Compound Information
Test on : RBC
Compound Name : roscovitine
Inchikey : BTIHMVBBUGXLCJ-OAHLLOKOSA-N
ChemSpider : 140922
Pubchem CID : 160355
ChEMBL : CHEMBL14762
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
AGC
AGC - PDK1
Bioactivity |
---|
Kinase | RBC |
---|
PDK1 | inactive (87.99%) |
AGC - Akt
Bioactivity |
---|
Kinase | RBC |
---|
AKT1 | inactive (90.35%) |
AKT2 | inactive (102.01%) |
AKT3 | inactive (84.63%) |
AGC - DMPK
Bioactivity |
---|
Kinase | RBC |
---|
DMPK1 | inactive (91.81%) |
MRCKa | inactive (98.42%) |
MRCKb | inactive (100.07%) |
ROCK1 | inactive (108.01%) |
ROCK2 | inactive (91.64%) |
AGC - GRK
Bioactivity |
---|
Kinase | RBC |
---|
BARK1 | inactive (107.9%) |
BARK2 | inactive (99.07%) |
GPRK4 | inactive (92.91%) |
GPRK5 | inactive (100.23%) |
GPRK6 | inactive (102.08%) |
GPRK7 | inactive (84.77%) |
AGC - RSK
Bioactivity |
---|
Kinase | RBC |
---|
MSK1 | inactive (97.35%) |
MSK2 | inactive (100.31%) |
p70S6K | inactive (100.87%) |
p70S6Kb | inactive (100.01%) |
RSK2 | inactive (98.4%) |
RSK4 | inactive (96.75%) |
RSK1 | inactive (102.94%) |
RSK3 | inactive (94.82%) |
AGC - PKA
Bioactivity |
---|
Kinase | RBC |
---|
PKACg | inactive (107.82%) |
PRKX | inactive (124.71%) |
PKACa | inactive (98.32%) |
AGC - PKC
Bioactivity |
---|
Kinase | RBC |
---|
PKCa | inactive (87.14%) |
PKCd | inactive (101.83%) |
PKCe | inactive (98.08%) |
PKCh | inactive (107.83%) |
PKCg | inactive (96.23%) |
PKCi | inactive (91.72%) |
PKCt | inactive (90.01%) |
PKCz | inactive (99.99%) |
PKCb | inactive (96.48%) |
AGC - PKG
Bioactivity |
---|
Kinase | RBC |
---|
PKG2 | inactive (102.47%) |
PKG1 | inactive (109.36%) |
AGC - PKN
Bioactivity |
---|
Kinase | RBC |
---|
PKN1 | inactive (97.83%) |
PKN2 | inactive (97.85%) |
AGC - SGK
Bioactivity |
---|
Kinase | RBC |
---|
SGK1 | inactive (120.43%) |
SGK2 | inactive (107.49%) |
SGK3 | inactive (96.63%) |
AGC - NDR
Bioactivity |
---|
Kinase | RBC |
---|
NDR1 | inactive (109.37%) |
TK
TK - Abl
Bioactivity |
---|
Kinase | RBC |
---|
ABL1 | inactive (102.2%) |
ABL2 | inactive (100.25%) |
TK - Ack
Bioactivity |
---|
Kinase | RBC |
---|
ACK | inactive (96.68%) |
TK - ALK
Bioactivity |
---|
Kinase | RBC |
---|
ALK | inactive (95.61%) |
LTK | inactive (93.49%) |
TK - Axl
Bioactivity |
---|
Kinase | RBC |
---|
AXL | inactive (100.38%) |
MER | inactive (111.82%) |
TYRO3 | inactive (100.69%) |
TK - Src
Bioactivity |
---|
Kinase | RBC |
---|
BLK | inactive (101.57%) |
BRK | inactive (102.56%) |
SRC | inactive (106.62%) |
FGR | inactive (85.22%) |
FRK | inactive (106.12%) |
FYN | inactive (105.74%) |
HCK | inactive (92.86%) |
LCK | inactive (81.06%) |
SRM | inactive (94.43%) |
YES | inactive (91.46%) |
LYN | inactive (95.57%) |
TK - Tec
Bioactivity |
---|
Kinase | RBC |
---|
BMX | inactive (111.19%) |
BTK | inactive (98.16%) |
ITK | inactive (104.68%) |
TEC | inactive (111.09%) |
TXK | inactive (106.44%) |
TK - PDGFR
Bioactivity |
---|
Kinase | RBC |
---|
KIT | inactive (101.46%) |
FLT3 | inactive (90.88%) |
FMS | inactive (109.91%) |
PDGFRb | inactive (91.23%) |
PDGFRa | inactive (98.3%) |
TK - Csk
Bioactivity |
---|
Kinase | RBC |
