Compound Information


Test on : Metz

Compound Name : MK-1775

Inchikey : BKWJAKQVGHWELA-UHFFFAOYSA-N

ChemSpider : 24808590

Pubchem CID : 24856436

ChEMBL : CHEMBL1976040




DRx RBC Metz Millipore GPCR
bioactivity Kd (nM) Remain Activity (%) Ki (nM) Remain Activity (%) Inhibition (%)
active criteria <3000nM <50% <1000nM <50% >50%

AGC


Test Member No. in Family
Familyno. Member on 518kinaseMetz
33
73
71
11
52
95
22
31
84
31
AGC - Akt

Bioactivity
KinaseMetz
AKT1-
AKT2-
AKT3-
AGC - DMPK

Bioactivity
KinaseMetz
MRCKa-
ROCK1inactive (>3981.07nM)
ROCK2-
AGC - GRK

Bioactivity
KinaseMetz
GPRK5inactive (>3981.07nM)
AGC - PDK1

Bioactivity
KinaseMetz
PDK1-
AGC - PKA

Bioactivity
KinaseMetz
PKACa-
PRKXinactive (>3162.28nM)
AGC - PKC

Bioactivity
KinaseMetz
PKCd-
PKCg-
PKCz-
PKCi-
PKCtactive (794.33nM)
AGC - PKG

Bioactivity
KinaseMetz
PKG1-
PKG2-
AGC - PKN

Bioactivity
KinaseMetz
PKN2inactive (>5011.87nM)
AGC - RSK

Bioactivity
KinaseMetz
RSK2inactive (>3162.28nM)
p70S6K-
MSK1-
MSK2-
AGC - SGK

Bioactivity
KinaseMetz
SGK1-

Atypical


Test Member No. in Family
Familyno. Member on 518kinaseMetz
61
Atypical - Alpha

Bioactivity
KinaseMetz
eEF2K-

CAMK


Test Member No. in Family
Familyno. Member on 518kinaseMetz
52
44
209
52
31
54
21
33
32
11
11
52
CAMK - CAMK1

Bioactivity
KinaseMetz
CaMK1a-
CaMK1dinactive (>2511.89nM)
CAMK - CAMK2

Bioactivity
KinaseMetz
CaMK2b-
CaMK2d-
CaMK2g-
CaMK2ainactive (>3981.07nM)
CAMK - CAMKL

Bioactivity
KinaseMetz
CHK1inactive (>3162.28nM)
BRSK1-
MARK2-
MARK3-
MELK-
AMPKa1inactive (>3162.28nM)
PASK-
MARK4-
QIK-
CAMK - DAPK

Bioactivity
KinaseMetz
DAPK3inactive (>5011.87nM)
DRAK1-
CAMK - DCAMKL

Bioactivity
KinaseMetz
DCLK1-
CAMK - MAPKAPK

Bioactivity
KinaseMetz
MAPKAPK2-
MAPKAPK3-
MNK2-
MAPKAPK5-
CAMK - PHK

Bioactivity
KinaseMetz
PHKg2-
CAMK - PIM

Bioactivity
KinaseMetz
PIM1inactive (>6309.57nM)
PIM2-
PIM3-
CAMK - PKD

Bioactivity
KinaseMetz
PKD3active (1000nM)
PKD2-
CAMK - RAD53

Bioactivity
KinaseMetz
CHK2-
CAMK - STK33

Bioactivity
KinaseMetz
STK33-
CAMK - TSSK

Bioactivity
KinaseMetz
TSSK1-
TSSK2-

CK1


Test Member No. in Family
Familyno. Member on 518kinaseMetz
75
CK1 - CK1

Bioactivity
KinaseMetz
CK1ainactive (3981.07nM)
CK1d-
CK1g1-
CK1g2-
CK1g3-

CMGC


Test Member No. in Family
Familyno. Member on 518kinaseMetz
207
31
42
106
22
148
31
CMGC - CDK

Bioactivity
KinaseMetz
CDC2-
CDK2-
CDK5active (630.96nM)
CDK8inactive (>3981.07nM)
CDK7inactive (>3981.07nM)
CDK9-
CDK11inactive (>100000nM)
CMGC - CK2

Bioactivity
KinaseMetz
CK2a1-
CMGC - CLK

Bioactivity
KinaseMetz
CLK2inactive (>3981.07nM)
CLK4active (1000nM)
CMGC - DYRK

Bioactivity
KinaseMetz
DYRK1A-
DYRK3-
DYRK4-
HIPK2-
HIPK4-
DYRK1Binactive (>2511.89nM)
CMGC - GSK

Bioactivity
KinaseMetz
GSK3Ainactive (>3981.07nM)
GSK3Binactive (>3981.07nM)
CMGC - MAPK

Bioactivity
KinaseMetz
Erk2-
p38g-
p38d-
JNK1inactive (>5011.87nM)
JNK2inactive (>3981.07nM)
p38ainactive (>3981.07nM)
JNK3-
NLK-
CMGC - SRPK

