Compound in Profiling

Compound Information

Test on : DRx, Metz

Compound Name
DRx : 5-indazolyl pyridine 24
Metz : Kinome_836

Inchikey
Same : BPNUQXPIQBZCMR-N
DRx : BPNUQXPIQBZCMR-LJQANCHMSA-N
Metz : BPNUQXPIQBZCMR-UHFFFAOYSA-N

ChemSpider
DRx : 23271831
Metz : 19576321

Pubchem CID
DRx : 23647015
Metz : 20744853

ChEMBL
DRx : CHEMBL212157
Metz : CHEMBL2002726

DRx	Metz

	DRx	RBC	Metz	Millipore	GPCR
bioactivity	Kd (nM)	Remain Activity (%)	Ki (nM)	Remain Activity (%)	Inhibition (%)
active criteria	<3000nM	<50%	<1000nM	<50%	>50%

Other

Test Member No. in Family
Family	no. Member on 518kinase	DRx	Metz
NAK	4	4	-
Aur	3	3	2
CAMKK	2	2	1
PEK	4	2	-
IRE	2	1	-
IKK	4	4	4
NEK	11	9	2
WEE	3	3	1
PLK	4	4	3
SgK496	1	1	-
NKF1	3	2	-
NKF4	2	1	-
ULK	5	4	-
TLK	2	2	-
TTK	1	1	-
CDC7	1	-	1
TOPK	1	-	1

Other - NAK

Bioactivity
Kinase	DRx	Metz
AAK1	active (43nM)	-
BIKE	active (120nM)	-
GAK	active (180nM)	-
MPSK1	inactive (10001nM)	-

Other - Aur

Bioactivity
Kinase	DRx	Metz
AurA	inactive (10001nM)	inactive (5011.87nM)
AurB	inactive (10001nM)	active (501.19nM)
AurC	inactive (8400nM)	-

Other - CAMKK

Bioactivity
Kinase	DRx	Metz
CaMKK1	active (810nM)	-
CaMKK2	active (740nM)	-

Other - PEK

Bioactivity
Kinase	DRx	Metz
HRI	inactive (10001nM)	-
PKR	active (2800nM)	-

Other - IRE

Bioactivity
Kinase	DRx	Metz
IRE1	inactive (10001nM)	-

Other - IKK

Bioactivity
Kinase	DRx	Metz
IKKa	inactive (10001nM)	inactive (2511.89nM)
IKKb	inactive (10001nM)	inactive (>3162.28nM)
IKKe	inactive (10001nM)	-
TBK1	inactive (10001nM)	-

Other - NEK

Bioactivity
Kinase	DRx	Metz
NEK1	inactive (10001nM)	-
NEK11	inactive (10001nM)	-
NEK2	inactive (10001nM)	inactive (>10000nM)
NEK3	inactive (10001nM)	-
NEK4	inactive (10001nM)	inactive (1584.89nM)
NEK5	inactive (10001nM)	-
NEK6	inactive (10001nM)	-
NEK7	inactive (10001nM)	-
NEK9	inactive (10001nM)	-

Other - WEE

Bioactivity
Kinase	DRx	Metz
MYT1	inactive (10001nM)	-
Wee1	inactive (10001nM)	-
Wee1B	inactive (10001nM)	-

Other - PLK

Bioactivity
Kinase	DRx	Metz
PLK1	inactive (10001nM)	inactive (>7943.28nM)
PLK2	inactive (10001nM)	-
PLK3	inactive (10001nM)	inactive (>7943.28nM)
PLK4	inactive (10001nM)	inactive (>3981.07nM)

Other - SgK496

Bioactivity
Kinase	DRx	Metz
SgK496	inactive (10001nM)	-

Other - NKF1

Bioactivity
Kinase	DRx	Metz
SBK	inactive (10001nM)	-
SgK110	inactive (10001nM)	-

Other - NKF4

Bioactivity
Kinase	DRx	Metz
CLIK1	inactive (10001nM)	-

Other - ULK

Bioactivity
Kinase	DRx	Metz
Fused	inactive (10001nM)	-
ULK1	inactive (8000nM)	-
ULK2	inactive (6000nM)	-
ULK3	inactive (10001nM)	-

