Compound in Profiling

Compound Information

Test on : DRx, RBC, Millipore

Compound Name
DRx, RBC : C35H30N4O4
Millipore : N-Benzoylstaurosporine

Inchikey
Same : BMGQWWVMWDBQGC-N
DRx, RBC : BMGQWWVMWDBQGC-PZFYLCKJSA-N
Millipore : BMGQWWVMWDBQGC-UHFFFAOYSA-N

ChemSpider
DRx, RBC : 21435595
Millipore : 19416722

Pubchem CID
DRx, RBC : 24202429
Millipore : 16760627

ChEMBL
DRx, RBC : CHEMBL338448
Millipore : -

DRx, RBC	Millipore

	DRx	RBC	Metz	Millipore	GPCR
bioactivity	Kd (nM)	Remain Activity (%)	Ki (nM)	Remain Activity (%)	Inhibition (%)
active criteria	<3000nM	<50%	<1000nM	<50%	>50%

Other

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC	Millipore
NAK	4	4	1	-
Aur	3	3	3	3
CAMKK	2	2	2	-
PEK	4	2	-	-
IRE	2	1	-	-
IKK	4	4	4	3
NEK	11	9	8	5
WEE	3	3	1	-
PLK	4	4	3	3
SgK496	1	1	1	-
NKF1	3	2	-	-
NKF4	2	1	-	-
ULK	5	4	3	2
TLK	2	2	1	1
TTK	1	1	1	-
Haspin	1	-	1	1
TOPK	1	-	1	-
WNK	4	-	2	2

Other - NAK

Bioactivity
Kinase	DRx	RBC	Millipore
AAK1	active (48nM)	-	-
BIKE	active (220nM)	-	-
GAK	active (380nM)	-	-
MPSK1	active (280nM)	active (47.89%)	-

Other - Aur

Bioactivity
Kinase	DRx	RBC	Millipore
AurA	active (120nM)	active (4.48%)	active (-3%)
AurB	active (62nM)	active (2.96%)	active (1%)
AurC	active (170nM)	active (12.02%)	inactive (62%)

Other - CAMKK

Bioactivity
Kinase	DRx	RBC	Millipore
CaMKK1	active (130nM)	active (20.39%)	-
CaMKK2	active (73nM)	active (3.9%)	-

Other - PEK

Bioactivity
Kinase	DRx	RBC	Millipore
HRI	inactive (10001nM)	-	-
PKR	inactive (6900nM)	-	-

Other - IRE

Bioactivity
Kinase	DRx	RBC	Millipore
IRE1	active (2300nM)	-	-

Other - IKK

Bioactivity
Kinase	DRx	RBC	Millipore
IKKa	inactive (3800nM)	inactive (89.61%)	inactive (101%)
IKKb	inactive (6300nM)	inactive (97.85%)	inactive (89%)
IKKe	active (160nM)	active (9.85%)	-
TBK1	active (9.3nM)	active (3.22%)	active (2%)

Other - NEK

Bioactivity
Kinase	DRx	RBC	Millipore
NEK1	inactive (10001nM)	inactive (66.2%)	-
NEK11	inactive (10001nM)	inactive (97.99%)	active (47%)
NEK2	inactive (10001nM)	inactive (100.82%)	inactive (82%)
NEK3	inactive (10001nM)	inactive (106.59%)	inactive (102%)
NEK4	inactive (10001nM)	inactive (97.59%)	-
NEK5	inactive (10001nM)	-	-
NEK6	inactive (10001nM)	inactive (109.97%)	inactive (93%)
NEK7	inactive (10001nM)	inactive (101.49%)	inactive (91%)
NEK9	inactive (10001nM)	inactive (64.36%)	-

Other - WEE

Bioactivity
Kinase	DRx	RBC	Millipore
MYT1	inactive (10001nM)	-	-
Wee1	inactive (4600nM)	inactive (89.34%)	-
Wee1B	inactive (10001nM)	-	-

Other - PLK

Bioactivity
Kinase	DRx	RBC	Millipore
PLK1	inactive (10001nM)	inactive (95.41%)	inactive (87%)
PLK2	inactive (10001nM)	inactive (97.47%)	inactive (100%)
PLK3	inactive (10001nM)	inactive (95.26%)	inactive (95%)
PLK4	active (66nM)	-	-

Other - SgK496

Bioactivity
Kinase	DRx	RBC	Millipore
SgK496	inactive (4700nM)	inactive (96.44%)	-

Other - NKF1

Bioactivity
Kinase	DRx	RBC	Millipore
SBK	inactive (10001nM)	-	-
SgK110	inactive (10001nM)	-	-

