Compound in Profiling

Compound Information

Test on : DRx, RBC, Metz

Compound Name
DRx, RBC, Metz : Pazopanib

Inchikey
Same : CUIHSIWYWATEQL-N
DRx, RBC, Metz : CUIHSIWYWATEQL-UHFFFAOYSA-N

ChemSpider
DRx, RBC, Metz : 8289501

Pubchem CID
DRx, RBC, Metz : 10113978

ChEMBL
DRx, RBC, Metz : CHEMBL477772

	DRx	RBC	Metz	Millipore	GPCR
bioactivity	Kd (nM)	Remain Activity (%)	Ki (nM)	Remain Activity (%)	Inhibition (%)
active criteria	<3000nM	<50%	<1000nM	<50%	>50%

Other

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC	Metz
NAK	4	4	1	-
Aur	3	3	3	2
CAMKK	2	2	2	1
PEK	4	2	-	-
IRE	2	1	-	-
IKK	4	4	4	4
NEK	11	9	8	2
WEE	3	3	1	1
PLK	4	4	3	3
SgK496	1	1	1	-
NKF1	3	2	-	-
NKF4	2	1	-	-
ULK	5	4	3	-
TLK	2	2	1	-
TTK	1	1	1	-
Haspin	1	-	1	-
TOPK	1	-	1	1
WNK	4	-	2	-
CDC7	1	-	-	1

Other - NAK

Bioactivity
Kinase	DRx	RBC	Metz
AAK1	active (2900nM)	-	-
BIKE	inactive (8800nM)	-	-
GAK	active (200nM)	-	-
MPSK1	active (360nM)	active (43.77%)	-

Other - Aur

Bioactivity
Kinase	DRx	RBC	Metz
AurA	inactive (7100nM)	active (38.44%)	active (630.96nM)
AurB	inactive (10001nM)	inactive (64.6%)	inactive (1258.93nM)
AurC	active (750nM)	inactive (70.88%)	-

Other - CAMKK

Bioactivity
Kinase	DRx	RBC	Metz
CaMKK1	inactive (10001nM)	inactive (72.03%)	-
CaMKK2	inactive (10001nM)	inactive (98.5%)	-

Other - PEK

Bioactivity
Kinase	DRx	RBC	Metz
HRI	inactive (10001nM)	-	-
PKR	active (1900nM)	-	-

Other - IRE

Bioactivity
Kinase	DRx	RBC	Metz
IRE1	inactive (10001nM)	-	-

Other - IKK

Bioactivity
Kinase	DRx	RBC	Metz
IKKa	inactive (10001nM)	inactive (99.39%)	-
IKKb	inactive (10001nM)	inactive (86.87%)	-
IKKe	inactive (10001nM)	inactive (87.03%)	inactive (>3162.28nM)
TBK1	inactive (10001nM)	inactive (99.52%)	inactive (>3162.28nM)

Other - NEK

Bioactivity
Kinase	DRx	RBC	Metz
NEK1	inactive (10001nM)	inactive (105.24%)	-
NEK11	inactive (10001nM)	inactive (94.75%)	-
NEK2	active (980nM)	inactive (110.04%)	active (398.11nM)
NEK3	inactive (10001nM)	inactive (94.24%)	-
NEK4	inactive (10001nM)	inactive (91.05%)	-
NEK5	inactive (7300nM)	-	-
NEK6	inactive (10001nM)	inactive (96.05%)	-
NEK7	inactive (10001nM)	inactive (100.7%)	-
NEK9	inactive (10001nM)	inactive (95.78%)	-

Other - WEE

Bioactivity
Kinase	DRx	RBC	Metz
MYT1	inactive (10001nM)	-	-
Wee1	inactive (10001nM)	inactive (95.35%)	-
Wee1B	inactive (10001nM)	-	-

Other - PLK

Bioactivity
Kinase	DRx	RBC	Metz
PLK1	inactive (10001nM)	inactive (99.51%)	-
PLK2	inactive (10001nM)	inactive (101.44%)	-
PLK3	inactive (10001nM)	inactive (101.02%)	-
PLK4	active (290nM)	-	-

Other - SgK496

Bioactivity
Kinase	DRx	RBC	Metz
SgK496	inactive (10001nM)	inactive (94.35%)	-

Other - NKF1

Bioactivity
Kinase	DRx	RBC	Metz
SBK	inactive (10001nM)	-	-
SgK110	inactive (10001nM)	-	-

