Compound Information
Test on : GPCR
Compound Name : GW513184X
Inchikey : AKHRMFAGIBQWDR-UHFFFAOYSA-N
ChemSpider : 26610572
Pubchem CID : 3805075
ChEMBL : CHEMBL1789961
|
DRx |
RBC |
Metz |
Millipore |
GPCR |
bioactivity |
Kd (nM) |
Remain Activity (%) |
Ki (nM) |
Remain Activity (%) |
Inhibition (%) |
active criteria |
<3000nM |
<50% |
<1000nM |
<50% |
>50% |
TK
TK - JakA
Bioactivity |
---|
Kinase | GPCR |
---|
JAK1 | inactive (3.21%) |
TYK2 | inactive (0.57%) |
JAK2 | inactive (8.82%) |
JAK3 | inactive (4.39%) |
TK - Fer
Bioactivity |
---|
Kinase | GPCR |
---|
FER | inactive (4.88%) |
FES | inactive (4.03%) |
TK - Abl
Bioactivity |
---|
Kinase | GPCR |
---|
ABL1 | active (73.71%) |
ABL2 | active (71.51%) |
TK - Csk
Bioactivity |
---|
Kinase | GPCR |
---|
CSK | inactive (5.56%) |
TK - Tec
Bioactivity |
---|
Kinase | GPCR |
---|
BMX | inactive (21.93%) |
BTK | inactive (2.34%) |
TXK | inactive (5.94%) |
TEC | inactive (12.87%) |
ITK | inactive (4.53%) |
TK - Src
Bioactivity |
---|
Kinase | GPCR |
---|
BRK | inactive (14.2%) |
SRM | inactive (4.56%) |
FRK | inactive (3.44%) |
BLK | active (65.45%) |
LCK | active (63.87%) |
HCK | inactive (41.61%) |
FGR | inactive (49.63%) |
FYN | inactive (47.5%) |
SRC | active (78.98%) |
YES | active (64.88%) |
TK - Eph
Bioactivity |
---|
Kinase | GPCR |
---|
EphA2 | inactive (11.41%) |
EphA4 | inactive (17.11%) |
EphA3 | inactive (8.46%) |
EphB4 | inactive (9.64%) |
EphB3 | inactive (-2.55%) |
EphB2 | inactive (18.22%) |
TK - FAK
Bioactivity |
---|
Kinase | GPCR |
---|
PYK2 | inactive (14.24%) |
TK - Syk
Bioactivity |
---|
Kinase | GPCR |
---|
SYK | inactive (43.15%) |
ZAP70 | inactive (9.72%) |
TK - ALK
Bioactivity |
---|
Kinase | GPCR |
---|
LTK | inactive (6.55%) |
ALK | inactive (6.69%) |
TK - Sev
Bioactivity |
---|
Kinase | GPCR |
---|
ROS | inactive (31.2%) |
TK - InsR
Bioactivity |
---|
Kinase | GPCR |
---|
INSR | inactive (2.58%) |
IGF1R | inactive (3.81%) |
IRR | inactive (2.41%) |
TK - DDR
Bioactivity |
---|
Kinase | GPCR |
---|
DDR2 | inactive (13.57%) |
TK - Musk
Bioactivity |
---|
Kinase | GPCR |
---|
MUSK | inactive (43.75%) |
TK - Trk
Bioactivity |
---|
Kinase | GPCR |
---|
TRKA | inactive (14.3%) |
TRKB | inactive (33.07%) |
TRKC | inactive (34.57%) |
TK - Met
Bioactivity |
---|
Kinase | GPCR |
---|
RON | active (64.45%) |
MET | active (88.64%) |
TK - Axl
Bioactivity |
---|
Kinase | GPCR |
---|
AXL | inactive (10.56%) |
MER | inactive (34.5%) |
TYRO3 | inactive (33.45%) |
TK - Ret
Bioactivity |
---|
Kinase | GPCR |
---|
RET | active (80.64%) |
TK - FGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FGFR1 | inactive (3.72%) |
FGFR2 | inactive (9.48%) |
FGFR3 | inactive (7.58%) |
FGFR4 | inactive (3.32%) |
TK - VEGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FLT1 | inactive (15.12%) |
KDR | inactive (49.6%) |
FLT4 | inactive (24.45%) |
TK - PDGFR
Bioactivity |
---|
Kinase | GPCR |
---|