Other - NKF4

Bioactivity
Kinase	DRx	RBC	Millipore
CLIK1	inactive (10001nM)	-	-

Other - ULK

Bioactivity
Kinase	DRx	RBC	Millipore
Fused	inactive (10001nM)	-	-
ULK1	inactive (10001nM)	inactive (99.21%)	-
ULK2	inactive (10001nM)	inactive (95.75%)	inactive (96%)
ULK3	active (1300nM)	active (37%)	active (17%)

Other - TLK

Bioactivity
Kinase	DRx	RBC	Millipore
TLK1	inactive (10001nM)	-	-
TLK2	inactive (10001nM)	inactive (75.02%)	inactive (95%)

Other - TTK

Bioactivity
Kinase	DRx	RBC	Millipore
TTK	active (350nM)	inactive (55.02%)	-

Other - Haspin

Bioactivity
Kinase	DRx	RBC	Millipore
Haspin	-	inactive (70.17%)	inactive (78%)

Other - TOPK

Bioactivity
Kinase	DRx	RBC	Millipore
PBK	-	-	-

Other - WNK

Bioactivity
Kinase	DRx	RBC	Millipore
Wnk2	-	inactive (111.01%)	inactive (90%)
Wnk3	-	inactive (91.37%)	inactive (91%)

TK

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC	Millipore
Abl	2	2	2	2
ALK	2	2	2	1
Axl	3	3	3	3
Src	11	11	11	10
Tec	5	5	5	4
PDGFR	5	5	5	5
Csk	2	2	2	1
DDR	2	2	1	1
EGFR	4	4	3	2
Eph	14	13	12	11
FAK	2	2	2	2
Fer	2	2	2	2
FGFR	4	4	4	4
VEGFR	3	3	3	3
InsR	3	3	3	3
JakA	4	4	4	2
Met	2	2	2	2
Musk	1	1	1	1
Ret	1	1	1	1
Sev	1	1	1	1
Syk	2	2	2	2
Tie	2	2	1	1
Ack	2	2	1	1
Trk	3	3	3	2

TK - Abl

Bioactivity
Kinase	DRx	RBC	Millipore
ABL1	inactive (10001nM)	inactive (82.69%)	inactive (89%)
ABL2	inactive (10001nM)	inactive (76.26%)	inactive (77%)

TK - ALK

Bioactivity
Kinase	DRx	RBC	Millipore
ALK	active (270nM)	active (49.16%)	active (32%)
LTK	active (3000nM)	inactive (50.06%)	-

TK - Axl

Bioactivity
Kinase	DRx	RBC	Millipore
AXL	active (620nM)	inactive (106.06%)	active (14%)
MER	active (2900nM)	inactive (78.66%)	active (8%)
TYRO3	inactive (10001nM)	inactive (98.76%)	inactive (83%)

TK - Src

Bioactivity
Kinase	DRx	RBC	Millipore
BLK	active (500nM)	active (48.75%)	active (7%)
BRK	inactive (10001nM)	inactive (96.23%)	inactive (98%)
FGR	active (730nM)	active (17.37%)	active (7%)
FRK	active (2400nM)	inactive (65.84%)	active (33%)
FYN	active (2100nM)	active (33.96%)	active (6%)
HCK	active (720nM)	active (14.9%)	active (7%)
LCK	active (280nM)	active (19.75%)	active (13%)
LYN	inactive (4200nM)	active (28.88%)	active (6%)
SRC	active (1200nM)	active (39.58%)	active (40%)
SRM	inactive (10001nM)	inactive (97.64%)	-
YES	active (950nM)	active (20.6%)	active (5%)

TK - Tec

Bioactivity
Kinase	DRx	RBC	Millipore
BMX	inactive (10001nM)	active (31.99%)	active (12%)
BTK	inactive (10001nM)	inactive (60.53%)	inactive (60%)
ITK	inactive (10001nM)	inactive (70.61%)	inactive (56%)
TEC	inactive (10001nM)	inactive (106.49%)	-
TXK	inactive (10001nM)	inactive (71.72%)	inactive (82%)

TK - PDGFR

Bioactivity
Kinase	DRx	RBC	Millipore
FMS	active (330nM)	active (6.65%)	active (0%)
FLT3	active (11nM)	active (2.41%)	active (1%)
KIT	active (220nM)	active (37.42%)	inactive (65%)
PDGFRa	active (380nM)	active (29.97%)	inactive (54%)
PDGFRb	active (110nM)	active (14.8%)	active (46%)

TK - Csk

Bioactivity
Kinase	DRx	RBC	Millipore
CSK	inactive (8700nM)	inactive (55.05%)	inactive (82%)
CTK	inactive (10001nM)	inactive (112.76%)	-