Other - NKF4

Bioactivity
Kinase	DRx	RBC	Metz
CLIK1	inactive (10001nM)	-	-

Other - ULK

Bioactivity
Kinase	DRx	RBC	Metz
Fused	active (470nM)	-	-
ULK1	inactive (10001nM)	inactive (97.25%)	-
ULK2	inactive (10001nM)	inactive (101.93%)	-
ULK3	inactive (10001nM)	inactive (102.34%)	-

Other - TLK

Bioactivity
Kinase	DRx	RBC	Metz
TLK1	inactive (10001nM)	-	-
TLK2	inactive (10001nM)	inactive (85.62%)	-

Other - TTK

Bioactivity
Kinase	DRx	RBC	Metz
TTK	active (150nM)	inactive (73.43%)	-

Other - Haspin

Bioactivity
Kinase	DRx	RBC	Metz
Haspin	-	inactive (90.41%)	-

Other - TOPK

Bioactivity
Kinase	DRx	RBC	Metz
PBK	-	inactive (100.97%)	-

Other - WNK

Bioactivity
Kinase	DRx	RBC	Metz
Wnk2	-	inactive (98.21%)	-
Wnk3	-	inactive (98.55%)	-

Other - CDC7

Bioactivity
Kinase	DRx	RBC	Metz
CDC7	-	-	-

TK

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC	Metz
Abl	2	2	2	1
ALK	2	2	2	2
Axl	3	3	3	2
Src	11	11	11	9
Tec	5	5	5	3
PDGFR	5	5	5	5
Csk	2	2	2	1
DDR	2	2	1	-
EGFR	4	4	3	3
Eph	14	13	12	1
FAK	2	2	2	2
Fer	2	2	2	2
FGFR	4	4	4	2
VEGFR	3	3	3	3
InsR	3	3	3	2
JakA	4	4	4	3
Met	2	2	2	2
Musk	1	1	1	-
Ret	1	1	1	1
Sev	1	1	1	1
Syk	2	2	2	1
Tie	2	2	1	-
Ack	2	2	1	1
Trk	3	3	3	3

TK - Abl

Bioactivity
Kinase	DRx	RBC	Metz
ABL1	active (620nM)	inactive (63.7%)	active (316.23nM)
ABL2	active (3000nM)	active (38.47%)	-

TK - ALK

Bioactivity
Kinase	DRx	RBC	Metz
ALK	active (2200nM)	inactive (85.31%)	inactive (1584.89nM)
LTK	inactive (6800nM)	inactive (80.19%)	inactive (1584.89nM)

TK - Axl

Bioactivity
Kinase	DRx	RBC	Metz
AXL	inactive (10001nM)	inactive (78.1%)	-
MER	inactive (3300nM)	inactive (57.22%)	-
TYRO3	inactive (10001nM)	inactive (91.97%)	inactive (>3162.28nM)

TK - Src

Bioactivity
Kinase	DRx	RBC	Metz
BLK	active (2600nM)	inactive (75.6%)	-
BRK	active (2300nM)	inactive (66.21%)	-
FGR	active (1600nM)	active (35.85%)	-
FRK	active (750nM)	inactive (58.07%)	-
FYN	active (2700nM)	inactive (79.61%)	inactive (1995.26nM)
HCK	inactive (5700nM)	inactive (64.78%)	-
LCK	active (1200nM)	active (43.29%)	active (501.19nM)
LYN	active (1100nM)	inactive (52.09%)	-
SRC	active (2800nM)	inactive (70.71%)	-
SRM	active (2500nM)	inactive (114.91%)	-
YES	inactive (5000nM)	inactive (52.59%)	-

TK - Tec

Bioactivity
Kinase	DRx	RBC	Metz
BMX	inactive (10001nM)	inactive (93.39%)	-
BTK	inactive (10001nM)	inactive (78.82%)	inactive (>6309.57nM)
ITK	inactive (10001nM)	inactive (114.66%)	-
TEC	inactive (10001nM)	inactive (101%)	-
TXK	active (2600nM)	active (40.2%)	-

TK - PDGFR

Bioactivity
Kinase	DRx	RBC	Metz
FMS	active (7.9nM)	active (10.97%)	active (19.95nM)
FLT3	active (1100nM)	active (40.66%)	inactive (>3162.28nM)
KIT	active (2.8nM)	active (10.87%)	-
PDGFRa	active (4.9nM)	active (13.94%)	active (630.96nM)
PDGFRb	active (2nM)	active (40.42%)	active (3.98nM)

TK - Csk

Bioactivity
Kinase	DRx	RBC	Metz
CSK	inactive (10001nM)	inactive (92.98%)	-
CTK	inactive (10001nM)	inactive (104.2%)	-