Other - TLK

Bioactivity
Kinase	DRx	Metz
TLK1	inactive (10001nM)	-
TLK2	inactive (10001nM)	-

Other - TTK

Bioactivity
Kinase	DRx	Metz
TTK	inactive (10001nM)	-

Other - CDC7

Bioactivity
Kinase	DRx	Metz
CDC7	-	active (12.59nM)

Other - TOPK

Bioactivity
Kinase	DRx	Metz
PBK	-	inactive (1258.93nM)

TK

Test Member No. in Family
Family	no. Member on 518kinase	DRx	Metz
Abl	2	2	1
ALK	2	2	2
Axl	3	3	2
Src	11	11	9
Tec	5	5	3
PDGFR	5	5	5
Csk	2	2	1
DDR	2	2	-
EGFR	4	4	3
Eph	14	13	1
FAK	2	2	2
Fer	2	2	2
FGFR	4	4	2
VEGFR	3	3	3
InsR	3	3	2
JakA	4	4	3
Met	2	2	2
Musk	1	1	-
Ret	1	1	1
Sev	1	1	1
Syk	2	2	1
Tie	2	2	-
Ack	2	2	1
Trk	3	3	3

TK - Abl

Bioactivity
Kinase	DRx	Metz
ABL1	inactive (10001nM)	inactive (>630.96nM)
ABL2	inactive (10001nM)	-

TK - ALK

Bioactivity
Kinase	DRx	Metz
ALK	inactive (10001nM)	inactive (>1258.93nM)
LTK	inactive (10001nM)	-

TK - Axl

Bioactivity
Kinase	DRx	Metz
AXL	inactive (10001nM)	inactive (>1995.26nM)
MER	inactive (10001nM)	-
TYRO3	inactive (10001nM)	inactive (>1995.26nM)

TK - Src

Bioactivity
Kinase	DRx	Metz
BLK	inactive (10001nM)	inactive (>1584.89nM)
BRK	inactive (10001nM)	inactive (>2511.89nM)
FGR	inactive (10001nM)	-
FRK	inactive (10001nM)	inactive (>2511.89nM)
FYN	inactive (10001nM)	inactive (>794.33nM)
HCK	inactive (10001nM)	-
LCK	inactive (10001nM)	inactive (>2511.89nM)
LYN	inactive (10001nM)	inactive (>1584.89nM)
SRC	inactive (10001nM)	inactive (>1995.26nM)
SRM	inactive (10001nM)	inactive (>1584.89nM)
YES	inactive (10001nM)	-

TK - Tec

Bioactivity
Kinase	DRx	Metz
BMX	inactive (10001nM)	-
BTK	inactive (10001nM)	inactive (>1258.93nM)
ITK	inactive (10001nM)	inactive (>1584.89nM)
TEC	inactive (10001nM)	-
TXK	inactive (10001nM)	-

TK - PDGFR

Bioactivity
Kinase	DRx	Metz
FMS	inactive (10001nM)	inactive (>2511.89nM)
FLT3	active (540nM)	active (630.96nM)
KIT	inactive (10001nM)	inactive (>1258.93nM)
PDGFRa	inactive (10001nM)	-
PDGFRb	inactive (10001nM)	-

TK - Csk

Bioactivity
Kinase	DRx	Metz
CSK	inactive (10001nM)	-
CTK	inactive (10001nM)	inactive (>1995.26nM)

TK - DDR

Bioactivity
Kinase	DRx	Metz
DDR1	inactive (10001nM)	-
DDR2	inactive (10001nM)	-

TK - EGFR

Bioactivity
Kinase	DRx	Metz
EGFR	inactive (10001nM)	inactive (>1995.26nM)
ErbB2	inactive (10001nM)	inactive (>1584.89nM)
ErbB3	inactive (10001nM)	-
ErbB4	inactive (10001nM)	inactive (>3981.07nM)