FMS | inactive (26.76%) |
KIT | active (66.98%) |
FLT3 | active (54.57%) |
PDGFRa | active (78.15%) |
PDGFRb | active (68.91%) |
TK - Tie
Bioactivity |
---|
Kinase | GPCR |
---|
TIE2 | active (52.35%) |
TK - Ack
Bioactivity |
---|
Kinase | GPCR |
---|
ACK | inactive (5.3%) |
TNK1 | active (51.11%) |
TK - EGFR
Bioactivity |
---|
Kinase | GPCR |
---|
EGFR | inactive (36.17%) |
ErbB2 | inactive (-2.49%) |
ErbB4 | inactive (6.51%) |
TKL
TKL
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
IRAK | 4 | 1 |
RAF | 5 | 1 |
TKL - IRAK
Bioactivity |
---|
Kinase | GPCR |
---|
IRAK4 | inactive (3.98%) |
TKL - RAF
Bioactivity |
---|
Kinase | GPCR |
---|
BRAF | inactive (2.66%) |
STE
STE
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
STE20 | 31 | 12 |
STE7 | 7 | 1 |
STE - STE20
Bioactivity |
---|
Kinase | GPCR |
---|
GCK | inactive (19.31%) |
MST1 | inactive (11.54%) |
MST2 | inactive (6.24%) |
MST4 | inactive (13.34%) |
HGK | active (70.63%) |
MINK | active (64.68%) |
LOK | inactive (26.12%) |
PAK1 | inactive (5.41%) |
PAK3 | inactive (2.83%) |
PAK2 | inactive (1.53%) |
PAK5 | inactive (0.18%) |
PAK6 | inactive (2.62%) |
STE - STE7
Bioactivity |
---|
Kinase | GPCR |
---|
MAP2K1 | inactive (1.06%) |
CK1
CK1
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
CK1 | 7 | 4 |
CK1 - CK1
Bioactivity |
---|
Kinase | GPCR |
---|
CK1a | inactive (6.98%) |
CK1g2 | inactive (18.13%) |
CK1g1 | inactive (3.26%) |
CK1g3 | inactive (5.99%) |
Other
Other
Test Member No. in Family |
---|
Family | no. Member on 518kinase | GPCR |
---|
PLK | 4 | 1 |
Aur | 3 | 3 |
NEK | 11 | 5 |
IKK | 4 | 4 |
TTK | 1 | 1 |
Other - PLK
Bioactivity |
---|
Kinase | GPCR |
---|
PLK1 | inactive (3.03%) |
Other - Aur
Bioactivity |
---|
Kinase | GPCR |
---|
AurB | active (56.77%) |
AurC | active (88.27%) |
AurA | active (94%) |
Other - NEK
Bioactivity |
---|
Kinase | GPCR |
---|
NEK1 | inactive (15.85%) |
NEK2 | inactive (3.58%) |
NEK9 | inactive (1.08%) |
NEK7 | inactive (5.26%) |
NEK6 | inactive (-0.37%) |
Other - IKK
Bioactivity |
---|
Kinase | GPCR |
---|
TBK1 | inactive (21.49%) |
IKKe | inactive (8.67%) |
IKKb | inactive (-0.52%) |
IKKa | inactive (-1.27%) |
Other - TTK
Bioactivity |
---|
Kinase | GPCR |
---|
TTK | inactive (10.53%) |
AGC
AGC - GRK
Bioactivity |
---|
Kinase | GPCR |
---|
GPRK7 | inactive (-4.38%) |
GPRK6 | inactive (-6.34%) |
AGC - PDK1
Bioactivity |
---|
Kinase | GPCR |
---|
PDK1 | inactive (14.53%) |
AGC - RSK
Bioactivity |
---|
Kinase | GPCR |
---|
MSK1 | inactive (-1.13%) |
MSK2 | inactive (4.55%) |
RSK1 | inactive (7.83%) |
RSK2 | inactive (6.18%) |
RSK4 | inactive (6.36%) |
RSK3 | inactive (7.02%) |
p70S6K | inactive (10.31%) |
AGC - Akt
Bioactivity |
---|
Kinase | GPCR |
---|
AKT2 | inactive (-2.91%) |
AKT1 | inactive (-1.12%) |
AKT3 | inactive (-1.19%) |
AGC - SGK
Bioactivity |
---|
Kinase | GPCR |
---|
SGK1 | inactive (12.34%) |
SGK3 | inactive (1.32%) |
