Compound Information
Test on : GPCR
Compound Name : GW778894X
Inchikey : CWRTWFWDDAJOMG-UHFFFAOYSA-N
ChemSpider : 8483988
Pubchem CID : 10308522
ChEMBL : CHEMBL495696
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
TK
TK - JakA
Bioactivity |
---|
Kinase | GPCR |
---|
JAK1 | inactive (14.89%) |
TYK2 | inactive (11%) |
JAK2 | inactive (22.14%) |
JAK3 | inactive (36.18%) |
TK - Fer
Bioactivity |
---|
Kinase | GPCR |
---|
FER | inactive (48.9%) |
FES | inactive (34.26%) |
TK - Abl
Bioactivity |
---|
Kinase | GPCR |
---|
ABL1 | inactive (47.52%) |
ABL2 | inactive (44.32%) |
TK - Csk
Bioactivity |
---|
Kinase | GPCR |
---|
CSK | inactive (13.39%) |
TK - Tec
Bioactivity |
---|
Kinase | GPCR |
---|
BMX | inactive (39.71%) |
BTK | inactive (5.13%) |
TXK | inactive (24.39%) |
TEC | inactive (39.33%) |
ITK | inactive (21.08%) |
TK - Src
Bioactivity |
---|
Kinase | GPCR |
---|
BRK | inactive (23.53%) |
SRM | inactive (14.72%) |
FRK | inactive (15.98%) |
BLK | inactive (26.48%) |
LCK | inactive (18.29%) |
HCK | inactive (35.91%) |
FGR | inactive (41.73%) |
FYN | inactive (39.23%) |
SRC | active (65.96%) |
YES | inactive (36.97%) |
TK - Eph
Bioactivity |
---|
Kinase | GPCR |
---|
EphA2 | inactive (15.02%) |
EphA4 | inactive (43.79%) |
EphA3 | inactive (19.24%) |
EphB4 | inactive (22.48%) |
EphB3 | inactive (3.9%) |
EphB2 | inactive (46.23%) |
TK - FAK
Bioactivity |
---|
Kinase | GPCR |
---|
PYK2 | active (71.04%) |
TK - Syk
Bioactivity |
---|
Kinase | GPCR |
---|
SYK | active (53.19%) |
ZAP70 | inactive (13.28%) |
TK - ALK
Bioactivity |
---|
Kinase | GPCR |
---|
LTK | inactive (12.73%) |
ALK | inactive (18.74%) |
TK - Sev
Bioactivity |
---|
Kinase | GPCR |
---|
ROS | active (74.2%) |
TK - InsR
Bioactivity |
---|
Kinase | GPCR |
---|
INSR | inactive (40.89%) |
IGF1R | inactive (38.2%) |
IRR | inactive (10.82%) |
TK - DDR
Bioactivity |
---|
Kinase | GPCR |
---|
DDR2 | inactive (7.43%) |
TK - Musk
Bioactivity |
---|
Kinase | GPCR |
---|
MUSK | inactive (24.59%) |
TK - Trk
Bioactivity |
---|
Kinase | GPCR |
---|
TRKA | active (65.74%) |
TRKB | active (75.34%) |
TRKC | active (87.55%) |
TK - Met
Bioactivity |
---|
Kinase | GPCR |
---|
RON | inactive (15.57%) |
MET | inactive (17.31%) |
TK - Axl
Bioactivity |
---|
Kinase | GPCR |
---|
AXL | inactive (33.8%) |
MER | inactive (46.05%) |
TYRO3 | inactive (47.82%) |
TK - Ret
Bioactivity |
---|
Kinase | GPCR |
---|
RET | inactive (37.35%) |
TK - FGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FGFR1 | inactive (8.94%) |
FGFR2 | inactive (23.43%) |
FGFR3 | inactive (17.21%) |
FGFR4 | inactive (5.22%) |
TK - VEGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FLT1 | inactive (28.26%) |
KDR | inactive (43.88%) |
FLT4 | inactive (22.26%) |
TK - PDGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FMS | active (79.4%) |
KIT | active (100.33%) |
FLT3 | active (67.97%) |