TK - Eph

Bioactivity
Kinase	DRx	Metz
EphA1	inactive (10001nM)	-
EphA2	inactive (10001nM)	inactive (>3162.28nM)
EphA3	inactive (10001nM)	-
EphA4	inactive (10001nM)	-
EphA5	inactive (10001nM)	-
EphA6	inactive (10001nM)	-
EphA7	inactive (10001nM)	-
EphA8	inactive (10001nM)	-
EphB1	inactive (10001nM)	-
EphB2	inactive (10001nM)	-
EphB3	inactive (10001nM)	-
EphB4	inactive (10001nM)	-
EphB6	inactive (10001nM)	-

TK - FAK

Bioactivity
Kinase	DRx	Metz
FAK	inactive (10001nM)	inactive (>1584.89nM)
PYK2	inactive (10001nM)	active (1000nM)

TK - Fer

Bioactivity
Kinase	DRx	Metz
FER	inactive (10001nM)	active (1000nM)
FES	inactive (10001nM)	inactive (>1995.26nM)

TK - FGFR

Bioactivity
Kinase	DRx	Metz
FGFR1	inactive (10001nM)	inactive (>5011.87nM)
FGFR2	inactive (10001nM)	-
FGFR3	inactive (10001nM)	inactive (>1995.26nM)
FGFR4	inactive (10001nM)	-

TK - VEGFR

Bioactivity
Kinase	DRx	Metz
FLT1	inactive (10001nM)	inactive (>398.11nM)
FLT4	inactive (10001nM)	inactive (3981.07nM)
KDR	inactive (10001nM)	inactive (>7943.28nM)

TK - InsR

Bioactivity
Kinase	DRx	Metz
IGF1R	inactive (10001nM)	inactive (>1995.26nM)
INSR	inactive (10001nM)	inactive (>5011.87nM)
IRR	inactive (10001nM)	-

TK - JakA

Bioactivity
Kinase	DRx	Metz
JAK1	inactive (10001nM)	-
JAK2	inactive (10001nM)	inactive (1258.93nM)
JAK3	active (1500nM)	inactive (>1584.89nM)
TYK2	inactive (10001nM)	inactive (>1995.26nM)

TK - Met

Bioactivity
Kinase	DRx	Metz
MET	inactive (10001nM)	inactive (>3162.28nM)
RON	inactive (10001nM)	-

TK - Musk

Bioactivity
Kinase	DRx	Metz
MUSK	inactive (10001nM)	-

TK - Ret

Bioactivity
Kinase	DRx	Metz
RET	inactive (10001nM)	inactive (>1258.93nM)

TK - Sev

Bioactivity
Kinase	DRx	Metz
ROS	inactive (10001nM)	inactive (>1995.26nM)

TK - Syk

Bioactivity
Kinase	DRx	Metz
SYK	inactive (10001nM)	inactive (>1584.89nM)
ZAP70	inactive (10001nM)	-

TK - Tie

Bioactivity
Kinase	DRx	Metz
TIE1	inactive (10001nM)	-
TIE2	inactive (10001nM)	-

TK - Ack

Bioactivity
Kinase	DRx	Metz
TNK1	inactive (10001nM)	-
ACK	inactive (10001nM)	-

TK - Trk

Bioactivity
Kinase	DRx	Metz
TRKA	inactive (10001nM)	inactive (>2511.89nM)
TRKB	inactive (10001nM)	inactive (>5011.87nM)
TRKC	inactive (10001nM)	inactive (>1258.93nM)

TKL

Test Member No. in Family
Family	no. Member on 518kinase	DRx	Metz
STKR	12	10	1
RIPK	5	4	-
RAF	5	2	1
MLK	10	8	2
IRAK	4	3	2
LISK	4	3	1
LRRK	2	1	1

TKL - STKR

Bioactivity
Kinase	DRx	Metz
ALK2	inactive (10001nM)	-
ALK4	inactive (10001nM)	-
ACTR2	inactive (10001nM)	-
ACTR2B	inactive (10001nM)	-
ALK1	inactive (10001nM)	-
BMPR1A	inactive (10001nM)	-
BMPR1B	inactive (10001nM)	-
BMPR2	inactive (10001nM)	-
TGFbR1	inactive (10001nM)	-
TGFbR2	inactive (10001nM)	-

