Compound Information
Test on : GPCR
Compound Name : GW627512B
Inchikey : CKYLEUNHWFIYOR-UHFFFAOYSA-N
ChemSpider : 4487005
Pubchem CID : 5329854
ChEMBL : CHEMBL443563
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
TK
TK - JakA
Bioactivity |
---|
Kinase | GPCR |
---|
JAK1 | inactive (-0.54%) |
TYK2 | inactive (6.55%) |
JAK2 | inactive (5.24%) |
JAK3 | inactive (12.65%) |
TK - Fer
Bioactivity |
---|
Kinase | GPCR |
---|
FER | inactive (2.66%) |
FES | inactive (-1.45%) |
TK - Abl
Bioactivity |
---|
Kinase | GPCR |
---|
ABL1 | active (52.34%) |
ABL2 | active (52.07%) |
TK - Csk
Bioactivity |
---|
Kinase | GPCR |
---|
CSK | inactive (-0.86%) |
TK - Tec
Bioactivity |
---|
Kinase | GPCR |
---|
BMX | inactive (8.49%) |
BTK | inactive (0.25%) |
TXK | inactive (16.18%) |
TEC | inactive (4.55%) |
ITK | inactive (2.92%) |
TK - Src
Bioactivity |
---|
Kinase | GPCR |
---|
BRK | inactive (4.16%) |
SRM | inactive (3.83%) |
FRK | inactive (4.26%) |
BLK | inactive (41.11%) |
LCK | inactive (25.02%) |
HCK | inactive (31.25%) |
FGR | inactive (29.4%) |
FYN | inactive (37.54%) |
SRC | active (72.42%) |
YES | inactive (46.61%) |
TK - Eph
Bioactivity |
---|
Kinase | GPCR |
---|
EphA2 | inactive (-1.26%) |
EphA4 | inactive (1.47%) |
EphA3 | inactive (-5.8%) |
EphB4 | inactive (3.25%) |
EphB3 | inactive (-2.19%) |
EphB2 | inactive (5.83%) |
TK - FAK
Bioactivity |
---|
Kinase | GPCR |
---|
PYK2 | inactive (5.39%) |
TK - Syk
Bioactivity |
---|
Kinase | GPCR |
---|
SYK | inactive (-1.68%) |
ZAP70 | inactive (0.62%) |
TK - ALK
Bioactivity |
---|
Kinase | GPCR |
---|
LTK | inactive (1.47%) |
ALK | inactive (-0.68%) |
TK - Sev
Bioactivity |
---|
Kinase | GPCR |
---|
ROS | inactive (15.84%) |
TK - InsR
Bioactivity |
---|
Kinase | GPCR |
---|
INSR | inactive (-0.22%) |
IGF1R | inactive (2.07%) |
IRR | inactive (-1.95%) |
TK - DDR
Bioactivity |
---|
Kinase | GPCR |
---|
DDR2 | inactive (8.58%) |
TK - Musk
Bioactivity |
---|
Kinase | GPCR |
---|
MUSK | inactive (14.47%) |
TK - Trk
Bioactivity |
---|
Kinase | GPCR |
---|
TRKA | inactive (23.09%) |
TRKB | inactive (28.27%) |
TRKC | inactive (25.25%) |
TK - Met
Bioactivity |
---|
Kinase | GPCR |
---|
RON | inactive (3.47%) |
MET | inactive (2.13%) |
TK - Axl
Bioactivity |
---|
Kinase | GPCR |
---|
AXL | inactive (-1.68%) |
MER | inactive (3.53%) |
TYRO3 | inactive (1.3%) |
TK - Ret
Bioactivity |
---|
Kinase | GPCR |
---|
RET | inactive (15.51%) |
TK - FGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FGFR1 | inactive (8.79%) |
FGFR2 | inactive (26.97%) |
FGFR3 | inactive (16.62%) |
FGFR4 | inactive (1.36%) |
TK - VEGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FLT1 | - |
KDR | inactive (47.95%) |
FLT4 | inactive (36.72%) |
TK - PDGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FMS | active (57.64%) |
KIT | active (98.71%) |
FLT3 | active (90.85%) |