TK - DDR

Bioactivity
Kinase	DRx	RBC	Metz
DDR1	active (57nM)	-	-
DDR2	active (98nM)	active (36.15%)	-

TK - EGFR

Bioactivity
Kinase	DRx	RBC	Metz
EGFR	inactive (10001nM)	inactive (91%)	-
ErbB2	inactive (10001nM)	inactive (103.15%)	-
ErbB3	inactive (10001nM)	-	-
ErbB4	inactive (10001nM)	inactive (86.9%)	-

TK - Eph

Bioactivity
Kinase	DRx	RBC	Metz
EphA1	inactive (10001nM)	inactive (84.96%)	-
EphA2	inactive (10001nM)	inactive (85.71%)	-
EphA3	inactive (10001nM)	inactive (94.13%)	-
EphA4	inactive (10001nM)	inactive (94.54%)	-
EphA5	inactive (10001nM)	inactive (99.69%)	-
EphA6	inactive (10001nM)	inactive (79.98%)	-
EphA7	inactive (10001nM)	inactive (94.07%)	-
EphA8	inactive (10001nM)	inactive (90.01%)	-
EphB1	inactive (10001nM)	inactive (92.21%)	-
EphB2	inactive (10001nM)	inactive (91.87%)	-
EphB3	inactive (10001nM)	inactive (71.66%)	-
EphB4	inactive (10001nM)	inactive (93.8%)	-
EphB6	active (81nM)	-	-

TK - FAK

Bioactivity
Kinase	DRx	RBC	Metz
FAK	inactive (10001nM)	inactive (75.97%)	inactive (5011.87nM)
PYK2	inactive (10001nM)	inactive (92%)	-

TK - Fer

Bioactivity
Kinase	DRx	RBC	Metz
FER	active (2700nM)	inactive (81.3%)	-
FES	active (1400nM)	inactive (81.01%)	-

TK - FGFR

Bioactivity
Kinase	DRx	RBC	Metz
FGFR1	active (990nM)	inactive (54.21%)	active (158.49nM)
FGFR2	active (210nM)	active (40.17%)	-
FGFR3	active (740nM)	active (39.25%)	-
FGFR4	active (2800nM)	inactive (68.31%)	-

TK - VEGFR

Bioactivity
Kinase	DRx	RBC	Metz
FLT1	active (14nM)	active (27.17%)	active (15.85nM)
FLT4	active (27nM)	active (18.69%)	-
KDR	active (14nM)	active (16.88%)	active (3.16nM)

TK - InsR

Bioactivity
Kinase	DRx	RBC	Metz
IGF1R	inactive (10001nM)	inactive (89.01%)	inactive (1995.26nM)
INSR	inactive (10001nM)	inactive (106.73%)	-
IRR	inactive (10001nM)	inactive (96.1%)	-

TK - JakA

Bioactivity
Kinase	DRx	RBC	Metz
JAK1	inactive (10001nM)	inactive (103.56%)	-
JAK2	active (1700nM)	inactive (101.4%)	inactive (>2511.89nM)
JAK3	inactive (6900nM)	inactive (95.3%)	inactive (>5011.87nM)
TYK2	inactive (3400nM)	inactive (94.04%)	-

TK - Met

Bioactivity
Kinase	DRx	RBC	Metz
MET	active (2000nM)	inactive (93.5%)	inactive (1584.89nM)
RON	inactive (10001nM)	inactive (97.77%)	inactive (>3981.07nM)

TK - Musk

Bioactivity
Kinase	DRx	RBC	Metz
MUSK	inactive (10001nM)	inactive (95.12%)	-

TK - Ret

Bioactivity
Kinase	DRx	RBC	Metz
RET	active (310nM)	active (25.68%)	active (79.43nM)

TK - Sev

Bioactivity
Kinase	DRx	RBC	Metz
ROS	active (920nM)	active (16.99%)	-

TK - Syk

Bioactivity
Kinase	DRx	RBC	Metz
SYK	inactive (4700nM)	inactive (101.17%)	-
ZAP70	inactive (10001nM)	inactive (92.57%)	-

TK - Tie

Bioactivity
Kinase	DRx	RBC	Metz
TIE1	active (700nM)	-	-
TIE2	inactive (3300nM)	inactive (69.29%)	-

TK - Ack

Bioactivity
Kinase	DRx	RBC	Metz
TNK1	inactive (10001nM)	-	-
ACK	inactive (10001nM)	inactive (90.17%)	inactive (3162.28nM)