Bioactivity
KinaseMetz
SRPK1-

Other


Test Member No. in Family
Familyno. Member on 518kinaseMetz
32
21
11
44
112
43
11
31
Other - Aur

Bioactivity
KinaseMetz
AurBinactive (>3981.07nM)
AurA-
Other - CAMKK

Bioactivity
KinaseMetz
CaMKK2-
Other - CDC7

Bioactivity
KinaseMetz
CDC7-
Other - IKK

Bioactivity
KinaseMetz
IKKeinactive (1584.89nM)
TBK1active (1000nM)
IKKa-
IKKb-
Other - NEK

Bioactivity
KinaseMetz
NEK2active (794.33nM)
NEK4-
Other - PLK

Bioactivity
KinaseMetz
PLK1-
PLK3-
PLK4-
Other - TOPK

Bioactivity
KinaseMetz
PBK-
Other - WEE

Bioactivity
KinaseMetz
Wee1-

STE


Test Member No. in Family
Familyno. Member on 518kinaseMetz
319
72
STE - STE20

Bioactivity
KinaseMetz
GCKinactive (>2511.89nM)
HGKinactive (1584.89nM)
KHS1active (1000nM)
MINKinactive (>5011.87nM)
PAK1-
PAK4inactive (2511.89nM)
SLK-
MST2inactive (>3162.28nM)
TAO1active (1000nM)
STE - STE7

Bioactivity
KinaseMetz
MAP2K1inactive (>3162.28nM)
MAP2K2inactive (>3981.07nM)

TK


Test Member No. in Family
Familyno. Member on 518kinaseMetz
21
21
22
32
21
43
141
22
22
42
32
43
22
55
11
11
119
21
53
33
33
TK - Abl

Bioactivity
KinaseMetz
ABL1active (316.23nM)
TK - Ack

Bioactivity
KinaseMetz
ACKactive (501.19nM)
TK - ALK

Bioactivity
KinaseMetz
ALKinactive (>3162.28nM)
LTKinactive (>2511.89nM)
TK - Axl

Bioactivity
KinaseMetz
TYRO3inactive (1995.26nM)
AXL-
TK - Csk

Bioactivity
KinaseMetz
CTK-
TK - EGFR

Bioactivity
KinaseMetz
EGFR-
ErbB2-
ErbB4-
TK - Eph

Bioactivity
KinaseMetz
EphA2-
TK - FAK

Bioactivity
KinaseMetz
FAKinactive (5011.87nM)
PYK2-
TK - Fer

Bioactivity
KinaseMetz
FER-
FES-
TK - FGFR

Bioactivity
KinaseMetz
FGFR1inactive (>3162.28nM)
FGFR3inactive (>3162.28nM)
TK - InsR

Bioactivity
KinaseMetz
IGF1Rinactive (>2511.89nM)
INSR-
TK - JakA

Bioactivity
KinaseMetz
JAK2inactive (1258.93nM)
JAK3inactive (1258.93nM)
TYK2-
TK - Met

Bioactivity
KinaseMetz
METinactive (>2511.89nM)
RONinactive (>3981.07nM)
TK - PDGFR

Bioactivity
KinaseMetz
FMSinactive (>2511.89nM)
FLT3inactive (>3162.28nM)
KIT-
PDGFRainactive (>2511.89nM)
PDGFRb-
TK - Ret

Bioactivity
KinaseMetz
RETinactive (>1995.26nM)
TK - Sev

Bioactivity
KinaseMetz
ROSinactive (>3162.28nM)
TK - Src

Bioactivity
KinaseMetz
BLK-
LCKactive (398.11nM)
LYN-
SRC-
FRK-
SRM-
FYNinactive (1584.89nM)
BRK-
HCK-
TK - Syk

Bioactivity
KinaseMetz
SYKactive (199.53nM)
TK - Tec

Bioactivity
KinaseMetz
BTKinactive (>5011.87nM)
ITK-
BMX-
TK - Trk

Bioactivity
KinaseMetz
TRKAinactive (>3162.28nM)
TRKBinactive (>3981.07nM)
TRKCinactive (>3162.28nM)
TK - VEGFR

Bioactivity
KinaseMetz
FLT4-
KDR-
FLT1inactive (>3162.28nM)

TKL


Test Member No. in Family
Familyno. Member on 518kinaseMetz
42
41
21
102
51
121
TKL - IRAK

Bioactivity
KinaseMetz
IRAK1-
IRAK4-
TKL - LISK

Bioactivity
KinaseMetz
LIMK1inactive (>3162.28nM)
TKL - LRRK

Bioactivity
KinaseMetz
LRRK2active (398.11nM)
TKL - MLK

Bioactivity
KinaseMetz
ZAK-
MLK2-
TKL - RAF

Bioactivity
KinaseMetz
BRAF-
TKL - STKR

Bioactivity
KinaseMetz
ALK2inactive (>3981.07nM)