PDGFRa | active (52.51%) |
PDGFRb | active (65.09%) |
TK - Tie
Bioactivity |
---|
Kinase | GPCR |
---|
TIE2 | inactive (18.65%) |
TK - Ack
Bioactivity |
---|
Kinase | GPCR |
---|
ACK | inactive (11.74%) |
TNK1 | active (52.28%) |
TK - EGFR
Bioactivity |
---|
Kinase | GPCR |
---|
EGFR | inactive (6.11%) |
ErbB2 | inactive (5.3%) |
ErbB4 | inactive (19.09%) |
TKL
TKL
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
IRAK | 4 | 1 |
RAF | 5 | 1 |
TKL - IRAK
Bioactivity |
---|
Kinase | GPCR |
---|
IRAK4 | inactive (15.07%) |
TKL - RAF
Bioactivity |
---|
Kinase | GPCR |
---|
BRAF | active (65.16%) |
STE
STE
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
STE20 | 31 | 12 |
STE7 | 7 | 1 |
STE - STE20
Bioactivity |
---|
Kinase | GPCR |
---|
GCK | inactive (45.77%) |
MST1 | inactive (27.62%) |
MST2 | inactive (24.35%) |
MST4 | inactive (3.34%) |
HGK | active (64.35%) |
MINK | active (53.38%) |
LOK | inactive (15.76%) |
PAK1 | inactive (7.42%) |
PAK3 | inactive (5.22%) |
PAK2 | inactive (3.52%) |
PAK5 | inactive (12.68%) |
PAK6 | inactive (-4.67%) |
STE - STE7
Bioactivity |
---|
Kinase | GPCR |
---|
MAP2K1 | active (63.04%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
CK1 | 7 | 4 |
CK1 - CK1
Bioactivity |
---|
Kinase | GPCR |
---|
CK1a | active (69.82%) |
CK1g2 | inactive (41.38%) |
CK1g1 | inactive (28.25%) |
CK1g3 | inactive (43.05%) |
Other
Other
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
PLK | 4 | 1 |
Aur | 3 | 3 |
NEK | 11 | 5 |
IKK | 4 | 4 |
TTK | 1 | 1 |
Other - PLK
Bioactivity |
---|
Kinase | GPCR |
---|
PLK1 | inactive (9.23%) |
Other - Aur
Bioactivity |
---|
Kinase | GPCR |
---|
AurB | active (64.02%) |
AurC | active (96.67%) |
AurA | active (74.47%) |
Other - NEK
Bioactivity |
---|
Kinase | GPCR |
---|
NEK1 | inactive (10.94%) |
NEK2 | inactive (6.24%) |
NEK9 | inactive (15.55%) |
NEK7 | inactive (4.18%) |
NEK6 | inactive (5.8%) |
Other - IKK
Bioactivity |
---|
Kinase | GPCR |
---|
TBK1 | inactive (22.05%) |
IKKe | inactive (27.9%) |
IKKb | inactive (20.48%) |
IKKa | inactive (30.99%) |
Other - TTK
Bioactivity |
---|
Kinase | GPCR |
---|
TTK | inactive (34.99%) |
AGC
AGC - GRK
Bioactivity |
---|
Kinase | GPCR |
---|
GPRK7 | inactive (21.59%) |
GPRK6 | inactive (8.01%) |
AGC - PDK1
Bioactivity |
---|
Kinase | GPCR |
---|
PDK1 | inactive (6.25%) |
AGC - RSK
Bioactivity |
---|
Kinase | GPCR |
---|
MSK1 | inactive (8.54%) |
MSK2 | inactive (8.46%) |
RSK1 | inactive (7.07%) |
RSK2 | inactive (4.03%) |
RSK4 | inactive (8.8%) |
RSK3 | inactive (4.16%) |
p70S6K | inactive (3.59%) |
AGC - Akt
Bioactivity |
---|
Kinase | GPCR |
---|
AKT2 | inactive (1.66%) |
AKT1 | inactive (1.36%) |
AKT3 | inactive (5.1%) |
AGC - SGK
Bioactivity |
---|
Kinase | GPCR |
---|
SGK1 | inactive (10.4%) |
SGK3 | inactive (7.33%) |
SGK2 | inactive (5.14%) |
AGC - PKC
Bioactivity |
---|