TK - DDR

Bioactivity
Kinase	DRx	RBC	Millipore
DDR1	inactive (7200nM)	-	-
DDR2	inactive (10001nM)	inactive (379.86%)	inactive (106%)

TK - EGFR

Bioactivity
Kinase	DRx	RBC	Millipore
EGFR	active (1300nM)	inactive (78.54%)	inactive (101%)
ErbB2	inactive (10001nM)	inactive (86.66%)	-
ErbB3	inactive (10001nM)	-	-
ErbB4	inactive (3100nM)	inactive (98.17%)	inactive (67%)

TK - Eph

Bioactivity
Kinase	DRx	RBC	Millipore
EphA1	inactive (10001nM)	inactive (93.51%)	inactive (87%)
EphA2	inactive (10001nM)	inactive (92.29%)	inactive (97%)
EphA3	inactive (10001nM)	inactive (94.06%)	inactive (97%)
EphA4	inactive (10001nM)	inactive (96.93%)	inactive (103%)
EphA5	inactive (10001nM)	inactive (95.82%)	inactive (97%)
EphA6	inactive (10001nM)	inactive (79.52%)	-
EphA7	inactive (10001nM)	inactive (87.23%)	inactive (94%)
EphA8	inactive (10001nM)	inactive (94.08%)	inactive (94%)
EphB1	inactive (10001nM)	inactive (96.36%)	inactive (97%)
EphB2	inactive (10001nM)	inactive (94.02%)	inactive (111%)
EphB3	inactive (10001nM)	inactive (90.52%)	inactive (119%)
EphB4	inactive (10001nM)	inactive (109.52%)	inactive (107%)
EphB6	inactive (3100nM)	-	-

TK - FAK

Bioactivity
Kinase	DRx	RBC	Millipore
FAK	inactive (10001nM)	inactive (87.45%)	inactive (90%)
PYK2	active (660nM)	inactive (58.16%)	active (16%)

TK - Fer

Bioactivity
Kinase	DRx	RBC	Millipore
FER	active (1200nM)	active (22.36%)	active (26%)
FES	inactive (10001nM)	active (48.3%)	active (15%)

TK - FGFR

Bioactivity
Kinase	DRx	RBC	Millipore
FGFR1	active (1600nM)	active (36.08%)	active (5%)
FGFR2	active (2400nM)	active (49.5%)	active (21%)
FGFR3	active (1700nM)	inactive (57.53%)	active (34%)
FGFR4	inactive (10001nM)	inactive (84.15%)	inactive (71%)

TK - VEGFR

Bioactivity
Kinase	DRx	RBC	Millipore
FLT1	active (450nM)	active (37.01%)	active (4%)
FLT4	active (670nM)	active (10.86%)	active (1%)
KDR	inactive (3200nM)	active (30.59%)	active (3%)

TK - InsR

Bioactivity
Kinase	DRx	RBC	Millipore
IGF1R	inactive (10001nM)	inactive (97.11%)	inactive (115%)
INSR	inactive (10001nM)	inactive (106.22%)	inactive (87%)
IRR	inactive (10001nM)	inactive (96.17%)	inactive (98%)

TK - JakA

Bioactivity
Kinase	DRx	RBC	Millipore
JAK1	active (670nM)	active (16.26%)	-
JAK2	active (94nM)	active (8.94%)	active (7%)
JAK3	active (12nM)	active (0.78%)	active (1%)
TYK2	active (250nM)	active (8.26%)	-

TK - Met

Bioactivity
Kinase	DRx	RBC	Millipore
MET	active (690nM)	inactive (89.4%)	active (35%)
RON	inactive (10001nM)	inactive (101.13%)	active (47%)

TK - Musk

Bioactivity
Kinase	DRx	RBC	Millipore
MUSK	inactive (10001nM)	active (44.61%)	active (32%)

TK - Ret

Bioactivity
Kinase	DRx	RBC	Millipore
RET	active (350nM)	active (15.6%)	active (8%)

TK - Sev

Bioactivity
Kinase	DRx	RBC	Millipore
ROS	active (430nM)	active (6.53%)	inactive (63%)

TK - Syk

Bioactivity
Kinase	DRx	RBC	Millipore
SYK	active (88nM)	active (16.82%)	active (2%)
ZAP70	active (2600nM)	inactive (65.4%)	inactive (70%)

TK - Tie

Bioactivity
Kinase	DRx	RBC	Millipore
TIE1	active (1400nM)	-	-
TIE2	active (1900nM)	inactive (95.83%)	inactive (133%)

