Compound Information
Test on : GPCR
Compound Name : GSK1023156A
Inchikey : BWZJWBWWGBNPLH-UHFFFAOYSA-N
ChemSpider : 24717480
Pubchem CID : 25263083
ChEMBL : CHEMBL518953
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
TK
TK - JakA
Bioactivity |
---|
Kinase | GPCR |
---|
JAK1 | inactive (3.98%) |
TYK2 | inactive (-4.77%) |
JAK2 | inactive (2.84%) |
JAK3 | inactive (0.23%) |
TK - Fer
Bioactivity |
---|
Kinase | GPCR |
---|
FER | inactive (3.22%) |
FES | inactive (4.01%) |
TK - Abl
Bioactivity |
---|
Kinase | GPCR |
---|
ABL1 | inactive (9.67%) |
ABL2 | inactive (7.23%) |
TK - Csk
Bioactivity |
---|
Kinase | GPCR |
---|
CSK | inactive (2.18%) |
TK - Tec
Bioactivity |
---|
Kinase | GPCR |
---|
BMX | inactive (4.96%) |
BTK | inactive (-0.19%) |
TXK | inactive (5.57%) |
TEC | inactive (4.76%) |
ITK | inactive (2.17%) |
TK - Src
Bioactivity |
---|
Kinase | GPCR |
---|
BRK | inactive (7.25%) |
SRM | inactive (-2.44%) |
FRK | inactive (3.29%) |
BLK | inactive (3.7%) |
LCK | inactive (5.49%) |
HCK | inactive (7.03%) |
FGR | inactive (6.14%) |
FYN | inactive (6.19%) |
SRC | inactive (12.87%) |
YES | inactive (7.85%) |
TK - Eph
Bioactivity |
---|
Kinase | GPCR |
---|
EphA2 | inactive (0.39%) |
EphA4 | inactive (9.89%) |
EphA3 | inactive (3.38%) |
EphB4 | inactive (3.37%) |
EphB3 | inactive (6.83%) |
EphB2 | inactive (10.93%) |
TK - FAK
Bioactivity |
---|
Kinase | GPCR |
---|
PYK2 | inactive (6.52%) |
TK - Syk
Bioactivity |
---|
Kinase | GPCR |
---|
SYK | inactive (-0.37%) |
ZAP70 | inactive (-2.62%) |
TK - ALK
Bioactivity |
---|
Kinase | GPCR |
---|
LTK | inactive (6.11%) |
ALK | inactive (6.94%) |
TK - Sev
Bioactivity |
---|
Kinase | GPCR |
---|
ROS | inactive (10.13%) |
TK - InsR
Bioactivity |
---|
Kinase | GPCR |
---|
INSR | inactive (5.25%) |
IGF1R | inactive (3.04%) |
IRR | inactive (3.4%) |
TK - DDR
Bioactivity |
---|
Kinase | GPCR |
---|
DDR2 | inactive (1.6%) |
TK - Musk
Bioactivity |
---|
Kinase | GPCR |
---|
MUSK | inactive (7.28%) |
TK - Trk
Bioactivity |
---|
Kinase | GPCR |
---|
TRKA | inactive (5.34%) |
TRKB | inactive (4.07%) |
TRKC | inactive (3.41%) |
TK - Met
Bioactivity |
---|
Kinase | GPCR |
---|
RON | inactive (9.57%) |
MET | inactive (6.5%) |
TK - Axl
Bioactivity |
---|
Kinase | GPCR |
---|
AXL | inactive (-4.14%) |
MER | inactive (2.98%) |
TYRO3 | inactive (1.89%) |
TK - Ret
Bioactivity |
---|
Kinase | GPCR |
---|
RET | inactive (12.66%) |
TK - FGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FGFR1 | inactive (6.22%) |
FGFR2 | inactive (4.79%) |
FGFR3 | inactive (4.87%) |
FGFR4 | inactive (0.92%) |
TK - VEGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FLT1 | inactive (4.57%) |
KDR | inactive (13.62%) |
FLT4 | inactive (4.24%) |
TK - PDGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FMS | inactive (7.89%) |
KIT | inactive (5.34%) |
FLT3 | inactive (1%) |
