Compound Information
Test on : RBC
Compound Name : Cdk1/2 Inhibitor III
Inchikey : ARIOBGGRZJITQX-UHFFFAOYSA-N
ChemSpider : 4487963
Pubchem CID : 5330812
ChEMBL : CHEMBL261720
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
AGC
AGC - PDK1
Bioactivity |
---|
Kinase | RBC |
---|
PDK1 | active (19.31%) |
AGC - Akt
Bioactivity |
---|
Kinase | RBC |
---|
AKT1 | inactive (103.09%) |
AKT2 | inactive (102.59%) |
AKT3 | inactive (96.41%) |
AGC - DMPK
Bioactivity |
---|
Kinase | RBC |
---|
DMPK1 | inactive (78.38%) |
MRCKa | inactive (54.62%) |
MRCKb | active (48.1%) |
ROCK1 | active (0.17%) |
ROCK2 | active (6.22%) |
AGC - GRK
Bioactivity |
---|
Kinase | RBC |
---|
BARK1 | inactive (97.77%) |
BARK2 | inactive (88%) |
GPRK4 | inactive (92.22%) |
GPRK5 | inactive (75.61%) |
GPRK6 | inactive (89.37%) |
GPRK7 | inactive (96.58%) |
AGC - RSK
Bioactivity |
---|
Kinase | RBC |
---|
MSK1 | inactive (68.09%) |
MSK2 | active (42.76%) |
p70S6K | active (30.05%) |
p70S6Kb | inactive (96.15%) |
RSK2 | active (-0.69%) |
RSK4 | active (2.42%) |
RSK1 | active (5.34%) |
RSK3 | active (2.08%) |
AGC - PKA
Bioactivity |
---|
Kinase | RBC |
---|
PKACg | - |
PRKX | inactive (76.27%) |
PKACa | inactive (78.23%) |
AGC - PKC
Bioactivity |
---|
Kinase | RBC |
---|
PKCa | active (46.22%) |
PKCd | active (22.2%) |
PKCe | active (11.55%) |
PKCh | active (45.74%) |
PKCg | inactive (92.98%) |
PKCi | inactive (78.86%) |
PKCt | active (15.14%) |
PKCz | inactive (83.71%) |
PKCb | inactive (74.46%) |
AGC - PKG
Bioactivity |
---|
Kinase | RBC |
---|
PKG2 | inactive (61.45%) |
PKG1 | inactive (91.3%) |
AGC - PKN
Bioactivity |
---|
Kinase | RBC |
---|
PKN1 | active (9.7%) |
PKN2 | active (19.1%) |
AGC - SGK
Bioactivity |
---|
Kinase | RBC |
---|
SGK1 | active (48.66%) |
SGK2 | active (42.01%) |
SGK3 | inactive (98.4%) |
AGC - NDR
Bioactivity |
---|
Kinase | RBC |
---|
NDR1 | active (0%) |
TK
TK - Abl
Bioactivity |
---|
Kinase | RBC |
---|
ABL1 | active (4.96%) |
ABL2 | active (10.52%) |
TK - Ack
Bioactivity |
---|
Kinase | RBC |
---|
ACK | active (6.41%) |
TK - ALK
Bioactivity |
---|
Kinase | RBC |
---|
ALK | active (16.69%) |
LTK | active (27.62%) |
TK - Axl
Bioactivity |
---|
Kinase | RBC |
---|
AXL | active (34.18%) |
MER | active (14.79%) |
TYRO3 | active (29.78%) |
TK - Src
Bioactivity |
---|
Kinase | RBC |
---|
BLK | active (38.62%) |
BRK | active (34.84%) |
SRC | active (41.55%) |
FGR | active (17.1%) |
FRK | inactive (70.63%) |
FYN | active (24.77%) |
HCK | active (37.94%) |
LCK | active (23.57%) |
SRM | inactive (93.96%) |
YES | active (10.54%) |
LYN | active (27.23%) |
TK - Tec
Bioactivity |
---|
Kinase | RBC |
---|
BMX | inactive (77.51%) |
BTK | inactive (84.12%) |
ITK | inactive (61.02%) |
TEC | inactive (106.32%) |
TXK | inactive (85.84%) |
TK - PDGFR
Bioactivity |
---|
Kinase | RBC |
---|
KIT | inactive (78.44%) |
FLT3 | active (1.07%) |
FMS | active (10.58%) |
PDGFRb | active (45.58%) |
PDGFRa | inactive (56.38%) |
TK - Csk
Bioactivity |
---|
Kinase | RBC |