---|
CSK | inactive (89.3%) |
CTK | inactive (77.64%) |
TK - DDR
Bioactivity |
---|
Kinase | RBC |
---|
DDR2 | inactive (102.43%) |
TK - EGFR
Bioactivity |
---|
Kinase | RBC |
---|
EGFR | inactive (93.41%) |
ErbB2 | inactive (103.46%) |
ErbB4 | inactive (97.64%) |
TK - Eph
Bioactivity |
---|
Kinase | RBC |
---|
EphA1 | inactive (96.59%) |
EphA2 | inactive (92.26%) |
EphA3 | inactive (94.23%) |
EphA4 | inactive (106.83%) |
EphA5 | inactive (104.42%) |
EphA6 | inactive (95.25%) |
EphA7 | inactive (94.96%) |
EphA8 | inactive (105.94%) |
EphB1 | inactive (105%) |
EphB2 | inactive (105.73%) |
EphB3 | inactive (71.62%) |
EphB4 | inactive (90.98%) |
TK - FAK
Bioactivity |
---|
Kinase | RBC |
---|
FAK | inactive (96.03%) |
PYK2 | inactive (99.76%) |
TK - Fer
Bioactivity |
---|
Kinase | RBC |
---|
FER | inactive (96.8%) |
FES | inactive (100.03%) |
TK - FGFR
Bioactivity |
---|
Kinase | RBC |
---|
FGFR1 | inactive (97.75%) |
FGFR2 | inactive (98.47%) |
FGFR3 | inactive (88.86%) |
FGFR4 | inactive (96.69%) |
TK - VEGFR
Bioactivity |
---|
Kinase | RBC |
---|
FLT1 | inactive (98%) |
FLT4 | inactive (93.96%) |
KDR | inactive (96.75%) |
TK - InsR
Bioactivity |
---|
Kinase | RBC |
---|
IGF1R | inactive (88.67%) |
IRR | inactive (94.49%) |
INSR | inactive (97.86%) |
TK - JakA
Bioactivity |
---|
Kinase | RBC |
---|
JAK1 | inactive (98.65%) |
JAK2 | inactive (103.7%) |
JAK3 | inactive (97.04%) |
TYK2 | inactive (87.03%) |
TK - Musk
Bioactivity |
---|
Kinase | RBC |
---|
MUSK | inactive (79.58%) |
TK - Ret
Bioactivity |
---|
Kinase | RBC |
---|
RET | inactive (96.32%) |
TK - Met
Bioactivity |
---|
Kinase | RBC |
---|
RON | inactive (91.49%) |
MET | inactive (95.25%) |
TK - Sev
Bioactivity |
---|
Kinase | RBC |
---|
ROS | inactive (95.21%) |
TK - Syk
Bioactivity |
---|
Kinase | RBC |
---|
SYK | inactive (103.2%) |
ZAP70 | inactive (104.09%) |
TK - Tie
Bioactivity |
---|
Kinase | RBC |
---|
TIE2 | inactive (96.61%) |
TK - Trk
Bioactivity |
---|
Kinase | RBC |
---|
TRKA | inactive (98.07%) |
TRKB | inactive (100.3%) |
TRKC | inactive (93.93%) |
TKL
TKL - STKR
Bioactivity |
---|
Kinase | RBC |
---|
ALK1 | inactive (102.74%) |
ALK2 | inactive (91.56%) |
ALK4 | inactive (112.44%) |
TGFbR1 | inactive (99.93%) |
TGFbR2 | inactive (94.57%) |
TKL - RAF
Bioactivity |
---|
Kinase | RBC |
---|
ARAF | inactive (101.56%) |
BRAF | inactive (92.82%) |
RAF1 | inactive (94.92%) |
TKL - IRAK
Bioactivity |
---|
Kinase | RBC |
---|
IRAK1 | inactive (97.16%) |
IRAK4 | inactive (89.27%) |
TKL - LISK
Bioactivity |
---|
Kinase | RBC |
---|
LIMK1 | inactive (99.01%) |
TKL - LRRK
Bioactivity |
---|
Kinase | RBC |
---|
LRRK2 | inactive (100.04%) |
TKL - MLK
Bioactivity |
---|
Kinase | RBC |
---|
MLK1 | inactive (112.12%) |
MLK2 | inactive (107.7%) |
MLK3 | inactive (100.28%) |
TAK1 | inactive (105.7%) |
ZAK | inactive (99.18%) |
TKL - RIPK
Bioactivity |
---|
Kinase | RBC |
---|
RIPK2 | inactive (101.56%) |
CAMK
CAMK - CAMKL
Bioactivity |
---|
Kinase | RBC |
---|
NuaK1 | inactive (101.72%) |
BRSK1 | inactive (92.02%) |
BRSK2 | inactive (116.04%) |
CHK1 | inactive (93.97%) |
LKB1 | inactive (98.16%) |