TK - Trk

Bioactivity
Kinase	DRx	RBC	Metz
TRKA	inactive (10001nM)	inactive (91.82%)	inactive (>3162.28nM)
TRKB	inactive (10001nM)	inactive (91.55%)	inactive (>3981.07nM)
TRKC	inactive (10001nM)	inactive (87.81%)	inactive (>3162.28nM)

TKL

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC	Metz
STKR	12	10	5	1
RIPK	5	4	1	-
RAF	5	2	3	1
MLK	10	8	5	2
IRAK	4	3	2	2
LISK	4	3	1	1
LRRK	2	1	1	1

TKL - STKR

Bioactivity
Kinase	DRx	RBC	Metz
ALK2	inactive (10001nM)	inactive (103.79%)	inactive (>3981.07nM)
ALK4	inactive (10001nM)	inactive (100.22%)	-
ACTR2	inactive (10001nM)	-	-
ACTR2B	active (2400nM)	-	-
ALK1	inactive (10001nM)	inactive (102.47%)	-
BMPR1A	inactive (10001nM)	-	-
BMPR1B	active (1000nM)	-	-
BMPR2	inactive (10001nM)	-	-
TGFbR1	inactive (10001nM)	inactive (102.82%)	-
TGFbR2	active (3000nM)	inactive (100.39%)	-

TKL - RIPK

Bioactivity
Kinase	DRx	RBC	Metz
SgK288	inactive (10001nM)	-	-
RIPK1	active (260nM)	-	-
RIPK2	active (580nM)	inactive (68.21%)	-
ANKRD3	inactive (10001nM)	-	-

TKL - RAF

Bioactivity
Kinase	DRx	RBC	Metz
BRAF	active (730nM)	inactive (83.14%)	-
RAF1	active (900nM)	active (9.43%)	-
ARAF	-	inactive (76.46%)	-

TKL - MLK

Bioactivity
Kinase	DRx	RBC	Metz
DLK	inactive (10001nM)	-	-
LZK	inactive (10001nM)	-	-
MLK1	active (290nM)	active (10.56%)	-
MLK2	active (2100nM)	active (28.53%)	-
MLK3	active (740nM)	active (15.84%)	-
TAK1	inactive (10001nM)	inactive (90.65%)	-
HH498	inactive (10001nM)	-	-
ZAK	inactive (10001nM)	inactive (96.88%)	-

TKL - IRAK

Bioactivity
Kinase	DRx	RBC	Metz
IRAK1	inactive (5900nM)	inactive (96.99%)	-
IRAK3	active (800nM)	-	-
IRAK4	inactive (10001nM)	inactive (98.37%)	-

TKL - LISK

Bioactivity
Kinase	DRx	RBC	Metz
LIMK1	active (720nM)	active (48.49%)	inactive (1258.93nM)
LIMK2	active (390nM)	-	-
TESK1	inactive (10001nM)	-	-

TKL - LRRK

Bioactivity
Kinase	DRx	RBC	Metz
LRRK2	inactive (10001nM)	inactive (109.36%)	inactive (>2511.89nM)

Atypical

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC	Metz
ABC1	5	2	-	-
PIKK	6	1	-	-
RIO	3	3	-	-
Alpha	6	1	-	1
PDHK	5	-	1	-

Atypical - ABC1

Bioactivity
Kinase	DRx	RBC	Metz
ADCK3	inactive (10001nM)	-	-
ADCK4	inactive (10001nM)	-	-

Atypical - PIKK

Bioactivity
Kinase	DRx	RBC	Metz
FRAP	inactive (10001nM)	-	-

Atypical - RIO

Bioactivity
Kinase	DRx	RBC	Metz
RIOK1	inactive (10001nM)	-	-
RIOK2	active (610nM)	-	-
RIOK3	inactive (10001nM)	-	-

Atypical - Alpha

Bioactivity
Kinase	DRx	RBC	Metz
ChaK2	inactive (10001nM)	-	-
eEF2K	-	-	-

Atypical - PDHK

Bioactivity
Kinase	DRx	RBC	Metz
PDHK1	-	inactive (93.02%)	-

AGC

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC	Metz
Akt	3	3	3	3
DMPK	7	7	5	3
GRK	7	3	6	1
NDR	4	4	1	-
MAST	5	1	-	-
PDK1	1	1	1	1
PKA	5	3	3	2
PKN	3	2	2	1
PKC	9	5	9	5
PKG	2	2	3	2
RSK	8	1	8	4
SGK	3	1	3	1
YANK	3	3	-	-

AGC - Akt

Bioactivity
Kinase	DRx	RBC	Metz
AKT1	inactive (10001nM)	inactive (91.17%)	-
AKT2	inactive (10001nM)	inactive (107.14%)	-
AKT3	inactive (10001nM)	inactive (93.35%)	-