TK - Ack

Bioactivity
Kinase	DRx	RBC	Millipore
TNK1	active (83nM)	-	-
ACK	active (120nM)	active (0.49%)	active (11%)

TK - Trk

Bioactivity
Kinase	DRx	RBC	Millipore
TRKA	active (380nM)	active (5.85%)	active (0%)
TRKB	active (310nM)	active (12.82%)	active (23%)
TRKC	active (1700nM)	active (3.76%)	-

TKL

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC	Millipore
STKR	12	10	5	2
RIPK	5	4	1	1
RAF	5	2	3	1
MLK	10	8	5	2
IRAK	4	3	2	2
LISK	4	3	1	1
LRRK	2	1	1	-

TKL - STKR

Bioactivity
Kinase	DRx	RBC	Millipore
ALK2	inactive (10001nM)	inactive (95.46%)	-
ALK4	inactive (10001nM)	inactive (101.69%)	inactive (128%)
ACTR2	inactive (10001nM)	-	-
ACTR2B	inactive (10001nM)	-	-
ALK1	inactive (10001nM)	inactive (94.34%)	-
BMPR1A	inactive (10001nM)	-	-
BMPR1B	inactive (10001nM)	-	-
BMPR2	inactive (10001nM)	-	-
TGFbR1	inactive (10001nM)	inactive (98.73%)	inactive (85%)
TGFbR2	inactive (10001nM)	inactive (99.06%)	-

TKL - RIPK

Bioactivity
Kinase	DRx	RBC	Millipore
SgK288	inactive (10001nM)	-	-
RIPK1	inactive (10001nM)	-	-
RIPK2	inactive (10001nM)	inactive (82.76%)	inactive (88%)
ANKRD3	inactive (10001nM)	-	-

TKL - RAF

Bioactivity
Kinase	DRx	RBC	Millipore
BRAF	inactive (10001nM)	inactive (106.05%)	-
RAF1	inactive (10001nM)	inactive (114.23%)	inactive (80%)
ARAF	-	inactive (121.61%)	-

TKL - MLK

Bioactivity
Kinase	DRx	RBC	Millipore
DLK	inactive (10001nM)	-	-
LZK	active (2800nM)	-	-
MLK1	active (15nM)	active (0.45%)	active (1%)
MLK2	active (790nM)	active (3.15%)	-
MLK3	active (17nM)	active (1.38%)	-
TAK1	active (130nM)	active (19%)	active (39%)
HH498	inactive (10001nM)	-	-
ZAK	inactive (10001nM)	inactive (94.19%)	-

TKL - IRAK

Bioactivity
Kinase	DRx	RBC	Millipore
IRAK1	inactive (10001nM)	inactive (86.31%)	inactive (85%)
IRAK3	active (180nM)	-	-
IRAK4	inactive (10001nM)	inactive (71.45%)	inactive (53%)

TKL - LISK

Bioactivity
Kinase	DRx	RBC	Millipore
LIMK1	inactive (10001nM)	active (19.6%)	active (22%)
LIMK2	inactive (10001nM)	-	-
TESK1	inactive (10001nM)	-	-

TKL - LRRK

Bioactivity
Kinase	DRx	RBC	Millipore
LRRK2	active (570nM)	active (8.46%)	-

Atypical

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC	Millipore
ABC1	5	2	-	-
PIKK	6	1	-	1
RIO	3	3	-	-
Alpha	6	1	-	1
PDHK	5	-	1	-

Atypical - ABC1

Bioactivity
Kinase	DRx	RBC	Millipore
ADCK3	inactive (10001nM)	-	-
ADCK4	inactive (10001nM)	-	-

Atypical - PIKK

Bioactivity
Kinase	DRx	RBC	Millipore
FRAP	inactive (10001nM)	-	inactive (95%)

Atypical - RIO

Bioactivity
Kinase	DRx	RBC	Millipore
RIOK1	active (1200nM)	-	-
RIOK2	active (97nM)	-	-
RIOK3	active (420nM)	-	-

Atypical - Alpha

Bioactivity
Kinase	DRx	RBC	Millipore
ChaK2	inactive (10001nM)	-	-
eEF2K	-	-	inactive (83%)

Atypical - PDHK

Bioactivity
Kinase	DRx	RBC	Millipore
PDHK1	-	active (21.75%)	-

AGC

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC	Millipore
Akt	3	3	3	3
DMPK	7	7	5	5
GRK	7	3	6	3
NDR	4	4	1	-
MAST	5	1	-	-
PDK1	1	1	1	1
PKA	5	3	3	2
PKN	3	2	2	1
PKC	9	5	9	8
PKG	2	2	3	-
RSK	8	1	8	7
SGK	3	1	3	3
YANK	3	3	-	-

