Compound Information
Test on : GPCR
Compound Name : SB-732881
Inchikey : BSHCILRNXWKQAL-UHFFFAOYSA-N
ChemSpider : 23317587
Pubchem CID : 135435015
ChEMBL : CHEMBL261129
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
TK
TK - JakA
Bioactivity |
---|
Kinase | GPCR |
---|
JAK1 | inactive (19.71%) |
TYK2 | inactive (-0.92%) |
JAK2 | inactive (1.49%) |
JAK3 | inactive (-2.24%) |
TK - Fer
Bioactivity |
---|
Kinase | GPCR |
---|
FER | inactive (5.19%) |
FES | inactive (2.01%) |
TK - Abl
Bioactivity |
---|
Kinase | GPCR |
---|
ABL1 | inactive (10.72%) |
ABL2 | inactive (4.33%) |
TK - Csk
Bioactivity |
---|
Kinase | GPCR |
---|
CSK | inactive (7.63%) |
TK - Tec
Bioactivity |
---|
Kinase | GPCR |
---|
BMX | inactive (3.63%) |
BTK | inactive (-2.64%) |
TXK | inactive (-0.68%) |
TEC | inactive (1.24%) |
ITK | inactive (-1.94%) |
TK - Src
Bioactivity |
---|
Kinase | GPCR |
---|
BRK | inactive (9.38%) |
SRM | inactive (-1.75%) |
FRK | inactive (2.31%) |
BLK | inactive (0.8%) |
LCK | inactive (7.96%) |
HCK | inactive (6.08%) |
FGR | inactive (4.79%) |
FYN | inactive (2.18%) |
SRC | inactive (9.87%) |
YES | inactive (10.63%) |
TK - Eph
Bioactivity |
---|
Kinase | GPCR |
---|
EphA2 | inactive (-2.77%) |
EphA4 | inactive (10.94%) |
EphA3 | inactive (-1.23%) |
EphB4 | inactive (-1.46%) |
EphB3 | inactive (1.83%) |
EphB2 | inactive (8.11%) |
TK - FAK
Bioactivity |
---|
Kinase | GPCR |
---|
PYK2 | inactive (12.93%) |
TK - Syk
Bioactivity |
---|
Kinase | GPCR |
---|
SYK | inactive (-0.04%) |
ZAP70 | inactive (2.21%) |
TK - ALK
Bioactivity |
---|
Kinase | GPCR |
---|
LTK | active (50.12%) |
ALK | inactive (31.61%) |
TK - Sev
Bioactivity |
---|
Kinase | GPCR |
---|
ROS | inactive (10.4%) |
TK - InsR
Bioactivity |
---|
Kinase | GPCR |
---|
INSR | inactive (4.73%) |
IGF1R | inactive (-5.49%) |
IRR | inactive (2.5%) |
TK - DDR
Bioactivity |
---|
Kinase | GPCR |
---|
DDR2 | inactive (0.35%) |
TK - Musk
Bioactivity |
---|
Kinase | GPCR |
---|
MUSK | inactive (9.34%) |
TK - Trk
Bioactivity |
---|
Kinase | GPCR |
---|
TRKA | inactive (1.2%) |
TRKB | inactive (3.32%) |
TRKC | inactive (4.91%) |
TK - Met
Bioactivity |
---|
Kinase | GPCR |
---|
RON | inactive (6.18%) |
MET | inactive (14.17%) |
TK - Axl
Bioactivity |
---|
Kinase | GPCR |
---|
AXL | inactive (-2.51%) |
MER | inactive (4.17%) |
TYRO3 | inactive (7.08%) |
TK - Ret
Bioactivity |
---|
Kinase | GPCR |
---|
RET | inactive (9.97%) |
TK - FGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FGFR1 | inactive (-0.75%) |
FGFR2 | inactive (2.81%) |
FGFR3 | inactive (1.79%) |
FGFR4 | inactive (-2.79%) |
TK - VEGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FLT1 | inactive (1.75%) |
KDR | inactive (24.46%) |
FLT4 | inactive (-13.48%) |
TK - PDGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FMS | inactive (0.92%) |
KIT | inactive (12.53%) |
FLT3 | inactive (5.59%) |