MARK1 | inactive (114.84%) |
MARK3 | inactive (97.02%) |
MARK4 | inactive (102.57%) |
MELK | inactive (84.67%) |
PASK | inactive (92.57%) |
QIK | inactive (101.21%) |
NuaK2 | inactive (98.31%) |
MARK2 | inactive (130.2%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | RBC |
---|
CaMK1a | inactive (98.59%) |
CaMK1b | inactive (106.21%) |
CaMK1d | inactive (108.4%) |
CaMK1g | inactive (100.94%) |
CaMK4 | inactive (89.65%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | RBC |
---|
CaMK2a | inactive (100.59%) |
CaMK2b | inactive (105.86%) |
CaMK2d | inactive (102.83%) |
CaMK2g | inactive (107.31%) |
CAMK - RAD53
Bioactivity |
---|
Kinase | RBC |
---|
CHK2 | inactive (96.92%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | RBC |
---|
DAPK1 | inactive (104.71%) |
DAPK2 | inactive (90.96%) |
DRAK1 | inactive (104.4%) |
DAPK3 | inactive (106.04%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | RBC |
---|
DCLK2 | inactive (98.85%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | RBC |
---|
MAPKAPK2 | inactive (100.61%) |
MAPKAPK3 | inactive (95.28%) |
MAPKAPK5 | inactive (97.78%) |
MNK1 | inactive (96.35%) |
MNK2 | inactive (100.29%) |
CAMK - MLCK
Bioactivity |
---|
Kinase | RBC |
---|
smMLCK | inactive (99.06%) |
skMLCK | inactive (102.27%) |
CAMK - PHK
Bioactivity |
---|
Kinase | RBC |
---|
PHKg1 | inactive (89.54%) |
PHKg2 | inactive (91.8%) |
CAMK - PIM
Bioactivity |
---|
Kinase | RBC |
---|
PIM1 | inactive (104.97%) |
PIM2 | inactive (96.27%) |
PIM3 | inactive (96.24%) |
CAMK - PKD
Bioactivity |
---|
Kinase | RBC |
---|
PKD1 | inactive (98.78%) |
PKD3 | inactive (89.4%) |
PKD2 | inactive (89.56%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | RBC |
---|
TSSK1 | inactive (82.11%) |
TSSK2 | inactive (85.27%) |
CAMK - STK33
Bioactivity |
---|
Kinase | RBC |
---|
STK33 | inactive (88.22%) |
STE
STE - STE11
Bioactivity |
---|
Kinase | RBC |
---|
MAP3K5 | inactive (101.32%) |
MAP3K2 | inactive (123.04%) |
MAP3K3 | inactive (110.61%) |
STE - STE-Unique
Bioactivity |
---|
Kinase | RBC |
---|
COT | inactive (93.37%) |
NIK | inactive (152.89%) |
STE - STE20
Bioactivity |
---|
Kinase | RBC |
---|
GCK | inactive (108.15%) |
HGK | inactive (102.06%) |
KHS1 | inactive (101.61%) |
LOK | inactive (92.04%) |
MINK | inactive (104.49%) |
MST1 | inactive (99.06%) |
MST2 | inactive (93.84%) |
MST3 | inactive (95.83%) |
MST4 | inactive (114.33%) |
OSR1 | inactive (98.35%) |
PAK1 | inactive (111.47%) |
PAK2 | inactive (98.29%) |
PAK3 | inactive (98.94%) |
PAK4 | inactive (92.83%) |
PAK5 | inactive (92.62%) |
PAK6 | inactive (101.34%) |
SLK | inactive (91.09%) |
YSK1 | inactive (95.44%) |
STLK3 | inactive (93.43%) |
TAO1 | inactive (99.1%) |
TAO2 | inactive (99.69%) |
TAO3 | inactive (96.78%) |
MYO3B | inactive (91.95%) |
STE - STE7
Bioactivity |
---|
Kinase | RBC |
---|
MAP2K1 | inactive (97.94%) |
MAP2K2 | inactive (96.29%) |
MAP2K6 | inactive (98.23%) |
Other
Other - Aur
Bioactivity |
---|
Kinase | RBC |
---|
AurA | inactive (89.39%) |
AurB | inactive (95.06%) |
AurC | inactive (92.23%) |
Other - CAMKK
Bioactivity |
---|
Kinase | RBC |
---|
CaMKK1 | inactive (90.78%) |