AGC - Akt

Bioactivity
Kinase	DRx	RBC	Millipore
AKT1	active (950nM)	inactive (81.28%)	inactive (97%)
AKT2	active (780nM)	inactive (77.21%)	inactive (80%)
AKT3	inactive (4400nM)	inactive (55.13%)	active (22%)

AGC - DMPK

Bioactivity
Kinase	DRx	RBC	Millipore
CRIK	inactive (10001nM)	-	-
DMPK1	inactive (3800nM)	inactive (112.42%)	inactive (98%)
DMPK2	inactive (10001nM)	-	-
MRCKa	inactive (10001nM)	inactive (95.98%)	inactive (93%)
MRCKb	inactive (10001nM)	inactive (95.89%)	inactive (85%)
ROCK1	inactive (7800nM)	inactive (85.32%)	inactive (110%)
ROCK2	active (2300nM)	inactive (80.88%)	inactive (79%)

AGC - GRK

Bioactivity
Kinase	DRx	RBC	Millipore
RHOK	active (85nM)	-	-
GPRK4	active (110nM)	inactive (94.4%)	-
GPRK7	active (48nM)	active (15.55%)	active (8%)
BARK1	-	inactive (101.85%)	-
BARK2	-	inactive (97.46%)	-
GPRK5	-	inactive (93.32%)	inactive (82%)
GPRK6	-	inactive (60.82%)	inactive (79%)

AGC - NDR

Bioactivity
Kinase	DRx	RBC	Millipore
LATS1	active (1100nM)	-	-
LATS2	active (2200nM)	-	-
NDR1	inactive (10001nM)	inactive (83.79%)	-
NDR2	inactive (10001nM)	-	-

AGC - MAST

Bioactivity
Kinase	DRx	RBC	Millipore
MAST1	active (190nM)	-	-

AGC - PDK1

Bioactivity
Kinase	DRx	RBC	Millipore
PDK1	active (190nM)	active (21.75%)	active (2%)

AGC - PKA

Bioactivity
Kinase	DRx	RBC	Millipore
PKACa	active (720nM)	active (34%)	active (13%)
PKACb	active (240nM)	-	-
PRKX	active (960nM)	inactive (55.36%)	active (24%)
PKACg	-	inactive (58.08%)	-

AGC - PKN

Bioactivity
Kinase	DRx	RBC	Millipore
PKN1	active (9.3nM)	active (1.37%)	-
PKN2	active (15nM)	active (11.43%)	active (2%)

AGC - PKC

Bioactivity
Kinase	DRx	RBC	Millipore
PKCd	active (320nM)	active (10.93%)	active (21%)
PKCe	active (540nM)	active (10.68%)	active (42%)
PKCh	active (290nM)	active (20.43%)	inactive (84%)
PKCi	inactive (10001nM)	inactive (96.43%)	inactive (79%)
PKCt	active (920nM)	inactive (76.87%)	active (15%)
PKCa	-	active (27.72%)	active (36%)
PKCg	-	active (35.59%)	active (15%)
PKCz	-	inactive (98.6%)	inactive (101%)
PKCb	-	active (9.54%)	-

AGC - PKG

Bioactivity
Kinase	DRx	RBC	Millipore
PKG1	active (250nM)	active (8.37%)	-
PKG2	active (74nM)	active (-9.42%)	-

AGC - RSK

Bioactivity
Kinase	DRx	RBC	Millipore
p70S6K	active (1300nM)	active (19.36%)	active (4%)
MSK1	-	active (13.22%)	active (13%)
MSK2	-	active (16.77%)	active (12%)
p70S6Kb	-	inactive (55.91%)	-
RSK2	-	active (3.19%)	active (1%)
RSK4	-	active (1.15%)	active (0%)
RSK1	-	active (0.43%)	active (1%)
RSK3	-	active (3.06%)	active (0%)

AGC - SGK

Bioactivity
Kinase	DRx	RBC	Millipore
SGK3	active (1400nM)	inactive (93.47%)	inactive (87%)
SGK1	-	inactive (81.87%)	inactive (57%)
SGK2	-	inactive (99.01%)	inactive (80%)

AGC - YANK

Bioactivity
Kinase	DRx	RBC	Millipore
YANK1	active (2400nM)	-	-
YANK2	inactive (10001nM)	-	-
YANK3	inactive (10001nM)	-	-