AGC - DMPK

Bioactivity
Kinase	DRx	RBC	Metz
CRIK	inactive (10001nM)	-	-
DMPK1	inactive (10001nM)	inactive (93.54%)	-
DMPK2	inactive (10001nM)	-	-
MRCKa	inactive (10001nM)	inactive (85.43%)	-
MRCKb	inactive (10001nM)	inactive (99.9%)	-
ROCK1	inactive (10001nM)	inactive (100.24%)	inactive (>3981.07nM)
ROCK2	inactive (10001nM)	inactive (91.14%)	-

AGC - GRK

Bioactivity
Kinase	DRx	RBC	Metz
RHOK	inactive (10001nM)	-	-
GPRK4	inactive (10001nM)	inactive (91.68%)	-
GPRK7	inactive (10001nM)	inactive (96.52%)	-
BARK1	-	inactive (90.25%)	-
BARK2	-	inactive (99.31%)	-
GPRK5	-	inactive (99.56%)	inactive (>3981.07nM)
GPRK6	-	inactive (101.98%)	-

AGC - NDR

Bioactivity
Kinase	DRx	RBC	Metz
LATS1	inactive (10001nM)	-	-
LATS2	inactive (10001nM)	-	-
NDR1	inactive (10001nM)	inactive (100.17%)	-
NDR2	inactive (10001nM)	-	-

AGC - MAST

Bioactivity
Kinase	DRx	RBC	Metz
MAST1	inactive (10001nM)	-	-

AGC - PDK1

Bioactivity
Kinase	DRx	RBC	Metz
PDK1	inactive (10001nM)	inactive (93.02%)	-

AGC - PKA

Bioactivity
Kinase	DRx	RBC	Metz
PKACa	inactive (10001nM)	inactive (94.55%)	inactive (>1258.93nM)
PKACb	inactive (10001nM)	-	-
PRKX	inactive (10001nM)	inactive (100.71%)	inactive (>3162.28nM)
PKACg	-	inactive (111.36%)	-

AGC - PKN

Bioactivity
Kinase	DRx	RBC	Metz
PKN1	inactive (10001nM)	inactive (102.37%)	-
PKN2	inactive (10001nM)	inactive (105.88%)	-

AGC - PKC

Bioactivity
Kinase	DRx	RBC	Metz
PKCd	inactive (10001nM)	inactive (105.73%)	-
PKCe	inactive (10001nM)	inactive (100.22%)	-
PKCh	inactive (10001nM)	inactive (110.38%)	-
PKCi	inactive (10001nM)	inactive (96.11%)	-
PKCt	inactive (10001nM)	inactive (93.14%)	inactive (>2511.89nM)
PKCa	-	inactive (94.43%)	-
PKCg	-	inactive (93.51%)	-
PKCz	-	inactive (97.66%)	-
PKCb	-	inactive (96.71%)	-

AGC - PKG

Bioactivity
Kinase	DRx	RBC	Metz
PKG1	inactive (10001nM)	inactive (95.08%)	-
PKG2	inactive (10001nM)	inactive (96.03%)	-

AGC - RSK

Bioactivity
Kinase	DRx	RBC	Metz
p70S6K	inactive (10001nM)	inactive (96.04%)	-
MSK1	-	inactive (100.85%)	-
MSK2	-	inactive (101.88%)	-
p70S6Kb	-	inactive (102.67%)	-
RSK2	-	inactive (99.15%)	inactive (>3981.07nM)
RSK4	-	inactive (96.77%)	-
RSK1	-	inactive (92.82%)	-
RSK3	-	inactive (93.22%)	-

AGC - SGK

Bioactivity
Kinase	DRx	RBC	Metz
SGK3	inactive (10001nM)	inactive (97.51%)	-
SGK1	-	inactive (124.92%)	-
SGK2	-	inactive (160%)	-

AGC - YANK

Bioactivity
Kinase	DRx	RBC	Metz
YANK1	inactive (10001nM)	-	-
YANK2	inactive (10001nM)	-	-
YANK3	inactive (10001nM)	-	-

CAMK

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC	Metz
CAMKL	20	19	13	9
CAMK1	5	4	5	2
CAMK2	4	4	4	4
CASK	1	1	-	-
RAD53	1	1	1	1
DAPK	5	5	4	2
DCAMKL	3	3	1	1
MAPKAPK	5	4	5	4
MLCK	5	4	2	-
PHK	2	2	2	1
PIM	3	3	3	3
PKD	3	3	3	2
STK33	1	1	-	1
TSSK	5	1	2	2