TKL - RIPK

Bioactivity
Kinase	DRx	Metz
SgK288	inactive (10001nM)	-
RIPK1	inactive (10001nM)	-
RIPK2	inactive (10001nM)	-
ANKRD3	inactive (10001nM)	-

TKL - RAF

Bioactivity
Kinase	DRx	Metz
BRAF	inactive (10001nM)	-
RAF1	inactive (10001nM)	-

TKL - MLK

Bioactivity
Kinase	DRx	Metz
DLK	inactive (10001nM)	-
LZK	inactive (10001nM)	-
MLK1	inactive (10001nM)	-
MLK2	inactive (10001nM)	-
MLK3	inactive (10001nM)	-
TAK1	active (640nM)	-
HH498	inactive (10001nM)	-
ZAK	inactive (10001nM)	inactive (>7943.28nM)

TKL - IRAK

Bioactivity
Kinase	DRx	Metz
IRAK1	inactive (3100nM)	active (1000nM)
IRAK3	inactive (10001nM)	-
IRAK4	active (2500nM)	active (1000nM)

TKL - LISK

Bioactivity
Kinase	DRx	Metz
LIMK1	inactive (10001nM)	active (1000nM)
LIMK2	inactive (10001nM)	-
TESK1	inactive (10001nM)	-

TKL - LRRK

Bioactivity
Kinase	DRx	Metz
LRRK2	active (1900nM)	-

Atypical

Test Member No. in Family
Family	no. Member on 518kinase	DRx	Metz
ABC1	5	2	-
PIKK	6	1	-
RIO	3	3	-
Alpha	6	1	1

Atypical - ABC1

Bioactivity
Kinase	DRx	Metz
ADCK3	inactive (10001nM)	-
ADCK4	inactive (10001nM)	-

Atypical - PIKK

Bioactivity
Kinase	DRx	Metz
FRAP	inactive (10001nM)	-

Atypical - RIO

Bioactivity
Kinase	DRx	Metz
RIOK1	active (620nM)	-
RIOK2	inactive (5300nM)	-
RIOK3	active (690nM)	-

Atypical - Alpha

Bioactivity
Kinase	DRx	Metz
ChaK2	inactive (10001nM)	-
eEF2K	-	inactive (>3981.07nM)

AGC

Test Member No. in Family
Family	no. Member on 518kinase	DRx	Metz
Akt	3	3	3
DMPK	7	7	3
GRK	7	3	1
NDR	4	4	-
MAST	5	1	-
PDK1	1	1	1
PKA	5	3	2
PKN	3	2	1
PKC	9	5	5
PKG	2	2	2
RSK	8	1	4
SGK	3	1	1
YANK	3	3	-

AGC - Akt

Bioactivity
Kinase	DRx	Metz
AKT1	active (76nM)	active (39.81nM)
AKT2	active (2900nM)	active (501.19nM)
AKT3	active (180nM)	active (79.43nM)

AGC - DMPK

Bioactivity
Kinase	DRx	Metz
CRIK	active (13nM)	-
DMPK1	active (92nM)	-
DMPK2	active (460nM)	-
MRCKa	active (380nM)	active (79.43nM)
MRCKb	active (95nM)	-
ROCK1	active (37nM)	active (19.95nM)
ROCK2	inactive (10001nM)	active (31.62nM)

AGC - GRK

Bioactivity
Kinase	DRx	Metz
RHOK	inactive (10001nM)	-
GPRK4	active (1400nM)	-
GPRK7	active (1900nM)	-
GPRK5	-	-

AGC - NDR

Bioactivity
Kinase	DRx	Metz
LATS1	active (1100nM)	-
LATS2	active (620nM)	-
NDR1	inactive (10001nM)	-
NDR2	inactive (10001nM)	-

AGC - MAST

Bioactivity
Kinase	DRx	Metz
MAST1	inactive (10001nM)	-

AGC - PDK1

Bioactivity
Kinase	DRx	Metz
PDK1	inactive (10001nM)	inactive (>3981.07nM)

AGC - PKA

Bioactivity
Kinase	DRx	Metz
PKACa	active (56nM)	active (19.95nM)
PKACb	active (90nM)	-
PRKX	active (97nM)	active (19.95nM)