PDGFRa | inactive (27.9%) |
PDGFRb | inactive (22.57%) |
TK - Tie
Bioactivity |
---|
Kinase | GPCR |
---|
TIE2 | inactive (7.84%) |
TK - Ack
Bioactivity |
---|
Kinase | GPCR |
---|
ACK | inactive (1.76%) |
TNK1 | inactive (6.51%) |
TK - EGFR
Bioactivity |
---|
Kinase | GPCR |
---|
EGFR | inactive (-1.83%) |
ErbB2 | inactive (7.03%) |
ErbB4 | inactive (8.49%) |
TKL
TKL
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
IRAK | 4 | 1 |
RAF | 5 | 1 |
TKL - IRAK
Bioactivity |
---|
Kinase | GPCR |
---|
IRAK4 | inactive (2.24%) |
TKL - RAF
Bioactivity |
---|
Kinase | GPCR |
---|
BRAF | inactive (16.04%) |
STE
STE
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
STE20 | 31 | 12 |
STE7 | 7 | 1 |
STE - STE20
Bioactivity |
---|
Kinase | GPCR |
---|
GCK | inactive (24.68%) |
MST1 | inactive (14.71%) |
MST2 | inactive (13.17%) |
MST4 | inactive (21.25%) |
HGK | inactive (35.36%) |
MINK | inactive (28.12%) |
LOK | inactive (13.52%) |
PAK1 | inactive (5.42%) |
PAK3 | inactive (5.02%) |
PAK2 | inactive (1.42%) |
PAK5 | inactive (-8.73%) |
PAK6 | inactive (-28.32%) |
STE - STE7
Bioactivity |
---|
Kinase | GPCR |
---|
MAP2K1 | inactive (5.03%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
CK1 | 7 | 4 |
CK1 - CK1
Bioactivity |
---|
Kinase | GPCR |
---|
CK1a | inactive (5.54%) |
CK1g2 | inactive (2.84%) |
CK1g1 | inactive (4.18%) |
CK1g3 | inactive (3.27%) |
Other
Other
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
PLK | 4 | 1 |
Aur | 3 | 3 |
NEK | 11 | 5 |
IKK | 4 | 4 |
TTK | 1 | 1 |
Other - PLK
Bioactivity |
---|
Kinase | GPCR |
---|
PLK1 | inactive (2.87%) |
Other - Aur
Bioactivity |
---|
Kinase | GPCR |
---|
AurB | inactive (4.6%) |
AurC | inactive (-7.86%) |
AurA | inactive (3.82%) |
Other - NEK
Bioactivity |
---|
Kinase | GPCR |
---|
NEK1 | inactive (5.56%) |
NEK2 | inactive (2.67%) |
NEK9 | inactive (13.68%) |
NEK7 | inactive (10.04%) |
NEK6 | inactive (6.77%) |
Other - IKK
Bioactivity |
---|
Kinase | GPCR |
---|
TBK1 | inactive (6.1%) |
IKKe | inactive (9.87%) |
IKKb | inactive (12.77%) |
IKKa | inactive (-1.54%) |
Other - TTK
Bioactivity |
---|
Kinase | GPCR |
---|
TTK | inactive (19.02%) |
AGC
AGC - GRK
Bioactivity |
---|
Kinase | GPCR |
---|
GPRK7 | inactive (16.69%) |
GPRK6 | inactive (20.14%) |
AGC - PDK1
Bioactivity |
---|
Kinase | GPCR |
---|
PDK1 | inactive (0.98%) |
AGC - RSK
Bioactivity |
---|
Kinase | GPCR |
---|
MSK1 | inactive (3.91%) |
MSK2 | inactive (5.51%) |
RSK1 | inactive (5.58%) |
RSK2 | inactive (6.6%) |
RSK4 | inactive (12.69%) |
RSK3 | inactive (7.9%) |
p70S6K | inactive (2.58%) |
AGC - Akt
Bioactivity |
---|
Kinase | GPCR |
---|
AKT2 | inactive (-1.57%) |
AKT1 | inactive (-3.1%) |
AKT3 | inactive (-0.95%) |
AGC - SGK
Bioactivity |
---|
Kinase | GPCR |
---|
SGK1 | inactive (10.36%) |
SGK3 | inactive (6.31%) |
SGK2 | inactive (6.79%) |
AGC - PKC
Bioactivity |
---|