PDGFRa | inactive (15.42%) |
PDGFRb | inactive (14.37%) |
TK - Tie
Bioactivity |
---|
Kinase | GPCR |
---|
TIE2 | inactive (6.42%) |
TK - Ack
Bioactivity |
---|
Kinase | GPCR |
---|
ACK | inactive (1.87%) |
TNK1 | inactive (18.87%) |
TK - EGFR
Bioactivity |
---|
Kinase | GPCR |
---|
EGFR | inactive (0.93%) |
ErbB2 | inactive (3.64%) |
ErbB4 | inactive (9.23%) |
TKL
TKL
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
IRAK | 4 | 1 |
RAF | 5 | 1 |
TKL - IRAK
Bioactivity |
---|
Kinase | GPCR |
---|
IRAK4 | inactive (2.57%) |
TKL - RAF
Bioactivity |
---|
Kinase | GPCR |
---|
BRAF | inactive (6.15%) |
STE
STE
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
STE20 | 31 | 12 |
STE7 | 7 | 1 |
STE - STE20
Bioactivity |
---|
Kinase | GPCR |
---|
GCK | inactive (8.46%) |
MST1 | inactive (7.07%) |
MST2 | inactive (5.83%) |
MST4 | inactive (-2.12%) |
HGK | inactive (11.28%) |
MINK | inactive (9.1%) |
LOK | active (60.62%) |
PAK1 | inactive (10.04%) |
PAK3 | inactive (5.89%) |
PAK2 | inactive (2.45%) |
PAK5 | inactive (5.06%) |
PAK6 | inactive (-4.72%) |
STE - STE7
Bioactivity |
---|
Kinase | GPCR |
---|
MAP2K1 | inactive (4.35%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
CK1 | 7 | 4 |
CK1 - CK1
Bioactivity |
---|
Kinase | GPCR |
---|
CK1a | inactive (7.23%) |
CK1g2 | inactive (5.04%) |
CK1g1 | inactive (5.15%) |
CK1g3 | inactive (3.56%) |
Other
Other
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
PLK | 4 | 1 |
Aur | 3 | 3 |
NEK | 11 | 5 |
IKK | 4 | 4 |
TTK | 1 | 1 |
Other - PLK
Bioactivity |
---|
Kinase | GPCR |
---|
PLK1 | active (95.28%) |
Other - Aur
Bioactivity |
---|
Kinase | GPCR |
---|
AurB | inactive (9.94%) |
AurC | inactive (8.84%) |
AurA | inactive (4.39%) |
Other - NEK
Bioactivity |
---|
Kinase | GPCR |
---|
NEK1 | inactive (2.24%) |
NEK2 | inactive (3.39%) |
NEK9 | inactive (23.51%) |
NEK7 | inactive (9.69%) |
NEK6 | inactive (2.86%) |
Other - IKK
Bioactivity |
---|
Kinase | GPCR |
---|
TBK1 | inactive (2.68%) |
IKKe | inactive (6.21%) |
IKKb | inactive (5.66%) |
IKKa | inactive (7.53%) |
Other - TTK
Bioactivity |
---|
Kinase | GPCR |
---|
TTK | inactive (12.99%) |
AGC
AGC - GRK
Bioactivity |
---|
Kinase | GPCR |
---|
GPRK7 | inactive (4.5%) |
GPRK6 | inactive (3.01%) |
AGC - PDK1
Bioactivity |
---|
Kinase | GPCR |
---|
PDK1 | inactive (3.04%) |
AGC - RSK
Bioactivity |
---|
Kinase | GPCR |
---|
MSK1 | inactive (10.03%) |
MSK2 | inactive (4.72%) |
RSK1 | inactive (3.02%) |
RSK2 | inactive (2.97%) |
RSK4 | inactive (5.17%) |
RSK3 | inactive (4.96%) |
p70S6K | inactive (4.06%) |
AGC - Akt
Bioactivity |
---|
Kinase | GPCR |
---|
AKT2 | inactive (3.59%) |
AKT1 | inactive (1.07%) |
AKT3 | inactive (4.09%) |
AGC - SGK
Bioactivity |
---|
Kinase | GPCR |
---|
SGK1 | inactive (2.46%) |
SGK3 | inactive (2.42%) |
SGK2 | inactive (4.07%) |
AGC - PKC
Bioactivity |
---|
Kinase | GPCR |
