Compound Information
Test on : RBC
Compound Name : Rho Kinase Inhibitor IV
Inchikey : CMKMGFAUKPAOMG-AWEZNQCLSA-N
ChemSpider : 10149930
Pubchem CID : 11976582
ChEMBL : CHEMBL3348907
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
AGC
AGC - PDK1
Bioactivity |
---|
Kinase | RBC |
---|
PDK1 | inactive (97.78%) |
AGC - Akt
Bioactivity |
---|
Kinase | RBC |
---|
AKT1 | inactive (103.5%) |
AKT2 | inactive (97.19%) |
AKT3 | inactive (98.85%) |
AGC - DMPK
Bioactivity |
---|
Kinase | RBC |
---|
DMPK1 | inactive (105.34%) |
MRCKa | inactive (95.07%) |
MRCKb | inactive (104.58%) |
ROCK1 | active (3.44%) |
ROCK2 | active (3.22%) |
AGC - GRK
Bioactivity |
---|
Kinase | RBC |
---|
BARK1 | inactive (100.9%) |
BARK2 | inactive (95.02%) |
GPRK4 | inactive (93.96%) |
GPRK5 | inactive (97.1%) |
GPRK6 | inactive (85.51%) |
GPRK7 | inactive (88.79%) |
AGC - RSK
Bioactivity |
---|
Kinase | RBC |
---|
MSK1 | inactive (100.02%) |
MSK2 | inactive (82.33%) |
p70S6K | inactive (93.25%) |
p70S6Kb | inactive (99.25%) |
RSK2 | inactive (91.82%) |
RSK4 | inactive (104.51%) |
RSK1 | inactive (90.44%) |
RSK3 | inactive (89.17%) |
AGC - PKA
Bioactivity |
---|
Kinase | RBC |
---|
PKACg | inactive (111.92%) |
PRKX | inactive (54.2%) |
PKACa | inactive (99.47%) |
AGC - PKC
Bioactivity |
---|
Kinase | RBC |
---|
PKCa | inactive (108.72%) |
PKCd | active (22.41%) |
PKCe | inactive (52.37%) |
PKCh | active (34.43%) |
PKCg | inactive (100.8%) |
PKCi | inactive (87.44%) |
PKCt | inactive (105.13%) |
PKCz | inactive (91.25%) |
PKCb | inactive (91.27%) |
AGC - PKG
Bioactivity |
---|
Kinase | RBC |
---|
PKG2 | inactive (88.06%) |
PKG1 | inactive (78.69%) |
AGC - PKN
Bioactivity |
---|
Kinase | RBC |
---|
PKN1 | active (25.35%) |
PKN2 | inactive (74.7%) |
AGC - SGK
Bioactivity |
---|
Kinase | RBC |
---|
SGK1 | inactive (102.5%) |
SGK2 | inactive (102.03%) |
SGK3 | inactive (96.04%) |
AGC - NDR
Bioactivity |
---|
Kinase | RBC |
---|
NDR1 | inactive (97.1%) |
TK
TK - Abl
Bioactivity |
---|
Kinase | RBC |
---|
ABL1 | inactive (99.33%) |
ABL2 | inactive (98.95%) |
TK - Ack
Bioactivity |
---|
Kinase | RBC |
---|
ACK | inactive (84.53%) |
TK - ALK
Bioactivity |
---|
Kinase | RBC |
---|
ALK | inactive (112.73%) |
LTK | inactive (93.02%) |
TK - Axl
Bioactivity |
---|
Kinase | RBC |
---|
AXL | inactive (98.84%) |
MER | inactive (95.44%) |
TYRO3 | inactive (98.86%) |
TK - Src
Bioactivity |
---|
Kinase | RBC |
---|
BLK | inactive (97.72%) |
BRK | inactive (87.81%) |
SRC | inactive (93.64%) |
FGR | inactive (94.06%) |
FRK | inactive (113.92%) |
FYN | inactive (94.22%) |
HCK | inactive (96.36%) |
LCK | inactive (97.02%) |
SRM | inactive (106.46%) |
YES | inactive (91.97%) |
LYN | inactive (101.43%) |
TK - Tec
Bioactivity |
---|
Kinase | RBC |
---|
BMX | inactive (93.97%) |
BTK | inactive (103.74%) |
ITK | inactive (97.25%) |
TEC | inactive (117.26%) |
TXK | inactive (103.08%) |
TK - PDGFR
Bioactivity |
---|
Kinase | RBC |
---|
KIT | inactive (92.88%) |
FLT3 | inactive (90.09%) |
FMS | inactive (95.63%) |
PDGFRb | inactive (104.11%) |
PDGFRa | inactive (93.5%) |
TK - Csk
Bioactivity |
---|
Kinase | RBC |
---|