CAMK

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC	Millipore
CAMKL	20	19	13	12
CAMK1	5	4	5	3
CAMK2	4	4	4	3
CASK	1	1	-	-
RAD53	1	1	1	1
DAPK	5	5	4	4
DCAMKL	3	3	1	1
MAPKAPK	5	4	5	4
MLCK	5	4	2	1
PHK	2	2	2	1
PIM	3	3	3	3
PKD	3	3	3	2
STK33	1	1	-	-
TSSK	5	1	2	2

CAMK - CAMKL

Bioactivity
Kinase	DRx	RBC	Millipore
AMPKa1	active (180nM)	-	active (10%)
AMPKa2	active (460nM)	-	active (1%)
NuaK1	active (41nM)	active (2.71%)	active (7%)
BRSK1	active (1200nM)	active (21.12%)	active (3%)
BRSK2	active (650nM)	active (16.4%)	active (4%)
CHK1	active (1300nM)	inactive (53%)	inactive (59%)
HUNK	active (240nM)	-	-
LKB1	active (350nM)	inactive (94.82%)	inactive (95%)
MARK1	active (170nM)	active (4.09%)	active (1%)
MARK2	active (100nM)	active (3.53%)	active (0%)
MARK3	active (21nM)	active (4.76%)	-
MARK4	active (370nM)	active (3.16%)	-
MELK	active (280nM)	active (4.87%)	active (5%)
NIM1	inactive (10001nM)	-	-
QSK	active (98nM)	-	-
SIK	active (160nM)	-	active (4%)
QIK	active (560nM)	active (11.7%)	-
NuaK2	active (63nM)	active (26.19%)	-
SNRK	inactive (10001nM)	-	-
PASK	-	inactive (90.86%)	inactive (85%)

CAMK - CAMK1

Bioactivity
Kinase	DRx	RBC	Millipore
CaMK1a	active (2000nM)	inactive (93%)	inactive (84%)
CaMK1d	active (670nM)	inactive (80.82%)	active (42%)
CaMK1g	active (1800nM)	inactive (96.65%)	-
CaMK4	inactive (10001nM)	inactive (102.97%)	inactive (98%)
CaMK1b	-	inactive (92.86%)	-

CAMK - CAMK2

Bioactivity
Kinase	DRx	RBC	Millipore
CaMK2a	active (20nM)	active (36.75%)	-
CaMK2b	active (210nM)	inactive (57.36%)	active (18%)
CaMK2d	active (36nM)	active (17.3%)	active (5%)
CaMK2g	active (140nM)	active (43.92%)	active (10%)

CAMK - CASK

Bioactivity
Kinase	DRx	RBC	Millipore
CASK	inactive (10001nM)	-	-

CAMK - RAD53

Bioactivity
Kinase	DRx	RBC	Millipore
CHK2	inactive (10001nM)	inactive (85.05%)	inactive (79%)

CAMK - DAPK

Bioactivity
Kinase	DRx	RBC	Millipore
DAPK1	inactive (4700nM)	inactive (84.03%)	inactive (63%)
DAPK2	active (890nM)	inactive (104.92%)	inactive (71%)
DAPK3	active (1800nM)	inactive (82.6%)	inactive (56%)
DRAK1	active (1900nM)	inactive (62.87%)	active (16%)
DRAK2	inactive (4700nM)	-	-

CAMK - DCAMKL

Bioactivity
Kinase	DRx	RBC	Millipore
DCLK1	inactive (10001nM)	-	-
DCLK2	inactive (10001nM)	inactive (101.11%)	inactive (75%)
DCLK3	inactive (10001nM)	-	-

CAMK - MAPKAPK

Bioactivity
Kinase	DRx	RBC	Millipore
MAPKAPK2	inactive (10001nM)	inactive (97.78%)	inactive (75%)
MAPKAPK5	inactive (10001nM)	inactive (91.96%)	inactive (102%)
MNK1	inactive (10001nM)	inactive (92.74%)	-
MNK2	active (950nM)	inactive (58.06%)	active (44%)
MAPKAPK3	-	inactive (91.52%)	inactive (68%)

CAMK - MLCK

Bioactivity
Kinase	DRx	RBC	Millipore
caMLCK	active (2300nM)	-	-
smMLCK	active (2000nM)	active (27.34%)	active (13%)
skMLCK	inactive (10001nM)	inactive (83.53%)	-
SgK085	active (640nM)	-	-

CAMK - PHK

Bioactivity
Kinase	DRx	RBC	Millipore
PHKg1	active (900nM)	active (2.34%)	-
PHKg2	active (1400nM)	inactive (79.71%)	active (44%)

CAMK - PIM

Bioactivity
Kinase	DRx	RBC	Millipore
PIM1	active (560nM)	active (41.18%)	active (33%)
PIM2	inactive (3100nM)	inactive (98.8%)	inactive (80%)
PIM3	active (560nM)	inactive (60.75%)	inactive (93%)

