Compound Information
Test on : GPCR
Compound Name : CHEMBL263796
Inchikey : DMGXXSZZNPKCTM-AATRIKPKSA-N
ChemSpider : 23278137
Pubchem CID : 44418547
ChEMBL : CHEMBL263796
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
TK
TK - JakA
Bioactivity |
---|
Kinase | GPCR |
---|
JAK1 | inactive (2.48%) |
TYK2 | inactive (-3.44%) |
JAK2 | inactive (2.6%) |
JAK3 | inactive (-3.71%) |
TK - Fer
Bioactivity |
---|
Kinase | GPCR |
---|
FER | inactive (5.39%) |
FES | inactive (4.62%) |
TK - Abl
Bioactivity |
---|
Kinase | GPCR |
---|
ABL1 | inactive (40.45%) |
ABL2 | inactive (35.68%) |
TK - Csk
Bioactivity |
---|
Kinase | GPCR |
---|
CSK | inactive (10.57%) |
TK - Tec
Bioactivity |
---|
Kinase | GPCR |
---|
BMX | inactive (22.8%) |
BTK | inactive (0.37%) |
TXK | inactive (22.66%) |
TEC | inactive (23.41%) |
ITK | inactive (-1.73%) |
TK - Src
Bioactivity |
---|
Kinase | GPCR |
---|
BRK | active (56.05%) |
SRM | inactive (8.71%) |
FRK | inactive (11.04%) |
BLK | inactive (5.69%) |
LCK | inactive (9.89%) |
HCK | inactive (44.86%) |
FGR | inactive (21.31%) |
FYN | inactive (15.07%) |
SRC | inactive (47.22%) |
YES | inactive (17.18%) |
TK - Eph
Bioactivity |
---|
Kinase | GPCR |
---|
EphA2 | inactive (17.3%) |
EphA4 | inactive (43.56%) |
EphA3 | inactive (5.3%) |
EphB4 | active (74.1%) |
EphB3 | inactive (2.92%) |
EphB2 | inactive (29.25%) |
TK - FAK
Bioactivity |
---|
Kinase | GPCR |
---|
PYK2 | inactive (7.83%) |
TK - Syk
Bioactivity |
---|
Kinase | GPCR |
---|
SYK | inactive (1%) |
ZAP70 | inactive (1.58%) |
TK - ALK
Bioactivity |
---|
Kinase | GPCR |
---|
LTK | inactive (5.04%) |
ALK | inactive (9.12%) |
TK - Sev
Bioactivity |
---|
Kinase | GPCR |
---|
ROS | inactive (11.75%) |
TK - InsR
Bioactivity |
---|
Kinase | GPCR |
---|
INSR | inactive (2.79%) |
IGF1R | inactive (-3%) |
IRR | inactive (2.34%) |
TK - DDR
Bioactivity |
---|
Kinase | GPCR |
---|
DDR2 | inactive (21.2%) |
TK - Musk
Bioactivity |
---|
Kinase | GPCR |
---|
MUSK | inactive (6.78%) |
TK - Trk
Bioactivity |
---|
Kinase | GPCR |
---|
TRKA | inactive (6.89%) |
TRKB | inactive (4.39%) |
TRKC | inactive (2.7%) |
TK - Met
Bioactivity |
---|
Kinase | GPCR |
---|
RON | inactive (-0.69%) |
MET | inactive (1.88%) |
TK - Axl
Bioactivity |
---|
Kinase | GPCR |
---|
AXL | inactive (-1.76%) |
MER | inactive (2.24%) |
TYRO3 | inactive (4.06%) |
TK - Ret
Bioactivity |
---|
Kinase | GPCR |
---|
RET | inactive (12.27%) |
TK - FGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FGFR1 | inactive (-1.56%) |
FGFR2 | inactive (7.15%) |
FGFR3 | inactive (1.39%) |
FGFR4 | inactive (1.17%) |
TK - VEGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FLT1 | inactive (4.61%) |
KDR | inactive (13.07%) |
FLT4 | inactive (-10.87%) |
TK - PDGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FMS | inactive (41.1%) |
KIT | inactive (33.41%) |
FLT3 | inactive (2.17%) |