CAMK - CAMKL

Bioactivity
Kinase	DRx	RBC	Metz
AMPKa1	inactive (10001nM)	-	inactive (>3162.28nM)
AMPKa2	inactive (10001nM)	-	-
NuaK1	inactive (10001nM)	inactive (53.44%)	-
BRSK1	inactive (10001nM)	inactive (97.19%)	-
BRSK2	inactive (10001nM)	inactive (101.4%)	-
CHK1	inactive (10001nM)	inactive (109.77%)	inactive (>3162.28nM)
HUNK	inactive (10001nM)	-	-
LKB1	inactive (10001nM)	inactive (92.15%)	-
MARK1	inactive (10001nM)	inactive (99.95%)	-
MARK2	inactive (10001nM)	inactive (111.14%)	-
MARK3	inactive (4000nM)	inactive (96.6%)	-
MARK4	inactive (10001nM)	inactive (97.97%)	-
MELK	inactive (10001nM)	inactive (87.47%)	-
NIM1	inactive (10001nM)	-	-
QSK	inactive (10001nM)	-	-
SIK	active (2200nM)	-	-
QIK	inactive (7300nM)	inactive (84.12%)	-
NuaK2	inactive (10001nM)	inactive (93.75%)	-
SNRK	inactive (10001nM)	-	-
PASK	-	inactive (100.81%)	-

CAMK - CAMK1

Bioactivity
Kinase	DRx	RBC	Metz
CaMK1a	active (2100nM)	inactive (87.43%)	-
CaMK1d	inactive (10001nM)	inactive (91.54%)	inactive (>2511.89nM)
CaMK1g	inactive (3700nM)	inactive (105.59%)	-
CaMK4	inactive (10001nM)	inactive (95.91%)	-
CaMK1b	-	inactive (95.85%)	-

CAMK - CAMK2

Bioactivity
Kinase	DRx	RBC	Metz
CaMK2a	inactive (10001nM)	inactive (95.62%)	inactive (>3981.07nM)
CaMK2b	inactive (10001nM)	inactive (95.46%)	-
CaMK2d	inactive (10001nM)	inactive (99.38%)	-
CaMK2g	inactive (10001nM)	inactive (106.23%)	-

CAMK - CASK

Bioactivity
Kinase	DRx	RBC	Metz
CASK	inactive (10001nM)	-	-

CAMK - RAD53

Bioactivity
Kinase	DRx	RBC	Metz
CHK2	inactive (10001nM)	inactive (95.11%)	-

CAMK - DAPK

Bioactivity
Kinase	DRx	RBC	Metz
DAPK1	inactive (10001nM)	inactive (105.19%)	-
DAPK2	inactive (10001nM)	inactive (93.04%)	-
DAPK3	inactive (10001nM)	inactive (92.26%)	inactive (>5011.87nM)
DRAK1	inactive (10001nM)	inactive (95.86%)	-
DRAK2	inactive (10001nM)	-	-

CAMK - DCAMKL

Bioactivity
Kinase	DRx	RBC	Metz
DCLK1	inactive (10001nM)	-	-
DCLK2	inactive (10001nM)	inactive (102.06%)	-
DCLK3	inactive (10001nM)	-	-

CAMK - MAPKAPK

Bioactivity
Kinase	DRx	RBC	Metz
MAPKAPK2	inactive (10001nM)	inactive (99.57%)	-
MAPKAPK5	inactive (10001nM)	inactive (100.18%)	-
MNK1	inactive (10001nM)	inactive (101.75%)	-
MNK2	inactive (10001nM)	inactive (107.13%)	-
MAPKAPK3	-	inactive (98.52%)	-

CAMK - MLCK

Bioactivity
Kinase	DRx	RBC	Metz
caMLCK	inactive (10001nM)	-	-
smMLCK	inactive (10001nM)	inactive (92.96%)	-
skMLCK	active (2000nM)	active (44.12%)	-
SgK085	inactive (10001nM)	-	-

CAMK - PHK

Bioactivity
Kinase	DRx	RBC	Metz
PHKg1	inactive (10001nM)	inactive (92.52%)	-
PHKg2	inactive (10001nM)	inactive (96.73%)	-

CAMK - PIM

Bioactivity
Kinase	DRx	RBC	Metz
PIM1	inactive (10001nM)	inactive (99.96%)	inactive (>6309.57nM)
PIM2	inactive (10001nM)	inactive (101.44%)	-
PIM3	inactive (10001nM)	inactive (81.61%)	-