CAMK - PKD

Bioactivity
Kinase	DRx	RBC	Millipore
PKD1	inactive (10001nM)	inactive (71.55%)	inactive (85%)
PKD2	inactive (6300nM)	inactive (62.87%)	inactive (101%)
PKD3	inactive (3200nM)	active (44.88%)	-

CAMK - STK33

Bioactivity
Kinase	DRx	RBC	Millipore
STK33	active (190nM)	active (46.43%)	active (25%)

CAMK - TSSK

Bioactivity
Kinase	DRx	RBC	Millipore
TSSK1	inactive (4800nM)	active (8.24%)	active (15%)
TSSK2	-	inactive (89.09%)	inactive (51%)

STE

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC	Millipore
STE11	8	8	3	1
STE20	31	27	23	14
STE7	7	7	3	3
STE-Unique	2	-	2	-

STE - STE11

Bioactivity
Kinase	DRx	RBC	Millipore
MAP3K5	inactive (10001nM)	inactive (100.89%)	inactive (96%)
MAP3K6	inactive (10001nM)	-	-
MAP3K1	inactive (10001nM)	-	-
MAP3K7	inactive (10001nM)	-	-
MAP3K2	active (140nM)	active (30.16%)	-
MAP3K3	active (210nM)	active (31.04%)	-
MAP3K4	inactive (10001nM)	-	-
MAP3K8	active (15nM)	-	-

STE - STE20

Bioactivity
Kinase	DRx	RBC	Millipore
HPK1	active (2100nM)	-	-
LOK	active (590nM)	active (19.25%)	active (21%)
GCK	active (2500nM)	active (5.17%)	active (4%)
KHS2	active (120nM)	-	-
HGK	active (650nM)	active (7.25%)	-
KHS1	active (1100nM)	active (7.01%)	-
MINK	active (170nM)	active (29.21%)	inactive (52%)
MST1	active (40nM)	active (5.58%)	active (1%)
MST2	active (220nM)	active (1.93%)	active (3%)
MST3	inactive (10001nM)	active (39.1%)	active (17%)
MST4	inactive (10001nM)	active (23.82%)	-
MYO3A	inactive (10001nM)	-	-
MYO3B	inactive (10001nM)	inactive (53.74%)	-
OSR1	inactive (10001nM)	inactive (98.17%)	-
PAK1	active (2100nM)	active (35.1%)	-
PAK2	inactive (3300nM)	inactive (66.62%)	inactive (72%)
PAK3	active (180nM)	inactive (54.74%)	active (33%)
PAK4	inactive (10001nM)	inactive (92.89%)	inactive (64%)
PAK6	inactive (10001nM)	inactive (96.4%)	active (49%)
PAK5	inactive (10001nM)	inactive (90.4%)	inactive (52%)
SLK	active (220nM)	active (30.49%)	-
STLK3	inactive (10001nM)	inactive (96.05%)	-
TAO1	inactive (10001nM)	inactive (60.77%)	active (50%)
TAO2	inactive (10001nM)	inactive (86.22%)	inactive (83%)
TAO3	inactive (10001nM)	active (38.08%)	active (42%)
TNIK	active (1600nM)	-	-
YSK1	active (1800nM)	inactive (54.97%)	-

STE - STE7

Bioactivity
Kinase	DRx	RBC	Millipore
MAP2K1	inactive (10001nM)	inactive (108.98%)	inactive (74%)
MAP2K2	inactive (10001nM)	inactive (81.5%)	-
MAP2K3	inactive (5300nM)	-	-
MAP2K4	inactive (4800nM)	-	-
MAP2K5	inactive (10001nM)	-	-
MAP2K6	inactive (6500nM)	inactive (91.43%)	inactive (52%)
MAP2K7	inactive (10001nM)	-	inactive (111%)

STE - STE-Unique

Bioactivity
Kinase	DRx	RBC	Millipore
COT	-	inactive (99.62%)	-
NIK	-	inactive (113.31%)	-

CMGC

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC	Millipore
CDK	20	8	-	-
CDKL	5	4	-	-
CLK	4	4	4	2
CK2	3	2	2	2
DYRK	10	8	9	4
MAPK	14	14	10	10
GSK	2	2	2	2
RCK	3	2	-	-
SRPK	3	3	3	3

