - PKC
Bioactivity |
---|
Kinase | GPCR |
---|
PKCh | inactive (7.25%) |
PKCg | inactive (7.9%) |
PKCa | inactive (17.76%) |
PKCt | inactive (4.84%) |
PKCi | inactive (2.03%) |
AGC - PKG
Bioactivity |
---|
Kinase | GPCR |
---|
PKG2 | inactive (13.71%) |
PKG1 | inactive (14.91%) |
AGC - PKA
Bioactivity |
---|
Kinase | GPCR |
---|
PRKX | inactive (4.27%) |
AGC - DMPK
Bioactivity |
---|
Kinase | GPCR |
---|
ROCK1 | inactive (9.36%) |
ROCK2 | inactive (13.71%) |
MRCKb | inactive (4.53%) |
MRCKa | inactive (4.32%) |
CAMK
CAMK - RAD53
Bioactivity |
---|
Kinase | GPCR |
---|
CHK2 | inactive (7.56%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
DCLK2 | inactive (1.64%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK4 | inactive (0.34%) |
CaMK1d | inactive (4.23%) |
CAMK - PHK
Bioactivity |
---|
Kinase | GPCR |
---|
PHKg1 | inactive (28.18%) |
PHKg2 | inactive (15.29%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK2d | inactive (14.34%) |
CaMK2a | inactive (4.21%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | GPCR |
---|
MAPKAPK5 | inactive (2.13%) |
MAPKAPK2 | inactive (2.01%) |
MAPKAPK3 | inactive (3.32%) |
MNK2 | inactive (8.84%) |
MNK1 | inactive (9.82%) |
CAMK - PKD
Bioactivity |
---|
Kinase | GPCR |
---|
PKD3 | active (62.61%) |
PKD1 | active (65.58%) |
PKD2 | active (64.4%) |
CAMK - CAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
MARK4 | inactive (18.94%) |
MARK3 | inactive (24.71%) |
MARK1 | inactive (20.88%) |
QIK | inactive (47.16%) |
SIK | inactive (24.05%) |
NuaK1 | active (84.33%) |
BRSK1 | inactive (3.16%) |
BRSK2 | inactive (10.61%) |
MELK | active (55.42%) |
CHK1 | inactive (11.62%) |
PASK | inactive (-0.46%) |
AMPKa1 | inactive (9.99%) |
AMPKa2 | inactive (12.74%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | GPCR |
---|
TSSK2 | inactive (2.16%) |
TSSK1 | inactive (26.46%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | GPCR |
---|
DAPK1 | inactive (1.28%) |
CAMK - PIM
Bioactivity |
---|
Kinase | GPCR |
---|
PIM2 | inactive (-0.59%) |
PIM3 | inactive (37.22%) |
PIM1 | inactive (23.02%) |
CMGC
CMGC - MAPK
Bioactivity |
---|
Kinase | GPCR |
---|
JNK2 | inactive (30.94%) |
p38a | inactive (13.08%) |
p38b | inactive (4.99%) |
p38d | inactive (9.25%) |
Erk2 | inactive (15.76%) |
Erk1 | inactive (7.61%) |
CMGC - GSK
Bioactivity |
---|
Kinase | GPCR |
---|
GSK3A | active (65.75%) |
GSK3B | active (62.32%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | GPCR |
---|
SRPK1 | inactive (-1.36%) |
MSSK1 | inactive (-0.22%) |
CMGC - CLK
Bioactivity |
---|
Kinase | GPCR |
---|
CLK3 | inactive (5.2%) |
CLK2 | active (91.72%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | GPCR |
---|
HIPK1 | active (71.86%) |
HIPK4 | active (59.04%) |
DYRK1B | active (69.19%) |
DYRK1A | active (87.98%) |
DYRK2 | inactive (25.66%) |
CMGC - CK2
Bioactivity |
---|
Kinase | GPCR |
---|
CK2a1 | inactive (31.11%) |