PDGFRa | inactive (21.13%) |
PDGFRb | inactive (17.8%) |
TK - Tie
Bioactivity |
---|
Kinase | GPCR |
---|
TIE2 | inactive (3.57%) |
TK - Ack
Bioactivity |
---|
Kinase | GPCR |
---|
ACK | inactive (10.97%) |
TNK1 | inactive (38.75%) |
TK - EGFR
Bioactivity |
---|
Kinase | GPCR |
---|
EGFR | inactive (0.79%) |
ErbB2 | inactive (3.13%) |
ErbB4 | inactive (8.83%) |
TKL
TKL
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
IRAK | 4 | 1 |
RAF | 5 | 1 |
TKL - IRAK
Bioactivity |
---|
Kinase | GPCR |
---|
IRAK4 | inactive (2.37%) |
TKL - RAF
Bioactivity |
---|
Kinase | GPCR |
---|
BRAF | inactive (10.49%) |
STE
STE
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
STE20 | 31 | 12 |
STE7 | 7 | 1 |
STE - STE20
Bioactivity |
---|
Kinase | GPCR |
---|
GCK | inactive (2.47%) |
MST1 | inactive (7.53%) |
MST2 | inactive (8.47%) |
MST4 | inactive (-0.15%) |
HGK | inactive (23.01%) |
MINK | inactive (19.33%) |
LOK | inactive (10.6%) |
PAK1 | inactive (10.97%) |
PAK3 | inactive (5.48%) |
PAK2 | inactive (0.88%) |
PAK5 | inactive (6.55%) |
PAK6 | inactive (-7.96%) |
STE - STE7
Bioactivity |
---|
Kinase | GPCR |
---|
MAP2K1 | inactive (1.76%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
CK1 | 7 | 4 |
CK1 - CK1
Bioactivity |
---|
Kinase | GPCR |
---|
CK1a | inactive (6.99%) |
CK1g2 | inactive (7.62%) |
CK1g1 | inactive (6.18%) |
CK1g3 | inactive (4.59%) |
Other
Other
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
PLK | 4 | 1 |
Aur | 3 | 3 |
NEK | 11 | 5 |
IKK | 4 | 4 |
TTK | 1 | 1 |
Other - PLK
Bioactivity |
---|
Kinase | GPCR |
---|
PLK1 | inactive (7.28%) |
Other - Aur
Bioactivity |
---|
Kinase | GPCR |
---|
AurB | inactive (2.43%) |
AurC | inactive (0.68%) |
AurA | inactive (0.47%) |
Other - NEK
Bioactivity |
---|
Kinase | GPCR |
---|
NEK1 | inactive (1.83%) |
NEK2 | inactive (3.38%) |
NEK9 | inactive (5.75%) |
NEK7 | inactive (9.84%) |
NEK6 | inactive (4.76%) |
Other - IKK
Bioactivity |
---|
Kinase | GPCR |
---|
TBK1 | inactive (4.76%) |
IKKe | inactive (6.17%) |
IKKb | inactive (11.42%) |
IKKa | inactive (0.72%) |
Other - TTK
Bioactivity |
---|
Kinase | GPCR |
---|
TTK | inactive (18.34%) |
AGC
AGC - GRK
Bioactivity |
---|
Kinase | GPCR |
---|
GPRK7 | inactive (8.22%) |
GPRK6 | inactive (4.35%) |
AGC - PDK1
Bioactivity |
---|
Kinase | GPCR |
---|
PDK1 | inactive (2.59%) |
AGC - RSK
Bioactivity |
---|
Kinase | GPCR |
---|
MSK1 | inactive (1.1%) |
MSK2 | inactive (3.75%) |
RSK1 | inactive (4.53%) |
RSK2 | inactive (1.94%) |
RSK4 | inactive (1.63%) |
RSK3 | inactive (2.54%) |
p70S6K | inactive (2.12%) |
AGC - Akt
Bioactivity |
---|
Kinase | GPCR |
---|
AKT2 | inactive (-2.77%) |
AKT1 | inactive (-2.11%) |
AKT3 | inactive (0.11%) |
AGC - SGK
Bioactivity |
---|
Kinase | GPCR |
---|
SGK1 | inactive (-0.45%) |
SGK3 | inactive (2.18%) |
SGK2 | inactive (0.48%) |
AGC - PKC
Bioactivity |
---|
