Compound Information
Test on : GPCR
Compound Name : SB-678557-A
Inchikey : CEWYEPGTYHBUBR-UHFFFAOYSA-N
ChemSpider : 28483703
Pubchem CID : 57400545
ChEMBL : CHEMBL1909344
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
TK
TK - JakA
Bioactivity |
---|
Kinase | GPCR |
---|
JAK1 | inactive (17.56%) |
TYK2 | inactive (-0.97%) |
JAK2 | inactive (1.05%) |
JAK3 | inactive (-0.3%) |
TK - Fer
Bioactivity |
---|
Kinase | GPCR |
---|
FER | inactive (5.92%) |
FES | inactive (3.43%) |
TK - Abl
Bioactivity |
---|
Kinase | GPCR |
---|
ABL1 | inactive (4.42%) |
ABL2 | inactive (2.58%) |
TK - Csk
Bioactivity |
---|
Kinase | GPCR |
---|
CSK | inactive (6.5%) |
TK - Tec
Bioactivity |
---|
Kinase | GPCR |
---|
BMX | inactive (3.87%) |
BTK | inactive (-0.24%) |
TXK | inactive (4.13%) |
TEC | inactive (4.52%) |
ITK | inactive (2.38%) |
TK - Src
Bioactivity |
---|
Kinase | GPCR |
---|
BRK | inactive (6.78%) |
SRM | inactive (-5.75%) |
FRK | inactive (2.86%) |
BLK | inactive (1.79%) |
LCK | inactive (4.09%) |
HCK | inactive (7.61%) |
FGR | inactive (4.46%) |
FYN | inactive (3.89%) |
SRC | inactive (8.13%) |
YES | inactive (3.47%) |
TK - Eph
Bioactivity |
---|
Kinase | GPCR |
---|
EphA2 | inactive (2.09%) |
EphA4 | inactive (8.45%) |
EphA3 | inactive (2.66%) |
EphB4 | inactive (1.12%) |
EphB3 | inactive (4.08%) |
EphB2 | inactive (3.41%) |
TK - FAK
Bioactivity |
---|
Kinase | GPCR |
---|
PYK2 | inactive (15.19%) |
TK - Syk
Bioactivity |
---|
Kinase | GPCR |
---|
SYK | inactive (-1.15%) |
ZAP70 | inactive (5.43%) |
TK - ALK
Bioactivity |
---|
Kinase | GPCR |
---|
LTK | inactive (4.51%) |
ALK | inactive (6.61%) |
TK - Sev
Bioactivity |
---|
Kinase | GPCR |
---|
ROS | inactive (9.8%) |
TK - InsR
Bioactivity |
---|
Kinase | GPCR |
---|
INSR | inactive (4.86%) |
IGF1R | inactive (4.17%) |
IRR | inactive (2.13%) |
TK - DDR
Bioactivity |
---|
Kinase | GPCR |
---|
DDR2 | inactive (1%) |
TK - Musk
Bioactivity |
---|
Kinase | GPCR |
---|
MUSK | inactive (5.06%) |
TK - Trk
Bioactivity |
---|
Kinase | GPCR |
---|
TRKA | inactive (1.65%) |
TRKB | inactive (5.68%) |
TRKC | inactive (6.56%) |
TK - Met
Bioactivity |
---|
Kinase | GPCR |
---|
RON | inactive (14.06%) |
MET | inactive (3.43%) |
TK - Axl
Bioactivity |
---|
Kinase | GPCR |
---|
AXL | inactive (-12.54%) |
MER | inactive (7.11%) |
TYRO3 | inactive (5.28%) |
TK - Ret
Bioactivity |
---|
Kinase | GPCR |
---|
RET | inactive (2.61%) |
TK - FGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FGFR1 | inactive (4.3%) |
FGFR2 | inactive (5.58%) |
FGFR3 | inactive (4.99%) |
FGFR4 | inactive (-0.57%) |
TK - VEGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FLT1 | inactive (2.94%) |
KDR | inactive (10.62%) |
FLT4 | inactive (3.3%) |
TK - PDGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FMS | inactive (3.05%) |
KIT | inactive (8.5%) |
FLT3 | inactive (1.88%) |