Kinase | GPCR |
---|
PKCh | inactive (8.67%) |
PKCg | inactive (7.76%) |
PKCa | inactive (7.49%) |
PKCt | inactive (7.83%) |
PKCi | inactive (8.06%) |
AGC - PKG
Bioactivity |
---|
Kinase | GPCR |
---|
PKG2 | inactive (8.41%) |
PKG1 | inactive (8.03%) |
AGC - PKA
Bioactivity |
---|
Kinase | GPCR |
---|
PRKX | inactive (6.6%) |
AGC - DMPK
Bioactivity |
---|
Kinase | GPCR |
---|
ROCK1 | inactive (2.13%) |
ROCK2 | inactive (7.61%) |
MRCKb | inactive (12.85%) |
MRCKa | inactive (21.59%) |
CAMK
CAMK - RAD53
Bioactivity |
---|
Kinase | GPCR |
---|
CHK2 | inactive (5.98%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
DCLK2 | inactive (5.44%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK4 | inactive (-1.76%) |
CaMK1d | inactive (15.58%) |
CAMK - PHK
Bioactivity |
---|
Kinase | GPCR |
---|
PHKg1 | inactive (16.13%) |
PHKg2 | inactive (9.01%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK2d | inactive (12.27%) |
CaMK2a | inactive (5.88%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | GPCR |
---|
MAPKAPK5 | inactive (3.66%) |
MAPKAPK2 | inactive (1.12%) |
MAPKAPK3 | inactive (2.79%) |
MNK2 | inactive (36.89%) |
MNK1 | active (77.6%) |
CAMK - PKD
Bioactivity |
---|
Kinase | GPCR |
---|
PKD3 | inactive (3.3%) |
PKD1 | inactive (5.76%) |
PKD2 | inactive (4.6%) |
CAMK - CAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
MARK4 | inactive (4.18%) |
MARK3 | inactive (2.99%) |
MARK1 | inactive (8.58%) |
QIK | inactive (9.87%) |
SIK | inactive (9.27%) |
NuaK1 | inactive (11.96%) |
BRSK1 | inactive (31.53%) |
BRSK2 | inactive (36.07%) |
MELK | inactive (11.65%) |
CHK1 | inactive (5.31%) |
PASK | inactive (1.4%) |
AMPKa1 | inactive (18.7%) |
AMPKa2 | inactive (10.22%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | GPCR |
---|
TSSK2 | inactive (5.78%) |
TSSK1 | inactive (7.56%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | GPCR |
---|
DAPK1 | inactive (2.5%) |
CAMK - PIM
Bioactivity |
---|
Kinase | GPCR |
---|
PIM2 | inactive (14.54%) |
PIM3 | inactive (48.52%) |
PIM1 | inactive (34.78%) |
CMGC
CMGC - MAPK
Bioactivity |
---|
Kinase | GPCR |
---|
JNK2 | inactive (16.55%) |
p38a | inactive (13%) |
p38b | inactive (17.5%) |
p38d | inactive (13.66%) |
Erk2 | inactive (12.09%) |
Erk1 | inactive (6.59%) |
CMGC - GSK
Bioactivity |
---|
Kinase | GPCR |
---|
GSK3A | active (83.24%) |
GSK3B | active (81.68%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | GPCR |
---|
SRPK1 | inactive (0.97%) |
MSSK1 | inactive (-0.76%) |
CMGC - CLK
Bioactivity |
---|
Kinase | GPCR |
---|
CLK3 | inactive (3.67%) |
CLK2 | inactive (3.04%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | GPCR |
---|
HIPK1 | inactive (20.05%) |
HIPK4 | inactive (5.87%) |
DYRK1B | active (66.79%) |
DYRK1A | inactive (43.38%) |
DYRK2 | inactive (33.74%) |
CMGC - CK2
Bioactivity |
---|
Kinase | GPCR |
---|
CK2a1 | inactive (13.27%) |