Kinase | GPCR |
---|
PKCh | inactive (5.49%) |
PKCg | inactive (1.44%) |
PKCa | inactive (-2.28%) |
PKCt | inactive (1.94%) |
PKCi | inactive (0.96%) |
AGC - PKG
Bioactivity |
---|
Kinase | GPCR |
---|
PKG2 | inactive (4.56%) |
PKG1 | inactive (5.23%) |
AGC - PKA
Bioactivity |
---|
Kinase | GPCR |
---|
PRKX | inactive (1.79%) |
AGC - DMPK
Bioactivity |
---|
Kinase | GPCR |
---|
ROCK1 | inactive (1.88%) |
ROCK2 | inactive (1.93%) |
MRCKb | inactive (0.52%) |
MRCKa | inactive (1.78%) |
CAMK
CAMK - RAD53
Bioactivity |
---|
Kinase | GPCR |
---|
CHK2 | inactive (9.62%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
DCLK2 | inactive (-0.73%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK4 | inactive (3.19%) |
CaMK1d | inactive (2.1%) |
CAMK - PHK
Bioactivity |
---|
Kinase | GPCR |
---|
PHKg1 | inactive (8.72%) |
PHKg2 | inactive (4.55%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK2d | inactive (8.55%) |
CaMK2a | inactive (4.95%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | GPCR |
---|
MAPKAPK5 | inactive (1.46%) |
MAPKAPK2 | inactive (2.98%) |
MAPKAPK3 | inactive (1.96%) |
MNK2 | inactive (16.29%) |
MNK1 | inactive (6.73%) |
CAMK - PKD
Bioactivity |
---|
Kinase | GPCR |
---|
PKD3 | inactive (4.45%) |
PKD1 | inactive (5%) |
PKD2 | inactive (3.77%) |
CAMK - CAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
MARK4 | inactive (3.08%) |
MARK3 | inactive (3.1%) |
MARK1 | inactive (2.47%) |
QIK | inactive (17.32%) |
SIK | active (50.9%) |
NuaK1 | inactive (7.27%) |
BRSK1 | inactive (7.3%) |
BRSK2 | inactive (9.33%) |
MELK | inactive (14.67%) |
CHK1 | inactive (4.57%) |
PASK | inactive (-0.36%) |
AMPKa1 | inactive (3.59%) |
AMPKa2 | inactive (1.77%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | GPCR |
---|
TSSK2 | inactive (3.45%) |
TSSK1 | inactive (4.44%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | GPCR |
---|
DAPK1 | inactive (0.5%) |
CAMK - PIM
Bioactivity |
---|
Kinase | GPCR |
---|
PIM2 | inactive (-0.92%) |
PIM3 | inactive (7.42%) |
PIM1 | inactive (1.79%) |
CMGC
CMGC - MAPK
Bioactivity |
---|
Kinase | GPCR |
---|
JNK2 | inactive (10.09%) |
p38a | inactive (8.04%) |
p38b | inactive (4.25%) |
p38d | inactive (5.05%) |
Erk2 | inactive (4.6%) |
Erk1 | inactive (3.8%) |
CMGC - GSK
Bioactivity |
---|
Kinase | GPCR |
---|
GSK3A | inactive (3.81%) |
GSK3B | inactive (1.92%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | GPCR |
---|
SRPK1 | inactive (-0.45%) |
MSSK1 | inactive (0.6%) |
CMGC - CLK
Bioactivity |
---|
Kinase | GPCR |
---|
CLK3 | inactive (-3.4%) |
CLK2 | inactive (5.66%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | GPCR |
---|
HIPK1 | inactive (4.11%) |
HIPK4 | inactive (7.87%) |
DYRK1B | inactive (3.55%) |
DYRK1A | inactive (-1.12%) |
DYRK2 | inactive (6.98%) |
CMGC - CK2
Bioactivity |
---|
Kinase | GPCR |
---|
CK2a1 | inactive (14.9%) |