CMGC - CDK

Bioactivity
Kinase	DRx	RBC	Millipore
PITSLRE	inactive (10001nM)	-	-
CHED	inactive (10001nM)	-	-
CDK11	inactive (7200nM)	-	-
PCTAIRE1	inactive (10001nM)	-	-
PCTAIRE2	inactive (10001nM)	-	-
PCTAIRE3	inactive (10001nM)	-	-
PFTAIRE2	inactive (10001nM)	-	-
PFTAIRE1	inactive (10001nM)	-	-

CMGC - CDKL

Bioactivity
Kinase	DRx	RBC	Millipore
CDKL1	inactive (10001nM)	-	-
CDKL2	inactive (10001nM)	-	-
CDKL3	inactive (10001nM)	-	-
CDKL5	inactive (10001nM)	-	-

CMGC - CLK

Bioactivity
Kinase	DRx	RBC	Millipore
CLK1	active (350nM)	inactive (55.8%)	-
CLK2	active (860nM)	active (36.04%)	active (17%)
CLK3	inactive (3600nM)	inactive (89.58%)	inactive (51%)
CLK4	active (410nM)	active (22.59%)	-

CMGC - CK2

Bioactivity
Kinase	DRx	RBC	Millipore
CK2a1	inactive (10001nM)	inactive (100.64%)	inactive (73%)
CK2a2	inactive (10001nM)	inactive (87.85%)	inactive (117%)

CMGC - DYRK

Bioactivity
Kinase	DRx	RBC	Millipore
DYRK1A	active (100nM)	active (32.24%)	-
DYRK1B	active (330nM)	active (35.6%)	-
DYRK2	inactive (10001nM)	inactive (108.17%)	inactive (90%)
HIPK1	inactive (10001nM)	inactive (101.41%)	inactive (95%)
HIPK2	inactive (3100nM)	inactive (106.09%)	inactive (75%)
HIPK3	active (2300nM)	inactive (93.33%)	inactive (80%)
HIPK4	active (950nM)	inactive (90.54%)	-
PRP4	active (55nM)	-	-
DYRK3	-	inactive (98.5%)	-
DYRK4	-	inactive (96.41%)	-

CMGC - MAPK

Bioactivity
Kinase	DRx	RBC	Millipore
Erk1	inactive (10001nM)	inactive (88.35%)	inactive (75%)
Erk2	inactive (10001nM)	inactive (88.85%)	inactive (101%)
Erk3	inactive (10001nM)	-	-
Erk4	inactive (10001nM)	-	-
Erk5	inactive (10001nM)	-	-
Erk7	inactive (10001nM)	-	-
JNK1	inactive (4400nM)	inactive (88.29%)	inactive (92%)
JNK2	inactive (5000nM)	inactive (82.67%)	inactive (99%)
JNK3	inactive (3600nM)	inactive (98.94%)	active (50%)
NLK	inactive (10001nM)	inactive (96.93%)	inactive (90%)
p38a	inactive (10001nM)	inactive (93.71%)	inactive (71%)
p38b	inactive (10001nM)	inactive (97.63%)	inactive (86%)
p38d	inactive (10001nM)	inactive (103.88%)	inactive (92%)
p38g	inactive (10001nM)	inactive (95.84%)	inactive (104%)

CMGC - GSK

Bioactivity
Kinase	DRx	RBC	Millipore
GSK3A	active (2500nM)	active (27.39%)	active (17%)
GSK3B	active (1800nM)	active (49.79%)	active (39%)

CMGC - RCK

Bioactivity
Kinase	DRx	RBC	Millipore
ICK	inactive (5900nM)	-	-
MAK	inactive (10001nM)	-	-

CMGC - SRPK

Bioactivity
Kinase	DRx	RBC	Millipore
SRPK1	active (42nM)	inactive (97.13%)	inactive (78%)
SRPK2	active (330nM)	inactive (83.15%)	inactive (64%)
MSSK1	active (80nM)	inactive (93.27%)	inactive (96%)

CK1

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC	Millipore
CK1	7	7	6	4
VRK	3	1	1	1

CK1 - CK1

Bioactivity
Kinase	DRx	RBC	Millipore
CK1a	inactive (10001nM)	inactive (96.25%)	-
CK1a2	inactive (10001nM)	-	-
CK1d	inactive (10001nM)	inactive (100.59%)	inactive (80%)
CK1e	inactive (10001nM)	inactive (96.57%)	-
CK1g1	inactive (10001nM)	inactive (102.98%)	inactive (66%)
CK1g2	inactive (10001nM)	inactive (98.3%)	inactive (82%)
CK1g3	inactive (10001nM)	inactive (95.34%)	inactive (66%)

CK1 - VRK

Bioactivity
Kinase	DRx	RBC	Millipore
VRK2	inactive (10001nM)	-	inactive (99%)
VRK1	-	inactive (90.82%)	-