CAMK - PKD

Bioactivity
Kinase	DRx	RBC	Metz
PKD1	inactive (10001nM)	inactive (96.94%)	-
PKD2	inactive (10001nM)	inactive (90.82%)	-
PKD3	inactive (10001nM)	inactive (90.03%)	inactive (>3981.07nM)

CAMK - STK33

Bioactivity
Kinase	DRx	RBC	Metz
STK33	inactive (10001nM)	inactive (87.06%)	-

CAMK - TSSK

Bioactivity
Kinase	DRx	RBC	Metz
TSSK1	inactive (10001nM)	inactive (99.04%)	-
TSSK2	-	inactive (101.63%)	-

STE

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC	Metz
STE11	8	8	3	-
STE20	31	27	23	9
STE7	7	7	3	2
STE-Unique	2	-	2	-

STE - STE11

Bioactivity
Kinase	DRx	RBC	Metz
MAP3K5	inactive (10001nM)	inactive (101.91%)	-
MAP3K6	inactive (10001nM)	-	-
MAP3K1	active (2900nM)	-	-
MAP3K7	inactive (10001nM)	-	-
MAP3K2	active (290nM)	inactive (110.49%)	-
MAP3K3	inactive (10001nM)	inactive (112.07%)	-
MAP3K4	inactive (10001nM)	-	-
MAP3K8	active (940nM)	-	-

STE - STE20

Bioactivity
Kinase	DRx	RBC	Metz
HPK1	active (750nM)	-	-
LOK	active (84nM)	inactive (50.12%)	-
GCK	active (2700nM)	inactive (72.55%)	inactive (>2511.89nM)
KHS2	active (1600nM)	-	-
HGK	active (2200nM)	inactive (77.36%)	active (316.23nM)
KHS1	active (3000nM)	active (30.31%)	-
MINK	inactive (10001nM)	inactive (73.73%)	-
MST1	inactive (10001nM)	inactive (98.38%)	-
MST2	inactive (10001nM)	inactive (95.36%)	-
MST3	inactive (10001nM)	inactive (105.72%)	-
MST4	inactive (10001nM)	inactive (107.6%)	-
MYO3A	inactive (10001nM)	-	-
MYO3B	inactive (10001nM)	inactive (83.38%)	-
OSR1	inactive (10001nM)	inactive (102.66%)	-
PAK1	inactive (10001nM)	inactive (89.15%)	-
PAK2	inactive (10001nM)	inactive (98.87%)	-
PAK3	inactive (10001nM)	inactive (90.57%)	-
PAK4	inactive (10001nM)	inactive (92.01%)	inactive (>5011.87nM)
PAK6	inactive (10001nM)	inactive (104.58%)	-
PAK5	inactive (10001nM)	inactive (95.37%)	-
SLK	active (240nM)	inactive (84.86%)	-
STLK3	inactive (10001nM)	inactive (95.9%)	-
TAO1	active (240nM)	active (28.87%)	active (794.33nM)
TAO2	active (1800nM)	active (26.75%)	-
TAO3	active (45nM)	inactive (55.53%)	-
TNIK	active (310nM)	-	-
YSK1	inactive (10001nM)	inactive (97.32%)	-

STE - STE7

Bioactivity
Kinase	DRx	RBC	Metz
MAP2K1	inactive (10001nM)	inactive (105.99%)	inactive (>3162.28nM)
MAP2K2	inactive (10001nM)	inactive (94.8%)	inactive (>3981.07nM)
MAP2K3	inactive (10001nM)	-	-
MAP2K4	active (590nM)	-	-
MAP2K5	active (480nM)	-	-
MAP2K6	inactive (4100nM)	inactive (98.35%)	-
MAP2K7	inactive (10001nM)	-	-

STE - STE-Unique

Bioactivity
Kinase	DRx	RBC	Metz
COT	-	inactive (95.25%)	-
NIK	-	inactive (103.66%)	-

CMGC

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC	Metz
CDK	20	8	-	7
CDKL	5	4	-	-
CLK	4	4	4	2
CK2	3	2	2	1
DYRK	10	8	9	6
MAPK	14	14	10	8
GSK	2	2	2	2
RCK	3	2	-	-
SRPK	3	3	3	1

CMGC - CDK

Bioactivity
Kinase	DRx	RBC	Metz
PITSLRE	active (2100nM)	-	-
CHED	inactive (10001nM)	-	-
CDK11	inactive (10001nM)	-	-
PCTAIRE1	active (1200nM)	-	-
PCTAIRE2	inactive (10001nM)	-	-
PCTAIRE3	inactive (10001nM)	-	-
PFTAIRE2	inactive (10001nM)	-	-
PFTAIRE1	inactive (10001nM)	-	-
CDC2	-	-	-
CDK2	-	-	-
CDK5	-	-	inactive (>3162.28nM)
CDK8	-	-	inactive (>3981.07nM)
CDK7	-	-	inactive (3981.07nM)
CDK9	-	-	inactive (>1584.89nM)