AGC - PKN

Bioactivity
Kinase	DRx	Metz
PKN1	active (210nM)	-
PKN2	active (590nM)	active (100nM)

AGC - PKC

Bioactivity
Kinase	DRx	Metz
PKCd	active (27nM)	active (7.94nM)
PKCe	active (11nM)	-
PKCh	active (9.5nM)	-
PKCi	inactive (10001nM)	inactive (3981.07nM)
PKCt	active (12nM)	-
PKCg	-	active (251.19nM)
PKCz	-	inactive (3162.28nM)

AGC - PKG

Bioactivity
Kinase	DRx	Metz
PKG1	active (270nM)	active (158.49nM)
PKG2	active (19nM)	active (398.11nM)

AGC - RSK

Bioactivity
Kinase	DRx	Metz
p70S6K	inactive (3600nM)	active (63.1nM)
RSK2	-	active (1000nM)
MSK1	-	active (100nM)
MSK2	-	active (39.81nM)

AGC - SGK

Bioactivity
Kinase	DRx	Metz
SGK3	inactive (5100nM)	-
SGK1	-	active (794.33nM)

AGC - YANK

Bioactivity
Kinase	DRx	Metz
YANK1	inactive (10001nM)	-
YANK2	inactive (10001nM)	-
YANK3	inactive (10001nM)	-

CAMK

Test Member No. in Family
Family	no. Member on 518kinase	DRx	Metz
CAMKL	20	19	9
CAMK1	5	4	2
CAMK2	4	4	4
CASK	1	1	-
RAD53	1	1	1
DAPK	5	5	2
DCAMKL	3	3	1
MAPKAPK	5	4	4
MLCK	5	4	-
PHK	2	2	1
PIM	3	3	3
PKD	3	3	2
STK33	1	1	1
TSSK	5	1	2

CAMK - CAMKL

Bioactivity
Kinase	DRx	Metz
AMPKa1	inactive (10001nM)	active (199.53nM)
AMPKa2	inactive (10001nM)	-
NuaK1	inactive (10001nM)	-
BRSK1	inactive (10001nM)	inactive (1258.93nM)
BRSK2	inactive (10001nM)	-
CHK1	inactive (10001nM)	inactive (>7943.28nM)
HUNK	inactive (10001nM)	-
LKB1	inactive (10001nM)	-
MARK1	inactive (10001nM)	-
MARK2	inactive (10001nM)	inactive (1995.26nM)
MARK3	inactive (10001nM)	inactive (1995.26nM)
MARK4	inactive (10001nM)	-
MELK	active (590nM)	active (630.96nM)
NIM1	inactive (10001nM)	-
QSK	inactive (10001nM)	-
SIK	inactive (10001nM)	-
QIK	inactive (10001nM)	-
NuaK2	inactive (4200nM)	-
SNRK	inactive (10001nM)	-
PASK	-	-

CAMK - CAMK1

Bioactivity
Kinase	DRx	Metz
CaMK1a	inactive (10001nM)	active (125.89nM)
CaMK1d	active (2400nM)	-
CaMK1g	inactive (10001nM)	-
CaMK4	active (710nM)	-

CAMK - CAMK2

Bioactivity
Kinase	DRx	Metz
CaMK2a	active (320nM)	-
CaMK2b	active (970nM)	active (316.23nM)
CaMK2d	active (270nM)	active (10nM)
CaMK2g	active (890nM)	active (25.12nM)

CAMK - CASK

Bioactivity
Kinase	DRx	Metz
CASK	inactive (10001nM)	-

CAMK - RAD53

Bioactivity
Kinase	DRx	Metz
CHK2	inactive (9800nM)	inactive (1258.93nM)

CAMK - DAPK

Bioactivity
Kinase	DRx	Metz
DAPK1	active (1600nM)	-
DAPK2	active (2500nM)	-
DAPK3	active (1200nM)	active (199.53nM)
DRAK1	inactive (5200nM)	inactive (3162.28nM)
DRAK2	inactive (5200nM)	-