PDGFRa | active (69.58%) |
PDGFRb | active (74.18%) |
TK - Tie
Bioactivity |
---|
Kinase | GPCR |
---|
TIE2 | inactive (5.14%) |
TK - Ack
Bioactivity |
---|
Kinase | GPCR |
---|
ACK | inactive (0.48%) |
TNK1 | inactive (28.38%) |
TK - EGFR
Bioactivity |
---|
Kinase | GPCR |
---|
EGFR | inactive (13.8%) |
ErbB2 | inactive (-1.74%) |
ErbB4 | inactive (-2.66%) |
TKL
TKL
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
IRAK | 4 | 1 |
RAF | 5 | 1 |
TKL - IRAK
Bioactivity |
---|
Kinase | GPCR |
---|
IRAK4 | inactive (0.55%) |
TKL - RAF
Bioactivity |
---|
Kinase | GPCR |
---|
BRAF | inactive (-1.94%) |
STE
STE
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
STE20 | 31 | 12 |
STE7 | 7 | 1 |
STE - STE20
Bioactivity |
---|
Kinase | GPCR |
---|
GCK | inactive (11.47%) |
MST1 | - |
MST2 | inactive (-1.87%) |
MST4 | inactive (-4.83%) |
HGK | inactive (26.44%) |
MINK | inactive (17.27%) |
LOK | inactive (11.12%) |
PAK1 | inactive (-0.52%) |
PAK3 | inactive (-0.07%) |
PAK2 | inactive (-0.61%) |
PAK5 | inactive (7.2%) |
PAK6 | inactive (-10.78%) |
STE - STE7
Bioactivity |
---|
Kinase | GPCR |
---|
MAP2K1 | inactive (0.69%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
CK1 | 7 | 4 |
CK1 - CK1
Bioactivity |
---|
Kinase | GPCR |
---|
CK1a | inactive (1.29%) |
CK1g2 | inactive (-0.69%) |
CK1g1 | inactive (-0.76%) |
CK1g3 | inactive (-0.18%) |
Other
Other
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
PLK | 4 | 1 |
Aur | 3 | 3 |
NEK | 11 | 5 |
IKK | 4 | 4 |
TTK | 1 | 1 |
Other - PLK
Bioactivity |
---|
Kinase | GPCR |
---|
PLK1 | inactive (2.1%) |
Other - Aur
Bioactivity |
---|
Kinase | GPCR |
---|
AurB | inactive (49.98%) |
AurC | active (71.77%) |
AurA | active (75.5%) |
Other - NEK
Bioactivity |
---|
Kinase | GPCR |
---|
NEK1 | inactive (1.71%) |
NEK2 | inactive (-0.62%) |
NEK9 | inactive (8.49%) |
NEK7 | inactive (3.67%) |
NEK6 | inactive (-3.53%) |
Other - IKK
Bioactivity |
---|
Kinase | GPCR |
---|
TBK1 | inactive (13.74%) |
IKKe | inactive (1.15%) |
IKKb | inactive (4.06%) |
IKKa | inactive (4.62%) |
Other - TTK
Bioactivity |
---|
Kinase | GPCR |
---|
TTK | inactive (-1.01%) |
AGC
AGC - GRK
Bioactivity |
---|
Kinase | GPCR |
---|
GPRK7 | inactive (-9.33%) |
GPRK6 | inactive (-0.02%) |
AGC - PDK1
Bioactivity |
---|
Kinase | GPCR |
---|
PDK1 | inactive (6.05%) |
AGC - RSK
Bioactivity |
---|
Kinase | GPCR |
---|
MSK1 | inactive (0.82%) |
MSK2 | inactive (0.02%) |
RSK1 | inactive (3.07%) |
RSK2 | inactive (2.83%) |
RSK4 | inactive (6.6%) |
RSK3 | inactive (6.88%) |
p70S6K | inactive (3.55%) |
AGC - Akt
Bioactivity |
---|
Kinase | GPCR |
---|
AKT2 | inactive (-1.88%) |
AKT1 | inactive (-1.61%) |
AKT3 | inactive (1.14%) |
AGC - SGK
Bioactivity |
---|
Kinase | GPCR |
---|
SGK1 | inactive (5.44%) |
SGK3 | inactive (0.29%) |
SGK2 | inactive (1.18%) |
AGC - PKC
Bioactivity |
---|
Kinase | GPCR |
---|