PDGFRa | inactive (16.48%) |
PDGFRb | inactive (7.79%) |
TK - Tie
Bioactivity |
---|
Kinase | GPCR |
---|
TIE2 | inactive (7%) |
TK - Ack
Bioactivity |
---|
Kinase | GPCR |
---|
ACK | inactive (1.85%) |
TNK1 | inactive (7.95%) |
TK - EGFR
Bioactivity |
---|
Kinase | GPCR |
---|
EGFR | inactive (7.57%) |
ErbB2 | inactive (14.15%) |
ErbB4 | inactive (24.22%) |
TKL
TKL
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
IRAK | 4 | 1 |
RAF | 5 | 1 |
TKL - IRAK
Bioactivity |
---|
Kinase | GPCR |
---|
IRAK4 | inactive (2.54%) |
TKL - RAF
Bioactivity |
---|
Kinase | GPCR |
---|
BRAF | inactive (7.83%) |
STE
STE
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
STE20 | 31 | 12 |
STE7 | 7 | 1 |
STE - STE20
Bioactivity |
---|
Kinase | GPCR |
---|
GCK | inactive (3.35%) |
MST1 | inactive (12.99%) |
MST2 | inactive (9.3%) |
MST4 | inactive (1.63%) |
HGK | inactive (14.08%) |
MINK | inactive (14.55%) |
LOK | inactive (9.99%) |
PAK1 | inactive (7.32%) |
PAK3 | inactive (6.46%) |
PAK2 | inactive (2.25%) |
PAK5 | inactive (6.52%) |
PAK6 | inactive (-6.17%) |
STE - STE7
Bioactivity |
---|
Kinase | GPCR |
---|
MAP2K1 | inactive (5.56%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
CK1 | 7 | 4 |
CK1 - CK1
Bioactivity |
---|
Kinase | GPCR |
---|
CK1a | inactive (4%) |
CK1g2 | inactive (6.16%) |
CK1g1 | inactive (5.43%) |
CK1g3 | inactive (4.71%) |
Other
Other
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
PLK | 4 | 1 |
Aur | 3 | 3 |
NEK | 11 | 5 |
IKK | 4 | 4 |
TTK | 1 | 1 |
Other - PLK
Bioactivity |
---|
Kinase | GPCR |
---|
PLK1 | inactive (4.03%) |
Other - Aur
Bioactivity |
---|
Kinase | GPCR |
---|
AurB | inactive (9.47%) |
AurC | inactive (-2.07%) |
AurA | inactive (8.78%) |
Other - NEK
Bioactivity |
---|
Kinase | GPCR |
---|
NEK1 | inactive (4.86%) |
NEK2 | inactive (4.22%) |
NEK9 | inactive (19.2%) |
NEK7 | inactive (4.97%) |
NEK6 | inactive (0.5%) |
Other - IKK
Bioactivity |
---|
Kinase | GPCR |
---|
TBK1 | inactive (3.05%) |
IKKe | inactive (6.54%) |
IKKb | inactive (12.45%) |
IKKa | inactive (1.13%) |
Other - TTK
Bioactivity |
---|
Kinase | GPCR |
---|
TTK | inactive (15.04%) |
AGC
AGC - GRK
Bioactivity |
---|
Kinase | GPCR |
---|
GPRK7 | inactive (15.64%) |
GPRK6 | inactive (14.5%) |
AGC - PDK1
Bioactivity |
---|
Kinase | GPCR |
---|
PDK1 | inactive (1%) |
AGC - RSK
Bioactivity |
---|
Kinase | GPCR |
---|
MSK1 | inactive (-1.22%) |
MSK2 | inactive (4.31%) |
RSK1 | inactive (3.41%) |
RSK2 | inactive (3.98%) |
RSK4 | inactive (1.86%) |
RSK3 | inactive (3.15%) |
p70S6K | inactive (2.47%) |
AGC - Akt
Bioactivity |
---|
Kinase | GPCR |
---|
AKT2 | inactive (1.57%) |
AKT1 | inactive (0.53%) |
AKT3 | inactive (2.79%) |
AGC - SGK
Bioactivity |
---|
Kinase | GPCR |
---|
SGK1 | inactive (6.62%) |
SGK3 | inactive (5.04%) |
SGK2 | inactive (3.52%) |
AGC - PKC
Bioactivity |
---|
Kinase | GPCR |