---|
PKCh | inactive (2.7%) |
PKCg | inactive (3.85%) |
PKCa | inactive (2.92%) |
PKCt | inactive (2.63%) |
PKCi | inactive (-0.46%) |
AGC - PKG
Bioactivity |
---|
Kinase | GPCR |
---|
PKG2 | inactive (5.73%) |
PKG1 | inactive (5.69%) |
AGC - PKA
Bioactivity |
---|
Kinase | GPCR |
---|
PRKX | inactive (5.64%) |
AGC - DMPK
Bioactivity |
---|
Kinase | GPCR |
---|
ROCK1 | inactive (3.15%) |
ROCK2 | inactive (3.77%) |
MRCKb | inactive (0.28%) |
MRCKa | inactive (4.94%) |
CAMK
CAMK - RAD53
Bioactivity |
---|
Kinase | GPCR |
---|
CHK2 | inactive (10.52%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
DCLK2 | inactive (-0.82%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK4 | inactive (2.57%) |
CaMK1d | inactive (2.21%) |
CAMK - PHK
Bioactivity |
---|
Kinase | GPCR |
---|
PHKg1 | inactive (6.49%) |
PHKg2 | inactive (5.93%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK2d | inactive (7.99%) |
CaMK2a | inactive (3.18%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | GPCR |
---|
MAPKAPK5 | inactive (0.91%) |
MAPKAPK2 | inactive (6.13%) |
MAPKAPK3 | inactive (12.67%) |
MNK2 | inactive (4.3%) |
MNK1 | inactive (11.66%) |
CAMK - PKD
Bioactivity |
---|
Kinase | GPCR |
---|
PKD3 | inactive (8.54%) |
PKD1 | inactive (9.59%) |
PKD2 | inactive (6.86%) |
CAMK - CAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
MARK4 | inactive (5.23%) |
MARK3 | inactive (5.83%) |
MARK1 | inactive (5.92%) |
QIK | inactive (9.83%) |
SIK | inactive (13.57%) |
NuaK1 | inactive (29.11%) |
BRSK1 | inactive (8.3%) |
BRSK2 | inactive (17.05%) |
MELK | inactive (10.06%) |
CHK1 | inactive (13.22%) |
PASK | inactive (-0.07%) |
AMPKa1 | inactive (4.09%) |
AMPKa2 | inactive (4.98%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | GPCR |
---|
TSSK2 | inactive (1.24%) |
TSSK1 | inactive (4.53%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | GPCR |
---|
DAPK1 | inactive (10.57%) |
CAMK - PIM
Bioactivity |
---|
Kinase | GPCR |
---|
PIM2 | inactive (0.78%) |
PIM3 | inactive (3.81%) |
PIM1 | inactive (3.08%) |
CMGC
CMGC - MAPK
Bioactivity |
---|
Kinase | GPCR |
---|
JNK2 | inactive (6%) |
p38a | inactive (23.07%) |
p38b | inactive (4.68%) |
p38d | inactive (5.08%) |
Erk2 | inactive (5.56%) |
Erk1 | inactive (4.22%) |
CMGC - GSK
Bioactivity |
---|
Kinase | GPCR |
---|
GSK3A | inactive (11.91%) |
GSK3B | inactive (11.81%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | GPCR |
---|
SRPK1 | inactive (-2.38%) |
MSSK1 | inactive (-0.72%) |
CMGC - CLK
Bioactivity |
---|
Kinase | GPCR |
---|
CLK3 | inactive (0.92%) |
CLK2 | inactive (5.2%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | GPCR |
---|
HIPK1 | inactive (7.12%) |
HIPK4 | inactive (7.54%) |
DYRK1B | inactive (2.25%) |
DYRK1A | inactive (4.57%) |
DYRK2 | inactive (5.8%) |
CMGC - CK2
Bioactivity |
---|
Kinase | GPCR |
---|
CK2a1 | inactive (5.76%) |