CaMKK2 | inactive (97.66%) |
Other - Haspin
Bioactivity |
---|
Kinase | RBC |
---|
Haspin | inactive (79.87%) |
Other - IKK
Bioactivity |
---|
Kinase | RBC |
---|
IKKa | inactive (96.78%) |
IKKb | inactive (92.4%) |
IKKe | inactive (97.63%) |
TBK1 | inactive (103.77%) |
Other - NEK
Bioactivity |
---|
Kinase | RBC |
---|
NEK1 | inactive (87.8%) |
NEK11 | inactive (95.96%) |
NEK2 | inactive (102.15%) |
NEK4 | inactive (104.85%) |
NEK6 | inactive (89%) |
NEK7 | inactive (100.2%) |
NEK9 | inactive (101.29%) |
NEK3 | inactive (99.62%) |
Other - TOPK
Bioactivity |
---|
Kinase | RBC |
---|
PBK | inactive (105.72%) |
Other - PLK
Bioactivity |
---|
Kinase | RBC |
---|
PLK1 | inactive (95.78%) |
PLK2 | inactive (99.49%) |
PLK3 | inactive (99.86%) |
Other - SgK496
Bioactivity |
---|
Kinase | RBC |
---|
SgK496 | inactive (100.44%) |
Other - NAK
Bioactivity |
---|
Kinase | RBC |
---|
MPSK1 | inactive (97.26%) |
Other - TTK
Bioactivity |
---|
Kinase | RBC |
---|
TTK | inactive (92.3%) |
Other - ULK
Bioactivity |
---|
Kinase | RBC |
---|
ULK1 | inactive (103.29%) |
ULK2 | inactive (101.59%) |
ULK3 | inactive (100.92%) |
Other - WEE
Bioactivity |
---|
Kinase | RBC |
---|
Wee1 | inactive (94.23%) |
Other - WNK
Bioactivity |
---|
Kinase | RBC |
---|
Wnk2 | inactive (95.59%) |
Wnk3 | inactive (91.2%) |
Other - TLK
Bioactivity |
---|
Kinase | RBC |
---|
TLK2 | inactive (88.53%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | RBC |
---|
CK1 | 7 | 6 |
VRK | 3 | 1 |
CK1 - CK1
Bioactivity |
---|
Kinase | RBC |
---|
CK1d | inactive (75.57%) |
CK1g1 | inactive (94.45%) |
CK1g2 | inactive (86.23%) |
CK1g3 | inactive (88.52%) |
CK1a | inactive (91.41%) |
CK1e | inactive (81.26%) |
CK1 - VRK
Bioactivity |
---|
Kinase | RBC |
---|
VRK1 | inactive (107.33%) |
CMGC
CMGC - CK2
Bioactivity |
---|
Kinase | RBC |
---|
CK2a1 | inactive (105.6%) |
CK2a2 | inactive (118.18%) |
CMGC - CLK
Bioactivity |
---|
Kinase | RBC |
---|
CLK1 | inactive (83.67%) |
CLK2 | inactive (55.45%) |
CLK3 | inactive (105.38%) |
CLK4 | inactive (97.3%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | RBC |
---|
DYRK1A | inactive (79.54%) |
DYRK1B | inactive (64.88%) |
DYRK2 | inactive (89.4%) |
DYRK3 | inactive (96.33%) |
DYRK4 | inactive (94.61%) |
HIPK1 | inactive (95.19%) |
HIPK2 | inactive (99.01%) |
HIPK3 | inactive (101.56%) |
HIPK4 | inactive (75.97%) |
CMGC - MAPK
Bioactivity |
---|
Kinase | RBC |
---|
Erk1 | inactive (97.02%) |
Erk2 | inactive (88.41%) |
JNK3 | inactive (100.83%) |
NLK | inactive (103.93%) |
p38a | inactive (96.23%) |
p38b | inactive (100.93%) |
p38d | inactive (97.27%) |
p38g | inactive (94.64%) |
JNK1 | inactive (97.74%) |
JNK2 | inactive (108.8%) |
CMGC - GSK
Bioactivity |
---|
Kinase | RBC |
---|
GSK3A | inactive (100.86%) |
GSK3B | inactive (96.36%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | RBC |
---|
MSSK1 | inactive (98.05%) |
SRPK1 | inactive (96.11%) |
SRPK2 | inactive (95.1%) |
Atypical
Atypical
Test Member No. in Family |
---|
Family | no. Member on 518kinase | RBC |
---|
PDHK | 5 | 1 |
Atypical - PDHK
Bioactivity |
---|
Kinase | RBC |
---|
PDHK1 | inactive (87.99%) |