PKCh | inactive (-4.38%) |
PKCg | inactive (1.46%) |
PKCa | inactive (1.1%) |
PKCt | inactive (-0.9%) |
PKCi | inactive (0.77%) |
AGC - PKG
Bioactivity |
---|
Kinase | GPCR |
---|
PKG2 | inactive (1.47%) |
PKG1 | inactive (1.3%) |
AGC - PKA
Bioactivity |
---|
Kinase | GPCR |
---|
PRKX | inactive (0.75%) |
AGC - DMPK
Bioactivity |
---|
Kinase | GPCR |
---|
ROCK1 | inactive (1.85%) |
ROCK2 | inactive (3.74%) |
MRCKb | inactive (0.86%) |
MRCKa | inactive (3.73%) |
CAMK
CAMK - RAD53
Bioactivity |
---|
Kinase | GPCR |
---|
CHK2 | inactive (1.28%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
DCLK2 | inactive (1.6%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK4 | inactive (0.09%) |
CaMK1d | inactive (-0.01%) |
CAMK - PHK
Bioactivity |
---|
Kinase | GPCR |
---|
PHKg1 | inactive (20.86%) |
PHKg2 | inactive (-2.15%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK2d | inactive (5.55%) |
CaMK2a | inactive (-0.38%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | GPCR |
---|
MAPKAPK5 | inactive (0.01%) |
MAPKAPK2 | inactive (-0.59%) |
MAPKAPK3 | inactive (-2.22%) |
MNK2 | inactive (24.2%) |
MNK1 | inactive (30.45%) |
CAMK - PKD
Bioactivity |
---|
Kinase | GPCR |
---|
PKD3 | inactive (-1.6%) |
PKD1 | inactive (-1.47%) |
PKD2 | inactive (-0.05%) |
CAMK - CAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
MARK4 | inactive (13.44%) |
MARK3 | inactive (22.12%) |
MARK1 | inactive (15.58%) |
QIK | inactive (30.6%) |
SIK | inactive (27.36%) |
NuaK1 | active (60.95%) |
BRSK1 | inactive (5.91%) |
BRSK2 | inactive (10.52%) |
MELK | inactive (5.74%) |
CHK1 | inactive (5.64%) |
PASK | inactive (-0.67%) |
AMPKa1 | inactive (9.16%) |
AMPKa2 | inactive (5.35%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | GPCR |
---|
TSSK2 | inactive (-1.3%) |
TSSK1 | inactive (-0.04%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | GPCR |
---|
DAPK1 | inactive (1.28%) |
CAMK - PIM
Bioactivity |
---|
Kinase | GPCR |
---|
PIM2 | inactive (1.06%) |
PIM3 | inactive (1.87%) |
PIM1 | inactive (2.12%) |
CMGC
CMGC - MAPK
Bioactivity |
---|
Kinase | GPCR |
---|
JNK2 | inactive (-3.35%) |
p38a | inactive (-4.25%) |
p38b | inactive (0.04%) |
p38d | inactive (-1.63%) |
Erk2 | inactive (-1.83%) |
Erk1 | inactive (1.29%) |
CMGC - GSK
Bioactivity |
---|
Kinase | GPCR |
---|
GSK3A | inactive (34.44%) |
GSK3B | inactive (35.8%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | GPCR |
---|
SRPK1 | inactive (1%) |
MSSK1 | inactive (0.18%) |
CMGC - CLK
Bioactivity |
---|
Kinase | GPCR |
---|
CLK3 | inactive (0.88%) |
CLK2 | inactive (3.33%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | GPCR |
---|
HIPK1 | inactive (11.24%) |
HIPK4 | inactive (3.87%) |
DYRK1B | inactive (3.72%) |
DYRK1A | inactive (6.39%) |
DYRK2 | inactive (-1.69%) |
CMGC - CK2
Bioactivity |
---|
Kinase | GPCR |
---|
CK2a1 | inactive (4.02%) |