---|
CSK | inactive (76.78%) |
CTK | inactive (133.06%) |
TK - DDR
Bioactivity |
---|
Kinase | RBC |
---|
DDR2 | inactive (130.22%) |
TK - EGFR
Bioactivity |
---|
Kinase | RBC |
---|
EGFR | inactive (95.15%) |
ErbB2 | inactive (104.11%) |
ErbB4 | inactive (97.96%) |
TK - Eph
Bioactivity |
---|
Kinase | RBC |
---|
EphA1 | active (37.4%) |
EphA2 | active (29.92%) |
EphA3 | inactive (85.87%) |
EphA4 | inactive (54.79%) |
EphA5 | inactive (56.75%) |
EphA6 | - |
EphA7 | active (14.23%) |
EphA8 | inactive (98.47%) |
EphB1 | active (19.41%) |
EphB2 | inactive (81.4%) |
EphB3 | inactive (90.43%) |
EphB4 | inactive (50.97%) |
TK - FAK
Bioactivity |
---|
Kinase | RBC |
---|
FAK | active (25.31%) |
PYK2 | active (33.61%) |
TK - Fer
Bioactivity |
---|
Kinase | RBC |
---|
FER | active (21.66%) |
FES | active (10.17%) |
TK - FGFR
Bioactivity |
---|
Kinase | RBC |
---|
FGFR1 | active (6.59%) |
FGFR2 | active (7.43%) |
FGFR3 | active (4.96%) |
FGFR4 | active (32.19%) |
TK - VEGFR
Bioactivity |
---|
Kinase | RBC |
---|
FLT1 | active (11.41%) |
FLT4 | active (3.75%) |
KDR | active (6.55%) |
TK - InsR
Bioactivity |
---|
Kinase | RBC |
---|
IGF1R | active (0.62%) |
IRR | inactive (86.54%) |
INSR | inactive (88.41%) |
TK - JakA
Bioactivity |
---|
Kinase | RBC |
---|
JAK1 | active (4.86%) |
JAK2 | active (3.16%) |
JAK3 | active (5.21%) |
TYK2 | active (5.11%) |
TK - Musk
Bioactivity |
---|
Kinase | RBC |
---|
MUSK | active (8.02%) |
TK - Ret
Bioactivity |
---|
Kinase | RBC |
---|
RET | active (3.09%) |
TK - Met
Bioactivity |
---|
Kinase | RBC |
---|
RON | inactive (56.03%) |
MET | active (40.43%) |
TK - Sev
Bioactivity |
---|
Kinase | RBC |
---|
ROS | active (1.68%) |
TK - Syk
Bioactivity |
---|
Kinase | RBC |
---|
SYK | active (15.54%) |
ZAP70 | inactive (86.91%) |
TK - Tie
Bioactivity |
---|
Kinase | RBC |
---|
TIE2 | active (5.06%) |
TK - Trk
Bioactivity |
---|
Kinase | RBC |
---|
TRKA | active (31.75%) |
TRKB | active (11.82%) |
TRKC | active (3.59%) |
TKL
TKL - STKR
Bioactivity |
---|
Kinase | RBC |
---|
ALK1 | active (15.06%) |
ALK2 | inactive (60.36%) |
ALK4 | inactive (92.15%) |
TGFbR1 | inactive (81.76%) |
TGFbR2 | inactive (89.25%) |
TKL - RAF
Bioactivity |
---|
Kinase | RBC |
---|
ARAF | inactive (129.43%) |
BRAF | inactive (87.21%) |
RAF1 | inactive (110.37%) |
TKL - IRAK
Bioactivity |
---|
Kinase | RBC |
---|
IRAK1 | active (16.89%) |
IRAK4 | active (19.65%) |
TKL - LISK
Bioactivity |
---|
Kinase | RBC |
---|
LIMK1 | active (-0.61%) |
TKL - LRRK
Bioactivity |
---|
Kinase | RBC |
---|
LRRK2 | active (1.33%) |
TKL - MLK
Bioactivity |
---|
Kinase | RBC |
---|
MLK1 | active (-0.37%) |
MLK2 | active (3%) |
MLK3 | active (1.33%) |
TAK1 | active (12.46%) |
ZAK | active (49.14%) |
TKL - RIPK
Bioactivity |
---|
Kinase | RBC |
---|
RIPK2 | active (19.69%) |
CAMK
CAMK - CAMKL
Bioactivity |
---|
Kinase | RBC |
---|
NuaK1 | active (2.13%) |
BRSK1 | active (2.61%) |
BRSK2 | active (9.03%) |
CHK1 | - |
LKB1 | active (23.52%) |
MARK1 | active (2.68%) |