CAMK - DCAMKL

Bioactivity
Kinase	DRx	Metz
DCLK1	inactive (10001nM)	inactive (>10000nM)
DCLK2	inactive (10001nM)	-
DCLK3	inactive (10001nM)	-

CAMK - MAPKAPK

Bioactivity
Kinase	DRx	Metz
MAPKAPK2	inactive (10001nM)	inactive (1258.93nM)
MAPKAPK5	inactive (10001nM)	inactive (>1584.89nM)
MNK1	inactive (10001nM)	-
MNK2	inactive (3400nM)	inactive (1258.93nM)
MAPKAPK3	-	inactive (>10000nM)

CAMK - MLCK

Bioactivity
Kinase	DRx	Metz
caMLCK	active (400nM)	-
smMLCK	active (870nM)	-
skMLCK	inactive (10001nM)	-
SgK085	active (1500nM)	-

CAMK - PHK

Bioactivity
Kinase	DRx	Metz
PHKg1	active (1200nM)	-
PHKg2	active (2600nM)	active (1000nM)

CAMK - PIM

Bioactivity
Kinase	DRx	Metz
PIM1	active (180nM)	active (100nM)
PIM2	active (220nM)	active (79.43nM)
PIM3	active (140nM)	active (63.1nM)

CAMK - PKD

Bioactivity
Kinase	DRx	Metz
PKD1	inactive (10001nM)	-
PKD2	inactive (10001nM)	active (316.23nM)
PKD3	active (1000nM)	active (158.49nM)

CAMK - STK33

Bioactivity
Kinase	DRx	Metz
STK33	active (220nM)	-

CAMK - TSSK

Bioactivity
Kinase	DRx	Metz
TSSK1	inactive (10001nM)	active (630.96nM)
TSSK2	-	inactive (>1584.89nM)

STE

Test Member No. in Family
Family	no. Member on 518kinase	DRx	Metz
STE11	8	8	-
STE20	31	27	9
STE7	7	7	2

STE - STE11

Bioactivity
Kinase	DRx	Metz
MAP3K5	inactive (10001nM)	-
MAP3K6	inactive (10001nM)	-
MAP3K1	inactive (10001nM)	-
MAP3K7	inactive (10001nM)	-
MAP3K2	inactive (10001nM)	-
MAP3K3	inactive (10001nM)	-
MAP3K4	inactive (10001nM)	-
MAP3K8	active (230nM)	-

STE - STE20

Bioactivity
Kinase	DRx	Metz
HPK1	inactive (10001nM)	-
LOK	inactive (10001nM)	-
GCK	active (1900nM)	active (63.1nM)
KHS2	inactive (10001nM)	-
HGK	active (140nM)	active (6.31nM)
KHS1	inactive (10001nM)	active (794.33nM)
MINK	active (100nM)	active (50.12nM)
MST1	inactive (10001nM)	-
MST2	inactive (5400nM)	active (630.96nM)
MST3	inactive (10001nM)	-
MST4	inactive (10001nM)	-
MYO3A	inactive (10001nM)	-
MYO3B	inactive (10001nM)	-
OSR1	inactive (10001nM)	-
PAK1	active (1500nM)	inactive (7943.28nM)
PAK2	active (1500nM)	-
PAK3	inactive (10001nM)	-
PAK4	active (980nM)	inactive (2511.89nM)
PAK6	active (760nM)	-
PAK5	active (670nM)	-
SLK	inactive (10001nM)	inactive (1584.89nM)
STLK3	inactive (10001nM)	-
TAO1	active (470nM)	active (1000nM)
TAO2	inactive (4900nM)	-
TAO3	active (1100nM)	-
TNIK	active (140nM)	-
YSK1	inactive (10001nM)	-

STE - STE7

Bioactivity
Kinase	DRx	Metz
MAP2K1	inactive (10001nM)	-
MAP2K2	inactive (10001nM)	-
MAP2K3	active (1200nM)	-
MAP2K4	inactive (10001nM)	-
MAP2K5	inactive (10001nM)	-
MAP2K6	inactive (10001nM)	-
MAP2K7	inactive (10001nM)	-