CSK | inactive (104.19%) |
CTK | inactive (94.37%) |
TK - DDR
Bioactivity |
---|
Kinase | RBC |
---|
DDR2 | inactive (103.49%) |
TK - EGFR
Bioactivity |
---|
Kinase | RBC |
---|
EGFR | inactive (98.7%) |
ErbB2 | inactive (99.74%) |
ErbB4 | inactive (78.37%) |
TK - Eph
Bioactivity |
---|
Kinase | RBC |
---|
EphA1 | inactive (89.19%) |
EphA2 | inactive (92%) |
EphA3 | inactive (98.71%) |
EphA4 | inactive (99.89%) |
EphA5 | inactive (95.07%) |
EphA6 | inactive (92.22%) |
EphA7 | inactive (90.75%) |
EphA8 | inactive (95.03%) |
EphB1 | inactive (88.73%) |
EphB2 | inactive (108.5%) |
EphB3 | inactive (99.56%) |
EphB4 | inactive (85.1%) |
TK - FAK
Bioactivity |
---|
Kinase | RBC |
---|
FAK | inactive (78.02%) |
PYK2 | inactive (92.49%) |
TK - Fer
Bioactivity |
---|
Kinase | RBC |
---|
FER | inactive (66.03%) |
FES | inactive (101.5%) |
TK - FGFR
Bioactivity |
---|
Kinase | RBC |
---|
FGFR1 | inactive (85.68%) |
FGFR2 | inactive (98.37%) |
FGFR3 | inactive (97.73%) |
FGFR4 | inactive (79.48%) |
TK - VEGFR
Bioactivity |
---|
Kinase | RBC |
---|
FLT1 | inactive (96.93%) |
FLT4 | inactive (113.44%) |
KDR | inactive (99.02%) |
TK - InsR
Bioactivity |
---|
Kinase | RBC |
---|
IGF1R | inactive (109.55%) |
IRR | inactive (103.03%) |
INSR | inactive (88.86%) |
TK - JakA
Bioactivity |
---|
Kinase | RBC |
---|
JAK1 | inactive (108.42%) |
JAK2 | inactive (93.88%) |
JAK3 | inactive (93.05%) |
TYK2 | inactive (86.65%) |
TK - Musk
Bioactivity |
---|
Kinase | RBC |
---|
MUSK | inactive (88.66%) |
TK - Ret
Bioactivity |
---|
Kinase | RBC |
---|
RET | inactive (94.44%) |
TK - Met
Bioactivity |
---|
Kinase | RBC |
---|
RON | inactive (99.28%) |
MET | inactive (103.7%) |
TK - Sev
Bioactivity |
---|
Kinase | RBC |
---|
ROS | inactive (60.33%) |
TK - Syk
Bioactivity |
---|
Kinase | RBC |
---|
SYK | inactive (100.26%) |
ZAP70 | inactive (101.64%) |
TK - Tie
Bioactivity |
---|
Kinase | RBC |
---|
TIE2 | inactive (98.58%) |
TK - Trk
Bioactivity |
---|
Kinase | RBC |
---|
TRKA | inactive (100.44%) |
TRKB | inactive (102.3%) |
TRKC | inactive (87.48%) |
TKL
TKL - STKR
Bioactivity |
---|
Kinase | RBC |
---|
ALK1 | inactive (99.2%) |
ALK2 | inactive (95.76%) |
ALK4 | inactive (99.99%) |
TGFbR1 | inactive (100.48%) |
TGFbR2 | inactive (131.61%) |
TKL - RAF
Bioactivity |
---|
Kinase | RBC |
---|
ARAF | inactive (97.54%) |
BRAF | inactive (94.59%) |
RAF1 | inactive (95.14%) |
TKL - IRAK
Bioactivity |
---|
Kinase | RBC |
---|
IRAK1 | inactive (135.02%) |
IRAK4 | inactive (109.17%) |
TKL - LISK
Bioactivity |
---|
Kinase | RBC |
---|
LIMK1 | inactive (91.91%) |
TKL - LRRK
Bioactivity |
---|
Kinase | RBC |
---|
LRRK2 | inactive (54.63%) |
TKL - MLK
Bioactivity |
---|
Kinase | RBC |
---|
MLK1 | inactive (94.43%) |
MLK2 | inactive (104.65%) |
MLK3 | inactive (98.42%) |
TAK1 | inactive (94.87%) |
ZAK | inactive (107.54%) |
TKL - RIPK
Bioactivity |
---|
Kinase | RBC |
---|
RIPK2 | inactive (94.37%) |
CAMK
CAMK - CAMKL
Bioactivity |
---|
Kinase | RBC |
---|
NuaK1 | inactive (91.05%) |
BRSK1 | inactive (94.16%) |
BRSK2 | inactive (85.42%) |
CHK1 | inactive (100.07%) |
LKB1 | inactive (86.49%) |
MARK1 | inactive (89.72%) |