MARK3 | active (0.29%) |
MARK4 | active (2.33%) |
MELK | active (32.74%) |
PASK | inactive (91.75%) |
QIK | active (16.09%) |
NuaK2 | active (9.73%) |
MARK2 | active (3.43%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | RBC |
---|
CaMK1a | - |
CaMK1b | inactive (89.08%) |
CaMK1d | inactive (93.42%) |
CaMK1g | inactive (95.87%) |
CaMK4 | inactive (98.79%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | RBC |
---|
CaMK2a | active (14.28%) |
CaMK2b | active (9.5%) |
CaMK2d | active (15.59%) |
CaMK2g | active (15.6%) |
CAMK - RAD53
Bioactivity |
---|
Kinase | RBC |
---|
CHK2 | active (1.96%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | RBC |
---|
DAPK1 | inactive (81.29%) |
DAPK2 | inactive (83.04%) |
DRAK1 | active (11.14%) |
DAPK3 | inactive (94.2%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | RBC |
---|
DCLK2 | active (40.44%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | RBC |
---|
MAPKAPK2 | inactive (91.13%) |
MAPKAPK3 | inactive (89.61%) |
MAPKAPK5 | inactive (52.2%) |
MNK1 | active (23.35%) |
MNK2 | active (17.21%) |
CAMK - MLCK
Bioactivity |
---|
Kinase | RBC |
---|
smMLCK | inactive (78.84%) |
skMLCK | inactive (66.62%) |
CAMK - PHK
Bioactivity |
---|
Kinase | RBC |
---|
PHKg1 | active (26.02%) |
PHKg2 | inactive (95.54%) |
CAMK - PIM
Bioactivity |
---|
Kinase | RBC |
---|
PIM1 | inactive (90.69%) |
PIM2 | inactive (106.06%) |
PIM3 | inactive (89.09%) |
CAMK - PKD
Bioactivity |
---|
Kinase | RBC |
---|
PKD1 | active (7.79%) |
PKD3 | active (7.37%) |
PKD2 | active (9.05%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | RBC |
---|
TSSK1 | active (13.7%) |
TSSK2 | inactive (91.33%) |
CAMK - STK33
Bioactivity |
---|
Kinase | RBC |
---|
STK33 | active (35.12%) |
STE
STE - STE11
Bioactivity |
---|
Kinase | RBC |
---|
MAP3K5 | active (1.12%) |
MAP3K2 | active (-0.5%) |
MAP3K3 | active (5.41%) |
STE - STE-Unique
Bioactivity |
---|
Kinase | RBC |
---|
COT | inactive (127.19%) |
NIK | active (29.09%) |
STE - STE20
Bioactivity |
---|
Kinase | RBC |
---|
GCK | active (2.13%) |
HGK | active (4.46%) |
KHS1 | active (1.71%) |
LOK | active (3.96%) |
MINK | active (3.06%) |
MST1 | active (2.16%) |
MST2 | active (1.33%) |
MST3 | active (2.88%) |
MST4 | active (4.54%) |
OSR1 | inactive (67.56%) |
PAK1 | active (28.96%) |
PAK2 | active (26.42%) |
PAK3 | active (35.4%) |
PAK4 | active (47.62%) |
PAK5 | active (43.78%) |
PAK6 | inactive (81.91%) |
SLK | active (4.58%) |
YSK1 | active (8.18%) |
STLK3 | inactive (76.55%) |
TAO1 | active (11.3%) |
TAO2 | active (11.45%) |
TAO3 | active (10%) |
MYO3B | active (0%) |
STE - STE7
Bioactivity |
---|
Kinase | RBC |
---|
MAP2K1 | inactive (94.61%) |
MAP2K2 | inactive (96.59%) |
MAP2K6 | inactive (62.74%) |
Other
Other - Aur
Bioactivity |
---|
Kinase | RBC |
---|
AurA | active (1.44%) |
AurB | active (12.91%) |
AurC | active (16.21%) |
Other - CAMKK
Bioactivity |
---|
Kinase | RBC |
---|
CaMKK1 | active (35.99%) |
CaMKK2 | active (5.4%) |
Other - Haspin
Bioactivity |