CMGC

Test Member No. in Family
Family	no. Member on 518kinase	DRx	Metz
CDK	20	8	7
CDKL	5	4	-
CLK	4	4	2
CK2	3	2	1
DYRK	10	8	6
MAPK	14	14	8
GSK	2	2	2
RCK	3	2	-
SRPK	3	3	1

CMGC - CDK

Bioactivity
Kinase	DRx	Metz
PITSLRE	inactive (10001nM)	-
CHED	inactive (3100nM)	-
CDK11	active (1300nM)	-
PCTAIRE1	active (1500nM)	-
PCTAIRE2	active (1900nM)	-
PCTAIRE3	inactive (7700nM)	-
PFTAIRE2	active (2100nM)	-
PFTAIRE1	active (790nM)	-
CDC2	-	active (158.49nM)
CDK2	-	active (79.43nM)
CDK5	-	active (125.89nM)
CDK8	-	-
CDK7	-	-
CDK9	-	-

CMGC - CDKL

Bioactivity
Kinase	DRx	Metz
CDKL1	inactive (10001nM)	-
CDKL2	active (700nM)	-
CDKL3	active (1100nM)	-
CDKL5	active (200nM)	-

CMGC - CLK

Bioactivity
Kinase	DRx	Metz
CLK1	active (1.4nM)	-
CLK2	active (0.51nM)	-
CLK3	active (160nM)	-
CLK4	active (0.53nM)	-

CMGC - CK2

Bioactivity
Kinase	DRx	Metz
CK2a1	inactive (5500nM)	active (316.23nM)
CK2a2	inactive (3800nM)	-

CMGC - DYRK

Bioactivity
Kinase	DRx	Metz
DYRK1A	active (2.1nM)	-
DYRK1B	active (3.9nM)	-
DYRK2	active (63nM)	-
HIPK1	active (230nM)	-
HIPK2	active (220nM)	active (251.19nM)
HIPK3	active (110nM)	-
HIPK4	active (760nM)	inactive (1258.93nM)
PRP4	inactive (4600nM)	-
DYRK3	-	active (251.19nM)
DYRK4	-	active (630.96nM)

CMGC - MAPK

Bioactivity
Kinase	DRx	Metz
Erk1	inactive (10001nM)	-
Erk2	inactive (10001nM)	active (398.11nM)
Erk3	inactive (10001nM)	-
Erk4	inactive (10001nM)	-
Erk5	inactive (10001nM)	-
Erk7	active (89nM)	-
JNK1	inactive (10001nM)	inactive (>3162.28nM)
JNK2	inactive (10001nM)	inactive (>3981.07nM)
JNK3	inactive (10001nM)	-
NLK	inactive (10001nM)	-
p38a	inactive (10001nM)	-
p38b	inactive (10001nM)	-
p38d	inactive (10001nM)	inactive (5011.87nM)
p38g	inactive (10001nM)	inactive (3162.28nM)

CMGC - GSK

Bioactivity
Kinase	DRx	Metz
GSK3A	inactive (3900nM)	active (316.23nM)
GSK3B	active (350nM)	active (63.1nM)

CMGC - RCK

Bioactivity
Kinase	DRx	Metz
ICK	active (550nM)	-
MAK	inactive (10001nM)	-

CMGC - SRPK

Bioactivity
Kinase	DRx	Metz
SRPK1	active (550nM)	inactive (5011.87nM)
SRPK2	active (1100nM)	-
MSSK1	active (1500nM)	-

CK1

Test Member No. in Family
Family	no. Member on 518kinase	DRx	Metz
CK1	7	7	5
VRK	3	1	-

CK1 - CK1

Bioactivity
Kinase	DRx	Metz
CK1a	active (2100nM)	inactive (1258.93nM)
CK1a2	inactive (4600nM)	-
CK1d	active (210nM)	active (251.19nM)
CK1e	active (120nM)	-
CK1g1	active (530nM)	active (398.11nM)
CK1g2	active (380nM)	active (316.23nM)
CK1g3	active (910nM)	active (501.19nM)

CK1 - VRK

Bioactivity
Kinase	DRx	Metz
VRK2	inactive (4000nM)	-