MARK3 | inactive (98.89%) |
MARK4 | inactive (95.69%) |
MELK | inactive (83.04%) |
PASK | inactive (104.69%) |
QIK | inactive (89.39%) |
NuaK2 | inactive (125.17%) |
MARK2 | inactive (89.11%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | RBC |
---|
CaMK1a | inactive (101.59%) |
CaMK1b | inactive (100.64%) |
CaMK1d | inactive (104.26%) |
CaMK1g | inactive (94.58%) |
CaMK4 | inactive (90.62%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | RBC |
---|
CaMK2a | inactive (93.23%) |
CaMK2b | inactive (92.43%) |
CaMK2d | inactive (107.87%) |
CaMK2g | inactive (93.98%) |
CAMK - RAD53
Bioactivity |
---|
Kinase | RBC |
---|
CHK2 | inactive (96.16%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | RBC |
---|
DAPK1 | inactive (97.9%) |
DAPK2 | inactive (102.9%) |
DRAK1 | inactive (93.45%) |
DAPK3 | inactive (90.42%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | RBC |
---|
DCLK2 | inactive (88.98%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | RBC |
---|
MAPKAPK2 | inactive (102.77%) |
MAPKAPK3 | inactive (98.8%) |
MAPKAPK5 | inactive (94.19%) |
MNK1 | inactive (90.54%) |
MNK2 | inactive (83.78%) |
CAMK - MLCK
Bioactivity |
---|
Kinase | RBC |
---|
smMLCK | inactive (103.32%) |
skMLCK | inactive (100.63%) |
CAMK - PHK
Bioactivity |
---|
Kinase | RBC |
---|
PHKg1 | inactive (65.35%) |
PHKg2 | inactive (90.46%) |
CAMK - PIM
Bioactivity |
---|
Kinase | RBC |
---|
PIM1 | inactive (105.05%) |
PIM2 | inactive (104.25%) |
PIM3 | inactive (103.05%) |
CAMK - PKD
Bioactivity |
---|
Kinase | RBC |
---|
PKD1 | inactive (96.69%) |
PKD3 | inactive (85.42%) |
PKD2 | inactive (96.04%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | RBC |
---|
TSSK1 | inactive (102.53%) |
TSSK2 | inactive (99.6%) |
CAMK - STK33
Bioactivity |
---|
Kinase | RBC |
---|
STK33 | inactive (100.06%) |
STE
STE - STE11
Bioactivity |
---|
Kinase | RBC |
---|
MAP3K5 | inactive (105.67%) |
MAP3K2 | inactive (92.09%) |
MAP3K3 | inactive (99.08%) |
STE - STE-Unique
Bioactivity |
---|
Kinase | RBC |
---|
COT | inactive (99.92%) |
NIK | inactive (108.88%) |
STE - STE20
Bioactivity |
---|
Kinase | RBC |
---|
GCK | inactive (105.8%) |
HGK | inactive (87.55%) |
KHS1 | inactive (102.96%) |
LOK | active (42%) |
MINK | inactive (97.16%) |
MST1 | inactive (95.41%) |
MST2 | inactive (103.79%) |
MST3 | inactive (92.39%) |
MST4 | inactive (106.82%) |
OSR1 | inactive (99.38%) |
PAK1 | inactive (98.12%) |
PAK2 | inactive (99.73%) |
PAK3 | inactive (105.24%) |
PAK4 | inactive (99.47%) |
PAK5 | inactive (100.5%) |
PAK6 | inactive (107.76%) |
SLK | inactive (90.42%) |
YSK1 | inactive (118.61%) |
STLK3 | inactive (95.3%) |
TAO1 | inactive (84.15%) |
TAO2 | inactive (93.97%) |
TAO3 | inactive (96.19%) |
MYO3B | inactive (104.07%) |
STE - STE7
Bioactivity |
---|
Kinase | RBC |
---|
MAP2K1 | inactive (94.94%) |
MAP2K2 | inactive (105.9%) |
MAP2K6 | inactive (106.9%) |
Other
Other - Aur
Bioactivity |
---|
Kinase | RBC |
---|
AurA | inactive (64.71%) |
AurB | active (34.86%) |
AurC | inactive (71.9%) |
Other - CAMKK
Bioactivity |
---|
Kinase | RBC |
---|
CaMKK1 | inactive (114.66%) |
CaMKK2 | inactive (114.9%) |