---|
Kinase | RBC |
---|
Haspin | inactive (85.35%) |
Other - IKK
Bioactivity |
---|
Kinase | RBC |
---|
IKKa | inactive (54.36%) |
IKKb | active (49.27%) |
IKKe | inactive (67.17%) |
TBK1 | active (10.26%) |
Other - NEK
Bioactivity |
---|
Kinase | RBC |
---|
NEK1 | active (6.11%) |
NEK11 | inactive (100.89%) |
NEK2 | inactive (98.28%) |
NEK4 | inactive (60.54%) |
NEK6 | inactive (78.81%) |
NEK7 | inactive (82.63%) |
NEK9 | active (39.07%) |
NEK3 | active (19.56%) |
Other - TOPK
Bioactivity |
---|
Kinase | RBC |
---|
PBK | inactive (104.96%) |
Other - PLK
Bioactivity |
---|
Kinase | RBC |
---|
PLK1 | inactive (92.06%) |
PLK2 | inactive (88.49%) |
PLK3 | inactive (92.17%) |
Other - SgK496
Bioactivity |
---|
Kinase | RBC |
---|
SgK496 | active (17.82%) |
Other - NAK
Bioactivity |
---|
Kinase | RBC |
---|
MPSK1 | active (42.48%) |
Other - TTK
Bioactivity |
---|
Kinase | RBC |
---|
TTK | inactive (60.59%) |
Other - ULK
Bioactivity |
---|
Kinase | RBC |
---|
ULK1 | active (5.03%) |
ULK2 | active (4.73%) |
ULK3 | active (0%) |
Other - WEE
Bioactivity |
---|
Kinase | RBC |
---|
Wee1 | inactive (100.43%) |
Other - WNK
Bioactivity |
---|
Kinase | RBC |
---|
Wnk2 | inactive (97.91%) |
Wnk3 | inactive (82.15%) |
Other - TLK
Bioactivity |
---|
Kinase | RBC |
---|
TLK2 | active (0%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | RBC |
---|
CK1 | 7 | 6 |
VRK | 3 | 1 |
CK1 - CK1
Bioactivity |
---|
Kinase | RBC |
---|
CK1d | inactive (83.7%) |
CK1g1 | active (16.71%) |
CK1g2 | active (14.81%) |
CK1g3 | active (20.81%) |
CK1a | inactive (90.16%) |
CK1e | inactive (91.76%) |
CK1 - VRK
Bioactivity |
---|
Kinase | RBC |
---|
VRK1 | inactive (94.6%) |
CMGC
CMGC - CK2
Bioactivity |
---|
Kinase | RBC |
---|
CK2a1 | inactive (76.55%) |
CK2a2 | inactive (81.92%) |
CMGC - CLK
Bioactivity |
---|
Kinase | RBC |
---|
CLK1 | active (2.26%) |
CLK2 | active (3.81%) |
CLK3 | active (4.64%) |
CLK4 | active (1.92%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | RBC |
---|
DYRK1A | active (15.25%) |
DYRK1B | active (14.08%) |
DYRK2 | inactive (60.39%) |
DYRK3 | inactive (98.52%) |
DYRK4 | inactive (96.5%) |
HIPK1 | inactive (104.59%) |
HIPK2 | inactive (62.07%) |
HIPK3 | inactive (78.15%) |
HIPK4 | inactive (50.59%) |
CMGC - MAPK
Bioactivity |
---|
Kinase | RBC |
---|
Erk1 | inactive (78.89%) |
Erk2 | inactive (76.24%) |
JNK3 | inactive (104.69%) |
NLK | active (45.1%) |
p38a | inactive (95.42%) |
p38b | inactive (78.46%) |
p38d | inactive (77.1%) |
p38g | inactive (95.22%) |
JNK1 | inactive (78.76%) |
JNK2 | inactive (80.93%) |
CMGC - GSK
Bioactivity |
---|
Kinase | RBC |
---|
GSK3A | active (6.3%) |
GSK3B | active (9.03%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | RBC |
---|
MSSK1 | active (48.65%) |
SRPK1 | active (25.9%) |
SRPK2 | active (17.1%) |
Atypical
Atypical
Test Member No. in Family |
---|
Family | no. Member on 518kinase | RBC |
---|
PDHK | 5 | 1 |
Atypical - PDHK
Bioactivity |
---|
Kinase | RBC |
---|
PDHK1 | active (19.31%) |