Kinase | GPCR |
---|
PKCh | inactive (31.91%) |
PKCg | inactive (31.17%) |
PKCa | active (72.84%) |
PKCt | inactive (14.17%) |
PKCi | inactive (1.84%) |
AGC - PKG
Bioactivity |
---|
Kinase | GPCR |
---|
PKG2 | inactive (25.9%) |
PKG1 | active (50.22%) |
AGC - PKA
Bioactivity |
---|
Kinase | GPCR |
---|
PRKX | inactive (2.66%) |
AGC - DMPK
Bioactivity |
---|
Kinase | GPCR |
---|
ROCK1 | inactive (5.33%) |
ROCK2 | inactive (12.38%) |
MRCKb | inactive (1.01%) |
MRCKa | inactive (2.93%) |
CAMK
CAMK - RAD53
Bioactivity |
---|
Kinase | GPCR |
---|
CHK2 | inactive (10.63%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
DCLK2 | inactive (0.56%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK4 | inactive (-0.33%) |
CaMK1d | inactive (3.54%) |
CAMK - PHK
Bioactivity |
---|
Kinase | GPCR |
---|
PHKg1 | active (58.31%) |
PHKg2 | inactive (22.19%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK2d | active (63.35%) |
CaMK2a | inactive (35.37%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | GPCR |
---|
MAPKAPK5 | inactive (4.15%) |
MAPKAPK2 | inactive (1.6%) |
MAPKAPK3 | inactive (5%) |
MNK2 | inactive (33.05%) |
MNK1 | inactive (22.51%) |
CAMK - PKD
Bioactivity |
---|
Kinase | GPCR |
---|
PKD3 | active (54.86%) |
PKD1 | inactive (49.46%) |
PKD2 | inactive (46.76%) |
CAMK - CAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
MARK4 | inactive (9.89%) |
MARK3 | inactive (13.11%) |
MARK1 | inactive (15.19%) |
QIK | inactive (11.94%) |
SIK | inactive (15.14%) |
NuaK1 | active (73.41%) |
BRSK1 | inactive (7.19%) |
BRSK2 | inactive (12.06%) |
MELK | active (55.85%) |
CHK1 | inactive (3.73%) |
PASK | inactive (0.01%) |
AMPKa1 | inactive (10.4%) |
AMPKa2 | inactive (12.52%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | GPCR |
---|
TSSK2 | inactive (2.95%) |
TSSK1 | inactive (10.64%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | GPCR |
---|
DAPK1 | inactive (3.93%) |
CAMK - PIM
Bioactivity |
---|
Kinase | GPCR |
---|
PIM2 | inactive (7.85%) |
PIM3 | inactive (34.05%) |
PIM1 | inactive (12.44%) |
CMGC
CMGC - MAPK
Bioactivity |
---|
Kinase | GPCR |
---|
JNK2 | inactive (44.31%) |
p38a | inactive (14.63%) |
p38b | inactive (13.97%) |
p38d | inactive (47.1%) |
Erk2 | active (59.37%) |
Erk1 | inactive (35.84%) |
CMGC - GSK
Bioactivity |
---|
Kinase | GPCR |
---|
GSK3A | active (89.47%) |
GSK3B | active (88.08%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | GPCR |
---|
SRPK1 | inactive (23.01%) |
MSSK1 | inactive (3.11%) |
CMGC - CLK
Bioactivity |
---|
Kinase | GPCR |
---|
CLK3 | active (78.39%) |
CLK2 | active (96.94%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | GPCR |
---|
HIPK1 | active (89.32%) |
HIPK4 | active (88.13%) |
DYRK1B | active (86.55%) |
DYRK1A | active (86.37%) |
DYRK2 | active (71.52%) |
CMGC - CK2
Bioactivity |
---|
Kinase | GPCR |
---|
CK2a1 | active (63.93%) |