---|
PKCh | inactive (5.6%) |
PKCg | inactive (5.3%) |
PKCa | inactive (1.72%) |
PKCt | inactive (3.84%) |
PKCi | inactive (0.85%) |
AGC - PKG
Bioactivity |
---|
Kinase | GPCR |
---|
PKG2 | inactive (4.4%) |
PKG1 | inactive (5.14%) |
AGC - PKA
Bioactivity |
---|
Kinase | GPCR |
---|
PRKX | inactive (6.09%) |
AGC - DMPK
Bioactivity |
---|
Kinase | GPCR |
---|
ROCK1 | inactive (1.3%) |
ROCK2 | inactive (7.43%) |
MRCKb | inactive (0.78%) |
MRCKa | inactive (2.63%) |
CAMK
CAMK - RAD53
Bioactivity |
---|
Kinase | GPCR |
---|
CHK2 | inactive (3.84%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
DCLK2 | inactive (-0.83%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK4 | inactive (-2.3%) |
CaMK1d | inactive (1.89%) |
CAMK - PHK
Bioactivity |
---|
Kinase | GPCR |
---|
PHKg1 | inactive (11.31%) |
PHKg2 | inactive (9.48%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK2d | inactive (3.34%) |
CaMK2a | inactive (3.81%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | GPCR |
---|
MAPKAPK5 | inactive (3.73%) |
MAPKAPK2 | inactive (-0.73%) |
MAPKAPK3 | inactive (-1.95%) |
MNK2 | inactive (8.1%) |
MNK1 | inactive (13.6%) |
CAMK - PKD
Bioactivity |
---|
Kinase | GPCR |
---|
PKD3 | inactive (5.47%) |
PKD1 | inactive (6.32%) |
PKD2 | inactive (6.42%) |
CAMK - CAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
MARK4 | inactive (3.02%) |
MARK3 | inactive (4.62%) |
MARK1 | inactive (5.96%) |
QIK | inactive (8.16%) |
SIK | inactive (7.57%) |
NuaK1 | inactive (3.89%) |
BRSK1 | inactive (4.22%) |
BRSK2 | inactive (6.52%) |
MELK | inactive (5.92%) |
CHK1 | inactive (-0.12%) |
PASK | inactive (0.71%) |
AMPKa1 | inactive (5.95%) |
AMPKa2 | inactive (5.01%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | GPCR |
---|
TSSK2 | inactive (6.08%) |
TSSK1 | inactive (6.95%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | GPCR |
---|
DAPK1 | inactive (-2.32%) |
CAMK - PIM
Bioactivity |
---|
Kinase | GPCR |
---|
PIM2 | inactive (1.49%) |
PIM3 | inactive (3.84%) |
PIM1 | inactive (3.41%) |
CMGC
CMGC - MAPK
Bioactivity |
---|
Kinase | GPCR |
---|
JNK2 | inactive (5.52%) |
p38a | inactive (5.41%) |
p38b | inactive (5.33%) |
p38d | inactive (5.59%) |
Erk2 | inactive (5.71%) |
Erk1 | inactive (7.39%) |
CMGC - GSK
Bioactivity |
---|
Kinase | GPCR |
---|
GSK3A | active (85.66%) |
GSK3B | active (84.18%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | GPCR |
---|
SRPK1 | inactive (-0.73%) |
MSSK1 | inactive (-1.01%) |
CMGC - CLK
Bioactivity |
---|
Kinase | GPCR |
---|
CLK3 | inactive (2.52%) |
CLK2 | inactive (2.3%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | GPCR |
---|
HIPK1 | inactive (9.2%) |
HIPK4 | inactive (4.44%) |
DYRK1B | inactive (31.87%) |
DYRK1A | inactive (33.93%) |
DYRK2 | inactive (9.37%) |
CMGC - CK2
Bioactivity |
---|
Kinase | GPCR |
---|
CK2a1 | inactive (12.23%) |