CMGC - CDKL

Bioactivity
Kinase	DRx	RBC	Metz
CDKL1	inactive (10001nM)	-	-
CDKL2	inactive (10001nM)	-	-
CDKL3	inactive (10001nM)	-	-
CDKL5	inactive (10001nM)	-	-

CMGC - CLK

Bioactivity
Kinase	DRx	RBC	Metz
CLK1	inactive (10001nM)	inactive (102.6%)	-
CLK2	inactive (10001nM)	inactive (90.94%)	inactive (>3981.07nM)
CLK3	inactive (10001nM)	inactive (107.06%)	-
CLK4	inactive (10001nM)	inactive (91.7%)	inactive (>2511.89nM)

CMGC - CK2

Bioactivity
Kinase	DRx	RBC	Metz
CK2a1	inactive (10001nM)	inactive (114.36%)	-
CK2a2	inactive (10001nM)	inactive (99.85%)	-

CMGC - DYRK

Bioactivity
Kinase	DRx	RBC	Metz
DYRK1A	inactive (10001nM)	inactive (105.22%)	inactive (>1995.26nM)
DYRK1B	inactive (10001nM)	inactive (93.28%)	inactive (>2511.89nM)
DYRK2	inactive (10001nM)	inactive (98.83%)	-
HIPK1	inactive (10001nM)	inactive (97.59%)	-
HIPK2	inactive (10001nM)	inactive (105.21%)	-
HIPK3	inactive (10001nM)	inactive (103.03%)	-
HIPK4	inactive (10001nM)	inactive (108.57%)	-
PRP4	inactive (10001nM)	-	-
DYRK3	-	inactive (95.94%)	-
DYRK4	-	inactive (106.1%)	-

CMGC - MAPK

Bioactivity
Kinase	DRx	RBC	Metz
Erk1	inactive (10001nM)	inactive (102.33%)	-
Erk2	inactive (10001nM)	inactive (103.15%)	-
Erk3	inactive (10001nM)	-	-
Erk4	inactive (10001nM)	-	-
Erk5	inactive (10001nM)	-	-
Erk7	inactive (10001nM)	-	-
JNK1	active (2000nM)	inactive (90.38%)	active (501.19nM)
JNK2	inactive (10001nM)	inactive (94.52%)	inactive (1995.26nM)
JNK3	active (1900nM)	inactive (106.1%)	-
NLK	inactive (4400nM)	inactive (69.04%)	-
p38a	inactive (10001nM)	inactive (91.19%)	inactive (>3981.07nM)
p38b	inactive (10001nM)	inactive (93.32%)	-
p38d	inactive (10001nM)	inactive (94.59%)	-
p38g	inactive (10001nM)	inactive (93.74%)	-

CMGC - GSK

Bioactivity
Kinase	DRx	RBC	Metz
GSK3A	inactive (10001nM)	inactive (101.45%)	inactive (>3981.07nM)
GSK3B	inactive (10001nM)	inactive (94.33%)	inactive (>3981.07nM)

CMGC - RCK

Bioactivity
Kinase	DRx	RBC	Metz
ICK	inactive (10001nM)	-	-
MAK	inactive (10001nM)	-	-

CMGC - SRPK

Bioactivity
Kinase	DRx	RBC	Metz
SRPK1	inactive (10001nM)	inactive (100.14%)	-
SRPK2	inactive (10001nM)	inactive (104.38%)	-
MSSK1	inactive (10001nM)	inactive (102.1%)	-

CK1

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC	Metz
CK1	7	7	6	5
VRK	3	1	1	-

CK1 - CK1

Bioactivity
Kinase	DRx	RBC	Metz
CK1a	inactive (10001nM)	inactive (100.14%)	inactive (>3981.07nM)
CK1a2	inactive (10001nM)	-	-
CK1d	inactive (10001nM)	inactive (95.4%)	-
CK1e	inactive (10001nM)	inactive (97.53%)	-
CK1g1	inactive (10001nM)	inactive (100.36%)	-
CK1g2	inactive (10001nM)	inactive (96.93%)	-
CK1g3	inactive (10001nM)	inactive (97.12%)	-

CK1 - VRK

Bioactivity
Kinase	DRx	RBC	Metz
VRK2	inactive (10001nM)	-	-
VRK1	-	inactive (100.05%)	-