SGK2 | inactive (12.27%) |
AGC - PKC
Bioactivity |
---|
Kinase | GPCR |
---|
PKCh | inactive (0.52%) |
PKCg | inactive (12.44%) |
PKCa | inactive (3.62%) |
PKCt | inactive (0.62%) |
PKCi | inactive (5.26%) |
AGC - PKG
Bioactivity |
---|
Kinase | GPCR |
---|
PKG2 | inactive (4.06%) |
PKG1 | inactive (1.52%) |
AGC - PKA
Bioactivity |
---|
Kinase | GPCR |
---|
PRKX | inactive (1.36%) |
AGC - DMPK
Bioactivity |
---|
Kinase | GPCR |
---|
ROCK1 | inactive (3.41%) |
ROCK2 | inactive (8.94%) |
MRCKb | inactive (2.48%) |
MRCKa | inactive (3.38%) |
CAMK
CAMK - RAD53
Bioactivity |
---|
Kinase | GPCR |
---|
CHK2 | inactive (-0.98%) |
CAMK - DCAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
DCLK2 | inactive (-4.27%) |
CAMK - CAMK1
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK4 | inactive (-1.35%) |
CaMK1d | inactive (2.96%) |
CAMK - PHK
Bioactivity |
---|
Kinase | GPCR |
---|
PHKg1 | inactive (11.29%) |
PHKg2 | inactive (2%) |
CAMK - CAMK2
Bioactivity |
---|
Kinase | GPCR |
---|
CaMK2d | inactive (12.38%) |
CaMK2a | inactive (5.31%) |
CAMK - MAPKAPK
Bioactivity |
---|
Kinase | GPCR |
---|
MAPKAPK5 | inactive (-0.53%) |
MAPKAPK2 | inactive (-2.21%) |
MAPKAPK3 | inactive (-2.84%) |
MNK2 | active (51.98%) |
MNK1 | inactive (49.94%) |
CAMK - PKD
Bioactivity |
---|
Kinase | GPCR |
---|
PKD3 | inactive (3%) |
PKD1 | inactive (3.18%) |
PKD2 | inactive (2.86%) |
CAMK - CAMKL
Bioactivity |
---|
Kinase | GPCR |
---|
MARK4 | inactive (11.32%) |
MARK3 | inactive (18.25%) |
MARK1 | inactive (8.38%) |
QIK | inactive (20.35%) |
SIK | inactive (18.49%) |
NuaK1 | active (57.33%) |
BRSK1 | inactive (40.11%) |
BRSK2 | inactive (43.46%) |
MELK | inactive (43.84%) |
CHK1 | inactive (-2.87%) |
PASK | inactive (-3.11%) |
AMPKa1 | inactive (4.76%) |
AMPKa2 | inactive (6.79%) |
CAMK - TSSK
Bioactivity |
---|
Kinase | GPCR |
---|
TSSK2 | inactive (-1.3%) |
TSSK1 | inactive (1.92%) |
CAMK - DAPK
Bioactivity |
---|
Kinase | GPCR |
---|
DAPK1 | inactive (-5.67%) |
CAMK - PIM
Bioactivity |
---|
Kinase | GPCR |
---|
PIM2 | inactive (2.11%) |
PIM3 | inactive (-0.21%) |
PIM1 | inactive (1.57%) |
CMGC
CMGC - MAPK
Bioactivity |
---|
Kinase | GPCR |
---|
JNK2 | inactive (6.67%) |
p38a | inactive (10.69%) |
p38b | inactive (9.09%) |
p38d | inactive (7.17%) |
Erk2 | inactive (2.08%) |
Erk1 | inactive (1.84%) |
CMGC - GSK
Bioactivity |
---|
Kinase | GPCR |
---|
GSK3A | active (79.21%) |
GSK3B | active (78.07%) |
CMGC - SRPK
Bioactivity |
---|
Kinase | GPCR |
---|
SRPK1 | inactive (0.63%) |
MSSK1 | inactive (4.19%) |
CMGC - CLK
Bioactivity |
---|
Kinase | GPCR |
---|
CLK3 | inactive (9.46%) |
CLK2 | inactive (9.02%) |
CMGC - DYRK
Bioactivity |
---|
Kinase | GPCR |
---|
HIPK1 | inactive (28.31%) |
HIPK4 | inactive (39.63%) |
DYRK1B | inactive (11.04%) |
DYRK1A | inactive (28.75%) |
DYRK2 | inactive (23.68%) |
CMGC - CK2
Bioactivity |
---|
Kinase | GPCR |
---|
CK2a1 | inactive (41.6%) |