Other - Haspin
Bioactivity |
---|
Kinase | RBC |
---|
Haspin | inactive (99.39%) |
Other - IKK
Bioactivity |
---|
Kinase | RBC |
---|
IKKa | inactive (104.95%) |
IKKb | inactive (109.39%) |
IKKe | inactive (95.02%) |
TBK1 | inactive (95.66%) |
Other - NEK
Bioactivity |
---|
Kinase | RBC |
---|
NEK1 | inactive (100.49%) |
NEK11 | inactive (84.23%) |
NEK2 | inactive (104.81%) |
NEK4 | inactive (95.25%) |
NEK6 | inactive (93.34%) |
NEK7 | inactive (102.73%) |
NEK9 | inactive (98.56%) |
NEK3 | inactive (91.1%) |
Other - TOPK
Bioactivity |
---|
Kinase | RBC |
---|
PBK | inactive (98.61%) |
Other - PLK
Bioactivity |
---|
Kinase | RBC |
---|
PLK1 | inactive (101.24%) |
PLK2 | inactive (101.3%) |
PLK3 | inactive (98.39%) |
Other - SgK496
Bioactivity |
---|
Kinase | RBC |
---|
SgK496 | inactive (104.82%) |
Other - NAK
Bioactivity |
---|
Kinase | RBC |
---|
MPSK1 | inactive (97.9%) |
Other - TTK
Bioactivity |
---|
Kinase | RBC |
---|
TTK | inactive (111.33%) |
Other - ULK
Bioactivity |
---|
Kinase | RBC |
---|
ULK1 | inactive (51.77%) |
ULK2 | inactive (98.75%) |
ULK3 | inactive (83.21%) |
Other - WEE
Bioactivity |
---|
Kinase | RBC |
---|
Wee1 | inactive (96.28%) |
Other - WNK
Bioactivity |
---|
Kinase | RBC |
---|
Wnk2 | inactive (98.03%) |
Wnk3 | inactive (97.25%) |
Other - TLK
Bioactivity |
---|
Kinase | RBC |
---|
TLK2 | inactive (97.68%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | RBC |
---|
CK1 | 7 | 6 |
VRK | 3 | 1 |
CK1 - CK1
Bioactivity |
---|
Kinase | RBC |
---|
CK1d | inactive (107.39%) |
CK1g1 | inactive (92.36%) |
CK1g2 | inactive (95.1%) |
CK1g3 | inactive (106.29%) |
CK1a | inactive (98.87%) |
CK1e | inactive (100.26%) |
CK1 - VRK
Bioactivity |
---|
Kinase | RBC |
---|
VRK1 | inactive (102.5%) |
CMGC
CMGC - CK2
Bioactivity |
---|
Kinase | RBC |
---|
CK2a1 | inactive (95.03%) |
CK2a2 | inactive (99.35%) |
CMGC - CLK
Bioactivity |
---|
Kinase | RBC |
---|
CLK1 | inactive (104.38%) |
CLK2 | inactive (101.84%) |
CLK3 | inactive (95.92%) |
CLK4 | inactive (105.39%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | RBC |
---|
DYRK1A | inactive (93.11%) |
DYRK1B | inactive (100.55%) |
DYRK2 | inactive (101.18%) |
DYRK3 | inactive (106.53%) |
DYRK4 | inactive (90.35%) |
HIPK1 | inactive (99.09%) |
HIPK2 | inactive (90.2%) |
HIPK3 | inactive (104.59%) |
HIPK4 | inactive (91.15%) |
CMGC - MAPK
Bioactivity |
---|
Kinase | RBC |
---|
Erk1 | inactive (102.77%) |
Erk2 | inactive (102.8%) |
JNK3 | inactive (103.45%) |
NLK | inactive (99.58%) |
p38a | inactive (110.24%) |
p38b | inactive (101.08%) |
p38d | inactive (119.15%) |
p38g | inactive (106.53%) |
JNK1 | inactive (98.81%) |
JNK2 | inactive (106.04%) |
CMGC - GSK
Bioactivity |
---|
Kinase | RBC |
---|
GSK3A | inactive (99.59%) |
GSK3B | inactive (106.2%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | RBC |
---|
MSSK1 | inactive (99.87%) |
SRPK1 | inactive (103.38%) |
SRPK2 | inactive (97.12%) |
Atypical
Atypical
Test Member No. in Family |
---|
Family | no. Member on 518kinase | RBC |
---|
PDHK | 5 | 1 |
Atypical - PDHK
Bioactivity |
---|
Kinase | RBC |
---|
PDHK1 | inactive (97.78%) |